Conditions | Yield |
---|---|
With 18-crown-6 ether; trimethyldodecylammonium chloride; tetra-n-butylphosphonium chloride; sodium hydroxide In water for 3h; pH=12; Reagent/catalyst; Williamson Ether Synthesis; Reflux; | 99.2% |
With sodium hydroxide In water at 60 - 80℃; for 2h; | 98.5% |
With sodium hydroxide Irradiation; | 97% |
Conditions | Yield |
---|---|
With potassium hydrogensulfate; water In methanol at 100℃; for 48h; | 100% |
With benzene-1,2-dicarboxylic acid at 250℃; under 7600 Torr; for 0.5h; microwave irradiation; | 79% |
With phthalic anhydride at 240 - 250℃; under 3040 Torr; for 1.5h; Hydrolysis; | 75% |
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20 - 60℃; | 75% |
Stage #1: phenol With sodium hydroxide In ethanol; water at 20℃; for 0.333333h; Stage #2: sodium monochloroacetic acid In ethanol; water at 102℃; for 5h; | 75% |
With sodium hydroxide In ethanol; water for 1h; Reflux; | 70.2% |
With sodium hydroxide In ethanol; water at 105℃; for 5h; | 67% |
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate; water at 0 - 20℃; for 12h; | 95% |
Stage #1: phenoxyacetic acid ethyl ester With sodium hydroxide In tetrahydrofuran at 20℃; for 24h; Stage #2: With acetic acid In tetrahydrofuran; water | 94% |
With sodium hydroxide In ethanol Reflux; | 81% |
Conditions | Yield |
---|---|
Stage #1: sodium monochloroacetic acid; sodium phenoxide In water at 90℃; for 2h; Stage #2: With hydrogenchloride In water at 30℃; pH=0; | 95% |
Conditions | Yield |
---|---|
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In aq. buffer at 20℃; for 5h; pH=9.8 - 10.1; Electrolysis; | 91% |
With Jones reagent In acetone at 0℃; for 1h; | 75% |
With potassium hydroxide In tert-butyl alcohol at 50℃; Electrochemical reaction; | 43% |
With NADH oxidase; nicotinamide adenine dinucleotide; 2-phenylethanol dehydrogenase; phenylacetaldehyde dehydrogenase at 25℃; under 760.051 Torr; for 12h; pH=9.0; | 35 % Chromat. |
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; sodium hydrogencarbonate; sodium carbonate In water; acetonitrile pH=10; Electrochemical reaction; chemoselective reaction; | 91 %Spectr. |
Conditions | Yield |
---|---|
With formic acid; triethylamine In acetonitrile at 80℃; for 2.5h; Inert atmosphere; | 86% |
With iodine; dimethyl sulfoxide for 0.5h; Heating; | 80% |
With [2-(dicyclohexylphosphino)ethyl]trimethylammonium chloride; phenylsilane In tetrahydrofuran; water at 20℃; for 2h; Inert atmosphere; | 70% |
Conditions | Yield |
---|---|
With borane-ammonia complex In water; isopropyl alcohol at 50℃; for 5h; Sealed tube; | 87% |
In methanol; water at 18 - 20℃; for 4h; electrochemical reactions; electrolyte: n-Bu4NBr, CF3COOH; cathode 5percent Pd/FE-600 carbon felt, anode Pt-foil; Yield given; | |
Stage #1: 2,4,5-Trichlorophenoxyacetic acid With 1,2-diphenyl-1,2-disodiumethane In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water chemoselective reaction; | |
Multi-step reaction with 2 steps 1: sodium hydroxide; hydrogen; / 25 °C / pH 11 / Inert atmosphere 2: sodium hydroxide; hydrogen; / 25 °C / pH 11 / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide; hydrogen; / 25 °C / pH 11 / Inert atmosphere 2: sodium hydroxide; hydrogen; / 25 °C / pH 11 / Inert atmosphere 3: sodium hydroxide; hydrogen; / 25 °C / pH 11 / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Stage #1: ethyl bromoacetate; phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Stage #2: With potassium hydroxide In methanol; water at 80℃; for 4h; | 65% |
Stage #1: ethyl bromoacetate; phenol With potassium carbonate In dimethyl sulfoxide at 50℃; for 6h; Stage #2: With water; sodium hydroxide In acetone at 50℃; for 3h; Stage #3: With hydrogenchloride In water at 25℃; pH=1 - 2; |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 25℃; for 72h; | 97% |
With potassium hydroxide In methanol at 35℃; for 1h; | 96% |
With potassium fluoride; thiophenol In various solvent(s) at 190℃; for 0.166667h; | 90% |
