N,N,N',N'-Tetramethylethylenediamine supplier

Name
N,N,N',N'-Tetramethylethylenediamine
EINECS 203-744-6
CAS No. 110-18-9
Article Data83
CAS DataBase
Density 0.817 g/cm³
Solubility miscible with water
Melting Point -55 °C(lit.)
Formula C₆H₁₆N₂
Boiling Point 121 °C at 760 mmHg
Molecular Weight 116.206
Flash Point 10 °C
Transport Information UN 2372 3/PG 2
Appearance Colorless to slightly yellow liquid
Safety 16-26-36/37/39-45
Risk Codes 11-20/22-34-20/21/22
Molecular Structure
Hazard Symbols F,C
Synonyms 1,2-Ethanediamine,N,N,N',N'-tetramethyl- (9CI);Ethylenediamine, N,N,N',N'-tetramethyl-(6CI,8CI);(2-(Dimethylamino)ethyl)dimethylamine;1,2-Bis(dimethylamino)ethane;2,5-Dimethyl-2,5-diazahexane;Dabco TMEDA;Dimethyl[2-(dimethylamino)ethyl]amine;Kaolizer 11;MR;MR (amine);N,N,N',N'-Tetramethyl-1,2-diaminoethane;N,N,N',N'-Tetramethyl-1,2-ethanediamine;N,N,N',N'-Tetramethyl-1,2-ethylenediamine;Propamine D;TEMED;TMED;TMEDA;Tetrameen;Toyocat TE;
PSA 6.48000
LogP 0.10960

Synthetic route

: 124-40-3
dimethyl amine

: 106-93-4
ethylene dibromide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In chloroform at 20℃; for 24h;	100%

: 124-40-3
dimethyl amine

: 74-86-2
acetylene

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With 1-ethyl-2-pyrrolidinone; sodium stannate(IV) trihydrate; alumina; calcium hydroxide at 45 - 80℃; for 6h; Reagent/catalyst; Temperature; Autoclave; Inert atmosphere;	98.6%

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With oxalic acid at 100 - 120℃; Eschweiler-Clarke methylation;	96%
With hydrogen In methanol at 130℃; under 15001.5 Torr; for 4.5h; Autoclave;	89%
With formic acid for 11h; Eschweiler-Clarke reaction; Reflux;	80%
at 130 - 160℃;
With water at 130 - 160℃; im Autoklaven;

: 67-56-1
methanol

: 107-15-3
ethylenediamine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With hydrogen at 180℃; under 7500.75 Torr;	91.6%
With hydrogen at 180℃; under 7500.75 Torr;	91.6%

: 89184-58-7
Li(1+)*((H3C)2NCH2)2*(C5H5)V(C3H5)2(1-)=(Li((H3C)2NCH2)2)((C5H5)V(C3H5)2)

: 201230-82-2
carbon monoxide

A: tetracarbonyl(η(5)-cyclopentadienyl)vanadium(I)

B: 592-42-7
1,5-Hexadien

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: dilithium (η-cyclopentadienyl)tri(carbonyl)vanadate

Conditions

Conditions	Yield
In tetrahydrofuran reaction of CO with (LiTMEDA)(CpV(C3H5)2) in THF (Ar); formation of 1,5-hexadiene in the reaction soln., extn. of the residue with toluene, filtering off the solid and drying to give Li2(CpV(CO)3), evapn. of the filtrate to dryness and subliming the residue in a high vacuum at 80°C to give CpV(CO)4;	A 91% B 46% C n/a D n/a

...Expand

: 366-18-7
[2,2]bipyridinyl

: [(N,N,N′,N′-tetramethylethylenediamine)Ni{CH2C(CH3)C(CH3)CH2COO}]

A: (CH2C(CH3)C(CH3)CH2COO)Ni((C5H4N)2)

