L-Hydroxyproline

1. Introduction of L-Hydroxyproline
L-Hydroxyproline, for being one kind of white crystalline powder, has the IUPAC Name of (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid. And it has the Classification Code: Mutation data. Besides, it belongs to the Product Categories which include Nitrogen cyclic compounds; PHARMACEUTICALS; Amino Acids; Pyrrole&Pyrrolidine & Pyrroline; Hydroxyproline [Hyp]; Unusual Amino Acids; Biochemistry; Biological-modified Amino Acids; L-Amino Acids; Amino Acids.

2. Properties of L-Hydroxyproline
L-Hydroxyproline has the following datas: (1)Melting Point: 273 °C (dec.)(lit.); (2)alpha: -75.5 o (c=5, H2O) ; (3)Refractive index: -75.5 °(C=4, H2O) ; (4)Storage temperature: Store at RT. ; (5)Solubility: H2O: 50 mg/mL; (6)Water Solubility: 357.8 g/L (20 °C) ; (7)Index of Refraction: 1.54; (8)Molar Refractivity: 29.49 cm3; (9)Molar Volume: 93.9 cm3; (10)Polarizability: 11.69×10-24 cm3; (11)Surface Tension: 62.2 dyne/cm; (12)Density: 1.395 g/cm3; (13)Flash Point: 168.6 °C; (14)Enthalpy of Vaporization: 69.51 kJ/mol; (15)Boiling Point: 355.2 °C at 760 mmHg; (16)Vapour Pressure: 1.8E-06 mmHg at 25 °C.

3. Structure Descriptors of L-Hydroxyproline
You could convert the following datas into the molecular structure:
(1).InChI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
(2).InChIKey: InChIKey=PMMYEEVYMWASQN-IMJSIDKUSA-N
(3).Smiles: C1[C@H](NC[C@H]1O)C(=O)O

4. Safety information of L-Hydroxyproline
Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37/39-27-26 
S24/25:Avoid contact with skin and eyes. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S27:Take off immediately all contaminated clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: TW3586500
Hazard Note: Irritant
HazardClass of L-Hydroxyproline: IRRITANT

5. Production of L-Hydroxyproline
L-Hydroxyproline is produced by hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase following protein synthesis (as a post-translational modification). The enzyme catalysed reaction takes place in the lumen of the endoplasmic reticulum.