Conditions | Yield |
---|---|
With hydrogenchloride at 15 - 25℃; for 1h; pH=5; Temperature; | 96.2% |
With hydrogenchloride In water pH=1; |
Conditions | Yield |
---|---|
Stage #1: 4-Chlorophenoxyacetic acid With 1,2-diphenyl-1,2-disodiumethane In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water chemoselective reaction; | |
With hydrogen; sodium hydroxide at 25℃; pH=11; Inert atmosphere; |
2,4-Dichlorophenoxyacetic acid
A
(2-chlorophenoxy)acetic acid
B
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With 0.5% Pd/Sibunit carbon material; hydrogen In water at 30℃; under 760.051 Torr; for 100h; | |
With hydrogen In water at 30℃; under 760.051 Torr; | |
With hydrogen; sodium hydroxide at 25℃; pH=11; Catalytic behavior; Reagent/catalyst; Inert atmosphere; | |
With biochar-supported nano-palladium/iron composite In water at 25℃; pH=7; Kinetics; Reagent/catalyst; pH-value; Concentration; Temperature; Inert atmosphere; |
Conditions | Yield |
---|---|
With sodium periodate; RuO2/BaTi4O9 In phosphate buffer; ethyl acetate at 20℃; for 72h; pH=6.88; | 78% |
Multi-step reaction with 2 steps 1: ozone / dichloromethane / -70 °C 2: semicarbazide hydrochloride / dichloromethane / -70 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: 4-Chlorophenoxyacetic acid With lithium dihydronaphthylide radical In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water | |
Stage #1: 4-Chlorophenoxyacetic acid With naphthalene radical anion sodium salt In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water |
Conditions | Yield |
---|---|
With sodium hydroxide; sodium iodide; potassium carbonate In water-d2; acetone | |
In potassium carbonate | |
With sodium hydroxide; sodium iodide; potassium carbonate In water-d2; acetone |
Conditions | Yield |
---|---|
Stage #1: 2,4-Dichlorophenoxyacetic acid With lithium dihydronaphthylide radical In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water |
Conditions | Yield |
---|---|
With borane-ammonia complex In water; isopropyl alcohol at 50℃; for 5h; Sealed tube; | 90% |
In methanol; water at 18 - 20℃; for 4h; electrochemical reactions; electrolyte: n-Bu4NBr, CF3COOH; cathode 5percent Pd/FE-600 carbon felt, anode Pt-foil; Yield given; | |
Stage #1: 2,4-Dichlorophenoxyacetic acid With 1,2-diphenyl-1,2-disodiumethane In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water chemoselective reaction; |
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With semicarbazide hydrochloride In dichloromethane at -70 - 20℃; |
Conditions | Yield |
---|---|
Stage #1: phenol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: bromoacetic acid In tetrahydrofuran; mineral oil Inert atmosphere; Reflux; | 83% |
With sodium hydride In tetrahydrofuran for 12h; Heating; | |
With sodium hydroxide In ethanol for 24h; Heating; | |
With sodium hydroxide for 6h; Heating; |
Conditions | Yield |
---|---|
With ammonia; pen V amidase In water pH=8.2; Enzymatic reaction; |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; |
Conditions | Yield |
---|---|
With semicarbazide hydrochloride In dichloromethane at -45 - 20℃; |
Conditions | Yield |
---|---|
at 105℃; pH=9 - 10; | 97.6% |
Conditions | Yield |
---|---|
With formic acid; tributyl-amine; 10-phenyl-10H-phenothiazine In acetonitrile at 20℃; for 22h; Inert atmosphere; UV-irradiation; | 100% |
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate In water; dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique; | 88% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 80℃; for 3h; | A 92% B 86% |
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate In water; dimethyl sulfoxide at 120℃; for 24h; Concentration; Reagent/catalyst; Time; Inert atmosphere; Schlenk technique; | A 87% B 12% |
N-(4-methoxyphenyl)-2-phenoxyacetamide
A
4-methoxy-aniline
B
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 80℃; for 3h; | A 77% B 70% |
