Propionaldehyde supplier | CasNO.123-38-6

Name
Propionaldehyde
EINECS 204-623-0
CAS No. 123-38-6
Article Data1109
CAS DataBase
Density 0.798 g/cm³
Solubility 540 g/L (20 °C) in water
Melting Point -81 °C
Formula C₃H₆O
Boiling Point 49.339 °C at 760 mmHg
Molecular Weight 58.08
Flash Point ?16°F
Transport Information UN 1275 3/PG 2
Appearance colourless liquid
Safety 9-16-29
Risk Codes 11-36/37/38
Molecular Structure
Hazard Symbols F,Xi
Synonyms 1-Propanal;1-Propanone;Ethylcarboxaldehyde;Methylacetaldehyde;NSC 6493;Propaldehyde;Propional;Propionic aldehyde;Propylic aldehyde;n-Propanal;n-Propionaldehyde;Propanal;
PSA 17.07000
LogP 0.59530

Synthetic route

: 107-18-6
allyl alcohol

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
(sulphos)Rh(CO)2 In octane; water at 100℃; for 1h; Product distribution; Further Variations:; Solvents; autoclave;	100%
With chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); silver(I) 4-methylbenzenesulfonate In toluene at 60℃; for 6h; Inert atmosphere;	100%
With [Ru(η3:η3-C10H16)Cl2(benzimidazole)] In glycerol at 75℃; for 12h; Sealed tube; Inert atmosphere; Green chemistry;	99%

: 107-02-8
acrolein

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With hydrogen; palladium(II) complex of ferrocenylamine sulfide (2) In acetone under 4137.2 Torr; for 1h; or with catalyst 3, 2 h;	100%
With hydrogen; Ni/AlPO4-SiO2; nickel In methanol at 47.9℃; for 0.666667h;	100%
With 2%Pd/Al2O3; hydrogen; palladium In water at 150℃; under 3750.38 Torr;	85%

: 1333-74-0
hydrogen

: 107-02-8
acrolein

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With C61H62ClN3P2Ru In dichloromethane-d2 at 50℃; under 3040.2 Torr; for 8h; Reagent/catalyst; Time;	100%

: 71-23-8
propan-1-ol

A: 123-38-6
propionaldehyde

B: 802294-64-0
propionic acid

Conditions

Conditions	Yield
With potassium hydroxide at 50℃; electrolysis;	A n/a B 99%
With C30H24N2O7W; dihydrogen peroxide In water; acetonitrile for 12h; Reflux;	A 64% B 23%
palladium at 50℃; for 4h; electrooxydation on Pt-Rh-electrode;	A 19.5% B 17%

: 74-85-1
ethene

: 201230-82-2
carbon monoxide

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
propylamine; di(rhodium)tetracarbonyl dichloride In ethanol at 110℃; under 50 Torr; for 1h;	99%
With ; hydrogen In N,N-dimethyl-formamide at 100℃; under 42753.4 Torr; for 4.5h; Product distribution; other alkene; selectivity of the hydroformylation;	74%
With hydrogen; silica gel; palladium var. Pd dispersion;

: 4-(1-propenyloxymethyl)-1,3-dioxalan-2-one

A: 931-40-8
4-hydroxymethyl-1,3-dioxolan-2-one

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With water; dichloro bis(acetonitrile) palladium(II) at 40℃; for 2h;	A 99% B n/a

: 71-23-8
propan-1-ol

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With tetrahexylammonium tetrakis(diperoxomolybdo)phosphate In chloroform at 40℃; for 48h;	98%
With C19H20N3O2Ru(2+)*2F6P(1-) In aq. buffer at 24.84℃; for 1h; pH=1.8; Thermodynamic data; Activation energy; Reagent/catalyst;	95%
With cetyltrimethylammonium bromochromate In dichloromethane for 2h; Heating;	92%

: 540-54-5
1-Chloropropane

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With C30H38Cl2Ir2N4 In dimethyl sulfoxide at 50℃; for 5h;	95%
With oxygen; kieselguhr; copper(l) chloride In dichloromethane for 1.5h; Oxidation; Heating;	91%

