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Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

Factory Supply (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Supplier Manufacturer With Competitive Price

Cas:22348-32-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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China Synchem Technology Co.,Ltd

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine, 22348-32-9 factory, 98% in stock Our Advantages: Rich experience in loading a great amount of containers in Chinese sea port; Fast shipment by well-reputed shipping line; P

(R)-α,α-Diphenyl-2-pyrrolidinemethanol 22348-32-9 Catalys good supplier t High quality

Cas:22348-32-9

Min.Order:10 Gram

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for th

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine TOP1 supplier

Cas:22348-32-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance White crystalline powder White crystalline powder Purity(GC)

High purity Various Specifications (R)-Diphenylprolinol CAS:22348-32-9

Cas:22348-32-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

good quality Appearance:liquid Storage:cold storage Package:meet the demand of customer Application:diagnostic reagent Transportation:by sea or by air Port:shanghai

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 2-Pyrrolidinemethanol,a,a-diphenyl-, (2R)- 22348-32-9 ISO Producer

Cas:22348-32-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

CHemwill -- (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine Basic information Product Name: (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine Synonyms: 2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-;ALPHA,ALPHA-DIPHE

TIANFU-CHEM CAS:22348-32-9 (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Cas:22348-32-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 22348-32-9 with competitive price

Cas:22348-32-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

high purity (R)-Diphenylhydroxymethyl CAS NO.22348-32-9

Cas:22348-32-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine/ LIDE PHARMA- Factory supply / Best price

Cas:22348-32-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol cas22348-32-9

Cas:22348-32-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyrrolidinemethanol,a,a-diphenyl-, (2R)- 22348-32-9

Cas:22348-32-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyrrolidinemethanol,a,a-diphenyl-, (2R)-

Cas:22348-32-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22348-32-9

Cas:22348-32-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol Synonyms: diphenyl-[(2R)-pyrrolidin-2-yl]methanol;2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-;(2R)-α,α-diphenyl-2-Pyrrolidinemethanol;2-PYRROLIDINEMETHANOL,

(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol supplier best quality

Cas:22348-32-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(R)-(+)-Diphenyl-2-Pyrrolidinemethanol

Cas:22348-32-9

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol

Cas:22348-32-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(R)-(+)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE

Cas:22348-32-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(R)-diphenyl(pyrrolidin-2-yl)methanol

Cas:22348-32-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(r)-(+)-2-(diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: (R)-(+)-2-(Diphenylhydroxymethyl)pyrro... CasNo: 22348-32-9 Molecular Formula: C17H19NO Appearance: off-white to white powder Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clien

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine TOP1 supplier CAS NO.22348-32-9

Cas:22348-32-9

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (R)-Diphenylprolinol

Cas:22348-32-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Cas:22348-32-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products R-(+)-α,α-Diphenyl-2-pyrrolidineMethanol

Cas:22348-32-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

Cas:22348-32-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Synthetic route

2-(hydroxy(diphenyl)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester
137496-68-5

2-(hydroxy(diphenyl)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 2.5h; Reflux;100%
With sodium hydroxide In ethanol at 79℃; for 4h;90%
(R)-1-tert-butyl-(λ1-oxidanyl)-(λ3-sulfanyl)-2-((methoxymethoxy)diphenylmethyl)pyrrolidine

(R)-1-tert-butyl-(λ1-oxidanyl)-(λ3-sulfanyl)-2-((methoxymethoxy)diphenylmethyl)pyrrolidine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Stage #1: (R)-1-tert-butyl-(λ1-oxidanyl)-(λ3-sulfanyl)-2-((methoxymethoxy)diphenylmethyl)pyrrolidine With hydrogenchloride In methanol at 0 - 70℃; for 4h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; methanol at 20℃; for 6h;
91%
diphenyl(pyrrolidin-2-yl)methanol
63401-04-7

diphenyl(pyrrolidin-2-yl)methanol

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-Tetrahydro-1H,3H-pyrrolo<1,2-c>oxazole-1,3-dione
90971-03-2

