PHOSGENE supplier | CasNO.75-44-5

Name
PHOSGENE
EINECS 200-870-3
CAS No. 75-44-5
Article Data628
CAS DataBase
Density 1.523 g/cm³
Solubility decomposes
Melting Point -118 C
Formula CCl2 O
Boiling Point 8.2 °C at 760 mmHg
Molecular Weight 98.9164
Flash Point 4°C
Transport Information UN 3384
Appearance colourless gas
Safety A human poison by inhalation. A severe eye, skin, and mucous membrane irritant. In the presence of moisture, phosgene decomposes to form hydrochloric acid and carbon monoxide. This occurs in the bronchioles and alveoli of the lungs, resulting in pulmonary edema followed by bronchopneumonia and occasionally lung abscess. There is little immediate irritating effect upon the respiratory tract, and the warning properties of the gas are therefore very slight. There may be no immediate warning that dangerous concentrations are being inhaled. After a latent period of 2 to 24 hours, the patient complains of burning in the throat and chest, shortness of breath, and increasing dyspnea. Where the exposure has been severe, the development of pulmonary edema may be so rapid that the patient dies within 36 hours after exposure. In cases where the exposure has been less, pneumonia may develop several days after the occurrence of the accident. In patients who recover, no permanent residual disability is thought to occur. A common air contaminant.
Under the appropriate conditions it undergoes hazardous reactions with Al, tert-butyl azido formate, 2,4-hexadiyn-1,6-diol, isopropyl alcohol, K, Na, sodium azide, hexafluoroisopropylideneamino lithium, lithium. When heated to decomposition or on contact with water or steam it will react to produce toxic and corrosive fumes of CO and Cl⁻. Caution: Arrangements should be made for monitoring its use.
Analytical Methods:

For occupational chemical analysis use OSHA: #ID-61.
Risk Codes 26-34
Molecular Structure
Hazard Symbols Very toxic via inhalation, strong irritant to eyes. TLV: 0.1 ppm.
Synonyms Phosgene(8CI); CG; Carbon dichloride oxide; Carbon oxychloride; Carbonyl chloride;Carbonyl dichloride; Chloroformyl chloride; Dichloroformaldehyde; Phosgen
PSA 17.07000
LogP 1.58400

Synthetic route

: 201230-82-2
carbon monoxide

: 7782-50-5
chlorine

: 75-44-5
phosgene

Conditions

Conditions	Yield
With catalyst: charcoal in laboratorium, at ambient temp., in a glas tube filled with charcoal;	100%
pyrographite at 40 - 85℃; under 1050.11 - 5250.53 Torr; Product distribution / selectivity; Continuous process;
pyrographite at 45 - 93.5℃; under 1500.15 - 3750.38 Torr; Shell-and-tube reactor;

: 32315-10-9
bis(trichloromethyl) carbonate

A: 56-23-5
tetrachloromethane

B: 75-44-5
phosgene

C: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With copper phthalocyanine at 90℃; for 0.583333h; Mechanism; Reagent/catalyst; Temperature; Time;	A n/a B 100% C n/a

...Expand

: 355-80-6
2,2,3,3,4,4,5,5-octafluoropentan-1-ol

: 32315-10-9
bis(trichloromethyl) carbonate

A: 75-44-5
phosgene

B: 2157-80-4
2,2,3,3,4,4,5,5-octafluoropentyl chloroformate

C: 4454-75-5
bis(2,2,3,3,4,4,5,5-octafluoropentyl) carbonate

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate With pyridine In pentane at -15℃; for 1h; Stage #2: 2,2,3,3,4,4,5,5-octafluoropentan-1-ol In pentane at -15℃; for 6h;	A n/a B 95% C 5%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: 440-60-8
(2,3,4,5,6-pentafluorophenyl)methanol

