Methyl-beta-chloroethylamine hydrochloride supplier

Name
2-METHYLAMINOETHYL CHLORIDE HYDROCHLORIDE
EINECS
CAS No. 4535-90-4
Article Data23
CAS DataBase
Density g/cm³
Solubility
Melting Point 89 °C
Formula C3H8 Cl N . Cl H
Boiling Point 110.3°Cat760mmHg
Molecular Weight 130.017
Flash Point 20.5°C
Transport Information
Appearance
Safety Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also AMINES.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ethanamine,2-chloro-N-methyl-, hydrochloride (9CI); Ethylamine, 2-chloro-N-methyl-,hydrochloride (6CI,7CI,8CI); 2-(Methylamino)ethyl chloride hydrochloride;2-Chloro-N-methylethylamine hydrochloride; N-Methyl-2-chloroethylaminehydrochloride
PSA 12.03000
LogP 1.63750

Synthetic route

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; thionyl chloride In dichloromethane Ambient temperature;	96%
With thionyl chloride In dichloromethane	96%
With thionyl chloride In chloroform for 6h; Heating;	95%

: 62640-03-3
2-(methylamino)ethan-1-ol hydrochloride

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

Conditions

Conditions	Yield
With sulfuryl dichloride In chloroform at 0℃; for 3h; Reflux;	80%
With thionyl chloride In chloroform at 0℃; Heating / reflux;

: 1072-44-2
N-methylaziridine

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

methyl-<2-hydroxy-ethyl>-amine hydrochloride: methyl-<2-hydroxy-ethyl>-amine hydrochloride

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 160 - 180℃;
With hydrogenchloride at 160 - 180℃;

N-methyl-N-β-naphthhydroxyethyl-p-toluenesulfonic acid amide: N-methyl-N-β-naphthhydroxyethyl-p-toluenesulfonic acid amide

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 170℃;

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 501-53-1
benzyl chloroformate

: 68767-11-3
benzyl (2-chloroethyl)methylcarbamate

Conditions

Conditions	Yield
With sodium hydroxide for 0.5h;	100%

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: C15H19ClN2O2S

Conditions

Conditions	Yield
With triethylamine In methanol	96%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 147000-89-3
N-tert-butyloxycarbonylsulfamoyl chloride

: 263719-70-6
N1-BOC,N3-methyl,N3-(2-chloroethyl) sulfamide

Conditions

Conditions	Yield
With isocyanate de chlorosulfonyle; triethylamine In dichloromethane; tert-butyl alcohol at 0 - 25℃; for 2h;	93%
With triethylamine In dichloromethane at 0 - 25℃; for 2.5h;	4.50 g

: 1261237-73-3
cis-[PdCl2(2,6-diisopropylphenylisonitrile)2]

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: C29H41Cl2N3Pt

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	88%

: 12107-56-1
dichloro(1,5-cyclooctadiene)palladium(II)

: 1′-(diphenylphosphino)-1-isocyanoferrocene

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: C26H25Cl2FeN2PPd

Conditions

Conditions	Yield
With triethylamine In dichloromethane Inert atmosphere; Schlenk technique;	85%

...Expand

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 124-40-3
dimethyl amine

: N,N,N′-trimethylethylenediamine hydrochloride

Conditions

Conditions	Yield
In water at 0℃; for 4h; Temperature; Green chemistry;	84.9%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 15291-77-7
ginkgolide B

: 914251-23-3
10-O-methylaminoethyl ginkgolide B

Conditions

Conditions	Yield
With calcium carbonate; potassium iodide In water; acetonitrile at 85℃; Flow reactor;	83.5%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 1-azido-2-(N-methylamino)ethane hydrochloride

Conditions

Conditions	Yield
Stage #1: N-methyl-2-chloroethylamine hydrochloride With sodium azide In water at 80℃; for 18h; Stage #2: With hydrogenchloride	80%
Stage #1: N-methyl-2-chloroethylamine hydrochloride With sodium azide In water at 80℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether	80%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 33744-33-1
β-methylaminoethanethiol hydrochloride

