N-Methylhydroxylamine hydrochloride supplier

Name
N-Methylhydroxylamine hydrochloride
EINECS 224-181-2
CAS No. 4229-44-1
Article Data11
CAS DataBase
Density 1.36 g/cm3
Solubility 0.1 g/mL in water, clear, very faintly yellow
Melting Point 86-88 °C(lit.)
Formula CH₆ClNO
Boiling Point 69.4 °C at 760 mmHg
Molecular Weight 83.5177
Flash Point 41.9 °C
Transport Information UN 1759
Appearance White to almost white crystals or cryst. powder
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Hydroxylamine,N-methyl-, hydrochloride (6CI,7CI,8CI);Methanamine, N-hydroxy-, hydrochloride(9CI);Methylhydroxylamine hydrochloride;Methylhydroxylammonium chloride;N-Hydroxy-N-methanamine hydrochloride;N-Hydroxy-N-methylammonium chloride;N-Hydroxymethanamine hydrochloride;N-Methylhydroxylammonium chloride;
PSA 32.26000
LogP 0.78790

Synthetic route

: 41106-02-9
C-(2-nitrophenyl)-N-methyl-nitrone

A: 4229-44-1
N-methylhydroxyamine hydrochloride

B: 3717-25-7, 4836-00-4, 6635-41-2
2-nitrobenzaldehyde oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; diethyl ether at 20℃; for 4h;	A 98% B n/a

: 67036-74-2, 67036-80-0
4-(N-methylnitrono)-2,2,5,5-tetramethyltetrahydrofuran-3-one E-isomer

A: 14744-18-4
2,2,5,5-Tetramethyl-furan-3,4-dione

B: 4229-44-1
N-methylhydroxyamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Heating;	A 46% B 94%
With hydrogenchloride Heating;	A 43% B 94%
With hydrogenchloride Product distribution; Heating;	A 43% B 94%

: 75-52-5
nitromethane

: 4229-44-1
N-methylhydroxyamine hydrochloride

Conditions

Conditions	Yield
With ammonium chloride; zinc In water for 0.5h;
With ammonium chloride; zinc In water at 0 - 15℃;

: 7647-01-0
hydrogenchloride

: 7500-79-0
N-methyl-diphenyl-nitrone

A: 119-61-9
benzophenone

B: 4229-44-1
N-methylhydroxyamine hydrochloride

Conditions

Conditions	Yield
Hydrolysis;

...Expand

: 80653-57-2
N,O-Dimesyl-N-methylhydroxylamin

A: 110-88-3
1,3,5-Trioxan

B: 50-00-0
formaldehyd

C: 593-77-1
N-Methylhydroxylamine

D: 4229-44-1
N-methylhydroxyamine hydrochloride

E: 2386-57-4
methanesulfonic acid sodium salt

F NH3: NH3

Conditions

Conditions	Yield
With sodium hydroxide In water Mechanism; Product distribution; hydrolysis with basic, neutral and acidic aqu. solutions;	A 5 % Spectr. B n/a C 1 % Spectr. D n/a E 33 % Spectr. F n/a

...Expand

: 314768-38-2, 919112-42-8
(Z)-C-(3,4-dimethoxyphenyl)-N-methyl-nitrone

A: 2169-98-4, 39627-82-2
3,4-Dimethoxy-benzaldehyde oxime

B: 4229-44-1
N-methylhydroxyamine hydrochloride

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; diethyl ether at 20℃; for 4h;

: 593-77-1
N-Methylhydroxylamine

: 4229-44-1
N-methylhydroxyamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 25℃; Cooling with ice;	333.4 g

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 555-16-8
4-nitrobenzaldehdye

: 16089-71-7, 57414-31-0, 97792-07-9
N-(p-nitrobenzylidene)methylamine N-oxide

Conditions

Conditions	Yield
With 3 A molecular sieve at 20℃; for 0.25h;	100%
With sodium hydroxide; silica gel at 20℃; for 0.166667h;	96%
With sodium hydrogencarbonate In dichloromethane for 0.1h; microwave irradiation;	95%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 552-89-6
2-nitro-benzaldehyde

: 41106-02-9
α-(2-nitrophenyl)-N-methylnitrone

Conditions

Conditions	Yield
With 3 A molecular sieve at 20℃; for 0.25h;	100%
With sodium hydroxide; silica gel at 20℃; for 0.166667h;	98%
With potassium carbonate In methanol Reflux;	96.5%
With ethanol; potassium acetate

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 88176-86-7
3a-(3,4-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one

: 91713-15-4
3a-(3,4-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

Conditions

Conditions	Yield
With sodium acetate In ethanol for 40h; Heating;	100%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 100-52-7
benzaldehyde

