Phthaloyl dichloride supplier

Name
Phthaloyl dichloride
EINECS 201-869-0
CAS No. 88-95-9
Article Data49
CAS DataBase
Density 1.427 g/cm³
Solubility decomposes with water
Melting Point 6-12 °C(lit.)
Formula C₈H₄Cl₂O₂
Boiling Point 281.7 °C at 760 mmHg
Molecular Weight 203.025
Flash Point 135.4 °C
Transport Information UN 3265 8/PG 2
Appearance clear yellow liquid
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Phthaloylchloride (6CI,8CI);1,2-Bis(chlorocarbonyl)benzene;NSC 44611;Phthalic aciddichloride;Phthalyl chloride;Phthalyl dichloride;o-Phthalic acid dichloride;Phthaloyl chloride;
PSA 34.14000
LogP 2.44460

Synthetic route

: 85-44-9
phthalic anhydride

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With phosgene; N,N-dibutylformamide In toluene at 70℃; for 7.5h; Product distribution / selectivity;	97.8%
With phosgene; N-methyl-N-stearylformamide In toluene at 75℃; for 7.5h; Product distribution / selectivity;	95%
With phosgene; N,N-dibutylformamide In toluene at 70℃; for 8h; Product distribution / selectivity;	91%

: 85-44-9
phthalic anhydride

: 5216-25-1
4-chlorotrichloromethylbenzene

A: 122-01-0
4-chloro-benzoyl chloride

B: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
zirconium(IV) chloride at 160℃; for 6h;	A 93% B 70%

...Expand

: 85-44-9
phthalic anhydride

A: 13358-73-1
N,N-dibutylcarbamoyl chloride

B: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With phosgene; N,N-dibutylformamide In toluene at 70℃; for 7.5h; Product distribution / selectivity;	A 0.9 %Chromat. B 89.3%

: 95-47-6
o-xylene

A: 933-88-0
ortho-toluoyl chloride

B: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
Stage #1: o-xylene With ruthenium(II) chloride; C88H48Cl8Fe2N8O; oxygen at 185℃; under 10501.1 Torr; Stage #2: With thionyl chloride Reagent/catalyst; Temperature; Pressure;	A 63.1% B 10.1%
Stage #1: o-xylene With ruthenium(II) chloride; C88H48Cl8Fe2N8O; oxygen at 185℃; under 10501.1 Torr; Stage #2: With thionyl chloride Reagent/catalyst; Temperature; Pressure;	A 24.1% B 38.7%

: 56-23-5
tetrachloromethane

: 85-44-9
phthalic anhydride

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With zinc(II) chloride at 220 - 300℃;

: 85-44-9
phthalic anhydride

: 67-66-3
chloroform

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With zinc(II) chloride at 220 - 300℃;

: 85-44-9
phthalic anhydride

: 67-72-1
hexachloroethane

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With zinc(II) chloride at 220 - 300℃;

: 85-44-9
phthalic anhydride

: 98-07-7
Benzotrichlorid

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With zinc(II) chloride at 110 - 200℃;

: 601-70-7
3,3-dichlorophthalide

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
at 130℃; Kinetik der Umwandlung;
durch Destillation;
at 100℃;
With hydrogenchloride
at 130℃;

: 13699-68-8
3-thioxo-3H-isobenzofuran-1-one

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With chlorine at 245℃;

: 2-trichloromethyl-benzoic acid ethyl ester

A: 85-44-9
phthalic anhydride

B: 75-00-3
chloroethane

C: 88-95-9
Phthaloyl dichloride

...Expand

: 88-99-3
benzene-1,2-dicarboxylic acid

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With phosphorus pentachloride
With thionyl chloride
With thionyl chloride at 60 - 65℃;

: 69246-89-5
2,5-dioxo-2,5-dihydrobenzotellurophene

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With chlorine In tetrachloromethane Yield given;

