Meldrum's acid supplier | CasNO.2033-24-1

Name
2,2-Dimethyl-1,3-dioxane-4,6-dione
EINECS 217-992-8
CAS No. 2033-24-1
Article Data56
CAS DataBase
Density 1.201 g/cm³
Solubility 2.5 g/100 mL (20 °C) in water
Melting Point 92-96 °C(lit.)
Formula C₆H₈O₄
Boiling Point 356.7 °C at 760 mmHg
Molecular Weight 144.127
Flash Point 195.1 °C
Transport Information
Appearance white to beige crystals
Safety 37/39-24/25-53-45-36-26
Risk Codes 36/37/38-45
Molecular Structure
Hazard Symbols Xi, T
Synonyms 2,2-Dimethyl-1,3-dioxan-4,6-dione;2,2-Dimethyl-4,6-dioxo-1,3-dioxane;2,2-Dimethyl-m-dioxane-4,6-dione;2,2-Propanediol cyclic malonate;Cyclic isopropylidene malonate;Isopropylidenemalonate;Meldrumic acid;
PSA 52.60000
LogP 0.21260

Synthetic route

: 34107-52-3
2,2-dimethyl-5-(phenyl-λ3-iodaneylidene)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 591-50-4
iodobenzene

C: 67-64-1
acetone

Conditions

Conditions	Yield
With dirhodium tetraacetate In dichloromethane at 20℃; Product distribution;	A 33% B 100% C 5%

...Expand

: 5-(bis(4-tert-phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 19099-48-0
1,1-bis(4-t-butylphenyl)methane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 99%

: 5-((2-methoxyphenyl)(phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 883-90-9
o-benzyl anisole

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 98%

: 1190929-81-7
5-(bis(4-methoxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 726-18-1
4,4'-dianisylmethane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 96%

: 5-((4-(tert-butyl)phenyl)(phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 16251-99-3
1-benzyl-4-tert-butylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 96%

: 5-((3-methoxyphenyl)(phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 23450-27-3
m-benzylanisole

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 95%

: 68695-08-9
6,6-dimethyl-4,8-dioxo-5,7-dioxa-1,2-diazaspiro<2.5>oct-1-ene

: 2033-24-1
cycl-isopropylidene malonate

Conditions

Conditions	Yield
With benzophenone In methanol Irradiation;	93%

: 5-(bis(3-methoxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 51095-48-8
bis(3-methoxyphenyl)methane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 93%

: 5-(2-(4-isopropylphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 100-18-5
1,4-bis(1-methylethyl)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 65℃; under 760.051 Torr; for 96h; Sealed tube;	A n/a B 91%

: 1190929-78-2
2,2-dimethyl-5-(2-(4-(octyloxy)phenyl)hexan-2-yl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 1190929-84-0
1-(hexan-2-yl)-4-(octyloxy)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 90%

: 1190929-75-9
2,2-dimethyl-5-(2-(2-(octyloxy)phenyl)propan-2-yl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 1190929-83-9
1-isopropyl-2-(octyloxy)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 48h;	A n/a B 90%

: 5-(2-(4-butylphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 55169-03-4
1-butyl-4-(1-methylethyl)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 90%

: 1190929-77-1
2,2-dimethyl-5-(2-(4-(octyloxy)phenyl)butan-2-yl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 148924-08-7
1-(sec-butyl)-4-octyloxybenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 86%

: 1098072-98-0
5-[1-(2-ethylphenyl)-1-methylethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 18970-44-0
1-ethyl-2-isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 83%

: 1190929-76-0
2,2-dimethyl-5(1-(4-(octyloxy)phenyl)cyclohexyl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 172752-17-9
1-cyclohexyl-4-(octyloxy)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 82%

: 5-(2-(4-isopropoxyphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 28530-36-1
1-isopropoxy-4-isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 82%

: 1266101-51-2
5-((4-fluorophenyl)(4-methoxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 38695-26-0
1-(4-fluorobenzyl)-4-methoxybenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 81%

: 1266101-38-5
5-((4-fluorophenyl)(phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 587-79-1
4-fluorodiphenylmethane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 81%

: 5-(2-(4-neopentylphenyl)propan-2-yl)-2,2-dimethy-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 37920-33-5
1-isopropyl-4-neopentylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 81%

: 81710-07-8
2,2-dimethyl-5-(1-methyl-1-phenylethyl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 98-82-8
Isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A 80% B n/a

: 1190929-69-1
5-(2-([1,1'-biphenyl]-4-yl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 7116-95-2
4-isopropylbiphenyl