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With sulphated SnO2; methoxybenzene In toluene for 4h; Heating; | 85% |
2-phenoxyacetic acid
phenoxymethyl phenoxyacetate
Conditions | Yield |
---|---|
With iodine; mercury(II) oxide In tetrachloromethane for 5h; Irradiation; | 100% |
Conditions | Yield |
---|---|
With (phthalocyaninato)iron(II); chlorine; acetic acid In water at 75℃; for 0.5h; Concentration; Time; | 99.8% |
With dihydrogen peroxide; chlorine In benzene at 100℃; for 1h; | 99% |
With iron(III) chloride; dimethylsulfide; chlorine In chloroform at 70℃; for 5h; Reagent/catalyst; Solvent; Temperature; | 99.4% |
Conditions | Yield |
---|---|
Stage #1: 2-phenoxyacetic acid for 1h; Reflux; Alkaline conditions; Stage #2: triethanolamine hydrochloride Reflux; | 99.7% |
Stage #1: 2-phenoxyacetic acid for 1h; Alkaline conditions; Reflux; Stage #2: triethanolamine hydrochloride Alkaline conditions; | 99.7% |
Conditions | Yield |
---|---|
With potassium hydroxide | 99.5% |
phenylmethanethiol
2-phenoxyacetic acid
Phenoxy-thioacetic acid S-benzyl ester
Conditions | Yield |
---|---|
With pyridine; O-phenyl phosphorodichloridate In 1,2-dimethoxyethane for 16h; Ambient temperature; | 99% |
Conditions | Yield |
---|---|
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere; | 99% |
Stage #1: 2-phenoxyacetic acid With titanium(IV) isopropylate In tetrahydrofuran at 40 - 70℃; Molecular sieve; Inert atmosphere; Stage #2: benzylamine In tetrahydrofuran at 70℃; Molecular sieve; Inert atmosphere; | 99% |
With bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Sealed tube; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With [ReOCl2(1,2-bis(diphenylphosphino)ethane)]; hydrogen; potassium tetraphenylborate In tetrahydrofuran at 160℃; under 30003 Torr; for 24h; Autoclave; Inert atmosphere; | 99% |
With sodium tetrahydroborate; titanium tetrachloride In 1,2-dimethoxyethane for 14h; Ambient temperature; | 95% |
With strain of the zygomycete fungus S. racemosum MUT 770 In dimethyl sulfoxide for 72h; Enzymatic reaction; | 94% |
Conditions | Yield |
---|---|
In water reflux (2 h), filtration (hot), cooling (pptn.), concn., cooling; elem. anal.; | 99% |
Conditions | Yield |
---|---|
In benzene refluxed for 12 h (equimol., Dean-Stark); cooled, filtered, evapd. to dryness; | 99% |
2-phenoxyacetic acid
5(6)-(1-adamantyl)-2-phenoxymethylbenzimidazole
Conditions | Yield |
---|---|
at 140 - 145℃; for 3h; | 99% |
Conditions | Yield |
---|---|
With iron(III) sulfate; bis[(2-pyridyl)methyl]amine In 1,2-dichloro-ethane at 20℃; for 12h; Inert atmosphere; Sealed tube; Irradiation; | 99% |
Conditions | Yield |
---|---|
With sulfuric acid; bentonite for 0.0333333h; microwave irradiation; | 98% |
sulfuric acid; silica gel In diethyl ether for 0.333333h; Heating; | 90% |
With hydrogen cation at 30℃; Rate constant; |
2-methylpropan-2-thiol
2-phenoxyacetic acid
Phenoxy-thioacetic acid S-tert-butyl ester
Conditions | Yield |
---|---|
With pyridine; O-phenyl phosphorodichloridate In 1,2-dimethoxyethane for 16h; Ambient temperature; | 98% |
benzyl (-)-(6S,7S)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2-phenoxyacetic acid
benzyl (-)-(6S,7S)-3-methyl-8-oxo-7-phenoxyacetamido-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran for 2h; Ambient temperature; | 98% |
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 2h; Acylation; | 91% |
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-2-amino-5-nitropyrimidine-3H-4-one
2-phenoxyacetic acid
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h; | 98% |
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane | 80% |
Conditions | Yield |
---|---|
With Iron(III) isopropoxide; zirconium(IV) tetraisopropoxide In n-heptane for 18h; | 98% |
2-amino-benzenethiol
2-phenoxyacetic acid
2-(phenoxymethyl)benzo[d]thiazole
Conditions | Yield |
---|---|
for 0.333333h; microwave irradiation; | 97% |
With trimethylsilyl polyphosphate ester at 140℃; for 3h; | 72% |