: 71-23-8
propan-1-ol

: 82807-94-1
[closo-3,3-(triphenylphosphine)2-3-HSO4-3,1,2-RhC2B9H11] tetrahydrofuran solvate

A: 53687-46-0
closo-3,3-(PPh3)2-3-H-3,1,2-RhC2B9H11

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
In propan-1-ol byproducts: H2SO4; under Ar, Rh complex suspended in 1-propanol, suspn. heated to 50°C in water bath for 10 min; ppt. filtered off, washed three times with ethanol and twice with diethyl ether, air-dried;	A 94% B n/a

...Expand

: 583-04-0
vinyl benzoate

A: 123-38-6
propionaldehyde

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; diethylene glycol dimethyl ether; 1,6-bis(diphenylphosphino)hexane; water In 1,2-dimethoxyethane; dichloromethane at 20 - 85℃; for 0.666667h; Inert atmosphere;	A 89 %Chromat. B 94%

: 543-67-9
n-propyl nitrite

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With dimethyl sulfoxide at 70℃; for 6h;	92.21%
With boron trifluoride diethyl etherate In diethyl ether for 4h; Ambient temperature;	91%
at 130 - 150℃;

: 94070-39-0
trans-n-PrOIr(CO)(PPh3)2

A: 33541-67-2
carbonylhydridotris(triphenylphosphine)iridium(I)

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With triphenylphosphine In toluene soln. of Ir complex and PPh3 (.approx. 2-3 equiv.) in toluene allowed to stir at 70°C for several hours; org. products detected by gas chromy.;	A n/a B 92%

: 78-85-3
2-methylpropenal

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
Stage #1: 2-methylpropenal With morpholine; TEMPOL In water for 0.5h; Stage #2: With formaldehyd In water at 20 - 70℃; for 1.08h; Reagent/catalyst;	90.8%

: 33931-80-5
1,1-diacetoxy-1-ethyl methane

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With caro's acid; silica gel In dichloromethane for 5h; Heating;	90%
With N-sulfonic acid poly(4-vinylpyridinium) chloride In methanol at 20℃; for 0.416667h;	90%
With N-Bromosuccinimide; water; silica gel at 20℃; for 0.05h; neat (no solvent); chemoselective reaction;	87%

: 15218-76-5
diethyl(2,2'-bipyridyl)nickel(II)

A: 14917-14-7
Ni(CO)2(2,2'-bipyridine)

B: 4437-51-8
3,4-hexanedione

C: 74-85-1
ethene

D: 123-38-6
propionaldehyde

E: 96-22-0
pentan-3-one

Conditions

Conditions	Yield
With carbon monoxide In tetrahydrofuran THF, room temp., 0.1 h;	A 50% B 0% C 0% D 0% E 90%

...Expand

: 22372-70-9, 18972-42-4
H2Os(CO)4

: 75149-83-6
ethylpentacarbonylrhenium

: 2206-26-0
[D3]acetonitrile

A: 98688-87-0
Os(CO)4(Re(CO)4(C(2)H3CN))2

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
In [D3]acetonitrile under N2 flow, EtRe(CO)5 in CD3CN was added via syringe to an NMR tube,the contents were frozen and degassed, H2Os(CO)4 (2 equiv) was added byvac. transfer, reaction was complete in 8 h at 62°C; monitored by (1)H NMR, solvent was removed in vacuo, residue taken up in CH2Cl2, addn. of hexane; organometallic product (presumably Re2Os(CO)12(CD3CN)2) was not obtained pure;	A n/a B 89%

...Expand

: 1009-14-9
phenyl butyl ketone

A: 123-38-6
propionaldehyde

B: 123-72-8
butyraldehyde

C: 802294-64-0
propionic acid

D: 65-85-0
benzoic acid

E: 107-92-6
butyric acid

Conditions

Conditions	Yield
With 5% active carbon-supported ruthenium; water; oxygen; calcium oxide at 100℃; for 12h; Reagent/catalyst; Time;	A n/a B n/a C n/a D 89% E n/a

...Expand

: 16457-30-0
hydridopentacarbonylrhenium(I)

: 75149-83-6
ethylpentacarbonylrhenium

: 2206-26-0
[D3]acetonitrile

A: 98688-84-7
Re2(CO)9(C(2)H3CN)