: 3376-23-6
N-methyl-α-phenylnitrone

Conditions

Conditions	Yield
With benzophenone Product distribution; Further Variations:; Reagents;	100%
With sodium hydrogencarbonate In dichloromethane at 50℃; for 4.5h;	100%
With magnesium oxide at 20℃; for 0.0416667h; Grinding; Neat (no solvent);	98%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 5,6,7-trideoxy-2,3-O-isopropylidene-α,β-D-lyxo-hept-6-enofuranose

: 158227-57-7
C11H19NO4

Conditions

Conditions	Yield
With pyridine for 20h; Ambient temperature;	100%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 133505-00-7
(2R*,3R*)-1-(4-methoxyphenyl)-3-methyl-4-oxoazetidine-2-carbaldehyde

: C13H16N2O3

Conditions

Conditions	Yield
With triethylamine In benzene at 20℃; for 16h;	100%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 159910-49-3, 638199-75-4, 154497-06-0
5,11,17,23-Tetraformyl-25,26,27,28-tetrapropoxycalix[4]arene

: p-propyloxycalix[4]arenenitrone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃;	100%

: 1256824-45-9
C7H5N3O2

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1-(4-fluorobenzyl)-N-hydroxy-N-methyl-1H-pyrazolo[3,4-c]pyridine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine; HATU In DMF (N,N-dimethyl-formamide)	100%

: 26260-02-6
2-iodobenzaldehyde

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1037396-94-3
(Z)-N-(2-iodobenzylidene)methylamine N-oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 20℃; for 2h;	100%

: 4265-16-1
2-formylbenzo[b]furan

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1037397-11-7
(Z)-N-(benzofuran-2-ylmethylidene)methylamine N-oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 20℃; for 0.5h;	100%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1037396-90-9, 33499-28-4
(Z)-1-(4-iodo phenyl)-N-methylmethanimine oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 20℃; for 1h;	100%
With magnesium sulfate; triethylamine In dichloromethane at 0 - 20℃; for 48h;	91%

: 110-62-3
pentanal

: 4229-44-1
N-methylhydroxyamine hydrochloride

: N-methylpentan-1-imine oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate; calcium chloride In diethyl ether; water for 1h;	100%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 2243-42-7
2-phenoxybenzoic acid

: C14H13NO3

Conditions

Conditions	Yield
Stage #1: 2-phenoxybenzoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 23℃; Stage #2: N-methylhydroxyamine hydrochloride With triethylamine In tetrahydrofuran; dichloromethane; water at 23℃;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 19689-97-5
N-(tert-butoxycarbonyl)-N-methylhydroxylamine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	99%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 5h;	97%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 5h;	97%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 91712-97-9
3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one

: 91712-99-1
3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

Conditions

Conditions	Yield
With sodium acetate In ethanol Heating;	99%

: 51801-01-5, 87246-94-4, 97996-32-2, 100017-27-4, 100017-28-5, 108033-84-7, 146566-19-0, 146566-20-3, 79594-08-4
(E)-1-acetoxy-1-phenyl-2-butene

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 118149-83-0
N-Methyl-N-((E)-1-methyl-3-phenyl-allyl)-hydroxylamine

Conditions

Conditions	Yield
With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran	99%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 645-45-4
hydrocinnamic acid chloride

: 111750-23-3
N-hydroxy-N-methyl-3-phenylpropanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	99%
With triethylamine In dichloromethane for 1h; Ambient temperature;	88%
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; Inert atmosphere;	75%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 501-53-1
benzyl chloroformate

: 15058-52-3
benzyl hydroxy(methyl)carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	99%
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 15.5h;	3%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 552-89-6
2-nitro-benzaldehyde

: 41106-02-9
C-(2-nitrophenyl)-N-methyl-nitrone

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h;	99%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 100-52-7
benzaldehyde

: 3376-23-6, 7372-59-0, 59862-60-1
N-(benzylidene)methylamine N-oxide

Conditions

Conditions	Yield
In sodium hydroxide at 20℃; for 0.5h;	99%
With sodium hydrogencarbonate In ethanol at 60℃; for 18h;	71%

: 40138-16-7
2-formylbenzene boronic acid

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1,2-dihydro-1,1-dihydroxy-3-methyl-1H-2,3,1,-benzoxazaborine

Conditions

Conditions	Yield
With aq. NaOH In ethanol; water standing (pH=7, room temp., 12 h); evapn. (50°C), dissolution (MeOH), filtration, evapn., dissolution (water), evapn., washing (Me2CO), drying;	99%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 2937-50-0
Allyl chloroformate

: 15151-43-6
allyl hydroxy(methyl)carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	99%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 541-41-3
chloroformic acid ethyl ester