at 140℃; for 3h; Neat (no solvent); | 72% |
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 0 - 20℃; | 97% |
4-amino-5-(3-fiuorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiol
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With dmap; tetrabutylammomium bromide; trichlorophosphate Microwave irradiation; Heating; | 97% |
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate In dichloromethane at 20℃; | 97% |
4-amino-5-mercapto-3-(4-chlorophenyl)-1,2,4-triazole
2-phenoxyacetic acid
Conditions | Yield |
---|---|
With dmap; tetrabutylammomium bromide; trichlorophosphate Microwave irradiation; Heating; | 96% |
With trichlorophosphate for 4h; Heating; |
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose
2-phenoxyacetic acid
1,2,5,6-di-O-isopropylidene-3-O-phenoxyacetyl-α-D-glucofuranose
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In pyridine at 20℃; for 15h; | 96% |
Conditions | Yield |
---|---|
With 2-iodo-1-methylpyridinium iodide on PS-DVB resin; triethylamine In dichloromethane at 80℃; for 0.1h; microwave irradiation; | 96% |
With tris(2-methoxyphenyl)bismuthine In benzene for 12h; Heating; | 73% |
With tris(2-methoxyphenyl)bismuthine In benzene for 12h; Heating; | 73% |
2-phenoxyacetic acid
(3-amino-propyl)-(1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 2-phenoxyacetic acid; (3-amino-propyl)-(1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester With polymer-bound EDC In chloroform at 20℃; for 6h; Stage #2: With acidic ion-exchange resin P-SO3H In chloroform for 5h; | 96% |
The Phenoxyacetic acid is an organic compound with the formula C8H8O3. The IUPAC name of this chemical is 2-phenoxyacetic acid. With the CAS registry number 122-59-8, it is also named as acetic acid, 2-phenoxy-. The product's classification code is Skin / Eye Irritant. Besides, it should be stored in a closed cool and dry place. It is mainly used for the manufacture of dyes, drugs, pesticides, fungicides and so on.
Physical properties about Phenoxyacetic acid are: (1)ACD/LogP: 1.34; (2)ACD/LogD (pH 5.5): -0.98; (3)ACD/LogD (pH 7.4): -2.29; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 35.53 Å2; (12)Index of Refraction: 1.54; (13)Molar Refractivity: 39.12 cm3; (14)Molar Volume: 124.5 cm3; (15)Polarizability: 15.51×10-24cm3; (16)Surface Tension: 46.6 dyne/cm; (17)Density: 1.221 g/cm3; (18)Flash Point: 115.1 °C; (19)Enthalpy of Vaporization: 55.35 kJ/mol; (20)Boiling Point: 285 °C at 760 mmHg; (21)Vapour Pressure: 0.00135 mmHg at 25°C.
Preparation: this chemical can be prepared by chloroacetic acid and phenol. This reaction will need reagent NaOH and solvent H2O by heating.
Uses of Phenoxyacetic acid: it can be used to produce phenoxymethyl phenoxyacatete. It will need reagent I2, HgO and solvent CCl4 with reaction time of 5 hours. The yield is about 100%.
When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)COc1ccccc1
(2)InChI: InChI=1/C8H8O3/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)
(3)InChIKey: LCPDWSOZIOUXRV-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C8H8O3/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)
(5)Std. InChIKey: LCPDWSOZIOUXRV-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | unreported | 1400mg/kg (1400mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981. | |
mouse | LD50 | intravenous | 1gm/kg (1000mg/kg) | Pharmazie. Vol. 18, Pg. 642, 1963. | |
mouse | LD50 | oral | 3750mg/kg (3750mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981. | |
rabbit | LD50 | oral | > 200mg/kg (200mg/kg) | Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979. | |
rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979. | |
rat | LD50 | intraperitoneal | 323mg/kg (323mg/kg) | Travaux de la Societe de Pharmacie de Montpellier. Vol. 34, Pg. 121, 1974. | |
rat | LD50 | oral | 1500mg/kg (1500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 94, 1990. |
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