N-BOC-4-Hydroxypiperidine supplier

Name
N-BOC-4-Hydroxypiperidine
EINECS -0
CAS No. 109384-19-2
Article Data179
CAS DataBase
Density 1.107 g/cm³
Solubility
Melting Point 60-65 ºC
Formula C₁₀H₁₉NO₃
Boiling Point 292.3 ºC at 760 mmHg
Molecular Weight 201.266
Flash Point 130.6 ºC
Transport Information
Appearance white or off-white crystalline powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,1-Dimethylethyl4-hydroxypiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-hydroxypiperidine;1-(tert-Butyloxycarbonyl)piperidin-4-ol;1-Boc-4-hydroxypiperidine;1-Boc-piperidin-4-ol;1-tert-Butoxycarbonyl-4-piperidinol;1-tert-Butyloxycarbonyl-4-hydroxypiperidine;4-Hydroxy-1-(tert-butoxycarbonyl)piperidine;4-Hydroxy-1-piperidinecarboxylicacid tert-butyl ester;4-Hydroxy-N-(tert-butoxycarbonyl)piperidine;4-Hydroxy-N-Boc-piperidine;4-Hydroxypiperidine-1-carboxylic acid tert-butylester;N-(tert-Butoxycarbonyl)-4-hydroxypiperidine;N-(tert-Butoxycarbonyl)piperidin-4-ol;N-(tert-Butyloxycarbonyl)-4-hydroxypiperidine;N-(tert-Butyloxycarbonyl)-4-piperidinol;N-Boc-4-hydroxy-1-piperidine;N-Boc-4-piperidinol;tert-Butyl4-hydroxy-1-piperidinecarboxylate;1-Piperidinecarboxylicacid, 4-hydroxy-, 1,1-dimethylethyl ester;
PSA 49.77000
LogP 1.31610

Synthetic route

: 5382-16-1
4-HYDROXYPIPERIDINE

: 24424-99-5
di-tert-butyl dicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In water; tert-butyl alcohol at 20℃;	100%
With sodium carbonate In dichloromethane; water for 72h;	100%
With sodium carbonate In dichloromethane; water for 72h; Inert atmosphere;	100%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol	100%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With sodium tetrahydroborate In ethanol at 0 - 20℃; for 4h; Stage #2: With water; ammonium chloride In ethanol	100%
With sodium hydroxide; sodium borohydrid In methanol	100%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With tert-butyldicarbonate; triethylamine In dichloromethane at 0℃; for 21h;	100%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 34619-03-9
tert-butyldicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane for 15h;	100%
In tetrahydrofuran at 20℃;	98.3%
With triethylamine In tetrahydrofuran at 20℃;	98.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 5382-17-2
piperidin-4-ol hydrochloride

: 144-55-8
sodium hydrogencarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
In 1,4-dioxane	100%
In 1,4-dioxane	100%

...Expand

: 626-64-2
pyridin-4-ol

: 24424-99-5
di-tert-butyl dicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: pyridin-4-ol With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 50℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube;	99%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 201230-82-2
carbon monoxide

: 75-65-0
tert-butyl alcohol

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With 2C7H9N4Au(1+)Cu(1+)*2I(1-) In toluene at 90℃; for 8h; Autoclave;	98%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; ethyl acetate	95%
Multi-step reaction with 2 steps 1: triethylamine / water; 1,4-dioxane / 0 - 20 °C 2: sodium tetrahydroborate; methanol / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0.8 h / 0 - 20 °C 2: sodium tetrahydroborate; methanol / 0.01 h / 0 - 20 °C View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

A: 75844-69-8
t-butyl piperidinecarboxylate

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; ethyl acetate	A n/a B 94%
With triethylamine In tetrahydrofuran; ethyl acetate	A n/a B 94%
With triethylamine In tetrahydrofuran; ethyl acetate	A n/a B 94%

