Methoxyammonium chloride supplier

Name
Methoxyammonium chloride
EINECS 209-798-7
CAS No. 593-56-6
Article Data33
CAS DataBase
Density 0.854 g/cm³
Solubility soluble in water
Melting Point 151-154 °C(lit.)
Formula CH₅NO^.HCl
Boiling Point 49.5 °C at 760 mmHg
Molecular Weight 83.5177
Flash Point 18.2 °C
Transport Information UN 3265 8/PG 2
Appearance White to very faintly yellow crystalline powder
Safety 3-24-26-36/37/39-45-61-24/25-27
Risk Codes 34-36/37/38-50-43-20/21/22
Molecular Structure
Hazard Symbols C,Xi,N
Synonyms Hydroxylamine,O-methyl-, hydrochloride (8CI,9CI);(Aminooxy)methane hydrochloride;Hydroxylamine methyl ether hydrochloride;Methoxyammonium chloride;N-Methoxylaminehydrochloride;O-Methoxyamine hydrochloride;O-Methylhydroxyaminehydrochloride;O-Methylhydroxylamine hydrochloride;
PSA 35.25000
LogP 1.00880

Synthetic route

: 1914-20-1
N-methoxyphthalimide

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: N-methoxyphthalimide With methylhydrazine In dichloromethane at 0 - 20℃; for 2h; Stage #2: With hydrogenchloride In 1,4-dioxane at 0℃;	90%
With hydrogenchloride for 0.5h; Hydrolysis; Heating;
With methylhydrazine In dichloromethane
Stage #1: N-methoxyphthalimide With hydrogenchloride; acetic acid In water for 1.5h; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride at 0 - 20℃; for 1h; Inert atmosphere;

: 5806-90-6
N-methoxyacetamide

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 65℃;	69.3%
With hydrogenchloride In ethanol; water at 65℃;	69.3%

: 100-39-0
benzyl bromide

: 87-42-3
6-chloropurine

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 25℃; for 10h;	48%

: N-Methoxy-acetimidic acid ethyl ester

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 0.25h; Heating;

: 2446-51-7
N-methoxybenzamide

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 0.25h; Hydrolysis; Heating;

: 7647-01-0
hydrogenchloride

: 29144-51-2
(MeON=C(Me)-CMe=NOMe)

A: 593-56-6
N-methoxylamine hydrochloride

B: 431-03-8
dimethylglyoxal

...Expand

ethylbenzhydroximic acid methyl ester: ethylbenzhydroximic acid methyl ester

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

methyl ether of benzaldoxime: methyl ether of benzaldoxime

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 5904-50-7
N-methoxysuccinimide

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 67-62-9
O-Methylhydroxylamin

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water
With hydrogenchloride In ethanol
With hydrogenchloride	30.2 g
With hydrogenchloride
With hydrogenchloride In water at 0 - 20℃; for 1h;

: 7647-01-0
hydrogenchloride

: 91572-26-8
(CH3O)H2N*BH3

: 7732-18-5
water

A: 593-56-6
N-methoxylamine hydrochloride

B: 11113-50-1
boric acid

Conditions

Conditions	Yield
In hydrogenchloride acidic hydrolysis;;

...Expand

: 112403-78-8
N-phenylacetyl-O-methylhydroxylamine

A: 103-82-2
phenylacetic acid

B: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With Escherichia coli penicillin acylase; potassium chloride; water at 24.84℃; Equilibrium constant; Enzymatic reaction;

: 77-78-1
dimethyl sulfate

: 593-56-6
N-methoxylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium meta bi sulfate; sulfur dioxide; sodium nitrite In water at 100℃; for 3h; pH=4; Alkaline conditions;

: 27685-12-7
(butan-2-ylidene)(methoxy)amine

A: 593-56-6
N-methoxylamine hydrochloride

B: 78-93-3
butanone

Conditions

Conditions	Yield
With hydrogenchloride at 120℃; for 2.33333h; Temperature; Overall yield = 91 percent;

: 69371-59-1
6-phenyl-hex-5-en-2-one

: 593-56-6
N-methoxylamine hydrochloride

: 134025-31-3
N-Methoxy-1-phenyl-1-hexen-5-one oxime

Conditions

Conditions	Yield
With sodium acetate In water Heating;	100%

: 593-56-6
N-methoxylamine hydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 70286-37-2, 87861-04-9, 33499-40-0
4-methoxybenzaldehyde O-methyl oxime

