Product Name

  • Name

    Piperidine hydrochloride

  • EINECS 228-033-8
  • CAS No. 6091-44-7
  • Article Data98
  • CAS DataBase
  • Density 1,12 g/cm3
  • Solubility Soluble in water and ethanol
  • Melting Point 245-249 °C
  • Formula C5H11N.HCl
  • Boiling Point 106.4 °C at 760 mmHg
  • Molecular Weight 121.61
  • Flash Point 4.4 °C
  • Transport Information UN 2811 6.1/PG 3
  • Appearance white fine crystalline powder
  • Safety 36/37/39-45-26
  • Risk Codes 36/37/38-23/24/25
  • Molecular Structure Molecular Structure of 6091-44-7 (Piperidine hydrochloride)
  • Hazard Symbols ToxicT
  • Synonyms Piperidine, hydrochloride (7CI,8CI,9CI);Piperidinium chloride;Piperidine, hydrochloride (1:1);Hexahydropyridine hydrochloride;NSC 27162;
  • PSA 16.61000
  • LogP -1.69310

Synthetic route

piperidine
110-89-4

piperidine

A

Succinimide
123-56-8

Succinimide

B

N,N'-thiodipiperidine
25116-80-7

N,N'-thiodipiperidine

C

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With N-chlorothiophthalimide In 1,2-dichloro-ethane at 20 - 25℃; for 2h;A n/a
B 77%
C 100%
piperidine
110-89-4

piperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With hydroxylamine hydrochloride In ethanol for 2h; Reflux;100%
With tetrachloromethane; dicarbonylchloro(2,1,3-benzothiadiazole)rhodium(I) for 360h; Ambient temperature; also with other chlorinated solvents and rhodium complex catalysts;50%
Multi-step reaction with 2 steps
1: 18 percent / CHCl3 / 8 h / Heating
2: 0.4 g / HCl / diethyl ether
View Scheme
pyridine
110-86-1

pyridine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
Stage #1: pyridine With palladium 10% on activated carbon; hydrogen; acetic acid at 24 - 28℃; for 15h;
Stage #2: With hydrogenchloride In methanol; water Catalytic behavior;
100%
Stage #1: pyridine With palladium on activated charcoal; hydrogen; acetic acid at 20℃; under 760.051 Torr; for 15h;
Stage #2: With hydrogenchloride In methanol; water Time;
100%
With hydrogenchloride; methanol; lithium triethylborohydride 1.) THF, RT. 0.5 h; Yield given. Multistep reaction;
Stage #1: pyridine With ammonium formate; 10percent palladium on carbon In methanol at 20℃; for 16h;
Stage #2: With hydrogenchloride In methanol Further stages.;
95 % Spectr.
Stage #1: pyridine With hydrogen In 1,4-dioxane at 100℃; under 15001.5 Torr; for 3.33333h; Autoclave;
Stage #2: With hydrogenchloride
2-chloropyridine-N-oxide
2402-95-1

2-chloropyridine-N-oxide

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloropyridine-N-oxide With ammonium formate; 10percent palladium on carbon In methanol at 20℃; for 16h;
Stage #2: With hydrogenchloride In methanol Further stages.;
100%
N-(2-chloropropionyl)piperidine
66203-96-1, 115871-51-7

N-(2-chloropropionyl)piperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With methanol at 50℃; for 0.5h;99%
2-(2'-nitrophenylsulphone)-1-chloroindane

2-(2'-nitrophenylsulphone)-1-chloroindane

A

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

B

2-(2'-nitrophenylsulphone)indene
100461-60-7

2-(2'-nitrophenylsulphone)indene

Conditions
ConditionsYield
With piperidine In tetrahydrofuran for 0.166667h; Ambient temperature;A n/a
B 99%
t-butyl piperidinecarboxylate
75844-69-8

t-butyl piperidinecarboxylate

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With sulfuric acid; sodium chloride In neat (no solvent) at 20℃; for 1h; Sealed tube;99%
piperidine
110-89-4

piperidine

tris(dimethylamino)isothiocyanatophosphonium chloride

tris(dimethylamino)isothiocyanatophosphonium chloride

A

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

B

C12H28N5PS

C12H28N5PS

Conditions
ConditionsYield
for 6h;A n/a
B 98%
N-Benzylpiperidine
2905-56-8

N-Benzylpiperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With 1,1,2-trichloroethane; 10% palladium on activated carbon; hydrogen In methanol under 760.051 Torr; for 1h; chemoselective reaction;98%
With dichloromethane; hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; atmospheric pressure;97%
With Na2K-SG(I) In tetrahydrofuran at 20℃; Inert atmosphere;82%
With hydrogenchloride; Vinyl chloroformate 1.) CH2Cl2, 0 deg C to room temperature;reflux, 4 h, 3.) MeOH, 50-60 deg C, 4.5 h; Yield given. Multistep reaction;
1-(cyclohex-1-en-1-yl)piperidine
2981-10-4

