N-Propyl formate supplier | CasNO.110-74-7

Name
PROPYL FORMATE
EINECS
CAS No. 110-74-7
Article Data53
CAS DataBase
Density 0.896g/cm³
Solubility 22g/L(22 oC)
Melting Point −93 °C(lit.)
Formula C4H8 O2
Boiling Point 81.9°Cat760mmHg
Molecular Weight 88.1063
Flash Point °C
Transport Information
Appearance clear colorless liquid
Safety Moderately toxic by ingestion. An irritant to skin, eyes, and mucous membranes. Narcotic in high concentration. Dangerous fire hazard when exposed to heat, flame, or oxidizers. Ignites on contact with potassium-tert-butoxide. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
Risk Codes 11-36/37-67
Molecular Structure
Hazard Symbols Flammable, dangerous fire risk.
Synonyms Propylformate; Propyl methanoate; n-Propyl formate
PSA 26.30000
LogP 1.20530

Synthetic route

: 123-72-8
butyraldehyde

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With oxygen; toluene-4-sulfonic acid; acetic acid at 20℃; for 2h; Baeyer-Villiger Ketone Oxidation;	97%

: 71-23-8
propan-1-ol

: 39689-37-7
sodium salt of β-mercaptonaphthalene

A: 110-74-7
propyl methanoate

B: 75052-54-9
naphthalene-2-yl(propyl)sulfane

Conditions

Conditions	Yield
With carbon monoxide at 150℃; under 75006 Torr; for 10h;	A n/a B 95%

...Expand

: 71-23-8
propan-1-ol

: 64-18-6
formic acid

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With pyridine; N,N'-dibromo-N,N'-(1,2-ethanediyl)bis(p-toluenesulfonamide); triphenylphosphine In dichloromethane at 20℃;	91%
With sulfuric acid In water for 4h; Reflux;	75%
With sulfuric acid In 1,4-dioxane at 60℃; Equilibrium constant;

: 71-23-8
propan-1-ol

: 57-48-7
D-Fructose

A: 1917-66-4
5-(n-propoxymethyl)-2-furancarboxadehyde

B: 111-43-3
Dipropyl ether

C: 110-74-7
propyl methanoate

D: 645-67-0
n-propyl levulinate

Conditions

Conditions	Yield
With poly(p-styrenesulfonic acid)-grafted carbon nanotubes at 120℃; for 24h; Sealed tube; Green chemistry; chemoselective reaction;	A n/a B n/a C n/a D 86%

...Expand

: 71-23-8
propan-1-ol

: 96-26-4
dihydroxyacetone

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With Cu/Al2O3; dihydrogen peroxide In chloroform at 80℃; for 24h;	83%

: 71-23-8
propan-1-ol

: 536-74-3
phenylacetylene

A: 110-74-7
propyl methanoate

B: 2315-68-6
propyl benzoate

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene at 60℃; for 15h; Sealed tube;	A n/a B 72%

...Expand

: 121393-39-3
5,10,15,20-tetra(2,4,6-trimethylphenyl)porphyrinate rhodium(II)

: 111-43-3
Dipropyl ether

: 342790-12-9
(5,10,15,20-tetra(2,4,6-trimethylphenyl)porphyrinato)rhodium(III) ethyl

B: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With water; tetraphenylphosphonium bromide; triphenylphosphine; potassium hydroxide at 25℃; Inert atmosphere; Darkness; regioselective reaction;	A 62% B n/a

...Expand

: 31144-05-5
2-(tert-butylperoxy)tetrahydrofuran

A: 96-48-0
4-butanolide

B: 110-74-7
propyl methanoate

C: formic acid 3-tert-butoxypropyl ester

D: 67-64-1
acetone

E: 75-65-0
tert-butyl alcohol

Conditions

Conditions	Yield
In various solvent(s) at 120℃; for 14h; Mechanism; Product distribution;	A 30% B 11% C 12% D 7% E 61%