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 0 - 20℃; for 1h;	100%
With sodium acetate In ethanol	92%

: 593-56-6
N-methoxylamine hydrochloride

: 874-60-2
4-methyl-benzoyl chloride

: 25563-06-8
N-methoxy-4-methylbenzamide

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate at 0 - 20℃; for 2h; Inert atmosphere;	100%
With potassium carbonate In water; ethyl acetate at 0 - 20℃;	99%
With potassium carbonate In water; ethyl acetate at 0 - 20℃;	93%

: 593-56-6
N-methoxylamine hydrochloride

: 100-07-2
4-methoxy-benzoyl chloride

: 24056-08-4
N-methoxy-4-methoxylbenzamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h;	100%
With sodium carbonate In water; benzene at 20℃; for 18h; Cooling;	98%
With potassium carbonate In water; ethyl acetate at 0 - 20℃;	98%

: 593-56-6
N-methoxylamine hydrochloride

: 501-53-1
benzyl chloroformate

: 121989-74-0
O-benzyl-N-methoxycarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 5h;	100%
With sodium carbonate In water; benzene for 5h; Ambient temperature;	98%
With sodium carbonate In water; toluene at 20℃; for 5h;	54%

: 593-56-6
N-methoxylamine hydrochloride

: 35647-02-0
2α-azido-5α-cholestan-3-one

: 2α-Azido-3-(methoxyimino)cholestane

Conditions

Conditions	Yield
With pyridine at 0℃; for 3.5h;	100%

: 1086-43-7
2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one

: 593-56-6
N-methoxylamine hydrochloride

: 145962-42-1
2-(4-methoxyphenyl)-1-indanone oxime methyl ether

Conditions

Conditions	Yield
With sodium acetate In methanol Ambient temperature;	100%

: 593-56-6
N-methoxylamine hydrochloride

: 2-(N-allylbenzylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde

: 183968-81-2
2-(Allyl-benzyl-amino)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde O-methyl-oxime

Conditions

Conditions	Yield
With sodium acetate In methanol for 3h; Ambient temperature;	100%

: 593-56-6
N-methoxylamine hydrochloride

: 2--4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde

: 2-[Benzyl-((E)-but-2-enyl)-amino]-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde O-methyl-oxime

Conditions

Conditions	Yield
With sodium acetate In methanol for 3.5h; Ambient temperature;	100%

: 593-56-6
N-methoxylamine hydrochloride

: 100-52-7
benzaldehyde

: 10229-53-5
(E)-benzaldehyde O-methyloxime

Conditions

Conditions	Yield
With sodium acetate In tetrahydrofuran; water at 20℃; for 4h;	100%
With hydrogenchloride In ethanol Heating;	71%
With sodium acetate In ethanol; water for 2h; Reflux;	68%

: 6060-06-6
platanic acid

: 593-56-6
N-methoxylamine hydrochloride

: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bS)-9-Hydroxy-1-{1-[(Z)-methoxyimino]-ethyl}-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carboxylic acid

Conditions

Conditions	Yield
With sodium acetate In methanol	100%

: 593-56-6
N-methoxylamine hydrochloride

: C17H24O5

: 626239-69-8
N-methoxy-4-(4-methoxy-3-methyl-phenyl)-butyramide

Conditions

Conditions	Yield
With triethylamine at 0℃; for 1h;	100%

: 3-(2,4-dimethoxy-phenyl)-2-methyl-propionic acid

: 593-56-6
N-methoxylamine hydrochloride

: O-methyl (+/-)-3-(2,4-dimethoxyphenyl)-2-methylpropiohydroxamate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 9h;	100%

: 906361-94-2
5-formyl-1-methyl-2-tert-butylindolizine

: 593-56-6
N-methoxylamine hydrochloride

: 2-tert-butyl-1-methyl-indolizine-5-carbaldehyde O-methyl-oxime

Conditions

Conditions	Yield
With pyridine In ethanol at 20℃; for 5h;	100%

: 593-56-6
N-methoxylamine hydrochloride

: 91-56-5
indole-2,3-dione

: 107976-78-3
1H-indole-2,3-dione 3-(O-methyloxime)