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In diethyl ether vigorously stirring a suspension of (3,4,5-η3)-3,4-dimethyl-3-pentenylato-N,N,N',N'-tetramethylethylenediaminenickel(II) in ether with 2,2'-bipyridine (CO2 or Ar); filtn. of the formed brown yellow ppt. after 24 h, shaking with THF fora few hours, filtn. and washing the residue with ether, drying in vacuo, elem. anal.;	A 90% B n/a

...Expand

: Roussin's red salt dianion

: C6H16N2*2HNO(1-)*Fe(2+)

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: Fe4H2N8O8S2(2-)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.333333h; Inert atmosphere; Schlenk technique;	A n/a B 86%

...Expand

: 141-46-8
Glycolaldehyde

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With platinum on carbon; hydrogen In ethanol at 25℃; under 30003 Torr; for 12h; Solvent; Pressure; Reagent/catalyst; Autoclave;	A 84% B 8%
With 5%-palladium/activated carbon; hydrogen In ethanol at 25 - 80℃; under 30003 Torr; for 3h; Autoclave;	A 35% B 40%

...Expand

: 1020084-83-6
[4-Et(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[4-Et(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 83% C n/a

...Expand

: 1020084-88-1
[2-OMe(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[2-OMe(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 82% C n/a

...Expand

: [3-OMe(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[3-OMe(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 79% C n/a

...Expand

: 1020084-86-9
[4-OMe(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[4-OMe(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 78% C n/a

...Expand

: 1020084-84-7
[4-n-Bu(C6H4)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: cis-[4-n-Bu(C6H4)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 70% C n/a

...Expand

: 1206534-47-5
[(3-C4H3O)C(NSiMe3)2]Li(TMEDA)

: 10026-11-6
zirconium(IV) chloride

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: cis-[(3-C4H3O)C(NSiMe3)2]2ZrCl2

C: lithium chloride

Conditions

Conditions	Yield
In toluene at 0℃; for 3h; Cooling; Schlenk technique;	A n/a B 68% C n/a

...Expand

: 112506-19-1
(tetramethylethylenediamine)lithium trihydro(2,4,6-tri-tert-butylphenyl)borate

A: 112506-16-8
5,7-di-tert-butylhydroxy-3,3-dimethyl-1-boraindane

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With hydrogenchloride; water In diethyl ether; water byproducts: H2, LiCl; addn. of HCl to ether soln. of borate (0°C), stirring (room temp., 1 h), aq. HCl addn.; drying of etheral phase (Na2SO4), solvent removal (vacuum), repptn. (pentane); elem. anal.;	A 53% B n/a

: 112506-19-1
(tetramethylethylenediamine)lithium trihydro(2,4,6-tri-tert-butylphenyl)borate

A: 112506-15-7
hydroxy(2,4,6-tri-tert-butylphenyl)borane

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With water In tert-butyl alcohol byproducts: H2, LiOH; stirring (0°C, 6h, room temp., 12 h); solvent removal (vacuum), addn. of ether/water, drying of ether phase (Na2SO4), solvent removal (vacuum), recrystn. (pentane); elem. anal.;	A 36% B n/a

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With methanol; nickel at 175 - 200℃; under 40452.9 Torr; Hydrogenation;

: 50-00-0
formaldehyd

: 22029-36-3
ethylenediammonium sulfate

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
at 130 - 140℃; Destillation des Reaktionsprodukts mit Kalilauge;

: 124-41-4
sodium methylate

: 19826-49-4
4,5-epoxy-3,6-dimethoxy-17,17-dimethyl-morphina-6,8-dienium; iodide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 4,5-epoxy-6-hydroxy-3-methoxy-17,17-dimethyl-1-sulfo-morphinanium betaine

: furan-2,3,5(4H)-trione pyridine (1:1)

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
at 140℃; unter Druck;

: 124-40-3
dimethyl amine

: 107-99-3
2-(dimethylamino)ethyl chloride

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With xylene

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 107-15-3
ethylenediamine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

...Expand

: 107-99-3
2-(dimethylamino)ethyl chloride

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With alkalies

: 74-85-1
ethene

: 124-40-3
dimethyl amine

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
Multistep reaction;