A: 75-44-5
phosgene

B: 53526-74-2
2,3,4,5,6-pentafluorobenzyl chloroformate

C: bis(pentafluorobenzyl)carbonate

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate With pyridine In pentane at -15℃; for 1h; Stage #2: (2,3,4,5,6-pentafluorophenyl)methanol In pentane at -15 - 0℃; for 6h;	A n/a B 92% C 8%

...Expand

: 56-23-5
tetrachloromethane

: 75-44-5
phosgene

Conditions

Conditions	Yield
With water; antimony(V) chloride In water reaction at 60°C on addn. of 0.1 mol SbCl5;;	90%
With water; Gallium trichloride In water reaction at 60°C on addn. of 0.1 mol GaCl3;;	89%
With air; fired clay fragments

: 32315-10-9
bis(trichloromethyl) carbonate

: 2192-55-4
2-(pentafluorophenoxy)ethanol

A: 75-44-5
phosgene

B: 2-(2,3,4,5,6-pentafluorophenoxy)ethyl chloroformate

C: di[(2-(perfluorophenoxy))ethyl]carbonate

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate With pyridine In pentane at -15℃; for 1h; Stage #2: 2-(pentafluorophenoxy)ethanol In pentane at -15 - 20℃; for 6h;	A n/a B 86% C 11%

...Expand

: 39149-80-9, 54631-38-8, 98104-35-9, 32821-07-1
tert-butyl 2-bromopropionate

: 106-93-4
ethylene dibromide

: 75-44-5
phosgene

Conditions

Conditions	Yield
With chloro-trimethyl-silane; ammonium chloride In tetrahydrofuran	73%

: 56-23-5
tetrachloromethane

A: 75-44-5
phosgene

B: 7719-09-7
thionyl chloride

Conditions

Conditions	Yield
With sulfur dioxide In neat (no solvent) reaction of CCl4 with SO2 on heating to 200°C;;	A n/a B 72%

: 13453-07-1
gold(III) chloride

A: 75-44-5
phosgene

: Au4Cl8

Conditions

Conditions	Yield
With CO In thionyl chloride AuCl3 suspended in SOCl2 under N2, reaction flask evacuated, filled with CO at atm. pressure, stirred at 20.1°C until Au2Cl6 disappeared(36 h); filtration, drying in vac.;	A n/a B 67%

: 106-93-4
ethylene dibromide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 75-44-5
phosgene

Conditions

Conditions	Yield
With chloro-trimethyl-silane In tetrahydrofuran	63%

: 79-37-8
oxalyl dichloride

: 460-19-5
ethanedinitrile

A: 75-44-5
phosgene

B: 124-38-9
carbon dioxide

C: 64738-53-0
2,3,7,8-tetrachloro-5H,10H-diimidazo<1,2-a:1',2'-d>pyrazine-5,10-dione

Conditions

Conditions	Yield
With hydrogenchloride; hydrogenchloride; NR4Cl (Adogen) In dichloromethane at 70 - 120℃; for 72h; Further byproducts given;	A n/a B n/a C 60%

...Expand

: 13463-40-6
iron pentacarbonyl

: 75-44-5
phosgene

Conditions

Conditions	Yield
With tetrachloromethane; oxygen In tetrachloromethane Irradiation (UV/VIS); Irradiation λ >350 nm, CCl4 satd. with dry air;; detected by IR sepctra;;	50%

: 7647-01-0
hydrogenchloride

: 530-62-1
1,1'-carbonyldiimidazole

: 75-44-5
phosgene

Conditions

Conditions	Yield
In neat (no solvent) condensing HCl onto N,N'-carbonyldiimidazole at -196°C, warming to -63°C, condensing excess HCl into a trap held at -196°C; contains some HCl;	49.8%

: 50960-82-2
carbonylgold(I) chloride

: 13453-07-1
gold(III) chloride

A: 75-44-5
phosgene

B: AuCl2

Conditions

Conditions	Yield
In dichloromethane N2-atmosphere; slight molar excess of Au(I), 1.5 h;	A n/a B 42%
In thionyl chloride N2-atmosphere; molar ratio Au(III):Au(I)=3:1 to 1:1, 3-28 h; filtration (under Ar), drying (vac.); elem. anal.; yield depending on molar ratio of educts, amt. of solvent and reaction time;	A n/a B 24%