: 54552-89-5
2-phenyl-isophosphindole-1,3-dione

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With chlorine In diethyl ether

: 85-44-9
phthalic anhydride

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 88-95-9
Phthaloyl dichloride

: 5698-59-9
benzo[c]thiophene-1,3-dione

: 7782-50-5
chlorine

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
at 245℃;

: 85-44-9
phthalic anhydride

: 10026-13-8, 874483-75-7
phosphorus pentachloride

A: 3199-08-4
1,1,3,3-tetrachloro-1,3-dihydroisobenzofuran

B: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
at 245℃;

...Expand

: 85-44-9
phthalic anhydride

phosphoric acid-dichloride: phosphoric acid-dichloride

A: 3199-08-4
1,1,3,3-tetrachloro-1,3-dihydroisobenzofuran

B: 76716-56-8
α,α,α-trichloro-o-toluic chloride

C: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
at 245℃;

...Expand

21.21.21-trichloro-o-toluic acid ethyl ester: 21.21.21-trichloro-o-toluic acid ethyl ester

: 88-95-9
Phthaloyl dichloride

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 88-99-3
benzene-1,2-dicarboxylic acid

: 88-95-9
Phthaloyl dichloride

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 88-99-3
benzene-1,2-dicarboxylic acid

A: 85-44-9
phthalic anhydride

B: 88-95-9
Phthaloyl dichloride

...Expand

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
In benzene

: N,N,N',N'-tetracyclohexyl-phthalamide

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
In benzene

: 79-37-8
oxalyl dichloride

: 88-99-3
benzene-1,2-dicarboxylic acid

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
With N,N-dimethyl-formamide

: 92635-22-8
N-<(3-chloro)-propanoxy>phtalimide

: 88-95-9
Phthaloyl dichloride

Conditions

Conditions	Yield
Stage #1: N-<(3-chloro)-propanoxy>phtalimide With hydrogenchloride In water at 100 - 105℃; for 3h; Stage #2: With thionyl chloride In toluene for 4h; Reflux;

: 15573-38-3
Tris(trimethylsilyl)phosphane

: 88-95-9
Phthaloyl dichloride

: 3-(trimethysiloxy)-1H-2-benzophosphol-1-one

Conditions

Conditions	Yield
In diethyl ether at -50℃; for 2h;	100%

sodium amalgam: sodium amalgam

: 38117-54-3
cyclopentadienyl iron(II) dicarbonyl dimer

: 88-95-9
Phthaloyl dichloride

: 1,2-C6H4(COFp)2

Conditions

Conditions	Yield
With mercury In tetrahydrofuran soln. of Na#Hg, Hg, Fp2, THF was stirred for 1h, excess amalgam was drained, filtration through celite (medium porosity frit), cooling to -78°C (dry ice/aceton), addn. of 1,2-C6H4(COCl)2, warming to room temp.(1h), drying in vac., Et2O, stirring;	0%

...Expand

: 1416857-67-4
chromeno[4,3,2-gh]phenanthridin-2-amine

: 88-95-9
Phthaloyl dichloride

: 1416857-68-5
2-(chromeno[4,3,2-gh]phenanthridin-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 17 - 25℃; for 0.166667h; Inert atmosphere;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 88-95-9
Phthaloyl dichloride

A: 85-44-9
phthalic anhydride

B: 67627-98-9
p-bromo-α,α-dichlorotoluene

Conditions

Conditions	Yield
With 1-pyrrolidinecarboxaldehyde In toluene at 60℃; for 17h;	A 100% B 89%

...Expand

: 33252-32-3
4-ethylpyridin-2-amine

: 88-95-9
Phthaloyl dichloride

: 416852-12-5
2-(4-ethylpyridin-2-yl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With dmap In dichloromethane at 0 - 20℃;	99.8%
With triethylamine In dichloromethane at 20℃; for 1h; Cooling;	90%
With triethylamine In dichloromethane at 20℃; for 1h;	90%
With triethylamine In dichloromethane at 20℃; for 1h;	90%