: 140-31-8
aminoethylpiperazine

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 107-06-2
1,2-dichloro-ethane

A: 106-58-1
N,N'-dimethylpiperazine

B: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: 1-<2-(diethylamino)ethyl>-4-methylpiperazine

E: N,N'-dimethyl-N,N'-bis<2-(4-methyl-1-piperazinyl)ethyl>ethylenediamine

Conditions

Conditions	Yield
Mechanism;

...Expand

: 140-31-8
aminoethylpiperazine

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 107-06-2
1,2-dichloro-ethane

A: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

C: 1-<2-(diethylamino)ethyl>-4-methylpiperazine

D: N,N'-dimethyl-N,N'-bis<2-(4-methyl-1-piperazinyl)ethyl>ethylenediamine

Conditions

Conditions	Yield
Multistep reaction. Further byproducts given;

...Expand

: 41203-22-9
1,4,8,11-tetramethyl-1,4,8,11-tetra-azacyclotetradecane

: 9-(n-propyl)fluorenyllithium tetramethylenediamine complex

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: 9-(n-propyl)fluorenyllithium hexamethyltetraazacyclotetradecane complex

Conditions

Conditions	Yield
In toluene at 25℃; Rate constant;

...Expand

: 32317-47-8
(1-ethyl-propenyl)-dimethyl-amine

: 71889-99-1
N,N,N',N'-tetramethyl-1,2-diaminoethane-H+

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: C7H15N*H(1+)

Conditions

Conditions	Yield
ICR double resonance, proton affinity;

...Expand

: 20916-47-6
N,N-Dimethylisobutenylamin

: 71889-99-1
N,N,N',N'-tetramethyl-1,2-diaminoethane-H+

A: 110-18-9
N,N,N,N,-tetramethylethylenediamine

B: C6H13N*H(1+)

Conditions

Conditions	Yield
ICR double resonance, proton affinity;

...Expand

: 107-21-1
ethylene glycol

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
With tris(triphenylphosphine)ruthenium(II) chloride at 120℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With ruthenium trichloride at 120℃; for 2.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 2622-05-1
allylmagnesium bromide

: Bis(allylmagnesiumchlorid-TMEDA)

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: C5H7BrMg*2C4H8O

: C6H16N2*C5H7BrMg

Conditions

Conditions	Yield
In tetrahydrofuran; pentane for 2h; Ambient temperature;	100%

: 109-99-9
tetrahydrofuran

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 829-85-6
diphenylphosphane

: 4C12H10PTe2(1-)*C6H16N2*14C4H8O*4Li(1+)

Conditions

Conditions	Yield
Stage #1: tetrahydrofuran; N,N,N,N,-tetramethylethylenediamine; diphenylphosphane With n-butyllithium In tetrahydrofuran; hexane Stage #2: With tellurium In tetrahydrofuran; hexane at -78 - 20℃;	100%

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 639-58-7
triphenyltin chloride

: 7440-66-6
zinc

: Ph3SnZnCl * N,N,N',N'-tetramethylethylenediamine

Conditions

Conditions	Yield
In acetonitrile; benzene Electrolysis; absence of oxygen and moisture; W-cathode, Zn suspended on Pt-anode, 30 V, 25 mA, 3.0 h, Et4NClO4 electrolyte; sepn. of pptd. product (further crop on addn. of petroleum ether), washing (petroleum ether), drying (vac.); elem. anal.;	100%

...Expand

: bis(η3-allyl-μ-chloropalladium(II))

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 80533-23-9
[η**3-2-propenyl](N,N,N',N'-tetramethylethylenediamine)palladium(II) dichloro(η**3-2-propenyl)palladate(II)

Conditions

Conditions	Yield
In acetone TMEDA added to -50°C soln.; stirred 1 h at -50°C; solvent vac. removed; recrystd. from acetone/toluene at -20°C; elem. anal.;	100%

