Mesitylene supplier | CasNO.108-67-8

Name
Mesitylene
EINECS 203-604-4
CAS No. 108-67-8
Article Data397
CAS DataBase
Density 0.869 g/cm³
Solubility 2.9 g/L (20 °C) in water
Melting Point -45 °C
Formula C₉H₁₂
Boiling Point 166.7 °C at 760 mmHg
Molecular Weight 120.194
Flash Point 44.4 °C
Transport Information UN 2325 3/PG 3
Appearance colorless liquid with a peculiar odor
Safety 61-45-36/37-16-7
Risk Codes 10-37-51/53-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols Xi,N,F,T
Synonyms Mesitylene(8CI);1,3,5-Trimethylbenzene;2,4,6-Trimethylbenzene;3,5-Dimethyltoluene;NSC9273;sym-Trimethylbenzene;
PSA 0.00000
LogP 2.61180

Synthetic route

: 3112-82-1
(2,4,6-trimethylphenyl) phenyl sulfone

A: 618-41-7
Benzenesulfinic acid

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With lithium amalgam In N,N-dimethyl-formamide for 2h; Ambient temperature;	A 99% B 100%

: 85656-15-1
C31H38OSi

A: 4705-87-7
1,2,3,3-tetramethyl-1H-indene

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
electrlysis, at 1.5 V, electrolyte: tetrabutylammonium perchlorate, in CH2Cl2;	A 100% B 166 %
In dichloromethane electrolysis, at 1.5 V; electrolyte: tetrabutylammonium perchlorate;	A 100% B 166 %

: 110-91-8
morpholine

: 75732-01-3
mesitylcopper(I)

A: 77590-49-9
C4H8NO(1-)*Cu(1+)

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of amine;; evapd. or filtered; elem. anal.;;	A n/a B 100%

...Expand

: 75732-01-3
mesitylcopper(I)

: 7664-41-7
ammonia

A: 77590-45-5
amino-copper

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of NH3;; evapd. or filtered; elem. anal.;;	A n/a B 100%

...Expand

: 99506-43-1
2,4,6-trimethylphenyl(m-carboran-9-yl)iodonium tetrafluoroborate

: 7647-14-5
sodium chloride

A: 17157-02-7
9-iodo-m-carborane

B: 17819-85-1
9-chloro-m-carborane

C: 4028-63-1
iodomesitylene

D: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In chloroform; water mixt. of aryl(m-carboran-9-yl)iodonium tetrafluoroborate, NaF, water and chloroform was vigorously stirred under reflux at 56°C, 2.5 h; internal standard (chlorobenzene) added and org. layer was analysed by GLC;	A 0% B 100% C 100% D 0%

...Expand

: 82965-02-4
hexyl 2,4,6-trimethylbenzenesulfonate

A: 108-67-8
1,3,5-trimethyl-benzene

B: 111-27-3
hexan-1-ol

Conditions

Conditions	Yield
With lithium amalgam In N,N-dimethyl-formamide; toluene Product distribution; Mechanism; further solvents;	A 85% B 99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With potassium fluoride In tetrahydrofuran; water at 80℃; for 8h; Time; Schlenk technique; Sealed tube; Inert atmosphere;	99%
With [2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine]ruthenium(II) chlorocarbonyl hydride; isopropyl alcohol; sodium t-butanolate at 100℃; for 48h; Inert atmosphere; Sealed tube; Green chemistry;	89%
With isopropyl alcohol at 20℃; for 24h; UV-irradiation; chemoselective reaction;	88%

: 75732-01-3
mesitylcopper(I)

: 109-73-9
N-butylamine

A: 77590-46-6
copper(I) n-butylamide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of amine;; evapd. or filtered; elem. anal.;;	A n/a B 98%

...Expand

: 3112-79-6
dimesityl sulfone

A: 59057-35-1
2,4,6-trimethylbenzenesulphinic acid

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With lithium amalgam In N,N-dimethyl-formamide for 2h; Ambient temperature;	A 92% B 97%

