Product Name

  • Name

    NONAETHYLENE GLYCOL MONODODECYL ETHER

  • EINECS 221-284-4
  • CAS No. 3055-99-0
  • Article Data10
  • CAS DataBase
  • Density 1.007 g/cm3
  • Solubility
  • Melting Point 33-36 °C
  • Formula C30H62O10
  • Boiling Point 615.857 °C at 760 mmHg
  • Molecular Weight 582.816
  • Flash Point 326.259 °C
  • Transport Information
  • Appearance
  • Safety 23-24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 3055-99-0 (NONAETHYLENE GLYCOL MONODODECYL ETHER)
  • Hazard Symbols
  • Synonyms Ethanol, 2-[2-[2-[2-[2-[2-[2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-;Nonaethylene glycol monododecyl ether;Dodecylnonaoxyethylene glycol monoether;
  • PSA 103.30000
  • LogP 4.04900

Synthetic route

oxirane
75-21-8

oxirane

1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
With K10 clay at 50℃;94%
With potassium hydroxide at 140 - 170℃;
Hexaethylene glycol monododecyl ether
3055-96-7

Hexaethylene glycol monododecyl ether

C6H12O6S

C6H12O6S

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Stage #1: Hexaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere;
Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;		77%
Stage #1: Hexaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: C6H12O6S In tetrahydrofuran at 20℃; for 3h;
Stage #3: With sulfuric acid In tetrahydrofuran; water at 20 - 80℃; for 2h;		77%
1-{2-[2-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-dodecane
17464-54-9

1-{2-[2-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-dodecane

2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
With sodium
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
4.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
4.2: pH 2 / Inert atmosphere
4.3: 2 h / 80 °C / Inert atmosphere
View Scheme
C6H12O6S

C6H12O6S

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C
1.2: 3 h / 20 °C
1.3: 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 3 h / 20 °C
2.3: 2 h / 20 - 80 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
3.2: 3 h / 20 °C
3.3: 2 h / 20 - 80 °C
View Scheme
2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol
3055-94-5

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
1.2: 3 h / 20 °C
1.3: 2 h / 20 - 80 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 3 h / 20 °C
2.3: 2 h / 20 - 80 °C
View Scheme
polidocanol
3055-99-0

polidocanol

methyl iodide
74-88-4

methyl iodide

C31H64O10

C31H64O10

Conditions
ConditionsYield
Stage #1: polidocanol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil Inert atmosphere;		94%
(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid
60705-96-6

(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid

polidocanol
3055-99-0

polidocanol

C40H67NO13

C40H67NO13

Conditions
ConditionsYield
With sulfuric acid In toluene at 150℃; for 35h; Molecular sieve;83.12%
polidocanol
3055-99-0

polidocanol

C6H12O6S

C6H12O6S

laureth-12
3056-00-6

laureth-12

Conditions
ConditionsYield
Stage #1: polidocanol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere;
Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;		59%
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

polidocanol
3055-99-0

polidocanol

polidocanol lactate

polidocanol lactate

Conditions
ConditionsYield
With sodium hydrogencarbonate at 62℃; under 15 Torr; for 24h; Enzymatic reaction;38.19 g
polidocanol
3055-99-0

polidocanol

C6H12O6S

C6H12O6S

C37H76O13

C37H76O13

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
View Scheme
polidocanol
3055-99-0

polidocanol

phenyl isocyanate
103-71-9

phenyl isocyanate

C37H67NO11

C37H67NO11

Conditions
ConditionsYield
In methanol; acetonitrile at 70℃; for 1h;
polidocanol
3055-99-0

polidocanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

C37H68O12S

C37H68O12S

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 50℃; for 12h;

Polidocanol Specification

The IUPAC name of Polidocanol is 2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol. With the CAS registry number 3055-99-0, it is also named as Dodecylnonaoxyethylene glycol monoether. Besides, it should be stored in sealed, cool and dry place at 2-8 °C. When you are using this chemical, please do not breathe vapour. And you should avoid contact with skin and eyes. In addition, its molecular formula is C30H62O10 and molecular weight is 582.8073.

The other characteristics of this product can be summarized as: (1)EINECS: 221-284-4; (2)ACD/LogP: 2.18; (3)# of Rule of 5 Violations: 2; (4)ACD/LogD (pH 5.5): 2.18; (5)ACD/LogD (pH 7.4): 2.18; (6)ACD/BCF (pH 5.5): 26.82; (7)ACD/BCF (pH 7.4): 26.82; (8)ACD/KOC (pH 5.5): 366.55; (9)ACD/KOC (pH 7.4): 366.55; (10)#H bond acceptors: 10; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 38; (13)Index of Refraction: 1.459; (14)Molar Refractivity: 158.27 cm3; (15)Molar Volume: 578.5 cm3; (16)Surface Tension: 36.2 dyne/cm; (17)Density: 1.007 g/cm3; (18)Flash Point: 326.3 °C; (19)Melting Point: 33-36 °C; (20)Enthalpy of Vaporization: 104.76 kJ/mol; (21)Boiling Point: 615.9 °C at 760 mmHg; (22)Vapour Pressure: 9.63E-18 mmHg at 25 °C.

Uses of Polidocanol: this chemical is a sclerosant. It causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

People can use the following data to convert to the molecule structure.
(1)SMILES: O(CCOCCOCCO)CCOCCOCCOCCCCCOCCOCCCCCCCCCCCC
(2)InChI: InChI=1/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3
(3)InChIKey: ONJQDTZCDSESIW-UHFFFAOYAX
(4)Std. InChI: InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3
(5)Std. InChIKey: ONJQDTZCDSESIW-UHFFFAOYSA-N

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