: 12146-37-1, 124717-04-0
(bicyclo[2.2.1]hepta-2,5-diene)tetracarbonylmolybdenum(0)

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

A: 23301-98-6
(N,N,N',N'-tetramethylethylenediamine)tetracarbonylmolybdenum(0)

B: 121-46-0
bicyclo[2.2.1]hepta-2,5-diene

Conditions

Conditions	Yield
In tetrahydrofuran reaction in a calorimeter under argon;	A 100% B n/a

...Expand

: {Li(μ-OB(CH(SiMe3)2)2}2

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 127161-53-9
LiOB(CH(SiMe3)2)2((Me2NCH2)2)

Conditions

Conditions	Yield
In hexane react. at 25°C; filtering, filtrate at -20°C;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 7550-45-0
titanium tetrachloride

: 19033-22-8
tetrachloro(N,N,N',N'-tetramethylethane-1,2-diamine)titanium(IV)

Conditions

Conditions	Yield
In hexane at 0℃; for 1h; Inert atmosphere;	100%
In benzene solns. mixed at 10-20°C; filtered, washed (benzene), dried (vac.); elem. anal.;	>99
In pentane solns. mixed at 10-20°C; filtered, washed (pentane), dried (vac.); elem. anal.;	>99

: aluminium hydride

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 72049-53-7
N,N,N',N',-tetramethylethylenediamine*2AlH3

Conditions

Conditions	Yield
In diethyl ether at 25°C; ppt. collected by centrifugation, washed with Et2O, dried, elem. anal.;	100%

: (cyclooctadienyl)(cyclopentadienyl)ruthenium chloride

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 260066-12-4
[(η5-C5H5)RuCl(N,N,N',N'-tetramethylethylenediamine)]

Conditions

Conditions	Yield
In acetone soln. of Ru-complex and ligand in acetone was stirred at room temp. for 2 h under Ar; solvent was removed under vac., washed with pentane;	100%

: 636-98-6
p-nitrobenzene iodide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 32005-36-0
bis(dibenzylideneacetone)-palladium(0)

: 191667-18-2
PdI(4-NO2C6H4)(N,N,N',N'-tetramethylethylenediamine)

Conditions

Conditions	Yield
In not given byproducts: dibenzylideneacetone; N2-atmosphere; according to Markies, A. J. et al.: J. Organomet. Chem. 482 (1994) 191; elem. anal.;	100%

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 13329-40-3
4-Iodoacetophenone

: 32005-36-0
bis(dibenzylideneacetone)-palladium(0)

: 191667-17-1
PdI(4-MeCOC6H4)(N,N,N',N'-tetramethylethylenediamine)

Conditions

Conditions	Yield
In not given byproducts: dibenzylideneacetone; N2-atmosphere; according to Markies, A. J. et al.: J. Organomet. Chem. 482 (1994) 191; elem. anal.;	100%

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: di-μ-chloro-bis[η**3-2-butenyl]dipalladium

: [(η**3-2-butenyl)(N,N,N',N'-tetramethylethylenediamine)palladium(II)] dichloro(η**3-2-butenyl)palladate

Conditions

Conditions	Yield
In acetone TMEDA added dropwise at -50°C, stirred 1 h at -50°C; solvent vac. evapd.; trituration with ether, dried in vac.; elem. anal.;	100%

: 14104-20-2
silver tetrafluoroborate

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: di-μ-chloro-bis[η**3-2-butenyl]dipalladium

: [η**3-2-butenyl](N,N,N',N'-tetramethylethylenediamine)palladium(II) tetrafluoroborate

Conditions

Conditions	Yield
In tetrahydrofuran byproducts: AgCl; π-2-butenylpalladium chloride dimer dissolved in THF; AgBF4 added; stirred 10 min; AgCl removed and washed with THF; TMEDA added dropwise toTHF extracts, stirred 10 min; solvent vac. removed; elem. anal.;	100%

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: di-μ-chloro-bis[η**3-3-phenyl-2-propenyl]dipalladium