: 1311186-22-7
tert-butyl 4-((4-methoxybenzyl)oxy)piperidine-1-carboxylate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With N,N,N,N-tetraethylammonium tetrafluoroborate In methanol Electrochemical reaction;	81%

: 75844-69-8
t-butyl piperidinecarboxylate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With D-glucose; cells of Sphingomonas sp. HXN-200 In phosphate buffer at 30℃; for 2h; pH=8.0;	69.5%

: 845305-79-5
4-[(1-{tert-butoxycarbonyl}-4-piperidinyl)oxy]-1-(1-methylethyl)pyridinium iodide

A: 845305-80-8
tert-butyl 4-{[1-(1-methylethyl)-4-piperidinyl]oxy}-1-piperidinecarboxylate

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With platinum (IV) oxide; hydrogen In ethanol at 20℃; under 2587.76 Torr; for 144h;	A 54% B 20%

: 24424-99-5
di-tert-butyl dicarbonate

: 5382-17-2
piperidin-4-ol hydrochloride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In water at 25℃; for 1h;

: 13169-00-1
Methoxyallene

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

A: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

B: N-(tert-butoxycarbonyl)-4-[(Z)-3-methoxyprop-2-enyl]piperidin-4-ol

C: N-(tert-butoxycarbonyl)-4-[(E)-3-methoxyprop-2-enyl]piperidin-4-ol

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol In tetrahydrofuran at 20℃; Title compound not separated from byproducts;

...Expand

: 950848-59-6
C13H18BrN3O2

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

A: 950848-60-9
C23H35BrN4O4

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: C18H26BrN3O4 With trifluoroacetic acid In dichloromethane for 0.5h; Stage #2: C13H18BrN3O2; N-tert-butyloxycarbonylpiperidin-4-one With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃; for 16h; Stage #3: With water; sodium hydrogencarbonate In dichloromethane; 1,2-dichloro-ethane

...Expand

: sodium potassium tartrate tetrahydrate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With diisobutylaluminium hydride In tetrahydrofuran; toluene

: 250681-69-7
3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 546-68-9
titanium(IV) isopropylate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 5368-28-5
2-phenyl-3-keto-piperazine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium cyanoborohydride In methanol

...Expand

: 163210-39-7
4-[3-(N-BOC-Piperidin-4-yl)propyl]benzoic acid

A: 4-[3-(Piperidin-4-yl)propyl]benzoyl-2(S)-phenyl-sulfonylamino-β-alanine

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 40064-34-4
4-piperidone monohydrochloride monohydrate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium borohydrid; N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; ethanol; water

: 5382-16-1
4-HYDROXYPIPERIDINE

: 250681-69-7
3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane

...Expand

: 5382-16-1
4-HYDROXYPIPERIDINE

: 24424-99-5
di-tert-butyl dicarbonate

A: 558448-73-0
4-[(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydroquinolin-8-yl)-amino]-piperidine-1-carboxylic Acid Amide (Hydrobromide Salt)

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran

...Expand

: 926291-23-8
(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

A: 1032818-37-3
4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

B: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In methanol at 60℃; for 16h;

...Expand

: 5382-16-1
4-HYDROXYPIPERIDINE

: 24608-52-4
tert-butyl chloroformate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 69395-49-9
4-hydroxypiperazine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 5h;	34 g

: 118811-07-7
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

: 245507-96-4
C9H15ClMg

A: C19H33NO2

B: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

C: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With dilithium tetrachlorocuprate In tetrahydrofuran at 40℃;

...Expand

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 245507-96-4
C9H15ClMg

A: C19H33NO2

B: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

C: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
With copper dichloride In tetrahydrofuran at 20℃;

...Expand

: 98-59-9
p-toluenesulfonyl chloride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 118811-07-7
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%
at 20℃; for 20h;	99%
With triethylamine In dichloromethane at 20℃;	89%

: 124-63-0
methanesulfonyl chloride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 3h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h;	100%