: 106-51-4
p-benzoquinone

: 2633-66-1
2-mesitylmagnesium bromide

A: 4-hydroxy-4-(2,4,6-trimethylphenyl)-2,5-cyclohexadiene

B: 123-31-9
hydroquinone

C: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran Grignard reaction;	A 97% B 3% C 4%

...Expand

: 75732-01-3
mesitylcopper(I)

: 111-92-2
dibutylamine

A: 77590-48-8
copper(I) N,N-di-n-butylamide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., stirring overnight;; evapd. in vac., washed with hexane, dried in vac., crystd. from hexane at -15°C; elem. anal.;;	A n/a B 95%

...Expand

: 95-49-8
2-methylchlorobenzene

: 5980-97-2
mesitylboronic acid

A: 89970-02-5
2,2',4,6-tetramethylbiphenyl

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With potassium phosphate; tris(dibenzylideneacetone)dipalladium (0); tricyclohexylphosphine In toluene at 90℃; for 37h; Suzuki cross-coupling; Title compound not separated from byproducts.;	A 93% B 5%

...Expand

: ethylmesitylsilane

A: 108-67-8
1,3,5-trimethyl-benzene

B: ethyl iodosilane

Conditions

Conditions	Yield
With hydrogen iodide at -35℃; for 168000h; sealed tube;	A n/a B 92%

: 75732-01-3
mesitylcopper(I)

: 109-89-7
diethylamine

A: 71426-07-8
copper(I) N,N-diethylamide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of amine;; evapd. or filtered; elem. anal.;;	A n/a B 92%

...Expand

: 480-63-7
mesitylenecarboxylic acid

: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With [Au(1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)(O2CAd)] In toluene at 140℃; for 20h;	90%
With triethylsilane; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane In toluene at 160℃; for 15h; chemoselective reaction;	90%
With Nafion-H In toluene at 100℃; for 12h;	80%

: 110-89-4
piperidine

: 75732-01-3
mesitylcopper(I)

A: 73680-02-1
copper piperidide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of amine;; evapd. or filtered; elem. anal.;;	A n/a B 90%

...Expand

: 82965-02-4
hexyl 2,4,6-trimethylbenzenesulfonate

A: 145385-15-5
lithium 2,4,6-trimethylbenzenesulfinate

B: 108-67-8
1,3,5-trimethyl-benzene

C: 111-27-3
hexan-1-ol

Conditions

Conditions	Yield
With lithium amalgam In 1,4-dioxane; toluene Product distribution; Mechanism; further solvents;	A 21% B 61% C 88%

...Expand

: 75732-01-3
mesitylcopper(I)

: 62-53-3
aniline

A: 77590-50-2
copper(I) anilide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of aniline;; evapd. or filtered; elem. anal.;;	A n/a B 88%

...Expand

: 75732-01-3
mesitylcopper(I)

: 75-64-9
tert-butylamine

A: 77590-47-7
copper(I) t-butylamide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In tetrahydrofuran THF, ambient temp., excess of amine;; evapd. or filtered; elem. anal.;;	A n/a B 87%

...Expand

: 82965-02-4
hexyl 2,4,6-trimethylbenzenesulfonate

A: 59057-35-1
2,4,6-trimethylbenzenesulphinic acid

B: 108-67-8
1,3,5-trimethyl-benzene

C: 111-27-3
hexan-1-ol

Conditions

Conditions	Yield
With lithium amalgam In 1,4-dioxane at 23℃; for 2h;	A 69% B 10% C 85%

...Expand

: C23H26BF6O(1-)*K(1+)

A: 1547-23-5
C5H3F5

B: 21223-06-3
1,1,1-trifluoro-2-trifluoromethyl-2-butene

C: 4,4,4-Trifluoro-3-trifluoromethyl-but-1-ene

D: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In solid at 200℃; under 0.07 Torr; for 0.0125h;	A 11% B 48% C 3% D 83%