...Expand

: 71-23-8
propan-1-ol

: 50-99-7
D-glucose

A: 64-18-6
formic acid

B: 110-74-7
propyl methanoate

C: 109-60-4
1-Propyl acetate

D: 124-38-9
carbon dioxide

E: 201230-82-2
carbon monoxide

F: 64-19-7
acetic acid

Conditions

Conditions	Yield
With H8[PMo7V5O40]; oxygen In water at 90℃; under 15001.5 Torr; for 24h; Autoclave;	A n/a B n/a C n/a D 24% E 21% F n/a

...Expand

: 621-76-1
tripropyl orthoformate

: 98-88-4
benzoyl chloride

A: 540-54-5
1-Chloropropane

B: 110-74-7
propyl methanoate

C: 2315-68-6
propyl benzoate

...Expand

: 621-76-1
tripropyl orthoformate

: 75-07-0
acetaldehyde

A: 105-82-8
acetaldehyde dipropyl acetal

B: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With sulfuric acid

...Expand

: 505-22-6
1,3-dioxane

A: 110-74-7
propyl methanoate

B: 124-38-9
carbon dioxide

C: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
In water Product distribution; Mechanism; Irradiation; γ irradiation;

...Expand

: 505-22-6
1,3-dioxane

A: 71-23-8
propan-1-ol

B: 50-00-0
formaldehyd

C: 290-13-1
1,3-dioxine

D: 74-85-1
ethene

E: 110-74-7
propyl methanoate

F: 107-18-6
allyl alcohol

Conditions

Conditions	Yield
Mechanism; Product distribution; Quantum yield; Heating; 185 nm vacuum-ultraviolet photolysis;

...Expand

: 505-22-6
1,3-dioxane

A: 110-74-7
propyl methanoate

B: 75-65-0
tert-butyl alcohol

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 120℃; Product distribution; Rate constant; other temperature, various concentrations of peroxide, in the presence of ethyl orthoformate;
With di-tert-butyl peroxide at 120℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 505-84-0
dipropoxymethane

: 6267-24-9
tris(ethylsulfanyl)methane

A: 4396-19-4
bis(ethylthio)methane

B: 4110-50-3
ethyl propyl sulfide

C: 110-74-7
propyl methanoate

D: (ethylthio)propoxymethane

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In various solvent(s) at 30℃; Product distribution; equilibrium concentrations; various temperature and reactant ratios, other catalysts;

...Expand

: 505-84-0
dipropoxymethane

A: 71-23-8
propan-1-ol

B: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With ozone In tetrachloromethane at 25℃; Rate constant; k= 0.7 liter/mole.sec;
With ozone In tetrachloromethane at 18℃; Rate constant; Mechanism;

: 505-84-0
dipropoxymethane

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 130℃; Rate constant; kinetic isotope effect; further temperatures;

: 621-76-1
tripropyl orthoformate

A: 74-98-6
propane

B: 110-74-7
propyl methanoate

C: 623-96-1
Dipropyl carbonate

D: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With di-tert-butyl peroxide In chlorobenzene at 140℃; for 4h; Kinetics; Mechanism; Product distribution; various temperatures, rates of formation;

...Expand

: 201230-82-2
carbon monoxide

A: 64-17-5
ethanol

B: 107-31-3
Methyl formate

C: 110-74-7
propyl methanoate

D: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With 2-hydroxypyridin; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 230℃; under 1499480 Torr; for 4.5h; Further byproducts given. Title compound not separated from byproducts;	A 191 mmol B 52 mmol C 29 mmol D 1000 mmol

...Expand

: 81381-75-1
1,3-Bis(1,3-dioxan-2-yloxy)propane

A: 2453-03-4
trimethylene carbonate

B: 110-74-7
propyl methanoate

C: 85533-20-6
2-propoxy-1,3-dioxane

D: 85533-24-0
3-([1,3]Dioxan-2-yloxy)-propionaldehyde

E: 85533-23-9
propyl 3-(1,3-dioxan-2-yloxy)propyl carbonate

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 130℃; for 0.5h; Product distribution;	A 0.02 mol B 0.01 mol C 0.02 mol D 0.01 mol E 0.06 mol

...Expand

: 85533-20-6
2-propoxy-1,3-dioxane

A: 2453-03-4
trimethylene carbonate

B: 74-98-6
propane

C: 110-74-7
propyl methanoate

D: 623-96-1
Dipropyl carbonate

E: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With di-tert-butyl peroxide In chlorobenzene at 130℃; Product distribution; Rate constant; Mechanism;