: 108-24-7
acetic anhydride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 850452-53-8
2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 5h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃;	55.17%
In pyridine at 25℃; for 6h;
With pyridine at 20℃;	3 g
With pyridine at 20℃; for 5h;	3 g

: 394-47-8
2-fluorobenzonitrile

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 647014-70-8
4-(2-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃;	100%
With (E)-[4-(hydroxy)piperidin-1-ylsulphonyl]-2-(3-pyridyl)ethene In DMF (N,N-dimethyl-formamide) for 15h;
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Stage #2: 2-fluorobenzonitrile at 50℃; for 1h;

: 19493-44-8
1-chloroisoquinoline

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 817187-34-1
1-tert-butoxycarbonyl-4-(1-isoquinolinyloxy)-piperidine

Conditions

Conditions	Yield
With crown ether; potassium tert-butylate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 611-20-1
salicylonitrile

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 2-(piperidin-4-yloxy)-benzonitrile hydrochloride

Conditions

Conditions	Yield
Stage #1: salicylonitrile; t-butyl 4-hydroxy piperidine-1-carboxylate With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h; Stage #2: With hydrogenchloride; water In 1,4-dioxane at 20℃; for 18h;	100%

: 7379-35-3
4-chlorpyridine hydrochloride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 127806-46-6
2-(piperidin-4-yloxy)pyridine

Conditions

Conditions	Yield
In tetrahydrofuran; dimethyl sulfoxide	100%
In tetrahydrofuran; dimethyl sulfoxide	100%
In tetrahydrofuran; dimethyl sulfoxide	100%

: 21567-18-0
4-(4-chlorophenoxy)phenol

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-[4-(4-chloro-phenoxy)-phenoxy]-piperidine-1-carboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 47℃; for 65.1667h;	100%

: 946859-60-5
2-(4-hydroxyphenyl)-5-methyl-2H-pyrazole-3-carboxylic acid cyclohexylamide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 946859-61-6
4-[4-(5-cyclohexylcarbamoyl-3-methylpyrazol-1-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;	100%

: 14508-49-7
2-chloropyrazin

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 442199-08-8
t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%
In hexane; dimethyl sulfoxide; ethyl acetate

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 287952-21-0
4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium t-butanolate In 1,2-dimethoxyethane at 2 - 17℃; for 0.5h; Stage #2: 4-trifluoromethoxybenzyl bromide In 1,2-dimethoxyethane at 12 - 23℃; for 3h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice; Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h; Cooling with ice;	78%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice; Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h;	78%

: 20266-00-6
chloroacetic acid pyrrolidide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1174044-60-0
tert-butyl 4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
With trifluoroacetic acid; sodium hydroxide In water; toluene at 25℃;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 442199-19-1
tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 1h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃; for 2h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; for 2h;	72%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃;	59%

: 1312756-30-1
3-bromo-5-hydroxy-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1312756-31-2
3-bromo-5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With diethylazodicarboxylate; triphenylphosphine In tetrahydrofuran at 50℃; for 1h;	100%

: 1355011-30-1
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1395284-49-7
methyl 6-(4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2,6-difluorophenyl)-5-fluoropicolinate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;	100%

: 39890-95-4
2-chloro-6-trifluoromethylpyridine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-{[6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Stage #2: 2-chloro-6-trifluoromethylpyridine In tetrahydrofuran; mineral oil at 20℃; for 48h;	100%

: 106-96-7
propargyl bromide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1219827-56-1
tert-butyl 4-(prop-2-yn-1-yloxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere;	100%
In tetrahydrofuran; toluene; mineral oil

: N-[(5-chloro-2-ethylsulfonylphenyl)methyl]-4-hydroxy-3-(trifluoromethyl)benzamide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 4-[4-[(5-chloro-2-ethylsulfonylphenyl)methylcarbamoyl]-2-(trifluoromethyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 50℃; for 19h;	100%