(R)-Tetrahydro-1H,3H-pyrrolo<1,2-c>oxazole-1,3-dione

phenylmagnesium chloride

phenylmagnesium chloride

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
In tetrahydrofuran Yield given;
diphenyl(pyrrolidin-2-yl)methanol
63401-04-7

diphenyl(pyrrolidin-2-yl)methanol

B

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Stage #1: diphenyl(pyrrolidin-2-yl)methanol With (R)-1,1'-Bi-2-naphthol; boric acid In acetonitrile Heating;
Stage #2: With hydrogenchloride In diethyl ether; water Further stages.;
benzophenone
119-61-9

benzophenone

zinc dust

zinc dust

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) s-BuLi, (-)-sparteine, 3.) AcOH
2: 90 percent / NaOH / ethanol / 4 h / 79 °C
View Scheme
phenylmagnesium chloride

phenylmagnesium chloride

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 70 percent / tetrahydrofuran / 24 h / 23 °C
2: 77 percent / BH3 / tetrahydrofuran
View Scheme
methyl 5-oxopyrrolidine-2-carboxylate
4931-66-2, 54571-66-3, 64700-65-8

methyl 5-oxopyrrolidine-2-carboxylate

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 70 percent / tetrahydrofuran / 24 h / 23 °C
2: 77 percent / BH3 / tetrahydrofuran
View Scheme
Pyroglutamic acid
149-87-1

Pyroglutamic acid

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / 5 molpercent hydrogen chloride (from acetyl chloride) / 24 h / 23 °C
2: 70 percent / tetrahydrofuran / 24 h / 23 °C
3: 77 percent / BH3 / tetrahydrofuran
View Scheme
5-(hydroxy-diphenyl-methyl)-pyrrolidin-2-one
21901-76-8

5-(hydroxy-diphenyl-methyl)-pyrrolidin-2-one

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 77 percent / BH3 / tetrahydrofuran
View Scheme
C24H25NO
356790-44-8

C24H25NO

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 18h; Inert atmosphere;
C20H23NO3

C20H23NO3

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
With potassium hydroxide In methanol for 48h; Reflux;
phenylmagnesium chloride
100-59-4

phenylmagnesium chloride

1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate
73323-65-6

1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Stage #1: phenylmagnesium chloride; 1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate In tetrahydrofuran at 10 - 60℃; Industrial scale;
Stage #2: With hydrogenchloride In water at 45℃; for 9h; Industrial scale;
Stage #3: With sodium hydroxide Industrial scale;
n/a
((methoxymethoxy)methylene)dibenzene
223930-75-4

((methoxymethoxy)methylene)dibenzene

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -40 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: hydrogenchloride / methanol / 4 h / 0 - 70 °C
2.2: 6 h / 20 °C
View Scheme
3-chloro-n-propanesulfonyl chloride
1633-82-5

3-chloro-n-propanesulfonyl chloride

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)diphenylmethanol
1370293-21-2

(R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;100%
Triisopropyl borate
5419-55-6

Triisopropyl borate

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

ethylene glycol
107-21-1

ethylene glycol

(R)-2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine

(R)-2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine

Conditions
ConditionsYield
In toluene at 80℃; for 1h; Inert atmosphere;100%
Stage #1: Triisopropyl borate; ethylene glycol In toluene Inert atmosphere; Reflux;
Stage #2: (R)-α,α-diphenylprolinol In toluene at 80℃; for 1h; Inert atmosphere; Reflux;
100%
Stage #1: Triisopropyl borate; ethylene glycol In toluene Inert atmosphere; Reflux;
Stage #2: (R)-α,α-diphenylprolinol In toluene at 80℃; for 1h; Inert atmosphere;
90%
phenylbis(diisopropylamino)borane
47127-05-9

phenylbis(diisopropylamino)borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazoborolidine

(S)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazoborolidine

Conditions
ConditionsYield
In tetrahydrofuran; toluene reflux for 30 min; solvents are removed;96%
butylbis(diisopropylamino)borane
151293-62-8

butylbis(diisopropylamino)borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole

(S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole

Conditions
ConditionsYield
In tetrahydrofuran; toluene reflux for 30 min; solvents are removed;95%
chloromethyldiphenylsilane
144-79-6

chloromethyldiphenylsilane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-2-(((methyldiphenylsilyl)oxy)diphenylmethyl)pyrrolidine