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 80%

: 1381982-75-7
5-(2-(3-(tert-butyl)phenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 20033-12-9
1-tert-butyl-3-isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 65℃; under 760.051 Torr; for 24h; Sealed tube;	A n/a B 80%

: 141-82-2
malonic acid

: 67-64-1
acetone

: 2033-24-1
cycl-isopropylidene malonate

Conditions

Conditions	Yield
With sulfuric acid; acetic anhydride at 60℃;	78%
Stage #1: malonic acid With sulfuric acid; acetic anhydride at 0℃; for 1h; Stage #2: acetone In acetic anhydride at 0℃; for 30h;	77%
With sulfuric acid; acetic anhydride at -5 - 0℃; for 3h;	70.9%

: 1190929-65-7
2,2-dimethyl-5-(2-(4-(octyloxy)phenyl)propan-2-yl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 1190929-82-8
1-isopropyl-4-(octyloxy)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 78%

: 1381982-70-2
5-(2-(4-(tert-butyl)phenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 4132-49-4
p-tert.-Butyl-cumol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 65℃; under 760.051 Torr; for 48h; Sealed tube;	A n/a B 76%

: 5-(2-(4-isobutylphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 34349-70-7
1-isobutyl-4-isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 72%

: 1190929-79-3
2,2-dimethyl-5-(3-methyl-2-(4-(octyloxy)phenyl)butan-2-yl)-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 1190929-85-1
1-(3-methylbutan-2-yl)-4-(octyloxy)benzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	A n/a B 70%

: 5-(2-(4-(tert-butoxy)phenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

A: 2033-24-1
cycl-isopropylidene malonate

B: 16215-76-2
1-tert-butoxy-4-isopropylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 48h;	A n/a B 70%

: 67-56-1
methanol

: 7270-63-5
5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dion

A: 68695-08-9
6,6-dimethyl-4,8-dioxo-5,7-dioxa-1,2-diazaspiro<2.5>oct-1-ene

B: 2033-24-1
cycl-isopropylidene malonate

C: 62609-79-4
methyl 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylate

D: 97801-91-7
2,2-dimethyl-4,6-dioxo-5-methoxy-1,3-dioxane

Conditions

Conditions	Yield
for 1.16667h; Product distribution; Irradiation;	A 4.5% B 3% C 64% D 2.5%
In tetrahydrofuran at 18 - 20℃; for 9h; UV-irradiation;	A 23% B 8% C 25% D n/a

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 96-17-3, 57456-98-1
2-Methylbutyraldehyde

: 2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-05-7
d,l-2-ethylhexanal

: 93498-12-5
5-(2-Ethyl-1-pyrrolidin-1-yl-hexyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 100-52-7
benzaldehyde

: 93498-11-4
2,2-Dimethyl-5-(phenyl-pyrrolidin-1-yl-methyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-38-6
propionaldehyde

: 93498-07-8
2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-72-8
butyraldehyde

: 93498-08-9
2,2-Dimethyl-5-(1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 78-84-2
isobutyraldehyde

: 93498-09-0
2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 674-82-8
4-methyleneoxetan-2-one

: 2033-24-1
cycl-isopropylidene malonate

: 84257-12-5
2,2-dimethyl-5-(1-hydroxy-3-oxobutylidene)-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%
Stage #1: 4-methyleneoxetan-2-one; cycl-isopropylidene malonate With triethylamine In dichloromethane at 0 - 20℃; for 2h; Stage #2: With hydrogenchloride In dichloromethane; water	100%
With triethylamine In dichloromethane at 20℃;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 39082-53-6
1,1-bis(phenylsulfonyl)ethylene

: 87625-91-0
5-(2,2-Bis-benzenesulfonyl-ethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
N-benzyl-trimethylammonium hydroxide In 1,4-dioxane	100%

: 2033-24-1
cycl-isopropylidene malonate

: 91238-98-1
(+/-)-3-Methyl-4,4,4-trichlorobutanoyl Chloride

: 91265-41-7
2,2-Dimethyl-5-(4,4,4-trichloro-3-methyl-butyryl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane 1. 1 h/-5 deg C 2. 30 min/room temperature;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 88373-61-9
Rhodinoic acid chloride

: 88373-62-0
5-(3,7-Dimethyl-oct-7-enoyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 107798-95-8
C18H14N4O2

: 103865-88-9
2-<(4,4-dimethyl-2,6-dioxo-3,5-dioxanylidene)methyl>-3-methylindole

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 0.333333h; Ambient temperature;	100%
With triethylamine In tetrahydrofuran for 0.5h; Ambient temperature; Yield given;