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate In methanol at 20℃; for 2h;	100%
With sodium hydrogencarbonate In methanol; water at 50℃; for 8h;	92%
With sodium hydrogencarbonate In methanol; water at 20℃; for 1.08333h;	80%

: 361576-47-8
methyl 2-[(4-hydroxyphenyl)methyl]-3-oxopentanoate

: 593-56-6
N-methoxylamine hydrochloride

: 851181-19-6
2-(4-hydroxy-benzyl)-3-methoxyimino-pentanoic acid methyl ester

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 5h;	100%
With sodium acetate In methanol	90%

: 593-56-6
N-methoxylamine hydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 70286-37-2
4-methoxy-benzaldehyde-(O-methyl-seqtrans-oxime )

Conditions

Conditions	Yield
	100%

: methyl (E)-3-methoxy-2-trans[2-(3-(2-(1-oxoheptyl-1-yl)cyclopropyl)phenoxymethyl)phenyl]-2-propenoate

: 593-56-6
N-methoxylamine hydrochloride

: methyl 3-methoxy-2-trans-[2-(3-(2-(methoximinohept-1-yl)cyclopropyl)phenoxymethyl)phenyl]-2-propenoate

Conditions

Conditions	Yield
In methanol at 20℃; for 12h;	100%

: 672318-77-3
C19H15N5O

: 593-56-6
N-methoxylamine hydrochloride

: 672319-03-8
C20H18N6O

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran; dichloromethane at 25℃; for 72h;	100%

: 2-(2,3,5-trimethylcyclopentadienyl)benzaldehyde

: 593-56-6
N-methoxylamine hydrochloride

: O-methyl-2-(2,3,5-trimethylcyclopentadienyl)benzaldehyde oxime

Conditions

Conditions	Yield
With sodium acetate In tetrahydrofuran; water at 25℃; for 0.5h;	100%

: 864074-10-2
(5-fluoro-4-methyl-3-thioxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-carbamic acid benzyl ester

: 593-56-6
N-methoxylamine hydrochloride

: (5-fluoro-3-methoxyimino-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-carbamic acid benzyl ester

Conditions

Conditions	Yield
With pyridine at 70℃;	100%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 593-56-6
N-methoxylamine hydrochloride

: 1012051-66-9
(E)-4-trifluoromethylbenzaldehyde O-methyloxime

Conditions

Conditions	Yield
	100%
With sodium acetate In ethanol; water at 70℃; for 2h;

: 34036-07-2
3,4 difluorobenzaldehyde

: 593-56-6
N-methoxylamine hydrochloride

: 646051-28-7
3,4-difluorobenzaldehyde O-methyloxime

Conditions

Conditions	Yield
	100%

: 3783-77-5
N-(3-oxobutyl)phthalimide

: 593-56-6
N-methoxylamine hydrochloride

: N-[3-(N-methoxyimino)butyl]-phthalimide

Conditions

Conditions	Yield
With sodium hydroxide In methanol	100%

: 193676-14-1
3-(3-acetyl-4-chloro-6-fluoro-2-methylbenzofuran-7-yl)-1-methyl-6-trifluoromethyluracil

: 593-56-6
N-methoxylamine hydrochloride

: 3-[4-chloro-6-fluoro-3-(1-methoxyiminoethyl)-2-methylbenzofuran-7-yl]-1-methyl-6-trifluoromethyluracil

Conditions

Conditions	Yield
With potassium acetate In methanol; ethyl acetate	100%

: 1029697-36-6
C18H20O4

: 593-56-6
N-methoxylamine hydrochloride

: C20H26N2O4

Conditions

Conditions	Yield
With pyridine; acetic acid at 20 - 40℃; for 2h;	100%

: 941568-39-4
1-ethyl-2,3,4,10,10a-pentaaza-cyclopenta[b]fluoren-9-one

: 593-56-6
N-methoxylamine hydrochloride

: 1022084-11-2
1-ethyl-2,3,4,10,10a-pentaaza-cyclopenta[b]fluoren-9-one O-methyl-oxime

Conditions

Conditions	Yield
With pyridine at 60℃; for 2 - 3h; Molecular sieve;	100%

: 1149581-07-6
C26H35BrN4O2

: 593-56-6
N-methoxylamine hydrochloride

: 1149581-81-6
4-bromo-2-{2-[4-(diethylamino)phenyl]-2-(methoxyimino)ethyl}-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one