...Expand

: 10036-47-2
tetrafluorohydrazine

: 79-37-8
oxalyl dichloride

A: 75-44-5
phosgene

B: 13637-87-1
chlorodifluoroamine

C: 10578-16-2
dinitrogen difluoride

D: 353-49-1
fluoroformyl chloride

E: 16847-30-6
difluorocarbamoyl chloride

Conditions

Conditions	Yield
other Radiation; UV photolysis, 6h, ratio of educts: (ClCO)2 112 Torr, N2F4 168 Torr; fractionated condensation, gaschromy.;	A n/a B n/a C n/a D n/a E 40%
other Radiation; UV photolysis, 6h, ratio of educts: (ClCO)2 112 Torr, N2F4 168 Torr; fractionated condensation, gaschromy.;	A n/a B n/a C n/a D n/a E 40%

...Expand

: 105968-23-8
perfluoro(N,N-diethylcarbamoyl fluoride)

A: 56-23-5
tetrachloromethane

B: 75-44-5
phosgene

C: perfluoro(2,4,4-trichloro-3-azapentene-2)

Conditions

Conditions	Yield
With aluminium trichloride at 100℃; for 100h;	A 0.03 g B 0.02 g C 38.7%

...Expand

: 6204-35-9
[11C]methane

A: 75-44-5
phosgene

B: [11C]carbon tetrachloride

Conditions

Conditions	Yield
With chlorine at 510 - 700℃;	A 35% B n/a

: 76-01-7
pentachloroethane

A: 75-44-5
phosgene

B: 76-02-8
Trichloroacetyl chloride

Conditions

Conditions	Yield
Irradiation (UV/VIS); with Cl2 sensibilized photochemical oxidn., 80 to 100°C;	A 20% B n/a

: 75-45-6
Chlorodifluoromethane

A: 75-44-5
phosgene

B: 353-50-4
Carbonyl fluoride

C: 353-49-1
fluoroformyl chloride

Conditions

Conditions	Yield
With oxygen for 0.5 - 4.5h; Product distribution / selectivity; UV-irradiation (500 W);	A 0.04% B 15.6% C 0.24%

...Expand

: 110-86-1
pyridine

: 98020-90-7
bis(trichloromethyl) oxalate

: 108-90-7
chlorobenzene

A: 75-44-5
phosgene

B: 79-37-8
oxalyl dichloride

...Expand

: 75-15-0
carbon disulfide

: 75-44-5
phosgene

Conditions

Conditions	Yield
With chlorine monoxide

: 56-23-5
tetrachloromethane

: 50-00-0
formaldehyd

: 75-44-5
phosgene

Conditions

Conditions	Yield
With aluminium trichloride

: 56-23-5
tetrachloromethane

: 542-88-1
bis(2-chloromethyl)ether

: 75-44-5
phosgene

Conditions

Conditions	Yield
With aluminium trichloride

: 56-23-5
tetrachloromethane

: 859807-24-2
(4-nitro-phenyl)-carbamic acid trichloromethyl ester

A: 75-44-5
phosgene

B: 100-28-7
4-Nitrophenyl isocyanate

...Expand

: 56-23-5
tetrachloromethane

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 75-44-5
phosgene

Conditions

Conditions	Yield
With pumice stone at 350℃;

: 56-23-5
tetrachloromethane

A: 75-44-5
phosgene

B: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
With zinc(II) oxide at 200℃;

: 127-18-4
1,1,2,2-tetrachloroethylene

A: 75-44-5
phosgene

B: 76-02-8
Trichloroacetyl chloride

Conditions

Conditions	Yield
With ozone
In gas byproducts: Cl; Irradiation (UV/VIS); with Cl2 sensibilized photochemical oxidn.;