: [η**3-3-phenyl-2-propenyl](N,N,N',N'-tetramethylethylenediamine)palladium(II) dichloro(η**3-3-phenyl-2-propenyl)palladate(II)

Conditions

Conditions	Yield
In acetone TMEDA added dropwise to -50°C soln.; stirred 1 h at -50°C; solvent vac. removed; elem. anal.;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 176650-93-4
3,5-bis(3,5-dimethoxybenzocarboxymethyl)benzyl bromide

: N,N'-ethane-1,2-diyl N,N'-[3,5-bis(3,5-dimethoxybenzyloxy)benzyloxy] N,N,N',N'-tetramethylammonium dibromide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 70℃; Inert atmosphere;	100%
In N,N-dimethyl-formamide at 70℃; for 15h; Inert atmosphere;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: ThCl4(dimethoxyethane)2

: ThCl4(N,N-tetramethylethylenediamine)2

Conditions

Conditions	Yield
In tetrahydrofuran excess N,N-tetramethylethylenediamine;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 639084-65-4
[ThCl4(1,2-dimethoxyethane)2]

: 159472-32-9
ThCl4(Me2NCH2CH2NMe2)2

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: [Zr(C5H4NC(CH3)(CH2NSitBuMe2)2)(NNPh2)(Li(py))(phenylacetylene(-1H))]

: [Zr(C5H4NC(CH3)(CH2NSitBuMe2)2)(NNPh2)(Li(tetramethylethylenediamine))(phenylacetylene(-1H))]

Conditions

Conditions	Yield
In toluene at 20℃;	100%

: 2314-97-8
iodotrifluoromethane

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 2CF3I*C6H16N2

Conditions

Conditions	Yield
at -78℃; for 0.333333h; Schlenk technique; Inert atmosphere; Reflux;	100%
at -78℃; for 0.333333h; Inert atmosphere; Reflux;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 5439-32-7
2-bromo-N-hexylethanamide

: C22H48N4O2(2+)*2Br(1-)

Conditions

Conditions	Yield
In chloroform at 85℃; for 24h;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 5326-97-6
2-Bromo-N-(n-octyl)acetamide

: C26H56N4O2(2+)*2Br(1-)

Conditions

Conditions	Yield
In chloroform at 85℃; for 24h;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 5345-68-6
2-bromo-N-decyl-acetamide

: C30H64N4O2(2+)*2Br(1-)

Conditions

Conditions	Yield
In chloroform at 85℃; for 24h;	100%
In acetonitrile for 1h; Reflux;	44%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: [(tris(tert-butoxy)siloxy)2chromium(II)]2

: [chromium(II)(tris(tert-butoxy)siloxy)2(N,N,N′,N′-tetramethylethylenediamine)]

Conditions

Conditions	Yield
In hexane at 25℃; Inert atmosphere; Glovebox;	100%

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: C38H68Li2N6O2

: C21H40LiN5

Conditions

Conditions	Yield
In diethyl ether for 1h;	100%

: 18908-66-2
2-ethylhexyl bromide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: N-(2-(dimethylamino)ethyl)-2-ethyl-N,N-dimethylhexan-1-aminium bromide

Conditions

Conditions	Yield
for 12h; Reflux;	100%

: 1,3,5-tris(1-imidazolyl)benzene

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 2H2NO3(1-)*(x)H2O*Pd(2+)

: C96H144N36Pd6

Conditions

Conditions	Yield
Stage #1: N,N,N,N,-tetramethylethylenediamine; 2H2NO3(1-)(x)H2OPd(2+) In dimethyl sulfoxide at 80℃; for 0.166667h; Stage #2: 1,3,5-tris(1-imidazolyl)benzene In dimethyl sulfoxide at 80℃; for 2h;	100%

...Expand

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 32752-54-8
4-(bromomethyl)benzophenone

: ethylenebis(4-benzoylbenzyldimethylammonium) dibromide

Conditions

Conditions	Yield
In chloroform at 20℃; for 72h;	99.7%
In chloroform at 20℃; for 72h;	99.7%
In chloroform