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
In [D3]acetonitrile under N2 flow EtRe(CO)5 in CD3CN was added via syringe to an NMR tube, the contents were frozen and degassed, and HRe(CO)5 (1:1 ratio) was added via vac. transfer, the tube was sealed and heated (60°C) for 27h; monitored by (1)H NMR, Re2(CO)9(CD3CN) was isolated by preparative layer chromy.; elem. anal., yield of EtCHO was detd. by the integration of the corresponding peak in the (1)H NMR spectrum;	A 70% B 88%

Yield

In [D3]acetonitrile under N2 flow EtRe(CO)5 in CD3CN was added via syringe to an NMR tube, the contents were frozen and degassed, and HRe(CO)5 (1:1 ratio) was added via vac. transfer, the tube was sealed and heated (60°C) for 27h; monitored by (1)H NMR, Re2(CO)9(CD3CN) was isolated by preparative layer chromy.; elem. anal., yield of EtCHO was detd. by the integration of the corresponding peak in the (1)H NMR spectrum;

A 70%
B 88%

...Expand

: 149935-82-0
2-(6,6-Dimethylbicyclo[3.1.1]hept-2-yl)propenal

: 107-02-8
acrolein

A: 178745-31-8
2-(6,6-Dimethylbicyclo[3.1.1]hept-2-yl)propanal

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
Pd on carbon	A 87% B n/a

...Expand

: (C4H9)3SnOCH2CH(CH3)Br

A: 1461-23-0
tributyltin bromide

B: 123-38-6
propionaldehyde

C: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
80% decompn. of the crude compound at 150°C (0.5 h);	A n/a B 13% C 87%

...Expand

: 802294-64-0
propionic acid

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With (CH3)2NCH2NpSiH2Ph at 150 - 170℃;	85%
Stage #1: propionic acid With 4-methyl-morpholine; 1,3,5-Triazine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride hydrate In tetrahydrofuran; water at 25℃; for 1h; Stage #2: With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran; water at 25℃; under 760.051 Torr; for 19h;	49%
With calcium carbonate at 450 - 500℃;

: 80253-84-5
Trifluoro-methanesulfonate14-(2-hydroxy-propyl)-7-phenyl-5,6,8,9-tetrahydro-dibenzo[c,h]acridinium;

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With 2,4,6-triphenylpyridine at 190℃; under 15 Torr;	85%

: 107-10-8
propylamine

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With potassium permanganate; iron(II) sulfate In dichloromethane for 5h; Heating;	84%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry;	80%
With N-Bromosuccinimide; perchloric acid; iridium(III) chloride; mercury(II) diacetate at 35℃; for 72h; Rate constant; Thermodynamic data; energy data: E(act); effect of conc. of reactants;

: 1266113-09-0
C13H12N2O

n-propyl halide: n-propyl halide

A: 1527-91-9
N-phenylbenzamidine

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
Stage #1: C13H12N2O; n-propyl halide In diethyl ether at 20℃; Inert atmosphere; Stage #2: With sodium carbonate In diethyl ether at 20℃; Inert atmosphere;	A n/a B 84%

...Expand

: 922-17-8
hexane-3,4-diol

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With sodium hypochlorite In acetonitrile at 20℃; for 0.25h;	83%

: 78108-64-2
trans-propenylamine N,N-disiliciee

: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With hydrogenchloride	82%

: 1256844-19-5, 1266113-11-4
C9H12N2O

n-propyl halide: n-propyl halide

A: 1783-25-1
N1,N1-dimethyl-N2-phenylformamidine

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
Stage #1: C9H12N2O; n-propyl halide In diethyl ether at 20℃; Inert atmosphere; Stage #2: With sodium carbonate In diethyl ether at 20℃; Inert atmosphere;	A n/a B 82%

...Expand

: 57-55-6
propylene glycol

A: 4359-46-0
2-ethyl-4-methyl-1,3-dioxolane

B: 123-38-6
propionaldehyde

Conditions

Conditions	Yield
With tungsten trioxide on silica; hydrogen In water at 250℃; for 5h; Concentration; Temperature; Inert atmosphere;	A 31.7% B 81.3%
With sulfuric acid In water at 130℃; Thermodynamic data; Kinetics; Activation energy; Further Variations:; Temperatures; reagent concentration; Dehydration; acetalization;
With ferrierite(20) at 300℃; chemoselective reaction;