: 2,4-bis-dichloromethylene-[1,3,5]trioxane

: 75-44-5
phosgene

Conditions

Conditions	Yield
bei laengerem Aufbewahren;

: 463-71-8
thiophosgene

: 75-44-5
phosgene

Conditions

Conditions	Yield
With air
With oxygen
an der Luft;

: 75-44-5
phosgene

: 103-67-3
benzyl-methyl-amine

: 32366-02-2
benzyl(methyl)carbamic chloride

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;	100%
With triethylamine In tetrahydrofuran at 0℃;	74%

: 75-44-5
phosgene

: 72-18-4
L-valine

: 24601-74-9
(S)-4-isopropyloxazolidine-2,5-dione

Conditions

Conditions	Yield
In tetrahydrofuran at 40℃; for 1.5h;	100%
In tetrahydrofuran at 40℃; for 5h;	99.7%
In tetrahydrofuran; toluene at 50 - 60℃; for 4h;	96%

: 75-44-5
phosgene

: 100-27-6
2-(4-nitrophenyl)ethanol

: 88091-68-3
2-(4-nitrophenyl)ethoxycarbonyl chloride

Conditions

Conditions	Yield
In dichloromethane; toluene 1.) r.t., 1 h; 2.) 50 deg C, 5 h;	100%
In dichloromethane; toluene for 1h; Ambient temperature;	98%

: 75-44-5
phosgene

: 732-26-3
2,4,6-tri-tert-butylphenoxol

: 4511-21-1
2,4,6-tri(tert-butyl)phenyl carbonochloridate

Conditions

Conditions	Yield
With n-butyllithium at 0℃;	100%
With n-butyllithium In 1,2-dimethoxyethane at 0℃;	98%
Stage #1: 2,4,6-tri-tert-butylphenoxol With sodium hydride In tetrahydrofuran Metallation; Stage #2: phosgene With N,N-dimethyl-aniline In toluene at 0 - 20℃; for 2.5h; Acylation;	75%

: 75-44-5
phosgene

: 612-25-9
2-Nitrobenzyl alcohol

: 42854-99-9
o-nitrobenzyl chloroformate

Conditions

Conditions	Yield
In tetrahydrofuran; toluene at 20℃; for 18h;	100%
In tetrahydrofuran; toluene for 21h; Esterification;	99%
In 1,4-dioxane for 24h; Ambient temperature;

: 75-44-5
phosgene

: 570-85-4
5α-cholestane-3β,6β-diol

: 3β,6β-bis(chlorocarbonyloxy)-5α-cholestane

Conditions

Conditions	Yield
With pyridine In chloroform at 23℃; for 17h;	100%

: 75-44-5
phosgene

: 127230-15-3
(2S,3R,4S)-1-amino-4-<<(tertbutyloxy)carbonyl>amino>-5-cyclohexyl-2-hydroxy-3-(methoxymethoxy)pentane

: 127230-16-4
(1'R,2'S,5S)-5-<2'-<<(tertbutyloxy)carbonyl>amino>-3'-cyclohexyl-1'-(methoxymethoxy)propyl>oxazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane; toluene 1.) a) 0 deg C, 1 h, b) RT, 1 h;	100%

: 75-44-5
phosgene

: 65253-04-5
(-)-8-phenylmenthol

: 126378-43-6
(1R,2S,5R)-(-)-8-phenylmenthyl chloroformate

Conditions

Conditions	Yield
With quinoline In toluene for 16h; Ambient temperature;	100%
With quinoline In toluene at 0 - 20℃; for 16.5h;
With quinoline In toluene at 0 - 20℃; for 16.5h;

: 75-44-5
phosgene

: 105970-12-5
2-(1-methyl-1-p-phenoxyphenylethyl)-5-methylcyclohexanol

: 137769-43-8
(1R,2S,5R)-8-(4-phenoxyphenyl)menthyl chloroformate

Conditions

Conditions	Yield
With quinoline In toluene for 16h; Ambient temperature;	100%

: 75-44-5
phosgene

: 134403-91-1
methyl 4-(2-hydroxyethyl)-3-nitrobenzoate

: 134403-97-7
2-(4-(methoxycarbonyl)-2-nitrophenyl)ethyl chloroformate

Conditions

Conditions	Yield
	100%
In dichloromethane; toluene a) 4 deg C, 30 min, b) room temperature, 3 h;	87%

