Pyridin-2-sulfonyl chloride supplier

Name
PYRIDINE-2-SULFONYL CHLORIDE
EINECS
CAS No. 66715-65-9
Article Data61
CAS DataBase
Density 1.489 g/cm³
Solubility
Melting Point
Formula C₅H₄ClNO₂S
Boiling Point 284.162 °C at 760 mmHg
Molecular Weight 177.611
Flash Point 125.657 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Pyridinylsulfonylchloride;2-Pyridylsulfonyl chloride;Pyridin-2-sulfonyl chloride;
PSA 55.41000
LogP 2.08990

Synthetic route

: 2637-34-5
2-Mercaptopyridine

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; chlorine at 5℃; for 0.5h;	97%
With Oxone; potassium chloride In water at 20℃; for 0.166667h;	88%
With hydrogenchloride; water; chlorine at 0℃; for 2h; Inert atmosphere;	85%

: 2127-03-9
2,2'-dipyridyldisulphide

A: 109-09-1
2-chloropyridine

B: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid In dichloromethane; water at 0 - 20℃; Inert atmosphere;	A 20% B 78%

: 2637-34-5
2-Mercaptopyridine

: 127-65-1
chloroamine-T

A: 66715-65-9
pyridine-2-sulfonyl chloride

B: N-chloro-N-(4-methylbenzenesulfonyl)-pyridine-2-sulfinamide

Conditions

Conditions	Yield
With N-chloro-succinimide In water; acetonitrile at 35℃; for 0.25h;	A 11% B 57%

...Expand

: 2637-34-5
2-Mercaptopyridine

: 7647-01-0
hydrogenchloride

: 7782-50-5
chlorine

: 66715-65-9
pyridine-2-sulfonyl chloride

...Expand

: 109-04-6
2-bromo-pyridine

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine With isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: With sulfur dioxide In tetrahydrofuran at -40℃; for 0.5h; Stage #3: With sulfuryl dichloride In tetrahydrofuran at -40 - 20℃;
Stage #1: 2-bromo-pyridine With n-butyllithium; dibutylmagnesium In tetrahydrofuran at -10℃; Inert atmosphere; Stage #2: With sulfuryl dichloride In tetrahydrofuran; toluene at -10 - 10℃;

: 2637-34-5
2-Mercaptopyridine

: sodium thiosulfate

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
In hydrogenchloride

: 2637-34-5
2-Mercaptopyridine

aq NaOCl: aq NaOCl

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With conc HCl In dichloromethane; water

: 2637-34-5
2-Mercaptopyridine

aqueous sodium hypochlorite: aqueous sodium hypochlorite

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With sulfuric acid; chlorine

: 2127-03-9
2,2'-dipyridyldisulphide

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; chlorine at -10 - -8℃; for 0.5h;
With hydrogenchloride; chlorine In water at -10℃; for 0.5h;

: 24367-66-6
2-pyridinesulfinic acid sodium salt

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
With N-chloro-succinimide In dichloromethane

: 111480-84-3
2-pyridinesulfonyl chloride hydrochloride

: 66715-65-9
pyridine-2-sulfonyl chloride

Conditions

Conditions	Yield
In dichloromethane

: 66715-65-9
pyridine-2-sulfonyl chloride

: 622-08-2
2-Benzyloxyethanol

: 123455-81-2
Pyridine-2-sulfonic acid 2-benzyloxy-ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	99%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 4099-85-8
((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 123455-86-7
Pyridine-2-sulfonic acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	99%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 111-87-5
octanol

: 1-(2-Pyridylsulfonyl)oxo-octane

Conditions

Conditions	Yield
With triethylamine In water; ethyl acetate	99%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 893733-67-0
C16H13NO

: 1443501-77-6
C21H16N2O3S

Conditions

Conditions	Yield
Stage #1: C16H13NO With sodium hydride In tetrahydrofuran at 0℃; Stage #2: pyridine-2-sulfonyl chloride In tetrahydrofuran at 0 - 20℃;	99%