: 107-10-8
propylamine

: 123-38-6
propionaldehyde

: 7707-70-2
N-propylidenepropylamine

Conditions

Conditions	Yield
In toluene for 1h; Ambient temperature;	100%
With potassium hydroxide 1.) 5-8 deg C, 2 h, 2.) room temperature, 30 min;	62%
Stage #1: propylamine; propionaldehyde at 0℃; for 1.5h; Inert atmosphere; Stage #2: With potassium hydroxide at -18℃; for 24h; Inert atmosphere;	29%

: 91-16-7
1,2-dimethoxybenzene

: 123-38-6
propionaldehyde

: 140648-13-1
9,10-diethyl-2,3,6,7-tetramethoxy-anthracene

Conditions

Conditions	Yield
With sulfuric acid; acetonitrile for 0.5h;	100%
With sulfuric acid at 5 - 10℃;	98%
With sulfuric acid In water at -10℃; for 2h;	46%

: 123-38-6
propionaldehyde

: 71-23-8
propan-1-ol

Conditions

Conditions	Yield
With hydrogen; mer-Os(PPh3)3HBr(CO) at 150℃; under 22800 Torr; for 1.66667h; Product distribution;	100%
With hydrogen; mer-Os(PPh3)3HBr(CO) In toluene at 150℃; under 22800 Torr; for 1.7h;	100%
With hydrogen In water at 60℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave;	100%

: 123-38-6
propionaldehyde

: 623-36-9
(E)-2-methylpent-2-enal

Conditions

Conditions	Yield
With sodium hydroxide In water at 50℃; for 1h;	100%
Stage #1: propionaldehyde With pyrrolidine In hexane at 20℃; for 48h; Stage #2: With hydrogenchloride In hexane; water at 20℃; for 4h; stereoselective reaction;	95%
With pyrrolidine; benzoic acid In pentane at 10℃; for 48h;	90%

: 7677-24-9
trimethylsilyl cyanide

: 123-38-6
propionaldehyde

: 24731-32-6
2-<(trimethylsilyl)oxy>butanenitrile

Conditions

Conditions	Yield
With trans-{(iBu)2ATIGeiPr}2Pt(CN)2 In chloroform-d1 at 50℃; for 2h; Catalytic behavior; Schlenk technique; Glovebox;	100%
With C29H38AlN4O2(1+)*CF3O3S(1-) at 20℃; for 0.0833333h; Catalytic behavior; Inert atmosphere; Schlenk technique;	99%
With C11H8N3O8S(3-)Fe(3+)6H2O In methanol at 20℃; for 4h;	98.1%

: 123-38-6
propionaldehyde

: 110-83-8
cyclohexene

: 1123-86-0
cyclohexyl ethyl ketone

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%
at 27℃; for 22h; (γ-irradiation);
Irradiation;

: 123-38-6
propionaldehyde

: 683-50-1
2-chloropropanal

Conditions

Conditions	Yield
With N-chloro-succinimide; rac-Pro-OH In chloroform at 0 - 20℃;	100%
With chlorine In dichloromethane; N,N-dimethyl-formamide at 10℃; for 4h; Reagent/catalyst; Inert atmosphere;	87.5%
With sulfuryl dichloride In dichloromethane at -10℃; Reflux; Inert atmosphere;	66%

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-38-6
propionaldehyde

: 93498-07-8
2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 95-14-7
1,2,3-Benzotriazole

: 123-38-6
propionaldehyde

: 111507-79-0
1-Benzotriazol-1-yl-propan-1-ol

Conditions

Conditions	Yield
at 25℃;	100%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 123-38-6
propionaldehyde