1-(cyclohex-1-en-1-yl)piperidine

methyl 3-phenyl-3-chloro-2-ketopropionate
32803-73-9

methyl 3-phenyl-3-chloro-2-ketopropionate

A

2-phenyl-1-(1-piperidinyl)ethanone
3626-62-8

2-phenyl-1-(1-piperidinyl)ethanone

B

methyl 1-(5-chloropentyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 1-(5-chloropentyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

C

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 4%
B 95%
C 1%
piperidine
110-89-4

piperidine

dichloromethane
75-09-2

dichloromethane

A

di(N-piperidinyl)methane
880-09-1

di(N-piperidinyl)methane

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
for 24h; Darkness;A 91%
B n/a
O,O-diethyl piperidinophosphate diester
4972-36-5

O,O-diethyl piperidinophosphate diester

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 70℃; for 1h; acid degradation;88%
N-allylpiperidine
14446-67-4

N-allylpiperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With Na2K-SG(I) In tetrahydrofuran at 20℃; Inert atmosphere;88%
N-tosylpiperidine
4703-22-4

N-tosylpiperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With perhydrodibenzo-18-crown-6 In diethylene glycol dimethyl ether for 3h; Ambient temperature;82%
methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate
160727-95-7

methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

4-tert-butyl-1-(1-piperidinyl)cyclohexene
67074-49-1

4-tert-butyl-1-(1-piperidinyl)cyclohexene

A

methyl 5-tert-butyl-1-(5-chloropentyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 5-tert-butyl-1-(5-chloropentyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 82%
B 11%
piperidine
110-89-4

piperidine

[palladium(II)dichloride(1,10-phenanthroline)]
14783-10-9

[palladium(II)dichloride(1,10-phenanthroline)]

carbon monoxide
201230-82-2

carbon monoxide

PdCl(CON(CH2)5)(1,10-phenanthroline)
301840-92-6

PdCl(CON(CH2)5)(1,10-phenanthroline)

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In acetonitrile to suspn. PdCl2(phen) in CH3CN was added piperidine (1:2), suspn. was allowed to react under stirring with CO (0.1 MPa) at 313 K for 3 h; filtered off, washed with CH3CN/CH3OH (10:1), and dried in vacuo; elem.anal.;A 80%
B n/a
piperidine
110-89-4

piperidine

1-(thien-2-yl)-3,4,4-trichloro-3-buten-1-one
1258431-65-0

1-(thien-2-yl)-3,4,4-trichloro-3-buten-1-one

A

4,4-dichloro-3-piperidino-1-(thien-2-yl)-2-buten-1-one
1258431-68-3

4,4-dichloro-3-piperidino-1-(thien-2-yl)-2-buten-1-one

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In diethyl ether at 15℃; Reflux;A 80%
B n/a
Glutaronitrile
544-13-8

Glutaronitrile

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
Stage #1: Glutaronitrile With C46H178O41Si42; titanium(IV)isopropoxide In toluene at 100℃; for 24h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In toluene at 20℃; for 4h; Inert atmosphere; chemoselective reaction;
80%
1-(cyclohex-1-en-1-yl)piperidine
2981-10-4

1-(cyclohex-1-en-1-yl)piperidine

methyl 3-(3-nitrophenyl)-3-chloro-2-oxopropionate
146736-30-3

methyl 3-(3-nitrophenyl)-3-chloro-2-oxopropionate

A

methyl 1-(5-chloropentyl)-2-(3-nitrophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 1-(5-chloropentyl)-2-(3-nitrophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 80%
B 15%
boron trichloride
10294-34-5

boron trichloride

B(OC2H5)2(CH2)5N3
120986-90-5

B(OC2H5)2(CH2)5N3

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In dichloromethane to soln. of azide was added soln. of BCl3 at -78°C; mixt. was allowed to warm up to room temp. overnight, MeOH added and solvents removed; characterized as benzoyl deriv.;79%
piperidine
110-89-4