: 75-44-5
phosgene

: 134020-63-6
2,4,5-Trichlorophenyl 4'-(2-hydroxyethyl)-3'-nitrobenzoate

: 134403-92-2
C16H9Cl4NO6

Conditions

Conditions	Yield
	100%
In dichloromethane; toluene a) 4 deg C, 30 min., b) room temperature, 3 h;	92%

: 75-44-5
phosgene

: 56239-25-9
2-Oxa-3-azabicyclo<2.2.2>oct-5-ene hydrochloride

: N-(chlorocarbamoyl)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 12h;	100%

: 75-44-5
phosgene

: 118526-72-0
[1-Phenyl-1-(3H-[1,2,3]triazol-4-yl)-meth-(Z)-ylidene]-hydrazine

: 118526-83-3
4-phenyl-6H-<1,2,3>triazolo<1,5-d><1,2,4>triazin-7-one

Conditions

Conditions	Yield
In 1,4-dioxane; toluene for 5h; Ambient temperature;	100%

: 75-44-5
phosgene

: 88002-35-1
N-(pyridin-2-yl)-1H-benzo[d]imidazol-2-amine

: 6H-benzimidazo<1,2-a>pyrido<2,1-d><1,3,5>triazin-6-one

Conditions

Conditions	Yield
With triethylamine In toluene for 6h; Ambient temperature;	100%

: 75-44-5
phosgene

: drim-7-en-9α,11-diol

: drim-7-en-9α,11-dioxolane-2-one

Conditions

Conditions	Yield
With pyridine In toluene at 0℃; for 1h;	100%

: 75-44-5
phosgene

: 103722-59-4
ethyl 2-(4-bromo-3-chlorophenyl)hydrazinecarboxylate

: C10H9BrCl2N2O3

Conditions

Conditions	Yield
In ethyl acetate at 45℃;	100%

: 75-44-5
phosgene

: 144331-15-7
(2S,3S)-Dimethyl N-(9'-phenylfluoren-9'-yl)-3-hydroxyaspartate

: 144331-17-9
(4S,5S)-2-Oxo-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidine-4,5-dicarboxylic acid dimethyl ester

Conditions

Conditions	Yield
With pyridine; dmap In toluene at 75℃; for 0.416667h;	100%

: 75-44-5
phosgene

: 157020-39-8
(Z)-(R)-9-Benzylamino-3,4,5,6,9,10-hexahydro-thiecin-2-one

: C17H20ClNO2S

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0℃; for 3.5h;	100%

: 75-44-5
phosgene

: (S)-3-{(S)-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-(2,2-Dimethoxy-ethyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-hydroxy-methyl}-3-hydroxy-2,2,6-trimethyl-cyclohexanone

: 174474-78-3
(4S,5S)-4-[(3R,3aR,5aS,6R,7R,9aS,9bS)-6-(2,2-Dimethoxy-ethyl)-3-((R)-1,5-dimethyl-hexyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl]-6,6,8-trimethyl-1,3-dioxa-spiro[4.5]decane-2,7-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃;	100%
With pyridine In dichloromethane at 0℃; Yield given;

: 75-44-5
phosgene

: 1(S)-(benzoyloxy)-4(R)-(phenylsulfonyl)cyclohexane-2(R),3(R)-diol

: Benzoic acid (3aR,4S,7R,7aR)-7-benzenesulfonyl-2-oxo-hexahydro-benzo[1,3]dioxol-4-yl ester