: 3016-84-0
ethyl hydroxyl(methyl)carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	99%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;

: C25H26O4

: 4229-44-1
N-methylhydroxyamine hydrochloride

: C26H29NO4

Conditions

Conditions	Yield
Stage #1: C25H26O4 With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide Stage #2: N-methylhydroxyamine hydrochloride With triethylamine In tetrahydrofuran; dichloromethane; water at 23℃;	99%

: 66223-54-9, 93614-80-3
(E)-3-(m-tolyl)acrylaldehyde

: 4229-44-1
N-methylhydroxyamine hydrochloride

: (Z)-N-((E)-3-(m-tolyl)allylidene)methanamine oxide

Conditions

Conditions	Yield
With sodium sulfate; triethylamine In dichloromethane at 0℃;	99%

: 1528764-16-0
5-(tertbutyldiphenylsilyloxymethyl)furfural

: 4229-44-1
N-methylhydroxyamine hydrochloride

: (Z)-1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)furan-2-yl)-N-methylmethanimine oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate; magnesium sulfate In isopropyl alcohol at 20℃; for 16h;	99%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 4229-44-1
N-methylhydroxyamine hydrochloride

: (Z)-1-(5-(hydroxymethyl)furan-2-yl)-N-methylmethanimine oxide

Conditions

Conditions	Yield
With sodium hydrogencarbonate; magnesium sulfate In isopropyl alcohol at 20℃; for 16h;	99%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 99-61-6
3-nitro-benzaldehyde

: 16089-77-3, 54420-44-9, 54420-46-1
α-(3-nitrophenyl)-N-methylnitrone

Conditions

Conditions	Yield
With 3 A molecular sieve at 20℃; for 0.25h;	98%
With sodium hydrogencarbonate In dichloromethane for 0.1h; microwave irradiation;	96%
With sodium hydroxide; silica gel at 20℃; for 0.166667h;	96%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 135-02-4
ortho-anisaldehyde

: 33499-30-8
N-(2-methoxybenzylidene)methanamine N-oxide

Conditions

Conditions	Yield
With triethylamine In chloroform for 22h;	98%
With magnesium oxide at 20℃; for 0.05h; Grinding; Neat (no solvent);	95%
With sodium hydrogencarbonate In dichloromethane for 0.25h; microwave irradiation;	88%

: 98-01-1
furfural

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 41106-11-0, 91328-46-0, 925933-52-4
N-[2-furylmethylene]methanamine N-oxide

Conditions

Conditions	Yield
With triethylamine In chloroform for 22h;	98%
With sodium sulfate; sodium carbonate at 20℃; for 0.05h; Neat (no solvent);	94%
With magnesium oxide at 20℃; for 0.0833333h; Grinding; Neat (no solvent);	92%

N-Methylhydroxylamine hydrochloride Chemical Properties

Molecular Formula: CH₆ClNO
Molecular Weight: 83.52
EINECS: 224-181-2
Polar Surface Area: 12.47 Å²
Flash Point: 41.9 °C
Sensitive Hygroscopic
Melting Point: 86-88 °C(lit.)
Enthalpy of Vaporization: 36.27 kJ/mol
Boiling Point: 69.4 °C at 760 mmHg
Vapour Pressure: 96.6 mmHg at 25°C
IUPAC Name: N-methylhydroxylamine hydrochloride
Solubility: H₂O: 0.1 g/mL, clear, very faintly yellow
Water Solubility of N-Methylhydroxylamine hydrochloride (CAS NO.4229-44-1): soluble
Synonyms of N-Methylhydroxylamine hydrochloride (CAS NO.4229-44-1): Methanamine,n-hydroxy-,Hydrochloride ; N-hydroxy-methanaminhydrochloride ; N-methylhydroxyaminehydrochloride ; Hydroxylaminomethane hydrochloride ; N-methylhydroxylamine hcl ; N-methylhydroxylamine hydrochloride ; N-methylhydroxylammonium chloride ; N-methylhydroxylaminehydrochloride,98%
Following is the molecular structure of N-Methylhydroxylamine hydrochloride (CAS NO.4229-44-1):

N-Methylhydroxylamine hydrochloride Safety Profile

Safety Information of N-Methylhydroxylamine hydrochloride (CAS NO.4229-44-1):
Hazard Codes: Xi
Xi: Irritant
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-24/25
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
24/25: Avoid contact with skin and eyes
RIDADR: 1759
WGK Germany: 3

Product Name

N-Methylhydroxylamine hydrochloride

Synthetic route

N-Methylhydroxylamine hydrochloride Chemical Properties

N-Methylhydroxylamine hydrochloride Safety Profile

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