(R)-2-(((methyldiphenylsilyl)oxy)diphenylmethyl)pyrrolidine

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 24h;93%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

2-iodo-4,4-dimethyl-cyclohex-2-enone
157952-85-7

2-iodo-4,4-dimethyl-cyclohex-2-enone

(S)-2-iodo-4,4-dimethyl-2-cyclohexen-1-ol

(S)-2-iodo-4,4-dimethyl-2-cyclohexen-1-ol

Conditions
ConditionsYield
Stage #1: (R)-α,α-diphenylprolinol With Trimethyl borate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: 2-iodo-4,4-dimethyl-cyclohex-2-enone With N,N-diethylaniline borane In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
92%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

N-((2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)-methyl)-tetrahydro-2H-pyran-2-yl)-2,2,2-trichloroacetamide
99701-64-1

N-((2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)-methyl)-tetrahydro-2H-pyran-2-yl)-2,2,2-trichloroacetamide

C52H54N2O7
1158857-93-2

C52H54N2O7

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 25℃; Inert atmosphere;90%
With caesium carbonate In N,N-dimethyl-formamide at 25℃; Schlenk technique; Inert atmosphere;90%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

ethylene glycol
107-21-1

ethylene glycol

(R)-2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine

(R)-2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine

Conditions
ConditionsYield
With Triisopropyl borate90%
Stage #1: ethylene glycol With Triisopropyl borate In toluene at 105℃; Inert atmosphere;
Stage #2: (R)-α,α-diphenylprolinol In toluene for 1h; Inert atmosphere;
methylbis(diisopropylamino)borane
151293-60-6

methylbis(diisopropylamino)borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In tetrahydrofuran; toluene reflux for 30 min; solvents are removed;89%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

(R)-(1-((2-nitrophenyl)sulfonyl)pyrrolidin-2-yl)diphenylmethanol

(R)-(1-((2-nitrophenyl)sulfonyl)pyrrolidin-2-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;85%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
112022-81-8

(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In n-heptane at 40℃; Solvent; Temperature; Inert atmosphere; Reflux; Large scale;83%
2,6-bis-(bromomethyl)pyridine
7703-74-4

2,6-bis-(bromomethyl)pyridine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(2R,2'R)-1,1'-(pyridine-2,6-diylbis(methylene))bis[2-(diphenylmethanol)pyrrolidine]
1310579-92-0

(2R,2'R)-1,1'-(pyridine-2,6-diylbis(methylene))bis[2-(diphenylmethanol)pyrrolidine]

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethanol at 20℃; for 8h;78%
2-(bromomethyl)pyridine hydrobromide
31106-82-8

2-(bromomethyl)pyridine hydrobromide

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-2-(diphenylmethanol)-1-(pyridin-2-ylmethyl)pyrrolidine
132902-42-2

(R)-2-(diphenylmethanol)-1-(pyridin-2-ylmethyl)pyrrolidine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethanol at 20℃; for 10h;76%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid
2950-83-6

4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid

(R)-1-(4-(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione
1204659-22-2

(R)-1-(4-(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;66%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

N-Benzyloxycarbonyl-L-proline
1148-11-4

N-Benzyloxycarbonyl-L-proline

(S)-2-[(R)-2-(Hydroxy-diphenyl-methyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid benzyl ester

(S)-2-[(R)-2-(Hydroxy-diphenyl-methyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In chloroform for 12h;65%
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

4-chlorophenylglyoxal
4998-15-6

4-chlorophenylglyoxal

1-(4-chlorophenyl)-2-[2-(diphenylmethylene)pyrrolidin-1-yl]ethane-1,2-dione
1620212-19-2

1-(4-chlorophenyl)-2-[2-(diphenylmethylene)pyrrolidin-1-yl]ethane-1,2-dione

Conditions
ConditionsYield
With gold(III) tribromide In dichloromethane at 60℃; for 12h; Schlenk technique;62%
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine
1236033-34-3

(R)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 22℃; for 12h; Inert atmosphere;56%
(2-formylphenyl)(diphenyl)phosphine
50777-76-9