: 2033-24-1
cycl-isopropylidene malonate

: 142-61-0
Hexanoyl chloride

: 254907-27-2
2,2-dimethyl-5-(1-oxohexyl)-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 16h; Inert atmosphere;	100%
With pyridine In dichloromethane	62%
With pyridine In dichloromethane Ambient temperature;

: 2033-24-1
cycl-isopropylidene malonate

: 122-51-0
orthoformic acid triethyl ester

: 15568-86-2
5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
at 80℃; for 3h;	100%
With zinc diacetate at 90℃; for 1h; Condensation;	85%
at 105℃; for 2h;	80%

: 2033-24-1
cycl-isopropylidene malonate

: 103-80-0
phenylacetyl chloride

: 66696-84-2
5-(1-hydroxy-2-phenylethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Acylation;	100%
With dmap Inert atmosphere;	75%
Stage #1: cycl-isopropylidene malonate With pyridine In dichloromethane at 0℃; Stage #2: phenylacetyl chloride In dichloromethane at 0 - 20℃; Stage #3: With hydrogenchloride In dichloromethane; water Cooling with ice;	71%

: 2033-24-1
cycl-isopropylidene malonate

: 75-65-0
tert-butyl alcohol

: 40052-13-9
mono-tert-butyl malonate

Conditions

Conditions	Yield
for 6h; Reflux;	100%
Reflux;	97%
Stage #1: cycl-isopropylidene malonate; tert-butyl alcohol for 5h; Reflux; Stage #2: With ammonia; water In ethanol at 5℃; for 0.0833333h; Stage #3: With hydrogenchloride In water	62%

: 2033-24-1
cycl-isopropylidene malonate

: 7270-63-5
5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dion

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; 4-toluenesulfonyl azide; triethylamine for 3h; Ambient temperature;	100%
With 2-azido-1,3-dimethylimidazolinium chloride; triethylamine In tetrahydrofuran at 0℃; for 0.166667h;	95%
With 2-azido-1,3-dimethylimidazolinium chloride; triethylamine In tetrahydrofuran at 0℃; for 0.166667h; Inert atmosphere;	95%

: 2033-24-1
cycl-isopropylidene malonate

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 109579-08-0
(S)-[1-benzyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h;	100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 12h; Inert atmosphere;	95%
Stage #1: cycl-isopropylidene malonate; N-tert-butoxycarbonyl-L-phenylalanine With dmap In dichloromethane for 0.166667h; Cooling with ice; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 10h; Cooling with ice;	77%

: 2033-24-1
cycl-isopropylidene malonate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 146380-13-4
5-(cyclopropyl(hydroxy)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Acylation;	100%
Stage #1: cycl-isopropylidene malonate With pyridine In dichloromethane at 0℃; for 0.25h; Stage #2: cyclopropanecarboxylic acid chloride In dichloromethane at 0 - 20℃; for 3h;	60%
With pyridine In dichloromethane at 0 - 20℃; for 3h; Acylation;

: 2033-24-1
cycl-isopropylidene malonate

: 123-08-0
4-hydroxy-benzaldehyde

: 17474-27-0
5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
at 50℃; for 1h; Knoevenagel condensation;	100%
In water; toluene at 23 - 33℃; for 4.66667h; Knoevenagel condensation; Large scale reaction;	99%
With cobalt(III) oxide In water for 0.0833333h; Knoevenagel Condensation; Reflux;	99%

: 2033-24-1
cycl-isopropylidene malonate

: 100-10-7
4-dimethylamino-benzaldehyde

: 15795-57-0
5-(4-N,N-dimethylaminobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
at 50℃; for 1h; Knoevenagel condensation;	100%
With ethylammonium nitrate at 20℃; for 0.5h; Knoevenagel condensation;	97%
In various solvent(s) at 20℃; for 0.5h; Knoevenagel condensation;	97%

: 2033-24-1
cycl-isopropylidene malonate

: 67-63-0
isopropyl alcohol

: 56766-77-9
i-propyl malonic half ester

Conditions

Conditions	Yield
In acetonitrile for 22h; Heating;	100%
Reflux;	76%
In toluene for 5h; Heating;

: 2033-24-1
cycl-isopropylidene malonate

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 112700-36-4, 112700-37-5
(2'S)-5-<(1-hydroxy-3-phenyl-2-t-butoxycarbonylamino)-propylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃; for 14h; Inert atmosphere;
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;

: 2033-24-1
cycl-isopropylidene malonate

: 18942-49-9
Boc-D-Phe-OH

: 112700-37-5
5-[(2R)-2-(tert-Butoxycarbonylamino)-1-hydroxy-3-phenylpropylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 2h;