: nido-NB10H13

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 22560-16-3
lithium triethylborohydride

: Li(1+)*2(CH3)2N(CH2)2N(CH3)2*{NB10H12}(1-)={Li((CH3)2N(CH2)2N(CH3)2)2}{NB10H12}

Conditions

Conditions	Yield
In tetrahydrofuran byproducts: B(C2H5)3, H2; addn. of Li(BHEt3) in THF to soln. of the borane at -78°C, stirred for 5 min at room temp., volatiles removed in vac., addn. of THF, addn. of tmeda;; concentrated, washed three times with pentane, dried;;	99%

...Expand

N,N,N',N'-Tetramethylethylenediamine Chemical Properties

Molecular formula: C₆H₁₆N₂
Molar mass: 116.24 g/mol
EINECS: 203-744-6
Index of Refraction: 1.437
Density: 0.817 g/cm³
Flash Point: 10 °C
Sensitive: Hygroscopic
Melting point: -55 °C(lit.)
Storage tempreture: Store at RT.
Water solubility: Miscible
Enthalpy of Vaporization: 35.91 kJ/mol
Boiling Point: 121 °C at 760 mmHg
Vapour Pressure: 14.9 mmHg at 25 °C
Solubility: H₂O: 10 mg/mL at 20 °C, clear, colorless
Appearance: Colorless to slightly yellow liquid
Structure of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9):

Product Category of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9): Biochemistry;Reagents for Electrophoresis

N,N,N',N'-Tetramethylethylenediamine Uses

N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9) is widely used as a ligand for metal ions. It is used with ammonium persulfate to catalyze the polymerization of acrylamide when making polyacrylamide gels, and can be used in gel electrophoresis for the separation of proteins or nucleic acids.

N,N,N',N'-Tetramethylethylenediamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	630mg/kg (630mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984.
quail	LD50	oral	> 316mg/kg (316mg/kg)		Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rabbit	LD50	skin	5390mg/kg (5390mg/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit	LD50	subcutaneous	1230mg/kg (1230mg/kg)		Toxicologist. Vol. 15, Pg. 19, 1995.
rat	LC50	inhalation	1318ppm/4H (1318ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: IRRITABILITY	Toxicologist. Vol. 8, Pg. 249, 1988.
rat	LD50	oral	268mg/kg (268mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES SPINAL CORD: OTHER DEGENERATIVE CHANGES	Toxicologist. Vol. 15, Pg. 19, 1995.

N,N,N',N'-Tetramethylethylenediamine Consensus Reports

Reported in EPA TSCA Inventory.

N,N,N',N'-Tetramethylethylenediamine Safety Profile

Moderately toxic by ingestion. Mildly toxic by skin contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.
Hazard Codes: F, Corrosive C,Xi
Risk Statements: 11-20/22-34-20/21/22
R11:Highly flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R20/22:Harmful by inhalation and if swallowed.
R34:Causes burns.
Safety Statements: 16-26-36/37/39-45
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

N,N,N',N'-Tetramethylethylenediamine Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

N,N,N',N'-Tetramethylethylenediamine Specification

N,N,N',N'-Tetramethylethylenediamine , its cas register number is 110-18-9. It also can be called 1,2-Di(dimethylamino)ethane ; TMEDA ; and TEMED . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.

Product Name

N,N,N',N'-Tetramethylethylenediamine

Synthetic route

N,N,N',N'-Tetramethylethylenediamine Chemical Properties

N,N,N',N'-Tetramethylethylenediamine Uses

N,N,N',N'-Tetramethylethylenediamine Toxicity Data With Reference

N,N,N',N'-Tetramethylethylenediamine Consensus Reports

N,N,N',N'-Tetramethylethylenediamine Safety Profile

N,N,N',N'-Tetramethylethylenediamine Standards and Recommendations

N,N,N',N'-Tetramethylethylenediamine Specification

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