: 88-95-9
Phthaloyl dichloride

: 87-41-2
2-benzofuran-1(3H)-one

Conditions

Conditions	Yield
With triethylsilane; iron(III)-acetylacetonate at 60℃; for 0.666667h;	99%
With triethylsilane; iron(III)-acetylacetonate at 60℃; for 0.666667h; other catalysts: Co(acac)2, Ni(acac)2; same reaction of iso- and terephthaloyl chloride;	99%
With tricyclohexylborane at 300℃; for 2h;	11.5%

: 88-95-9
Phthaloyl dichloride

: 5698-59-9
benzo[c]thiophene-1,3-dione

Conditions

Conditions	Yield
With N,N-dimethylthioformamide; hydrogen sulfide In dichloromethane at 25℃;	99%
With sodium sulfide; cetyltributylphosphonium bromide In dichloromethane at 0℃; for 1.33333h;	95%
With sodium disulfide; cetyltributylphosphonium bromide In water; benzene for 0.5h; Ambient temperature; also Na2S as reagent;	87%

: 88-95-9
Phthaloyl dichloride

: 175854-39-4
1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

: 175854-41-8
1,1'-phthaloylbis<4,7,10-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane>

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 1h; Ambient temperature;	99%

: 17356-08-0
thiourea

: 88-95-9
Phthaloyl dichloride

: 101883-39-0
2,2'-Thiocarbonyl-bis(2H-isoindol-1,3-dion)

Conditions

Conditions	Yield
With sodium carbonate In dichloromethane for 4h; Heating;	98%
With N,N-dimethyl-aniline; acetone

: 868-77-9
2-methyl-2-propenoic acid 2-hydroxyethyl ester

: 88-95-9
Phthaloyl dichloride

: 10552-43-9
α,ω-bis(methacryloylethyleneglycol)phthalate

Conditions

Conditions	Yield
With pyridine In benzene for 5h; Heating;	98%

: 88-95-9
Phthaloyl dichloride

: 174192-40-6
bis(1,1-dimethylethyl) 1,5,9-triazacyclododecane-1,5-dicarboxylate

: 175854-44-1
1,1'-phthaloylbis<5,9-bis(tert-butyloxycarbonyl)-1,5,9-triazacyclododecane>

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 1h; Ambient temperature;	98%

: 148448-11-7
(phthalocyanine-2,3:9,10:16,17:23,24-tetrakis(dicarboxanhydride))cobalt(II)

: 88-95-9
Phthaloyl dichloride

: cobalt octa-4,5-(chlorocarbonyl)phthalocyanine

Conditions

Conditions	Yield
With zinc(II) chloride In neat (no solvent) a mixt. of complex, phthaloyl chloride and anhydrous zinc chloride was stirred for 24 h at 210-215°C;	98%

: 117011-70-8
2-(4-aminophenoxy)-2-methyl propionic acid

: 88-95-9
Phthaloyl dichloride

: phthaloyl dichloride

Conditions

Conditions	Yield
With sodium hydroxide at 20℃;	98%

: 86-71-5
3,6-diamino-9H-carbazole

: 88-95-9
Phthaloyl dichloride

: 166272-33-9
3,6-diphthalimidocarbazole

Conditions

Conditions	Yield
With pyridine for 6h; Heating;	97%
With pyridine Yield given;

: 14243-23-3
(μ-dithio)bis(tricarbonyliron)

: 88-95-9
Phthaloyl dichloride

: 4294-57-9
para-methylphenylmagnesium bromide

: {Fe(CO)3(SC6H4CH3S)Fe(CO)3}2C(O)C6H4C(O)

Conditions

Conditions	Yield
In tetrahydrofuran p-TolMgBr in THF was added under N2 with stirring to a THF soln. of Fe2-complex at -78°C, o-C6H4(COCl)2 was added to the resulting anionsoln. at -78°C, mixt. was allowed to warm to room temp.; volatiles were removed, residue purified by column chromy.; elem. anal.;	97%