piperidine

1-(4-hydroxyphenyl)-3,4,4-trichloro-3-buten-1-one
1258431-66-1

1-(4-hydroxyphenyl)-3,4,4-trichloro-3-buten-1-one

A

4,4-dichloro-3-piperidino-1-(4-hydroxyphenyl)-2-buten-1-one
1258431-71-8

4,4-dichloro-3-piperidino-1-(4-hydroxyphenyl)-2-buten-1-one

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In diethyl ether at 15℃; Reflux;A 79%
B n/a
methyl 3-phenyl-3-chloro-2-ketopropionate
32803-73-9

methyl 3-phenyl-3-chloro-2-ketopropionate

4-tert-butyl-1-(1-piperidinyl)cyclohexene
67074-49-1

4-tert-butyl-1-(1-piperidinyl)cyclohexene

A

methyl 5-tert-butyl-1-(5-chloropentyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 5-tert-butyl-1-(5-chloropentyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 79%
B 15%
piperidine
110-89-4

piperidine

dichloro(2,2'-bipyridine)palladium(II)
14871-92-2

dichloro(2,2'-bipyridine)palladium(II)

carbon monoxide
201230-82-2

carbon monoxide

PdCl(CON(CH2)5)(2,2'-dipyridine)
301840-91-5

PdCl(CON(CH2)5)(2,2'-dipyridine)

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In acetonitrile to suspn. PdCl2(dipy) in CH3CN was added piperidine (1:2), suspn. was allowed to react under stirring with CO (0.1 MPa) at room temp. for 3 h; filtered off, washed with CH3CN/CH3OH (10:1), and dried in vacuo; elem.anal.;A 78%
B n/a
piperidine
110-89-4

piperidine

furfural
98-01-1

furfural

A

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

B

2-furfurylpiperidinium chloride

2-furfurylpiperidinium chloride

Conditions
ConditionsYield
Stage #1: piperidine; furfural In diethyl ether at 20℃; for 1.5h;
Stage #2: With acetyl chloride In diethyl ether at 20℃; for 0.333333h; Further stages.;
A 7%
B 77%
1-(methanesulfonyl)piperidine
3989-48-8

1-(methanesulfonyl)piperidine

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With perhydrodibenzo-18-crown-6 In diethylene glycol dimethyl ether for 3h; Ambient temperature;76%
1-(cyclohex-1-en-1-yl)piperidine
2981-10-4

1-(cyclohex-1-en-1-yl)piperidine

3-(3-bromo-phenyl)-3-chloro-2-oxo-propionic acid methyl ester
1108172-76-4

3-(3-bromo-phenyl)-3-chloro-2-oxo-propionic acid methyl ester

A

methyl 2-(3-bromophenyl)-1-(5-chloropentyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 2-(3-bromophenyl)-1-(5-chloropentyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 76%
B 18%
1-(cyclohex-1-en-1-yl)piperidine
2981-10-4

1-(cyclohex-1-en-1-yl)piperidine

3-Chloro-3-(4-nitro-phenyl)-2-oxo-propionic acid methyl ester
146736-31-4

3-Chloro-3-(4-nitro-phenyl)-2-oxo-propionic acid methyl ester

A

methyl 1-(5-chloropentyl)-2-(4-nitrophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 1-(5-chloropentyl)-2-(4-nitrophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

C

2-(4-nitrophenyl)-1-(piperidin-1-yl)ethan-1-one
105072-35-3

2-(4-nitrophenyl)-1-(piperidin-1-yl)ethan-1-one

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 76%
B 14%
C 6%
1-(cyclohex-1-en-1-yl)piperidine
2981-10-4

1-(cyclohex-1-en-1-yl)piperidine

methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate
53173-90-3

methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate

A

methyl 1-(5-chloropentyl)-2-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

methyl 1-(5-chloropentyl)-2-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;A 75%
B 12%
piperidine
110-89-4

piperidine

dichloro(2,2'-bipyridine)palladium(II)
14871-92-2

dichloro(2,2'-bipyridine)palladium(II)

carbon monoxide
201230-82-2

carbon monoxide

Pd(CON(CH2)5)2(2,2'-dipyridine)
301840-95-9

Pd(CON(CH2)5)2(2,2'-dipyridine)

B

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
In acetonitrile to suspn. PdCl2(dipy) in MeCN was added piperidine (1:10), mixt. was reacted with CO (0.1 MPa) at room temp. for 2 h; mixt. was concd. and filtered; elem. anal.;A 72%
B n/a
(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride
130004-33-0, 145926-28-9, 376354-47-1

(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

[(RuCl(C6H5)2PC10H6C10H6P(C6H5)2)2Cl3](1-)*[C5H10NH2](1+)=[(RuCl(C6H5)2PC10H6C10H6P(C6H5)2)2Cl3][C5H10NH2]