: 2033-24-1
cycl-isopropylidene malonate

: 89-95-2
2-methyl-benzyl alcohol

: 531-81-7
2-oxo-2H-chromene-3-carboxylic acid

Conditions

Conditions	Yield
With piperdinium acetate In ethanol for 2h; Heating;	100%
With piperidine; acetic acid In benzene Knoevenagel condensation; Heating;	92%
With lithium perchlorate for 0.0138889h; Irradiation;	89%

: 2033-24-1
cycl-isopropylidene malonate

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 2555-20-6
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid

Conditions

Conditions	Yield
With piperdinium acetate In ethanol for 2h; Heating;	100%
In water for 1h; Reflux;	99%
With β‐cyclodextrin In water at 70℃; for 0.25h; Green chemistry;	97%

: 2033-24-1
cycl-isopropylidene malonate

: 106-28-5
Farnesol

: 3-oxo-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyloxy)propanoic acid

Conditions

Conditions	Yield
In toluene at 100℃; Inert atmosphere;	100%
In toluene Heating;	85%

: 2033-24-1
cycl-isopropylidene malonate

: 642442-36-2
[3-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-5-hydroxymethyl-phenyl]-methanol

: Malonic acid mono-[3-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-5-(2-carboxy-acetoxymethyl)-benzyl] ester

Conditions

Conditions	Yield
at 120℃; for 4h;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 642442-37-3
{3-[3,5-bis-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-benzyloxy]-5-hydroxymethyl-phenyl}-methanol

: Malonic acid mono-[3-[3,5-bis-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-benzyloxy]-5-(2-carboxy-acetoxymethyl)-benzyl] ester

Conditions

Conditions	Yield
at 120℃; for 4h;	100%

: 2033-24-1
cycl-isopropylidene malonate

: C113H164O41

: C119H168O47

Conditions

Conditions	Yield
at 120℃; for 4h;	100%

Meldrum's acid Consensus Reports

Reported in EPA TSCA Inventory.

Meldrum's acid Standards and Recommendations

ASSAY: 98.0% min
LOSS ON DRYING: 0.5% max

Meldrum's acid Specification

Meldrum's acid , its cas register number is 2033-24-1. It also can be called 2,2-Dimethyl-1,3-dioxane-4,6-dione; 2,2-Dimethyl-4,6-dioxo-m-dioxane; 2,2-Dimethyl-m-dioxane-4,6-dione; Isopropylidene malonate; m-Dioxane-4,6-dione, 2,2-dimethyl-; 1,3-Dioxane-4,6-dione, 2,2-dimethyl- ; Malonic acid, cyclic isopropylidene ester (8CI). It is a brown white solid. Meldrum's acid is an intermediate for different organic syntheses. It is an important intermediate in syntheses of vitamins B1 and B6, barbiturate, non-steroidal anti-inflammatory agent, other numerous pharmaceutical, agrochemical and flavor & fragrance compound. As an alternative to its original preparation, Meldrum's acid can be synthesized from malonic acid, isopropenyl acetate, and catalytic sulfuric acid.

Physical properties about Meldrum's acid are: (1)ACD/LogP: -1.579; (2)ACD/LogD (pH 5.5): -1.58; (3)ACD/LogD (pH 7.4): -1.58; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 3.30; (7)ACD/KOC (pH 7.4): 3.30; (8)#H bond acceptors: 4; (9)Index of Refraction: 1.434; (10)Molar Refractivity: 31.24 cm³; (11)Molar Volume: 119.95 cm³; (12)Polarizability: 12.384 10-24cm³; (13)Surface Tension: 33.2239990234375 dyne/cm; (14)Density: 1.202 g/cm³; (15)Flash Point: 195.118 °C; (16)Enthalpy of Vaporization: 60.204 kJ/mol; (17)Boiling Point: 356.749 °C at 760 mmHg

When you are using Meldrum's acid, please be cautious about it as the following:
1. Wear suitable gloves and eye/face protection;
2. Avoid contact with skin and eyes;
3. Avoid exposure - obtain special instruction before use;
4. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
5. Wear suitable protective clothing;
6. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3;
(2)InChIKey=GXHFUVWIGNLZSC-UHFFFAOYSA-N;
(3)SmilesC1(OC(CC(O1)=O)=O)(C)C;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04102,

Product Name

2,2-Dimethyl-1,3-dioxane-4,6-dione

Synthetic route

Meldrum's acid Consensus Reports

Meldrum's acid Standards and Recommendations

Meldrum's acid Specification

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