...Expand

: 13477-53-7
4-amino-2-hydroxybutyric acid

: 88-95-9
Phthaloyl dichloride

: 40732-91-0
γ-phthalimidoimino-α-hydroxybutyric acid

Conditions

Conditions	Yield
With dmap; sodium methylate at 60 - 100℃; for 1.36667h; Reagent/catalyst; Temperature;	96.3%

: 95-54-5
1,2-diamino-benzene

: 88-95-9
Phthaloyl dichloride

: 1,4,9,12-tetraazacyclo-2,3,6,7,10,11,14,15-tetrabenzo-cetanan-5,8,13,16-tetraone

Conditions

Conditions	Yield
With PEG-400; sodium hydroxide In dichloromethane for 1h; Product distribution; Heating; other reagent, solvent;	96%

: 88-95-9
Phthaloyl dichloride

: 73270-65-2
N-allyl (L)-leucine methyl ester

: 313969-96-9
(S)-2-(Allyl-{2-[allyl-((S)-1-methoxycarbonyl-3-methyl-butyl)-carbamoyl]-benzoyl}-amino)-4-methyl-pentanoic acid methyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; Acylation;	96%

: 4214-75-9
2-amino-3-nitropyridine

: 88-95-9
Phthaloyl dichloride

: 928163-49-9
3-nitro-2-phthalimidopyridine

Conditions

Conditions	Yield
With pyridine In toluene for 42h; Heating;	96%

: 88-95-9
Phthaloyl dichloride

: 69246-88-4
cyclic phthalic selenoanhydride

Conditions

Conditions	Yield
Stage #1: Phthaloyl dichloride With selenium; lithium aluminium tetrahydride In tetrahydrofuran; dichloromethane at 50℃; for 1h; Stage #2: With sulfuric acid In tetrahydrofuran; dichloromethane for 0.0833333h;	95%
Stage #1: Phthaloyl dichloride With lithium hydrogen selenide In tetrahydrofuran; dichloromethane at 50℃; for 1h; Stage #2: With sulfuric acid In tetrahydrofuran; dichloromethane for 0.0833333h; Reagent/catalyst; Solvent;	80%
With triethylamine; p-methylselenobenzamide In dichloromethane at 0℃; for 2h; Acylation; cyclization;	59.6%
With LiAlHSeH In tetrahydrofuran at 20℃; for 2h;	57%
With aluminium trichloride; selen(o) hydrogen

: 3025-88-5
2,5-dimethyl-2,5-dihydroperoxyhexane

: 543-20-4
succinoyl dichloride

: 88-95-9
Phthaloyl dichloride

: 78491-83-5
2-(4-{2-[4-(3-{4-[3-(4-Hydroperoxy-1,1,4-trimethyl-pentylperoxycarbonyl)-propionylperoxy]-1,1,4-trimethyl-pentylperoxycarbonyl}-propionylperoxy)-1,1,4-trimethyl-pentylperoxycarbonyl]-benzoylperoxy}-1,1,4-trimethyl-pentylperoxycarbonyl)-benzoic acid

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 1.5h;	95%

...Expand

: 594-39-8
2-methyl-2-butylamine

: 88-95-9
Phthaloyl dichloride

: 93272-72-1
N-tert-amylisophthalimide

Conditions

Conditions	Yield
With triethylamine In benzene at 6 - 7℃; for 0.05h;	95%

: 5813-64-9
2,2-dimethylpropylamine

: 88-95-9
Phthaloyl dichloride

: tert-amylisophtalimide

Conditions

Conditions	Yield
With triethylamine In benzene at 20℃; for 0.05h;	95%
With triethylamine In benzene at 20℃; for 0.0833333h;	92%