[(RuCl(C6H5)2PC10H6C10H6P(C6H5)2)2Cl3](1-)*[C5H10NH2](1+)=[(RuCl(C6H5)2PC10H6C10H6P(C6H5)2)2Cl3][C5H10NH2]

Conditions
ConditionsYield
In tetrahydrofuran (Ar); heating a soln. of ruthenium complex with ammonium salt in THF for 6 h; evapn., washing;100%
3-phenyl-1,2,4-oxadiazole[4,5-a]piridinium chloride

3-phenyl-1,2,4-oxadiazole[4,5-a]piridinium chloride

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

3-phenyl-5-[(1E,3E)-4-(piperidin-1-yl)buta-1,3-dien-1-yl]-1,2,4-oxadiazole

3-phenyl-5-[(1E,3E)-4-(piperidin-1-yl)buta-1,3-dien-1-yl]-1,2,4-oxadiazole

Conditions
ConditionsYield
With triethylamine In methanol at 20℃;99%
formaldehyd
50-00-0

formaldehyd

3,3-dimethylcyclohexanone
2979-19-3

3,3-dimethylcyclohexanone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1-[(4,4-dimethyl-2-ketocyclohexyl-1-yl)methyl]piperidine

1-[(4,4-dimethyl-2-ketocyclohexyl-1-yl)methyl]piperidine

Conditions
ConditionsYield
With trifluoroacetic acid In ethanol at 30℃; for 22h; Mannich Aminomethylation;98%
piperidine hydrochloride
6091-44-7

piperidine hydrochloride

sodium N,N-dimethylcarbamoselenothioate
98897-40-6

sodium N,N-dimethylcarbamoselenothioate

Piperidinium N,N-dimethylthioselenocarbamate
98897-41-7

Piperidinium N,N-dimethylthioselenocarbamate

Conditions
ConditionsYield
In methanol97%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

4'-methylpropiophenone
5337-93-9

4'-methylpropiophenone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Tolperisone hydrochloride

Tolperisone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 8h;96%
formaldehyd
50-00-0

formaldehyd

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

4-Oxo-1-phenyl-4,5,6,7-tetrahydrobenopyrazole
14823-31-5

4-Oxo-1-phenyl-4,5,6,7-tetrahydrobenopyrazole

1-Phenyl-5-piperidin-1-ylmethyl-1,5,6,7-tetrahydro-indazol-4-one

1-Phenyl-5-piperidin-1-ylmethyl-1,5,6,7-tetrahydro-indazol-4-one

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol for 60h; Heating;95%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

1-(4-ethylphenyl)-1-propanone
27465-51-6

1-(4-ethylphenyl)-1-propanone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

eperisone hydrochloride
56839-43-1

eperisone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 6.5h;95%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

(+/-)-2-methyl-1-phenyl-3-piperidino-propan-1-one; hydrochloride
6281-80-7

(+/-)-2-methyl-1-phenyl-3-piperidino-propan-1-one; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 8h; Product distribution; other ketones, var. solvents and acids;95%
With hydrogenchloride at 90℃; for 8h;95%
piperidine
110-89-4

piperidine

2-methoxy-1-pyrroline
5264-35-7

2-methoxy-1-pyrroline

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1-(3,4-dihydro-2H-pyrrol-5-yl)piperidine
1196-64-1

1-(3,4-dihydro-2H-pyrrol-5-yl)piperidine

Conditions
ConditionsYield
at 70℃; for 24h;95%
piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1,3,5-trimethyl-1H-pyrazole-4-sulfonic acid chloride
59340-27-1

1,3,5-trimethyl-1H-pyrazole-4-sulfonic acid chloride

1-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)piperidin-4-one

1-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)piperidin-4-one

Conditions
ConditionsYield
Stage #1: piperidine hydrochloride With magnesium sulfate In dichloromethane at 20℃; for 0.25h;
Stage #2: 1,3,5-trimethyl-1H-pyrazole-4-sulfonic acid chloride With triethylsilane In dichloromethane at 20℃;
95%
piperidine hydrochloride
6091-44-7

piperidine hydrochloride

sodium salt of 3-(1-adamantyl)-1-hydroxy-1-propen-3-one
94696-08-9

sodium salt of 3-(1-adamantyl)-1-hydroxy-1-propen-3-one

3-(1-adamantyl)-1-piperidino-1-propen-3-one

3-(1-adamantyl)-1-piperidino-1-propen-3-one

Conditions
ConditionsYield
In ethanol for 12h; Substitution; Heating;91%
In ethanol for 12h; Heating;91%
methanesulfonic acid
75-75-2

methanesulfonic acid

4'-methylpropiophenone
5337-93-9

4'-methylpropiophenone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Conditions
ConditionsYield
With 1,3-DIOXOLANE at 80℃; for 24h; Sealed tube;91%
(2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one
54750-12-8