Conditions

Conditions	Yield
In ethanol at 80℃; for 1h;	100%

: 521-18-6
Stanolone

: 593-56-6
N-methoxylamine hydrochloride

: stanolone 3-Z,E-methyloxime

Conditions

Conditions	Yield
With triethylamine; sodium hydroxide In tetrahydrofuran; water at 20 - 60℃; for 5h;	100%

: 1221444-84-3
8-fluoro-2,2-dimethyl-7-(piperidin-1-yl)chroman-4-one

: 593-56-6
N-methoxylamine hydrochloride

: 1221444-85-4
(E)-8-fluoro-2,2-dimethyl-7-(piperidin-1-yl)chroman-4-one O-methyl oxime

Conditions

Conditions	Yield
With pyridine at 20℃; for 16h;	100%
With pyridine at 20℃; for 16h;	100%

Methoxyammonium chloride Chemical Properties

Detail of METHYLOXYLAMMONIUM CHLORIDE(593-56-6).
Molecular Structure:

Name:METHYLOXYLAMMONIUM CHLORIDE
CAS Number:593-56-6
Molecular Formula:CH₅NO^.ClH
Molecular Weight:83.53
EINECS:209-798-7
Density:0.854g/cm³
Melting Point:148-153^°C
Boiling Point:105-110^°C
liansport Information:UN 3261
Properties:Prisms.
density:1.1 g/mL at 25^°C
refractive index:n20/D 1.4021
Water Solubility:SOLUBLE
Sensitive:Hygroscopic
Merck:14,5989
BRN:3589723
CAS DataBase Reference:593-56-6(CAS DataBase Reference)
EPA Substance Registry System:593-56-6(EPA Substance)
Synonyms of METHYLOXYLAMMONIUM CHLORIDE(593-56-6):O-METHYLHYDROXYAMINE HYDROCHLORIDE;O-METHYLHYDROXYLAMINE HCL;O-METHYLHYDROXYLAMINE HYDROCHLORIDE;O-METHYLHYDROXYLAMMONIUM CHLORIDE;MOX REAGENT;MOX(TM) REAGENT;HYDROXYLAMINE METHYL ETHER HYDROCHLORIDE;MAH

Methoxyammonium chloride Uses

METHYLOXYLAMMONIUM CHLORIDE(593-56-6) can be used as methoxy amine, but also used in the production of drugs cefuroxime side chain and other drugs.

Methoxyammonium chloride Toxicity Data With Reference

1.		oms-bcs 900 mmol/L		DKBSAS Doklady Biological Sciences (English Translation). 257 (1981),154.
2.		msc-ham:lng 2 g/L		SOGEBZ Soviet Genetics. Translation of GNKAA5. 11 (1975),475.

Methoxyammonium chloride Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Methoxyammonium chloride Safety Profile

Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl, NH₃ and NO_x. See also AMINES.
Safety Information of METHYLOXYLAMMONIUM CHLORIDE(593-56-6).
Hazard Codes:C,Xi,N
Risk Statements:34-36/37/38-50-43-20/21/22
Safety Statements:3-24-26-36/37/39-45-61-24/25-27
RIDADR:UN 3265 8/PG 2
WGK Germany:3
RTECS:NC3980000
F:3-10
Hazard Note:Corrosive/Hygroscopic
HazardClass:8
PackingGroup:III

Methoxyammonium chloride Specification

Stability and Reactivity of METHYLOXYLAMMONIUM CHLORIDE(593-56-6).
Chemical Stability: Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials Exposure to moist air or water, strong bases, acid chlorides, acid anhydrides.
Hazardous Decomposition Products Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization Has not been reported.
First Aid Measures of METHYLOXYLAMMONIUM CHLORIDE(593-56-6).
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.
Handling and Storage of METHYLOXYLAMMONIUM CHLORIDE(593-56-6).
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

Methoxyammonium chloride

Synthetic route

Methoxyammonium chloride Chemical Properties

Methoxyammonium chloride Uses

Methoxyammonium chloride Toxicity Data With Reference

Methoxyammonium chloride Consensus Reports

Methoxyammonium chloride Safety Profile

Methoxyammonium chloride Specification

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