...Expand

: 576-83-0
2,4,6-trimethylphenyl bromide

: 1631-73-8
trimethylstannane

A: 1527-99-7
n-butyltrimethyltin

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With n-butyllithium In hexane 2-bromomesitylene (1 equiv.) and TMTH (1 equiv.) in hexane cooled to 0°C under Ar, n-BuLi (1 equiv., 2.40 M in hexane) added, stirred for 5 h at reflux temp., quenched with water; analyzed by GC;	A 83% B 38%
With n-butyllithium In hexane 2-bromomesitylene (1 equiv.) and TMTH (1 equiv.) in hexane cooled to 0°C under Ar, n-BuLi (1 equiv., 2.40 M in hexane) added, stirred for 15 min, quenched with water; analyzed by GC;	A 33% B 11%

...Expand

: 576-83-0
2,4,6-trimethylphenyl bromide

A: 392-69-8
1-fluoro-2,4,6-trimethylbenzene

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
Stage #1: 2,4,6-trimethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; Flow reactor; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at 0℃; Reagent/catalyst; Flow reactor;	A 82% B 10%

: 2571-52-0
cyanomesitylene

: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triisopropyl phosphite; chlorotriisopropylsilane In ethyl-cyclohexane at 160℃; for 15h; Inert atmosphere;	81%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triisopropyl phosphite; chlorotriisopropylsilane In ethylcyclohexane at 160℃; for 15h; Inert atmosphere;	81%

: 392-69-8
1-fluoro-2,4,6-trimethylbenzene

: 128190-66-9, 25088-58-8
potassium enolate of acetone

A: 42797-68-2
1-(2,4,6-trimethylphenyl)-2-propanone

B: 27645-30-3
1-(2,4,6-Trimethylphenyl)-2-propanol

C: 88-05-1
2,4,6-trimethylaniline

D: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With ammonia; potassium amide at -33℃; Product distribution; Rate constant;	A 2.8% B 5.6% C 11.7% D 80%
With ammonia; potassium amide at -33℃;	A 1.8 % Chromat. B 3.1 % Chromat. C 18.2 % Chromat. D 77 % Chromat.
With ammonia; potassium amide at -33℃;	A 2.8 % Chromat. B 5.6 % Chromat. C 11.7 % Chromat. D 80 % Chromat.

...Expand

: bis(mesityl)(η8-cyclo-octatetraene)zirconium(IV)*0.5Et2O

A: bis{zirconium(IV)(η8-cyclooctatetraene)(μ-2,4-dimethyl-6-CH2C6H2)}

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In diethyl ether complex is suspended in Et2O at room temp. for 2 d, thermal decomposition (N2); elem. anal.;	A 50% B 78%

: 99506-43-1
2,4,6-trimethylphenyl(m-carboran-9-yl)iodonium tetrafluoroborate

: sodium fluoride

A: 17157-02-7
9-iodo-m-carborane

B: 73050-37-0
9-fluoro-m-carborane

C: 4028-63-1
iodomesitylene

D: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In chloroform; water mixt. of aryl(m-carboran-9-yl)iodonium tetrafluoroborate, NaF, water and chloroform was vigorously stirred under reflux at 56°C, 2.5 h; internal standard (chlorobenzene) added and org. layer was analysed by GLC;	A 16% B 78% C 75% D 14%

...Expand

: 85014-36-4
1,3-dimethyl-5-methylenecyclohexane

: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With n-butyllithium; potassium 2-methylbutan-2-olate Mechanism; 1) r.t., 16 h, 2) reflux, 6 h; further reagent: D2O;	76%

: 1272-71-5
bis(mesitylene)vanadium(0)

A: 25377-37-1, 27790-75-6, 82009-22-1
Tetrakis(pyridin)-dichlorovanadin(II)

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With pyridine; 3-chloroprop-1-ene In toluene soln. of V-complex in toluene was treated with CH2=CHCH2Cl (inert atmosphere), the mixt. was stirred at room temp. for 24 h; the mother liquor contained org. compounds, products of the reaction of CH2=CHCH2Cl with either toluene or mesitylene (CLG-MS); filtered, ppt. was dissolved in pyridine, soln. was filtered and concd.to give the crystals of VCl2*4Py; identified by comparison of the IR spectrum with that of authentic sample;	A 75% B 75%