...Expand

: Formic acid 4-formyloxy-3-methyl-butyl ester

A: 589-40-2
sec-butyl formate

B: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 140℃; for 3h; conversion, concentration of products;

: 2807-30-9
2-propoxyethanol

A: 2568-96-9
2-ethyl-1,3-dioxolane

B: 110-74-7
propyl methanoate

C: 67365-39-3
n-propoxyacetaldehyde

Conditions

Conditions	Yield
With hydroxide at 23.85℃; under 760 Torr; Rate constant; Product distribution; Mechanism;	A 5.4 % Chromat. B 47 % Chromat. C 15 % Chromat.

...Expand

: 71-23-8
propan-1-ol

: 6819-41-6
sodium n-propoxide

CO: CO

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
Geschwindigkeit der Umsetzung;

...Expand

: 111-43-3
Dipropyl ether

A: 106-36-5
propyl propionate

B: 110-74-7
propyl methanoate

C: 75-07-0
acetaldehyde

D: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With nitric oxide Kinetics; Oxidation; UV-irradiation;

...Expand

: 71-23-8
propan-1-ol

: 124-38-9
carbon dioxide

A: 64-18-6
formic acid

B: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With hydrogen; triethylamine; TpRu(PPh3)(CH3CN)H at 100℃; under 38000 Torr; for 16h;

...Expand

: 71-23-8
propan-1-ol

: 124-38-9
carbon dioxide

: 201230-82-2
carbon monoxide

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With hydrogen; potassium carbonate at 169.84℃; under 22502.3 Torr; for 2h;

...Expand

: 71-23-8
propan-1-ol

Reaxys ID: 11463886: Reaxys ID: 11463886

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
Conversion of starting material;

: 109-99-9
tetrahydrofuran

: 110-74-7
propyl methanoate

Conditions

Conditions	Yield
With oxygen; [Ru(CO)2Cp]2 under 375.038 Torr; for 168h;

: 111-86-4
n-Octylamine

: 110-74-7
propyl methanoate

: 6282-06-0
N-octylformamide

Conditions

Conditions	Yield
With Cp*2Sm(THF)2 In toluene Ambient temperature; further reagent: SmI2;	99%

: 110-74-7
propyl methanoate

: 111-92-2
dibutylamine

: 761-65-9
N,N-dibutylformamide

Conditions

Conditions	Yield
With Cp*2Sm(THF)2 In toluene Ambient temperature;	99%

: 110-74-7
propyl methanoate

: (S)-2-tert-butoxycarbonylamino-pentanedioic acid 1-benzyl ester 5-ethyl ester

: N-tert-butoxycarbonyl-2-benzyloxycarbonyl-4-ethoxycarbonyl-2,3-dihydro-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: (S)-2-tert-butoxycarbonylamino-pentanedioic acid 1-benzyl ester 5-ethyl ester With sodium t-butanolate In tetrahydrofuran at -70℃; for 3h; Inert atmosphere; Stage #2: propyl methanoate In tetrahydrofuran at -70℃; for 5h; Stage #3: With trifluoroacetic acid In dichloromethane at 5 - 25℃; for 4h;	95.7%

: 1072-85-1
o-fluorobromobenzene

: 110-74-7
propyl methanoate

: 446-52-6
2-Fluorobenzaldehyde

Conditions

Conditions	Yield
With magnesium; lithium chloride In tetrahydrofuran; dichloromethane at 20 - 67℃; for 1.5h; Time;	91.1%

: 110-74-7
propyl methanoate

: 19382-38-8
1-(Aminomethyl)isoquinoline dihydrochloride

: 58021-71-9
2-formamidomethylisoquinoline

Conditions

Conditions	Yield
With TEA In ethanol for 2h; Heating;	89%

: 110-74-7
propyl methanoate

: 402-43-7
p-trifluoromethylphenyl bromide

: 959101-12-3
1-propyl 4-(trifluoromethyl)benzoate

Conditions

Conditions	Yield
Stage #1: p-trifluoromethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: propyl methanoate In tetrahydrofuran; hexane at -78℃; for 3h; Stage #3: With propan-1-ol; iodine; potassium carbonate In tetrahydrofuran; hexane at -78 - 20℃; for 14h;	86%