: 14092-31-0
1-ethyl-4-(tetrahydro-2-pyranyloxy)-2-butyn-1-ol

Conditions

Conditions	Yield
Stage #1: 3-(tetrahydropyran-2'-yloxy)propyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: propionaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Further stages.;	100%
Stage #1: 3-(tetrahydropyran-2'-yloxy)propyne With copper(l) iodide; ethylmagnesium bromide In tetrahydrofuran at -10 - 20℃; for 4h; Metallation; Stage #2: propionaldehyde In tetrahydrofuran at -10 - 20℃; for 14h; Grignard reaction;	86%
Stage #1: 3-(tetrahydropyran-2'-yloxy)propyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; Stage #2: propionaldehyde In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;	80%

: 931-88-4, 931-87-3
(Z)-Cyclooctene

: 123-38-6
propionaldehyde

: 85359-51-9
cyclooctyl-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 591-49-1
1-methylcyclohex-1-ene

: 123-38-6
propionaldehyde

: 85995-78-4
(methyl-2' cyclohexyl)-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 59983-39-0
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 123-38-6
propionaldehyde

: 70113-32-5
[(S)-2-methoxymethylpyrrolidin-1-yl]-N-propylideneamine

Conditions

Conditions	Yield
In diethyl ether at 20℃;	100%
With magnesium sulfate In dichloromethane at 20℃; for 12h;	89%
With 4 A molecular sieve In dichloromethane	79%

: 59983-39-0
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 123-38-6
propionaldehyde

: 72203-94-2
N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine

Conditions

Conditions	Yield
at 20℃; for 16h;	100%
at 20℃;	100%
In dichloromethane at 20℃; for 20h;	98%

: 80-56-8, 177698-18-9
Pinene

: 123-38-6
propionaldehyde

: 31375-17-4
ethyl(p-menthene-1-yl-6) cetone

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 693-89-0
1-methylcyclopent-1-ene

: 123-38-6
propionaldehyde

: 81977-75-5
(methyl-2' cyclopentyl)-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 628-92-2
Cycloheptene

: 123-38-6
propionaldehyde

: 89932-42-3
cycloheptyl-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 1453-25-4
1-methylcycloheptene

: 123-38-6
propionaldehyde

: 89932-43-4
(methyl-2' cycloheptyl)-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 15840-64-9
1-methylcyclooctene

: 123-38-6
propionaldehyde

: 89932-44-5
(methyl-2' cyclooctyl)-1 propanone-1

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 86340-68-3
Chlorodifluoromethyl n-hexyl ketone

: 123-38-6
propionaldehyde

: 127894-36-4
4,4-difluoro-3-hydroxy-5-undecanone

Conditions

Conditions	Yield
With copper(l) chloride; zinc In tetrahydrofuran for 4h; Heating;	100%

: Lithium; 4,6-dimethoxy-benzofuran-3-olate

: 123-38-6
propionaldehyde

: 131403-04-8
2-(1-Hydroxy-propyl)-4,6-dimethoxy-benzofuran-3-one

Conditions

Conditions	Yield
at -78℃; for 0.166667h;	100%

: 142252-83-3
C6H6O2(2-)*2Li(1+)

: 123-38-6
propionaldehyde

: 2-(1-hydroxypropyl)hexa-3,5-dienoic acid

Conditions

Conditions	Yield
In tetrahydrofuran Product distribution; Mechanism; regioselectivity of addition; 1.) -70 deg C, 30 min; 2.) 30 deg C, 2 h; further aldehyde, ketones and usaturated ketones;	100%
In tetrahydrofuran 1.) -70 deg C, 30 min; 2.) 30 deg C, 2 h;	100%

: 75790-42-0
2-<<1-(trifluoromethyl)-1,2,2,2-tetrafluoroethyl>thio>-4-(trifluoromethyl)-4,5,5,5-tetrafluoro-1-pentene-1,3-dione

: 123-38-6
propionaldehyde

: 75782-04-6
2-Ethyl-6-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-5-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethylsulfanyl)-[1,3]dioxin-4-one

Conditions

Conditions	Yield
	100%
	100%

: 123-38-6
propionaldehyde

: 134-81-6
benzil

: 2,3-dihydroxy-1,2-diphenyl-1-pentanone

Conditions

Conditions	Yield
With titanium(III) chloride In acetone at 0℃; for 1h;	100%

: 123-38-6
propionaldehyde

: 142-29-0
cyclopentene

: 6635-67-2
1-cyclopentyl-1-propanone

Conditions

Conditions	Yield
With dibenzoyl peroxide at 90℃; for 10h;	100%

: 123-38-6
propionaldehyde

: 829-85-6
diphenylphosphane

: Ph2PCH(OH)Et

Conditions

Conditions	Yield
at 20℃; neat (no solvent);	100%
at -20℃; for 0.25h;	92%

: 123-38-6
propionaldehyde

: 175443-13-7
((R)-6-Bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine

: 175443-11-5
((R)-6-Bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-propyl-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane	100%

Propionaldehyde Consensus Reports

Community Right-To-Know List. Reported in EPA TSCA Inventory.