Yield

With pyridine; 3-chloroprop-1-ene In toluene soln. of V-complex in toluene was treated with CH2=CHCH2Cl (inert atmosphere), the mixt. was stirred at room temp. for 24 h; the mother liquor contained org. compounds, products of the reaction of CH2=CHCH2Cl with either toluene or mesitylene (CLG-MS); filtered, ppt. was dissolved in pyridine, soln. was filtered and concd.to give the crystals of VCl2*4Py; identified by comparison of the IR spectrum with that of authentic sample;

A 75%
B 75%

: 67-56-1
methanol

: 67-64-1
acetone

A: 700-12-9
pentamethylbenzene,

B: 87-85-4
Hexamethylbenzene

C: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With aluminum oxide at 420℃; flowrate: 33 ml/ h;	A n/a B 74% C n/a

...Expand

: 98-88-4
benzoyl chloride

: 108-67-8
1,3,5-trimethyl-benzene

: 954-16-5
2,4,6-Trimethylbenzophenon

Conditions

Conditions	Yield
With iron oxide supported on HY zeolite In neat (no solvent) at 110℃; for 3h; Friedel-Crafts Acylation;	100%
With iodine; phosphorus trichloride at 160℃; for 36h; Inert atmosphere;	99%
With C4F9SO3H at 165℃; for 2h;	98%

: 64-19-7
acetic acid

: 108-67-8
1,3,5-trimethyl-benzene

: 1667-01-2
2,4,6-Trimethylacetophenone

Conditions

Conditions	Yield
With heptafluorobutyric anhydride at 100℃; for 3h; Friedel-Crafts acetylation;	100%
With cross-linked polystyrene-supported aluminum triflate at 80℃; for 2.8h; Friedel-Crafts acylation; Neat (no solvent); chemoselective reaction;	94%
With trifluoromethylsulfonic anhydride at 20℃; for 0.0666667h; Friedel-Crafts acylation;	93%

: 75-36-5
acetyl chloride

: 108-67-8
1,3,5-trimethyl-benzene

: 1667-01-2
2,4,6-Trimethylacetophenone

Conditions

Conditions	Yield
With hierarchical nanocrystalline zeolite ZSM-5 at 50℃; for 2h; Temperature;	100%
With iron(III) oxide at 20℃; for 0.166667h; Friedel Crafts acylation; regioselective reaction;	96%
With benzyltributylammonium tetrachloroferrate at 50℃; for 0.0666667h; Friedel-Crafts reaction;	94%

: 108-67-8
1,3,5-trimethyl-benzene

: 1839-63-0
1,3,5-trimethylcyclohexane

Conditions

Conditions	Yield
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 120℃; under 7600.51 Torr; for 8h;	100%
With Ti8O8(14+)6C8H4O4(2-)4O(2-)3.3Li(1+)0.7Co(2+)0.7C4H8O0.7H(1-); hydrogen In neat (no solvent) at 160℃; under 37503.8 Torr; for 18h;	84%
at 108℃; Thermodynamic data; Hydrogenation;

: 108-67-8
1,3,5-trimethyl-benzene

: 603-71-4
nitromesitylene

Conditions

Conditions	Yield
With dinitrogen tetraoxide In dichloromethane at -78℃; for 3h; Irradiation;	100%
With dinitrogen tetraoxide In dichloromethane at 25℃; for 24h;	100%
With nitric acid; sulfuric acid In dichloromethane at 25℃; for 0.03h;	100%

: 108-67-8
1,3,5-trimethyl-benzene

: 1667-04-5
2-bromomesitylene

Conditions

Conditions	Yield
With hydrogenchloride; sodium peroxide In acetic acid at 20 - 25℃; for 4h;	100%
With 1-Cl+SbCl6- In dichloromethane at 25℃; for 1h;	98%
With sodium chlorite; trichloroacetic acid In dichloromethane at 20℃; for 1h; Chlorination;	95%

: 50-00-0
formaldehyd

: 108-67-8
1,3,5-trimethyl-benzene

: 21988-87-4
1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 95℃; for 12h;	100%
With hydrogen bromide; acetic acid at 95℃; for 12h; Inert atmosphere;	99%
With sulfuric acid; potassium bromide In acetic acid at 90 - 95℃; for 6h;	97%