: 89719-92-6
2,5-dichloro-4-(trifluoromethyl)pyridine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-((5-chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In 1,2-dimethoxyethane; mineral oil at 20℃; for 1h; Inert atmosphere; Stage #2: 2,5-dichloro-4-(trifluoromethyl)pyridine In 1,2-dimethoxyethane; mineral oil for 2h; Inert atmosphere; Reflux;	100%

: 45767-66-6
2-chloro-4-fluorobenzylbromide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-((2-chloro-4-fluorobenzyl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Stage #2: 2-chloro-4-fluorobenzylbromide With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 48h;	100%

: 97966-00-2
5-bromo-2,3-dichloropyridine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-((5-bromo-3-chloropyridin-2-yl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl-formamide; mineral oil at 70℃; for 16h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl acetamide at 20℃; for 1h; Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl acetamide at 80℃; Inert atmosphere;	57%

: 28478-46-8
methyl 4-hydroxy-2-methoxybenzoate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 162045-37-6
4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 40℃; for 2h; Inert atmosphere; Sonication;	100%

: 27805-12-5
2-hydroxyl nicotinic acid ethyl ester

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: C18H26N2O5

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; Mitsunobu Displacement;	100%

: 51834-97-0
6-methoxypyridine-3-ol

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: tert-butyl 4-((6-methoxypyridin-3-yl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran at 20℃; for 9h; Inert atmosphere;	100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere;

: 124-63-0
methanesulfonyl chloride

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; ethyl acetate	100%
With triethylamine In dichloromethane; ethyl acetate	100%
With triethylamine In dichloromethane; ethyl acetate	100%

N-BOC-4-Hydroxypiperidine Chemical Properties

The Molecular Structure of N-BOC-4-Hydroxypiperidine (CAS NO.109384-19-2):

Empirical Formula: C₁₀H₁₉NO₃
Molecular Weight: 201.2628
IUPAC Name: tert-butyl 4-hydroxypiperidine-1-carboxylate
Appearance: White to cream powder
storage temp. Store at -15°C
Nominal Mass: 201 Da
Average Mass: 201.2628 Da
Monoisotopic Mass: 201.136493 Da
Index of Refraction: 1.495
Molar Refractivity: 53.03 cm³
Molar Volume: 181.6 cm³
Surface Tension: 42.5 dyne/cm
Density: 1.107 g/cm³
Flash Point: 130.6 °C
Enthalpy of Vaporization: 61.7 kJ/mol
Boiling Point: 292.3 °C at 760 mmHg
Vapour Pressure: 0.000198 mmHg at 25°C
Product Categories: Alcohols and Derivatives;Amines and Anilines;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;Piperidines;Pyrans, Piperidines & Piperazines

N-BOC-4-Hydroxypiperidine Uses

N-BOC-4-Hydroxypiperidine (CAS NO.109384-19-2) is used as pharmaceutical intermediates.

N-BOC-4-Hydroxypiperidine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice.
S36: Wear suitable protective clothing
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

N-BOC-4-Hydroxypiperidine Specification

N-BOC-4-Hydroxypiperidine (CAS NO.109384-19-2) is also called as Tert-butyl 4-hydroxypiperidine-1-carboxylate ; Tert-butyl 4-hydroxy-1-piperidinecarboxylate ; N-(tert-butoxycarbonyl)-4-hydroxypiperidine ; N-(tert-butoxycarbonyl)-4-piperidinol ; N-boc-4-piperidinol ; N-boc-4-hydroxypiperidine ; N-boc-4-hydroxylpiperidine .

Product Name

N-BOC-4-Hydroxypiperidine

Synthetic route

N-BOC-4-Hydroxypiperidine Chemical Properties

N-BOC-4-Hydroxypiperidine Uses

N-BOC-4-Hydroxypiperidine Safety Profile

N-BOC-4-Hydroxypiperidine Specification

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