Conditions

Conditions	Yield
In dichloromethane; toluene at 0℃; for 3h;	100%

: 75-44-5
phosgene

: 35963-78-1
12,14-diaminodehydroabietic acid methyl ester

: 145024-46-0
(1R,4aS,10aR)-6,8-Diisocyanato-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methyl ester

Conditions

Conditions	Yield
In toluene for 0.5h; Ambient temperature;	100%

: 20880-92-6
2,3;4,5-di-O-isopropylidene-β-D-fructopyranose

: 75-44-5
phosgene

: 157719-19-2
2,3:4,5-di-O-isopropylidene-β-D-fructopyranose-10-chloroformate

Conditions

Conditions	Yield
In diethyl ether; toluene Ambient temperature;	100%

: 75-44-5
phosgene

: 68847-33-6
2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine

: 212701-44-5
tert-butyl(2-isocyanatobenzyloxy)dimethylsilane

Conditions

Conditions	Yield
In toluene at 110℃;	100%
In toluene at 60℃; for 1h;

: 75-44-5
phosgene

: 190248-51-2
(2-Cyano-ethyl)-(2-phenylamino-ethyl)-carbamic acid tert-butyl ester

: 223486-43-9
C17H22ClN3O3

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water; toluene for 0.5h; Acylation;	100%

: 75-44-5
phosgene

: (2S,3S)-3-Amino-1,1,1-trifluoro-4-(4-nitro-phenyl)-butan-2-ol

: (4S,5S)-4-(4-Nitro-benzyl)-5-trifluoromethyl-oxazolidin-2-one

Conditions

Conditions	Yield
With TEA In dichloromethane	100%

: 75-44-5
phosgene

: (2R,3S)-3-Amino-1,1,1-trifluoro-4-(4-nitro-phenyl)-butan-2-ol

: (4S,5R)-4-(4-Nitro-benzyl)-5-trifluoromethyl-oxazolidin-2-one

Conditions

Conditions	Yield
With TEA In dichloromethane	100%

: 75-44-5
phosgene

: 250280-32-1
(9H-fluoren-9-yl)methyl1-methylhydrazinecarboxylate

: 250280-33-2
2-(chlorocarbonyl)-1-Fmoc-methylhydrazine

Conditions

Conditions	Yield
In 1,4-dioxane at 10 - 20℃; Acylation;	100%

: 75-44-5
phosgene

: 250280-34-3
(9H-fluoren-9-yl)methyl 2-methylhydrazine-1-carboxylate

: 250280-35-4
1-chlorocarbonyl-2-(9H-fluoren-9-methoxycarbonylamino)-1-methylhydrazine

Conditions

Conditions	Yield
In 1,4-dioxane at 10 - 20℃; Acylation;	100%
With sodium hydrogencarbonate In dichloromethane; water for 0.5h;	97%
With sodium hydrogencarbonate In dichloromethane; water; toluene for 0.5h;	97%
In 1,4-dioxane; toluene at 20℃; for 2h;
In dichloromethane; toluene at 0℃;

: 75-44-5
phosgene

: 34281-92-0
(1S,2R)-trans-2-phenyl-1-cyclohexanol

: 195820-85-0
C13H15ClO2

Conditions

Conditions	Yield
With pyridine In diethyl ether; toluene at -78 - 20℃; Acylation;	100%

: 75-44-5
phosgene

: 136453-59-3
[2,7-di-(tert-butyl)-9H-fluoren-9-yl]methanol

: 287381-46-8
2,7-di-tert-butyl-9-fluorenylmethoxycarbonyl chloride

Conditions

Conditions	Yield
In dichloromethane; toluene at 20℃; for 72h; chloroacylation;	100%
In toluene

PHOSGENE Chemical Properties

Molecular formula: CCl₂O
Molar mass: 98.92 g mol^-1
Structure:

Appearance: colorless gas
Density: 4.248 g/dm³ (15 °C); 1.432 g/cm³ (0 °C)
Melting point: -118 °C, 155 K, -180 °F
Boiling point: 8.3 °C, 281 K, 47 °F
Flash point: 4 °C
Solubility in water: hydrolysis
Solubility: soluble in benzene, toluene, acetic acid; decomposes in alcohol and acid

PHOSGENE History

In 1812, Phosgene(75-44-5) was synthesized by the chemist John Davy (1790-1868) by exposing a mixture of carbon monoxide and chlorine to sunlight. He named it in reference to use of light to promote the reaction; from Greek, phos (light) and gene (born). It gradually became important in the chemical industry as the 19th century progressed, particularly in dye manufacturing.