: 166112-18-1
4-aminofuroxan-3-carboxylic acid azide

: 108-67-8
1,3,5-trimethyl-benzene

: 433683-21-7
3-azidocarbonyl-4-(2,4,6-trimethylphenylazo)furoxan

Conditions

Conditions	Yield
Stage #1: 4-aminofuroxan-3-carboxylic acid azide With phosphoric acid; sulfuric acid; sodium nitrite at 0 - 2℃; for 1h; Stage #2: 1,3,5-trimethyl-benzene In pyridine at 0 - 20℃;	100%

: 124-38-9
carbon dioxide

: 108-67-8
1,3,5-trimethyl-benzene

: 480-63-7
mesitylenecarboxylic acid

Conditions

Conditions	Yield
With Et3SiB(C6F5)4 at 20℃; under 22502.3 Torr; for 18h; Reagent/catalyst;	100%
With aluminum tri-bromide; Triphenylsilyl chloride at 20℃; under 22502.3 Torr; for 3h; Autoclave;	97%
With aluminum (III) chloride at 30℃; under 15001.5 Torr; for 5h; Pressure; Temperature;	95.2%

: 108-67-8
1,3,5-trimethyl-benzene

: 766-97-2
4-n-methylphenylacetylene

: 612824-37-0
1-(4-methylphenyl)-1-(2,4,6-trimethylphenyl)ethene

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 30℃; for 24h; Cooling with ice;	100%
With Cu-exchanged tungstophosphoric acid at 80℃; for 3h; neat (no solvent); regioselective reaction;	91%
With trifluorormethanesulfonic acid; copper(II) bis(trifluoromethanesulfonate) at 20℃; for 20h;	84%

: 70316-95-9
tri-μ-chlorobis[(.eta-benzene)ruthenium(II)] tetrafluoroborate

: 108-67-8
1,3,5-trimethyl-benzene

: (η-benzene)(η-mesitylene)ruthenium tetrafluoroborate

Conditions

Conditions	Yield
In water; trifluoroacetic acid under dry conditions mixt. of Ru complex, mesitylene, and CF3COOH refluxed for 1.5 h, 48% aq. HBF4 added; pptd. by careful addn. of Et2O; elem. anal.;	100%

: 86197-44-6
bis(pentafluorophenyl)(η6-anisole)cobalt(II)

: 108-67-8
1,3,5-trimethyl-benzene

: bis(pentafluorophenyl)(η6-mesitylene)cobalt(II)

Conditions

Conditions	Yield
In chloroform-d1 byproducts: anisole; mol. ratio 1/1; not isolated, detected by NMR;	100%

: 623-73-4
diazoacetic acid ethyl ester

: 108-67-8
1,3,5-trimethyl-benzene

: ethyl 1,3,5-trimethylcyclohepta-1,3,5-triene-7-carboxylate

Conditions

Conditions	Yield
With Ag3(μ2-(3,5-(CF3)2PyrPy))3 In dichloromethane at 20℃; Buchner Ring Enlargement;	100%
With dirhodium tetraacetate In dichloromethane at 25℃; for 60h; Buchner Ring Enlargement; Inert atmosphere;	77%
Stage #1: 1,3,5-trimethyl-benzene With dirhodium tetraacetate In dichloromethane Inert atmosphere; Stage #2: diazoacetic acid ethyl ester In dichloromethane at 23℃; for 60h; Inert atmosphere;	77%

: (η6-toluene)Ni(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)

: 108-67-8
1,3,5-trimethyl-benzene

: [(η6-mesitylene)Ni(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)]

Conditions

Conditions	Yield
In pentane at 20℃; Inert atmosphere;	100%

: 1,3-dihydroxy-1H-1λ3-benzo[d][1,2]iodoxol-1-yl trifluoromethanesulfonate

: 108-67-8
1,3,5-trimethyl-benzene

: 2-(mesityl-λ3-iodanyl)benzoic acid triflate salt

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 24h; Inert atmosphere;	100%
In 2,2,2-trifluoroethanol at 20℃; for 24h;	89%