(2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

(2S,4S,5R)-3,4-dimethyl-5-phenyl-2-piperidyl-1,3,2-oxazaphospholidin-2-one

(2S,4S,5R)-3,4-dimethyl-5-phenyl-2-piperidyl-1,3,2-oxazaphospholidin-2-one

Conditions
ConditionsYield
With triethylamine In dichloromethane Substitution;90%
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1-piperidin-1-yl-ethanone
618-42-8

1-piperidin-1-yl-ethanone

Conditions
ConditionsYield
In methanol at 135℃; for 0.25h; Microwave irradiation;90%
carbon monoxide
201230-82-2

carbon monoxide

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1,1'-carbonyldipiperidine
5395-04-0

1,1'-carbonyldipiperidine

Conditions
ConditionsYield
With sodium carbonate In toluene at 60℃; Autoclave;90%
methyl 3-(methylthio)propionate
13532-18-8

methyl 3-(methylthio)propionate

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

3-methylsulfanyl-1-piperidin-1-yl-propan-1-one

3-methylsulfanyl-1-piperidin-1-yl-propan-1-one

Conditions
ConditionsYield
Stage #1: piperidine hydrochloride With diisobutylaluminium hydride In tetrahydrofuran; toluene
Stage #2: methyl 3-(methylthio)propionate In tetrahydrofuran at 45℃; for 2h;
89%
piperidine hydrochloride
6091-44-7

piperidine hydrochloride

N-(4-bromophenyl)-2-chloroacetamide
2564-02-5

N-(4-bromophenyl)-2-chloroacetamide

N-(4-bromophenyl)-2-(1-piperidyl)acetamide
58479-86-0

N-(4-bromophenyl)-2-(1-piperidyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 6h;89%
formaldehyd
50-00-0

formaldehyd

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

cyclohexanone
108-94-1

cyclohexanone

2-piperidin-1-ylmethyl-cyclohexanone
534-84-9

2-piperidin-1-ylmethyl-cyclohexanone

Conditions
ConditionsYield
With acetic acid Reflux; Inert atmosphere;88%

Piperidine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Piperidine hydrochloride Specification

The Piperidine hydrochloride, with the CAS registry number 6091-44-7, is also known as Piperidine, hydrochloride (1:1). It belongs to the product categories of Piperidine; Building Blocks; Heterocyclic Building Blocks; Piperidines. Its EINECS number is 228-033-8. This chemical's molecular formula is C5H11N.HCl and molecular weight is 121.63. What's more, its systematic name is Piperidinium chloride. Its classification code is Drug / Therapeutic Agent. It is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. This chemical is used in organic synthesis.

Physical properties of Piperidine hydrochloride are: (1)ACD/LogP: 0.932; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.17; (4)ACD/LogD (pH 7.4): -2.10; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Flash Point: 4.4 °C; (13)Enthalpy of Vaporization: 34.53 kJ/mol; (14)Boiling Point: 106.4 °C at 760 mmHg; (15)Vapour Pressure: 28.3 mmHg at 25°C.

Preparation: this chemical can be prepared by N-(2-chloropropionyl)piperidine at the temperature of 50 °C. This reaction will need reagent methanol with the reaction time of 30 min. The yield is about 99%.

Piperidine hydrochloride can be prepared by N-(2-chloropropionyl)piperidine at the temperature of 50 °C

Uses of Piperidine hydrochloride: it can be used to produce 2,8-Dimethyl-6-(1-piperidyl)-9H-purin at the temperature of 200 °C. It will need reagents P2O5, NEt3·HCl with the reaction time of 3 hours. The yield is about 76%.

Piperidine hydrochloride can be used to produce 2,8-Dimethyl-6-(1-piperidyl)-9H-purin at the temperature of 200 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].[NH2+]1CCCCC1
(2)Std. InChI: InChI=1S/C5H11N.ClH/c1-2-4-6-5-3-1;/h6H,1-5H2;1H
(3)Std. InChIKey: VEIWYFRREFUNRC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo subcutaneous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
mouse LD50 intraperitoneal 330mg/kg (330mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967.
mouse LD50 intravenous 160mg/kg (160mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 36, 1957.
mouse LDLo subcutaneous 657mg/kg (657mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
mouse LDLo subcutaneous 657mg/kg (657mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
rat LD50 oral 133mg/kg (133mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 289, 1972.

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