Conditions

Conditions	Yield
Stage #1: N-methyl-2-chloroethylamine hydrochloride With sodium thiosulfate In water for 26h; Heating; Stage #2: With hydrogenchloride at 85℃; for 3h; Further stages.;	79%
Stage #1: N-methyl-2-chloroethylamine hydrochloride With Sodium thiosulfate pentahydrate In water at 120℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 85℃; for 3h; Inert atmosphere;	56.1%
Stage #1: N-methyl-2-chloroethylamine hydrochloride With sodium thiosulfate In water for 48h; Reflux; Stage #2: With hydrogenchloride In water at 90℃; for 4h;

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 87-62-7
2,6-dimethylaniline

: N1-(2,6-dimethylphenyl)-N2-methylethane-1,2-diamine

Conditions

Conditions	Yield
at 130℃;	76%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 106-95-6
allyl bromide

: 98280-66-1
N-allyl-N-methyl-2-chloroethylamine

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water for 3h; Ambient temperature;	74%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 829-85-6
diphenylphosphane

: 350021-81-7
2-(diphenylphosphino)-N-methylethanamine

Conditions

Conditions	Yield
Stage #1: diphenylphosphane With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: N-methyl-2-chloroethylamine hydrochloride In tetrahydrofuran Reflux; Schlenk technique; Inert atmosphere;	74%
With potassium tert-butylate In tetrahydrofuran for 20h; Heating;	30%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 4376-01-6
sodium diphenylphosphide

: 350021-81-7
2-(diphenylphosphino)-N-methylethanamine

Conditions

Conditions	Yield
Stage #1: N-methyl-2-chloroethylamine hydrochloride With sodium hydroxide In tetrahydrofuran for 2h; Stage #2: sodium diphenylphosphide In tetrahydrofuran Reflux;	74%

: 24424-99-5
di-tert-butyl dicarbonate

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 220074-38-4
1,1-dimethylethyl N-(2-chloroethyl)-N-methylcarbamate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; water at 21℃; for 17h;	71%
With triethylamine In tetrahydrofuran; water at 21℃; for 17h;	71%
With triethylamine In tetrahydrofuran; water at 21℃; for 16h;	71%
With triethylamine In tetrahydrofuran; water for 2h; Ambient temperature;

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 770-12-7
O-phenyl phosphorodichloridate

: 131636-35-6
phenyl N-methyl-N-(2-chloroethyl)phosphoramidate chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 14h; Ambient temperature;	70%

: trans-8-chloro-1-[4-(5-methyl-isoxazol-3-yl)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: trans-(2-{8-chloro-1-[4-(5-methyl-isoxazol-3-yl)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl}-ethyl)-methyl-amine

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 70℃; for 20h;	66%
With caesium carbonate In acetonitrile at 70℃; for 20h;	66%

: 1666-13-3
diphenyl diselenide

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: N-methyl-2-(phenylselanyl)ethan-1-amine

Conditions

Conditions	Yield
Stage #1: diphenyl diselenide With sodium tetrahydroborate In ethanol at 0℃; for 0.25h; Inert atmosphere; Stage #2: N-methyl-2-chloroethylamine hydrochloride In ethanol at 0℃; for 3h; Reflux;	65%

: 24544-04-5
2,6-diisopropylbenzenamine

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: N1-(2,6-diisopropylphenyl)-N2-methylethane-1,2-diamine

Conditions

Conditions	Yield
at 130℃;	64%

: 574-66-3
Benzophenone oxime

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 953772-61-7
benzophenone O-(2-N-methylaminoethyl)oxime

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2.5h;	62%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2.5h;	62%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2.5h;	62%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2.5h;	62%
Stage #1: Benzophenone oxime; N-methyl-2-chloroethylamine hydrochloride With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2.5h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 0℃; pH=2.5; Stage #3: With potassium hydroxide In water pH=10;	62%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 89865-33-8
1-azido-2-(N-methylamino)ethane

Conditions

Conditions	Yield
With sodium azide In water at 80℃;	56%
With sodium azide In water for 7h;	37%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 765-30-0
Cyclopropylamine

: 483303-55-5
N-cyclopropyl-N’-methylethylenediamine

Conditions

Conditions	Yield
In ethanol at 50℃; for 16h;	55%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: sodium cyclopentadienide