: 2-(4,4,4-trifluoro-3-hydroxy-3-phenylbut-1-yn-1-yl)phenol

: 108-67-8
1,3,5-trimethyl-benzene

: 4-mesityl-2-phenyl-2-(trifluoromethyl)-2H-chromene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 50℃; for 16h;	100%

: 108-24-7
acetic anhydride

: 108-67-8
1,3,5-trimethyl-benzene

: 1667-01-2
2,4,6-Trimethylacetophenone

Conditions

Conditions	Yield
With indium(III) triflate; lithium perchlorate In nitromethane at 20℃;	99%
With antimonypentachloride; lithium perchlorate In dichloromethane for 0.5h; Heating;	95%
With nano-sulfated titania at 50℃; for 1h; Friedel Crafts acylation; neat (no solvent);	95%

: 65-85-0
benzoic acid

: 108-67-8
1,3,5-trimethyl-benzene

: 954-16-5
2,4,6-Trimethylbenzophenon

Conditions

Conditions	Yield
With trifluoroacetic anhydride; bismuth(lll) trifluoromethanesulfonate at 30℃; for 12h; Friedel-Crafts acetylation;	99%
With pyridin-2-yl trifluoromethanesulfonate; trifluoroacetic acid for 5h; Heating;	96%
With cross-linked polystyrene-supported aluminum triflate at 80℃; for 2.9h; Friedel-Crafts acylation; Neat (no solvent); chemoselective reaction;	93%

: 108-67-8
1,3,5-trimethyl-benzene

: 4028-63-1
iodomesitylene

Conditions

Conditions	Yield
With tetrafluoroboric acid; [bis(pyridine)iodine]+ tetrafluoroborate In diethyl ether; dichloromethane for 0.1h; Ambient temperature;	99%
With Oxone; potassium iodide In methanol at 20℃; for 24h;	99%
With ammonium nitrate; sulfuric acid; iodine In water; acetonitrile at 60℃; for 0.166667h; regioselective reaction;	98%

: 108-67-8
1,3,5-trimethyl-benzene

: 53779-84-3
2,4-diiodomesitylene

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 28h;	99%
With iodine; 1-(p-methylbenzenesulfonyloxy)-1,2-benziodoxol-3(1H)-one In acetonitrile for 18h; Ambient temperature;	99%
With iodine; 1-(p-methylbenzenesulfonyloxy)-1,2-benziodoxol-3(1H)-one In acetonitrile for 16h; Ambient temperature;	99%

: 108-67-8
1,3,5-trimethyl-benzene

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With N-Bromosuccinimide; perchloric acid In tetrachloromethane for 22h; Ambient temperature;	99%
With hydrogen bromide; dihydrogen peroxide In water at 20℃; for 24h; Darkness;	98%
With gold(III) chloride; N-Bromosuccinimide In dichloromethane at 20℃; for 12h; Inert atmosphere;	98%

: 874-60-2
4-methyl-benzoyl chloride

: 108-67-8
1,3,5-trimethyl-benzene

: 1146-84-5
2,4,6,4'-tetramethylbenzophenone

Conditions

Conditions	Yield
With C4F9SO3H at 165℃; for 2h;	99%
With In(OSO2CF3)3 for 0.0666667h; Friedel-Crafts acylation reaction; microwave irradiation;	88%
With copper(II) ferrite In neat (no solvent) at 80℃; for 18h; Friedel-Crafts Acylation;	79%

: 108-67-8
1,3,5-trimethyl-benzene

: 3112-79-6
dimesityl sulfone

Conditions

Conditions	Yield
With sulfuric acid; trifluoroacetic anhydride	99%
With trifluoromethylsulfonic anhydride; bis(N-methylpyridinium) sulfate for 0.0833333h;	95%

: 108-67-8
1,3,5-trimethyl-benzene

/PBXSD024-1560/: /PBXSD024-1560/

/PBXSD024-1570/: /PBXSD024-1570/

A: 99-51-4
4-nitro-o-xylene

B: 99321-72-9
2-nitro-2',4,4',5,6'-pentamethylbiphenyl

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.0166667h;	A 1% B 99%

...Expand

Mesitylene Chemical Properties

Molecular structure of Mesitylene (CAS NO.108-67-8) is:

Product Name: Mesitylene
CAS Registry Number: 108-67-8
IUPAC Name: 1,3,5-trimethylbenzene
Molecular Weight: 120.19158 [g/mol]
Molecular Formula: C₉H₁₂
XLogP3: 3.4
EINECS: 203-604-4
Melting Point: -45 °C
Water Solubility: 2.9 g/L (20 °C)
Surface Tension: 28.7 dyne/cm
Refractive index: n20/D 1.499(lit.)
Density: 0.869 g/cm³
Flash Point: 44.4 °C
Enthalpy of Vaporization: 38.66 kJ/mol
Boiling Point: 166.7 °C at 760 mmHg
Vapour Pressure: 2.32 mmHg at 25°C
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Product Categories: Benzene derivates;Analytical Chemistry;Standard Solution of Volatile Organic Compounds for Water & Soil Analysis;Standard Solutions (VOC)

Mesitylene Uses

Mesitylene (CAS NO.108-67-8) is used in the production of trimesic acid and antioxygen, epoxy firming agent, polyester resin stabilizer, alkyd resin plasticizers and dye. It is commonly used as a solvent in research and industry. In the electronics industry,it has also been used as a developer for photopatternable silicones due to its solvent properties.

Mesitylene Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraperitoneal	1303mg/kg (1303mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 227, 1954.
human	TCLo	inhalation	10ppm (10ppm)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI	Zeitschrift fuer Unfallmedizin und Berufskrankheiten. Revue de Medecine des Accidents et des Maladies Professionelles. Vol. 49, Pg. 265, 1956.
rat	LC50	inhalation	24gm/m³/4H (24000mg/m³)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(5), Pg. 15, 1979.

Mesitylene Safety Profile

Poison by inhalation. Moderately toxic by intraperitoneal route. Human systemic effects by inhalation: sensory changes involving peripheral nerves, somnolence (general depressed activity), and structural or functional change in trachea or bronchi. Reports of leukopenia and thrombocytopenia in experimental animals. A mild skin and eye irritant. A flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. Violent reaction with HNO₃. To fight fire, use water spray, fog, foam, CO₂. Emitted from modern building materials ( CENEAR    Chemical and Engineering News. 69 (1991),22. ). When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Xi,N,F,T
Risk Statements: 10-37-51/53-39/23/24/25-23/24/25-11
10: Flammable
37: Irritating to the respiratory system
51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
11: Highly Flammable
Safety Statements: 61-45-36/37-16-7
61: Avoid release to the environment. Refer to special instructions safety data sheet
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37: Wear suitable protective clothing and gloves
16: Keep away from sources of ignition - No smoking
7: Keep container tightly closed
RIDADR: UN 2325 3/PG 3
WGK Germany: 2
RTECS: OX6825000
F: 10: Keep under argon.
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29029080

Mesitylene Standards and Recommendations

OSHA PEL: TWA 25 ppm
ACGIH TLV: TWA 25 ppm
DFG MAK: 20 ppm
DOT Classification: 3; Label: Flammable Liquid

Mesitylene Analytical Methods

Mesitylene (CAS NO.108-67-8) is prepared by distillation of acetone with sulfuric acid or by trimerization of propyne in sulfuric acid, which, in both cases, acts as a catalyst and dehydrating agent.

Mesitylene Specification

Mesitylene , its cas register number is 108-67-8. It also can be called 1,3,5-Trimethylbenzene ; 3,5-Dimethyltoluene ; Benzene, 1,3,5-trimethyl- ; Fleet-X ; Trimethylbenzol ; sym-Trimethylbenzene .It is a colorless liquid with a peculiar odor. It insoluble in water and less dense than water. It may be toxic by ingestion and inhalation.

Product Name

Mesitylene

Synthetic route

Mesitylene Chemical Properties

Mesitylene Uses

Mesitylene Toxicity Data With Reference

Mesitylene Safety Profile

Mesitylene Standards and Recommendations

Mesitylene Analytical Methods

Mesitylene Specification

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