PHOSGENE Uses

Uses of phosgene(75-44-5) include the manufacture of toluene diisocyanate, methylone diisocyanate, and polycarbonate resins.

PHOSGENE Production

Phosgene(75-44-5) is manufactured by reacting chlorine gas and carbon monoxide in the presence of activated carbon.
CO + Cl₂ → O=CCl₂

PHOSGENE Toxicity Data With Reference

1.	ihl-hmn LC50:3200 mg/m3	SCJUAD Science Journal. 4 (1967),33.
2.	ihl-hmn TCLo:25 ppm/30M:PUL	29ZWAE Practical Toxicology of Plastics Lefaux, R.,Cleveland, OH.: Chemical Rubber Company,1968,207.
3.	ihl-man LCLo:360 mg/m3/30M	85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,99.
4.	ihl-mam LCLo:50 ppm/5M	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 138 (1928),65.
5.	ihl-cat LCLo:190 mg/m3/15M	85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,99.
6.	ihl-uns LCLo:50 ppm/5M	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 138 (1928),65.
7.	ihl-uns LCLo:11 mg/m3/30M	TABIA2 Tabulae Biologicae. 3 (1933),231.

PHOSGENE Consensus Reports

EPA Extremely Hazardous Substances List. Community Right-To-Know List. Reported in EPA TSCA Inventory.

PHOSGENE Safety Profile

A human poison by inhalation. A severe eye, skin, and mucous membrane irritant. In the presence of moisture, phosgene decomposes to form hydrochloric acid and carbon monoxide. This occurs in the bronchioles and alveoli of the lungs, resulting in pulmonary edema followed by bronchopneumonia and occasionally lung abscess. There is little immediate irritating effect upon the respiratory tract, and the warning properties of the gas are therefore very slight. There may be no immediate warning that dangerous concentrations are being inhaled. After a latent period of 2 to 24 hours, the patient complains of burning in the throat and chest, shortness of breath, and increasing dyspnea. Where the exposure has been severe, the development of pulmonary edema may be so rapid that the patient dies within 36 hours after exposure. In cases where the exposure has been less, pneumonia may develop several days after the occurrence of the accident. In patients who recover, no permanent residual disability is thought to occur. A common air contaminant.

Under the appropriate conditions it undergoes hazardous reactions with Al, tert-butyl azido formate, 2,4-hexadiyn-1,6-diol, isopropyl alcohol, K, Na, sodium azide, hexafluoroisopropylideneamino lithium, lithium. When heated to decomposition or on contact with water or steam it will react to produce toxic and corrosive fumes of CO and Cl⁻. Caution: Arrangements should be made for monitoring its use.

PHOSGENE Standards and Recommendations

OSHA PEL: TWA 0.1 ppm
ACGIH TLV: TWA 0.1 ppm
DFG MAK: 0.02 ppm (0.082 mg/m³)
NIOSH REL: (Phosgene) TWA 0.1 ppm; CL 0.2 ppm/15M
DOT Classification: 2.3; Label: Poison Gas, Corrosive

PHOSGENE Analytical Methods

For occupational chemical analysis use OSHA: #ID-61.

Product Name

PHOSGENE

Synthetic route

PHOSGENE Chemical Properties

PHOSGENE History

PHOSGENE Uses

PHOSGENE Production

PHOSGENE Toxicity Data With Reference

PHOSGENE Consensus Reports

PHOSGENE Safety Profile

PHOSGENE Standards and Recommendations

PHOSGENE Analytical Methods

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