: 110-74-7
propyl methanoate

: 645-36-3
2,2-diethoxy-ethanamine

: 53089-10-4
2,2-diethoxy-1-formylaminoethane

Conditions

Conditions	Yield
for 3h; Reflux;	86%

: 110-74-7
propyl methanoate

: 55-21-0
benzamide

: 2315-68-6
propyl benzoate

Conditions

Conditions	Yield
With hydrogenchloride; iron(III) chloride hexahydrate In hexane; water at 80℃; for 14h;	86%

: 124-04-9
Adipic acid

: 110-74-7
propyl methanoate

A: 6939-72-6
Hexanedioic acid monopropyl ester

B: 106-19-4
di-n-propyl adipate

Conditions

Conditions	Yield
With Dowex 50W-X2 (50-100 mesh) In octane at 70℃; for 2.66667h;	A 85% B 6%
With Dowex 50Wx2 In octane at 70℃; for 2.66667h; Esterification;	A 85% B 6%

...Expand

: 110-74-7
propyl methanoate

: 18004-62-1
quinolin-2-ylmethanamine bischlorohydrate

: 63111-81-9
N-(2-Quinolylmethyl)formamide

Conditions

Conditions	Yield
With TEA In ethanol for 2h; Heating;	83%

: 110-74-7
propyl methanoate

: 65-85-0
benzoic acid

: 2315-68-6
propyl benzoate

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 130℃; for 12h; Sealed tube;	82%

: 110-74-7
propyl methanoate

: 62-53-3
aniline

: 103-70-8
Formanilid

Conditions

Conditions	Yield
With Cp*2Sm(THF)2 In toluene Ambient temperature;	80%

: 110-74-7
propyl methanoate

: 56563-07-6
N-cyanoacetamidine

: 931-86-2
5-azacytosine

Conditions

Conditions	Yield
at 115℃; for 2h;	80%

: 79-37-8
oxalyl dichloride

: 110-74-7
propyl methanoate

: 65611-08-7
dichloromethyl propyl ether

Conditions

Conditions	Yield
With N-methyl-N-phenylformamide at 60℃; for 9h;	76%

: 110-74-7
propyl methanoate

: 3-(aminomethyl)isoquinoline dihydrochloride

: 157405-78-2
3-formamidomethylisoquinoline

Conditions

Conditions	Yield
With TEA In ethanol for 2h; Heating;	75%

: 530-53-0
deoxyvasicinone

: 110-74-7
propyl methanoate

: 62062-74-2
α-hydroxymethylenedeoxyvasicin-4-one

Conditions

Conditions	Yield
Stage #1: deoxyvasicinone; propyl methanoate With sodium at 0 - 20℃; Stage #2: With water Cooling with ice;	75%

: 110-74-7
propyl methanoate

: 76278-33-6
2-(Aminomethyl)-4-methoxyquinoline dihydrochloride

: 132833-02-4
<(4-Methoxy-2-quinolyl)methyl>formamide

Conditions

Conditions	Yield
With TEA In ethanol for 2h; Heating;	74%

: 110-74-7
propyl methanoate

: 65611-08-7
dichloromethyl propyl ether

Conditions

Conditions	Yield
With oxalyl dichloride; N-methyl-N-phenylformamide at 60℃; for 17h;	74%
With oxalyl dichloride; N-methyl-N-phenylformamide

: 110-74-7
propyl methanoate

: 5-(4'-cyanobiphenyl-4-oxy)pentylamine

: 1-formamido-5-(4'-cyanobiphenyl-4-oxy)pentane

Conditions

Conditions	Yield
for 24h; Inert atmosphere; Reflux;	73%

: 292638-84-7
styrene

: 110-74-7
propyl methanoate

: 74513-58-9
(E)-propyl cinnamate

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; trimethylsilyl cyanide; 4-cyano-1-isopropoxypyridin-1-ium trifluoromethanesulfonate at 20℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;	72%