: 13195-81-8, 110814-87-4, 110814-88-5
1-amino-2,6-dicyanopiperidine

: 88-95-9
Phthaloyl dichloride

: 110814-92-1, 110814-93-2
1-phthalimido-2,6-dicyanopiperidine

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 16h; Ambient temperature;	95%

: 88-95-9
Phthaloyl dichloride

: 4469-71-0
3,3-(α-hydroxypentamethylene)diaziridine

: 72866-28-5
2-Hydroxyspiro-diazirino<1,2-b>phthalazine>-3',8'-dione

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 5 - 10℃; for 5h;	95%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 88-95-9
Phthaloyl dichloride

: phthalic acid 5-hydroxymethylfurfural di-ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0 - 20℃; for 10h; Product distribution / selectivity;	95%

: 873430-63-8
(phthalocyanine-2,3:9,10:16,17:23,24-tetrakis(dicarboxanhydride))zinc(II)

: 88-95-9
Phthaloyl dichloride

: zinc octa-4,5-(chlorocarbonyl)phthalocyanine

Conditions

Conditions	Yield
With zinc(II) chloride In neat (no solvent) a mixt. of complex, phthaloyl chloride and anhydrous zinc chloride was stirred for 24 h at 210-215°C;	95%

: 64-17-5
ethanol

: C14H15N3O

: 88-95-9
Phthaloyl dichloride

: 3-(2-ethoxycarbonylphenyl)-4-(4'-methoxyphenyl)-5-phenyl-4H-1,2,4-triazole dihydrochloride

Conditions

Conditions	Yield
With triethylamine Reflux;	95%

...Expand

: 108-98-5
thiophenol

: 88-95-9
Phthaloyl dichloride

: 42797-33-1
1,2-bis(phenyl thioester)benzene

Conditions

Conditions	Yield
With sodium methylate In methanol at 0℃;	94%
With triethylamine In chloroform at 25℃; for 12h;	77%
With sodium methylate

Phthaloyl dichloride Specification

The Phthaloyl chloride with cas registry number of 88-95-9 belongs to the classes of acid chlorides. Its EINECS registry number is 201-869-0. Its systematic name and IUPAC name are the same which is called benzene-1,2-dicarbonyl chloride. With appearance of clear yellow liquid, this chemical is also known as 1,2-Benzenedicarbonyl dichloride; o-Phthaloyl chloride.

Physical properties about this chemical are: (1)ACD/LogP: 1.65; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.65; (4)ACD/LogD (pH 7.4): 1.65; (5)ACD/BCF (pH 5.5): 10.58; (6)ACD/BCF (pH 7.4): 10.58; (7)ACD/KOC (pH 5.5): 188.35; (8)ACD/KOC (pH 7.4): 188.35; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 34.14 Å²; (13)Index of Refraction: 1.571; (14)Molar Refractivity: 46.74 cm³; (15)Molar Volume: 142.2 cm³; (16)Surface Tension: 48.2 dyne/cm; (17)Density: 1.427 g/cm³; (18)Flash Point: 135.4 °C; (19)Enthalpy of Vaporization: 52.05 kJ/mol; (20)Boiling Point: 281.7 °C at 760 mmHg; (21)Vapour Pressure: 0.00351 mmHg at 25°C; (22)Refractive index: n20/D 1.568(lit.).

When you are using this chemical, please be cautious about it as the following:
This chemical is sensitive to moisture. It can cause burns. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you feel unwell, seek medical advice immediately (show the label whenever possible.). So you'd better wear suitable protective clothing, gloves and eye/face protection when you are using it.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Cl)c1ccccc1C(Cl)=O;
(2)InChI: InChI=1/C8H4Cl2O2/c9-7(11)5-3-1-2-4-6(5)8(10)12/h1-4H;
(3)InChIKey: FYXKZNLBZKRYSS-UHFFFAOYAB

Product Name

Phthaloyl dichloride

Synthetic route

Phthaloyl dichloride Specification

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