(2-formylphenyl)(diphenyl)phosphine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(2R,5R)-1-aza-2-(2-diphenylphosphino)phenyl-3-oxa-4,4-diphenylbicyclo[3.3.0]octane

(2R,5R)-1-aza-2-(2-diphenylphosphino)phenyl-3-oxa-4,4-diphenylbicyclo[3.3.0]octane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 24h; Cycloaddition; Heating;54%
(1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octane-2,5-diene-2-carboxylic acid
1252606-18-0

(1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octane-2,5-diene-2-carboxylic acid

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

((R)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)((1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-dien-2-yl)methanone

((R)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)((1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-dien-2-yl)methanone

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃; for 16h; Inert atmosphere; Schlenk technique;31%
Trimethylboroxine
823-96-1

Trimethylboroxine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
112022-83-0

(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Conditions
ConditionsYield
In toluene Heating;
With borane In toluene at 20 - 150℃; for 4.5h;
In toluene at 20℃; for 0.5h;
Trimethyl borate
121-43-7

Trimethyl borate

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-2-methoxy-CBS-oxazaborolidine

(R)-2-methoxy-CBS-oxazaborolidine

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 45℃; for 10h;
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
In tetrahydrofuran
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #1: Trimethyl borate; (R)-α,α-diphenylprolinol In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
Stage #2: With dimethylsulfide borane complex In tetrahydrofuran Inert atmosphere;
(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-(+)-2-methyl-CBS-oxazaborolidine

(R)-(+)-2-methyl-CBS-oxazaborolidine

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 45℃; for 10h;
With dimethylsulfide borane complex In tetrahydrofuran; toluene at 20℃; for 1h; Inert atmosphere;
With borane-THF
tri-o-tolylboroxine
7294-50-0

tri-o-tolylboroxine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

bis(trifluoromethanesulfonyl)amide
82113-65-3

bis(trifluoromethanesulfonyl)amide

(R)-(+)-3,3-diphenyl-1-o-tolyl-tetrahydropyrrolo-(1,2-c)(1,3,2)oxazaborole-1,1,1-trifluoro-N-((trifluoromethyl)-sulfonyl)methanesulfonamide

(R)-(+)-3,3-diphenyl-1-o-tolyl-tetrahydropyrrolo-(1,2-c)(1,3,2)oxazaborole-1,1,1-trifluoro-N-((trifluoromethyl)-sulfonyl)methanesulfonamide

Conditions
ConditionsYield
Stage #1: tri-o-tolylboroxine; (R)-α,α-diphenylprolinol With 4A MS In toluene for 3h; Heating;
Stage #2: bis(trifluoromethanesulfonyl)amide In dichloromethane at -25℃; for 0.25h;
tri-o-tolylboroxine

tri-o-tolylboroxine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

bis(trifluoromethanesulfonyl)amide
82113-65-3

bis(trifluoromethanesulfonyl)amide

(R)-(+)-3,3-diphenyl-1-o-tolyl-tetrahydropyrrolo-(1,2-c)(1,3,2)oxazaborole-1,1,1-trifluoro-N-((trifluoromethyl)-sulfonyl)methanesulfonamide

(R)-(+)-3,3-diphenyl-1-o-tolyl-tetrahydropyrrolo-(1,2-c)(1,3,2)oxazaborole-1,1,1-trifluoro-N-((trifluoromethyl)-sulfonyl)methanesulfonamide

Conditions
ConditionsYield
Stage #1: tri-o-tolylboroxine; (R)-α,α-diphenylprolinol In toluene at 145℃; for 3h;
Stage #2: bis(trifluoromethanesulfonyl)amide In toluene at -20℃; for 0.333333h;
tri-o-tolylboroxine
7294-50-0

tri-o-tolylboroxine

(R)-α,α-diphenylprolinol
22348-32-9

(R)-α,α-diphenylprolinol

(R)-2-(o-methyl)phenyl-CBS-oxazaborolidine

(R)-2-(o-methyl)phenyl-CBS-oxazaborolidine

Conditions
ConditionsYield
In toluene Heating;
With 4 A molecular sieve In toluene Heating;
In toluene for 20h; Reflux;
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