: 857023-53-1
N-methyl-1,3-cyclopentadiene-1-ethanamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 4h; Reflux; Schlenk technique; Inert atmosphere;	50%

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: {2-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]ethyl}methyl-amine hydrochloride salt

Conditions

Conditions	Yield
Stage #1: N-methyl-2-chloroethylamine hydrochloride With potassium carbonate; sodium iodide In DMF (N,N-dimethyl-formamide) at 100℃; for 1h; Stage #2: N-methyl-2-chloroethylamine hydrochloride With potassium carbonate at 100℃; for 4h;	49%

: 616-47-7
1-methyl-1H-imidazole

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: C7H14N3(1+)*Cl(1-)

Conditions

Conditions	Yield
Stage #1: 1-methyl-1H-imidazole; N-methyl-2-chloroethylamine hydrochloride In acetonitrile at 100℃; Sealed tube; Stage #2: With sodium hydrogencarbonate In methanol at 20℃;	49%

: trans-1-(4-benzo[d]isothiazol-3-yl-cyclohexyl)-8-chloro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene hydrochloride

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 1345046-03-8
trans-{2-[1-(4-benzo[d]isothiazol-3-yl-cyclohexyl)-8-chloro-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-yl]-ethyl}-methyl-amine

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 70℃; for 20h;	48%

: 1345046-02-7
trans-1-(4-benzo[d]isothiazol-3-yl-cyclohexyl)-8-chloro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 1345046-03-8
trans-{2-[1-(4-benzo[d]isothiazol-3-yl-cyclohexyl)-8-chloro-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-yl]-ethyl}-methyl-amine

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 70℃; for 20h;	48%

: 1431985-54-4
6-methoxy-1,7-naphthyridin-4(1H)-one

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 1431985-23-7
C23H24F2N6O2

Conditions

Conditions	Yield
Stage #1: 6-methoxy-1,7-naphthyridin-4(1H)-one With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.75h; Stage #2: N-methyl-2-chloroethylamine hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 66h;	47%

: 5825-62-7
N-(4-nitrophenyl)methanesulfonamide

: 4535-90-4
N-methyl-2-chloroethylamine hydrochloride

: 328289-85-6
N-(2-(dimethylamino)ethyl)-N-(4-nitrophenyl)methanesulfonamide

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone at 0 - 50℃; for 20h; Inert atmosphere;	43%

Methyl-beta-chloroethylamine hydrochloride Chemical Properties

IUPAC Name: 2-Chloroethyl(methyl)azanium chloride
The MF of Methyl-beta-chloroethylamine hydrochloride (CAS NO.4535-90-4) is C₃H₉Cl₂N.

The MW of Methyl-beta-chloroethylamine hydrochloride (CAS NO.4535-90-4) is 130.01626.
Synonyms of Methyl-beta-chloroethylamine hydrochloride (CAS NO.4535-90-4): N-Methyl-beta-chloroethylamine hydrochloride ; 2-Chloroethyl(methyl)ammonium chloride ; Ethylamine, 2-chloro-N-methyl-, hydrochloride
Flash Point: 20.5 °C
Boiling Point: 110.3 °C
EINECS: 224-882-3

Methyl-beta-chloroethylamine hydrochloride Uses

Methyl-beta-chloroethylamine hydrochloride (CAS NO.4535-90-4) is used as chemical reagent, organic intermediates, fine chemicals, pharmaceutical research and development.

Methyl-beta-chloroethylamine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	2301mg/kg (2301mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
mouse	LD50	intravenous	100mg/kg (100mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947.

Methyl-beta-chloroethylamine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Methyl-beta-chloroethylamine hydrochloride Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also AMINES.

Product Name

2-METHYLAMINOETHYL CHLORIDE HYDROCHLORIDE

Synthetic route

Methyl-beta-chloroethylamine hydrochloride Chemical Properties

Methyl-beta-chloroethylamine hydrochloride Uses

Methyl-beta-chloroethylamine hydrochloride Toxicity Data With Reference

Methyl-beta-chloroethylamine hydrochloride Consensus Reports

Methyl-beta-chloroethylamine hydrochloride Safety Profile

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