: 110-74-7
propyl methanoate

: N-(2-[2,2-bis(decyloxymethyl)ethoxy]carbonylethyl)amine

: N-formyl-[2-(2,2-bis(decyloxymethyl)ethoxy)carbonylethyl]amine

Conditions

Conditions	Yield
With potassium carbonate for 21h; Inert atmosphere; Reflux;	68%

: 110-74-7
propyl methanoate

: N-[2-(2,2-bis[2,2-di(decyloxymethyl)ethoxymethyl]ethoxy)carbonylethyl]amine

: N-formyl-[2-(2,2-bis(2,2-di(decyloxymethyl)ethoxymethyl)ethoxy)carbonylethyl]amine

Conditions

Conditions	Yield
With potassium carbonate for 41h; Inert atmosphere; Reflux;	68%

: 110-74-7
propyl methanoate

: 71-23-8
propan-1-ol

Conditions

Conditions	Yield
dodecacarbonyl-triangulo-triruthenium; P(C4H9)3 In pyridine at 180℃; for 8h;	67%

: 503-17-3
dimethylacetylene

: 110-74-7
propyl methanoate

: 49587-60-2
(2E,5E)-3,5-dimethylhepta-2,5-dien-4-ol

Conditions

Conditions	Yield
With isobutylmagnesium bromide; titanocene dichloride	65%

N-Propyl formate Chemical Properties

IUPAC Name: Propyl formate
Synonyms of N-Propyl formate (CAS NO.110-74-7) : Formic acid, propyl ester ; Propyl formate ; Formic acid n-propyl ester ; Formic acid propyl ester ; N-Propyl formate
Product Categories: Organics
CAS NO:110-74-7
Molecular Formula:C₄H₈O₂
Molecular Weight:88.11
Molecular Structure:
EINECS: 203-798-0
Index of Refraction: 1.375
Surface Tension: 25 dyne/cm
Density: 0.896 g/cm³
Flash Point: 25 °F
Enthalpy of Vaporization: 33.61 kJ/mol
Boiling Point: 81.9 °C at 760 mmHg
Vapour Pressure: 80.3 mmHg at 25°C
Melting point: -93 °C(lit.)
Storage temp: Flammables area
Appearance:A clear colorless liquid
Water solubility:Slightly soluble in water.

N-Propyl formate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	3400mg/kg (3400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
rat	LD50	oral	3980mg/kg (3980mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

N-Propyl formate Consensus Reports

Reported in EPA TSCA Inventory.

N-Propyl formate Safety Profile

Moderately toxic by ingestion. An irritant to skin, eyes, and mucous membranes. Narcotic in high concentration. Dangerous fire hazard when exposed to heat, flame, or oxidizers. Ignites on contact with potassium-tert-butoxide. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
Hazard CodesF, Irritant Xi
Risk Statements 11-36/37-67
R11: N-Propyl formate (CAS NO.110-74-7) is highly flammable.
R36/37:Irritating to eyes and respiratory system.
R67:Vapours may cause drowsiness and dizziness.
Safety Statements 9-16-24-33
S9:Keep container in a well-ventilated place.
S16:Keep away from sources of ignition.
S24:Avoid contact with skin.
S33:Take precautionary measures against static discharges.
RIDADR UN 1281 3/PG 2
WGK Germany 1
RTECS LR0175000
HazardClass 3
PackingGroup II

N-Propyl formate Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

N-Propyl formate Specification

1.General Description : Slightly soluble in water and less dense than water. Hence floats on water. Vapors are heavier than air. 2.Air & Water Reactions: Highly flammable.
3.Reactivity Profile : Propyl formates are esters. React with acids to liberate heat along with propanols and formic acid. Strong oxidizing acids may cause a reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides.
4.Health Hazard :May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
5.Fire Hazard: Highly flammable: N-Propyl formate (CAS NO.110-74-7) will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Product Name

PROPYL FORMATE

Synthetic route

N-Propyl formate Chemical Properties

N-Propyl formate Toxicity Data With Reference

N-Propyl formate Consensus Reports

N-Propyl formate Safety Profile

N-Propyl formate Standards and Recommendations

N-Propyl formate Specification

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