Propionaldehyde Standards and Recommendations

ACGIH TLV: TWA 20 ppm
DOT Classification: 3; Label: Flammable Liquid

Propionaldehyde Specification

The Propionaldehyde, with the CAS registry number 123-38-6, is also known as Propionic aldehyde. Its EINECS registry number is 204-623-0. This chemical's molecular formula is C₃H₆O and molecular weight is 58.07914. Its IUPAC name is called Propanal. What's more, this chemical's classification codes are Mutation Data; Skin / Eye Irritant.

Physical properties of Propionaldehyde: (1)ACD/LogP: 0.40; (2)ACD/LogD (pH 5.5): 0.404; (3)ACD/LogD (pH 7.4): 0.404; (4)ACD/BCF (pH 5.5): 1.194; (5)ACD/BCF (pH 7.4): 1.194; (6)ACD/KOC (pH 5.5): 39.517; (7)ACD/KOC (pH 7.4): 39.517; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.348; (11)Molar Refractivity: 16.134 cm³; (12)Molar Volume: 75.374 cm³; (13)Surface Tension: 20.503 dyne/cm; (14)Density: 0.771 g/cm³; (15)Enthalpy of Vaporization: 28.31 kJ/mol; (16)Boiling Point: 49.339 °C at 760 mmHg; (17)Vapour Pressure: 299.383 mmHg at 25°C.

Preparation: Propionaldehyde is mainly produced industrially through hydroformylation, by combining synthesis gas (carbon monoxide and hydrogen) with ethylene using a metal catalyst:

CO + H₂ + C₂H₄ → CH₃CH₂CHO

Uses of Propionaldehyde: It is principally used as a precursor to trimethylolethane (CH₃C(CH₂OH)₃) through a condensation reaction with methanol; this triol is an important intermediate in the production of alkyd resins. Condensation of propionaldehyde with tert-butylamine gives CH₃CH₂CH=N-t-Bu, a three-carbon building block used in organic synthesis. Deprotonation of this imine with LDA produces CH₃CHLiCH=N-t-Bu, which in turn condenses with aldehydes.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is highly flammable. In addition, it is irritating to eyes, respiratory system and skin. There will be a explosive when mixed with combustible material. Contact with water, it will liberate toxic gas.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCC=O
(2)InChI: InChI=1S/C3H6O/c1-2-3-4/h3H,2H2,1H3
(3)InChIKey: NBBJYMSMWIIQGU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	10mL/kg (10mL/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0533450,
mammal (species unspecified)	LC50	inhalation	21800mg/m³ (21800mg/m³)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 12(7), Pg. 16, 1968.
mammal (species unspecified)	LD50	oral	1400mg/kg (1400mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
mouse	LC50	inhalation	21800mg/m³/2H (21800mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 102, 1982.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	National Technical Information Service. Vol. OTS0533450,
mouse	LD50	subcutaneous	680mg/kg (680mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
mouse	LDLo	oral	800mg/kg (800mg/kg)		Kodak Company Reports. Vol. 21MAY1971,
rabbit	LD50	skin	2460mg/kg (2460mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	National Technical Information Service. Vol. OTS0543436,
rat	LCLo	inhalation	8000ppm/4H (8000ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	intraperitoneal	200mg/kg (200mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS	National Technical Information Service. Vol. OTS0533450,
rat	LD50	oral	1410mg/kg (1410mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	subcutaneous	820mg/kg (820mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.

Product Name

Propionaldehyde

Synthetic route

Propionaldehyde Consensus Reports

Propionaldehyde Standards and Recommendations

Propionaldehyde Specification

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