: 110-89-4
piperidine

: 66715-65-9
pyridine-2-sulfonyl chloride

: 106762-43-0
Piperidin-1-yl pyridin-2-yl sulfone

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether at 0℃; for 3.5h;	98%
In dichloromethane at 25℃; for 12h; Inert atmosphere;	98%
In dichloromethane at 0 - 25℃; for 12h; Inert atmosphere;	81%
In dichloromethane at 20℃; Cooling with ice;

: 66715-65-9
pyridine-2-sulfonyl chloride

: 5003-71-4
3-bromopropylamine hydrochloride

: 171825-88-0
N-(3-bromopropyl)-pyridine-2-sulfonamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0℃; for 1h;	98%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 124-02-7
diallylamine

: N,N-Diallylpyridine-2-sulfonamide

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether at 0℃; for 1.5h;	98%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 100-46-9
benzylamine

: 370839-64-8
pyridine-2-sulfonic acid benzylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane	98%
	86%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 6306-52-1
L-valine methylester hydrochloride

: 1384331-68-3
(S)-mehyl 3-mehyl-2-(pyridine-2-sulfonamido)butanoate

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine In acetonitrile at 20℃; for 16h;	98%
With pyridine In acetonitrile at 0 - 20℃; for 18h; Inert atmosphere; Sealed tube;	98%
With triethylamine In dichloromethane at 0 - 20℃;	117 mg

: 66715-65-9
pyridine-2-sulfonyl chloride

: 7383-20-2
non-1-yn-3-ol

: 123455-80-1
Pyridine-2-sulfonic acid 1-ethynyl-heptyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	97%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 4064-06-6
1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

: 123455-87-8
Pyridine-2-sulfonic acid (3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	97%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 16874-17-2
L-phenylalanine tert-butyl ester

: tert-Butyl 2-benzyl-2-<(pyridine-2-sulfonyl)amino>acetate

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether at 0℃; for 6h;	97%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 6-isopropyl-1H-indole-3-carbaldehyde

: 1443501-79-8
C17H16N2O3S

Conditions

Conditions	Yield
Stage #1: 6-isopropyl-1H-indole-3-carbaldehyde With sodium hydride In tetrahydrofuran at 0℃; Stage #2: pyridine-2-sulfonyl chloride In tetrahydrofuran at 0 - 20℃;	97%

: 123-75-1
pyrrolidine

: 66715-65-9
pyridine-2-sulfonyl chloride

: 106762-45-2
2-(pyrrolidin-1-ylsulfonyl)pyridine

Conditions

Conditions	Yield
In dichloromethane at 0 - 25℃; for 12h; Inert atmosphere;	97%
In dichloromethane at 20℃; Cooling with ice;

: 66715-65-9
pyridine-2-sulfonyl chloride

: 46460-23-5, 46460-24-6, 82830-84-0, 124044-66-2
ethyl L-2-amino-4-phenylbutyrate

: ethyl 4-phenyl-2-(pyridine-2-sulfonamido)butanoate

Conditions

Conditions	Yield
With pyridine In acetonitrile at 0 - 20℃; for 18h; Inert atmosphere; Sealed tube;	97%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 103-49-1
dibenzylamine

: 167958-91-0
N,N-dibenzyl-pyridine-2-sulfonamide

Conditions

Conditions	Yield
	96%
With potassium carbonate In diethyl ether at 0℃; for 3h;	93%
With potassium carbonate In diethyl ether; water at 0℃;

: 66715-65-9
pyridine-2-sulfonyl chloride

: 959996-08-8
tert-butyl 3-(phenylamino)butanoate

: 959996-28-2
tert-butyl 3-(N-phenylpyridine-2-sulfonamido)butanoate

Conditions

Conditions	Yield
With pyridine at 0 - 20℃;	96%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 103-67-3
benzyl-methyl-amine

: N-benzyl-N-methylpyridine-2-sulfonamide

Conditions

Conditions	Yield
	95%
With potassium carbonate In diethyl ether; water at 0℃;

: 66715-65-9
pyridine-2-sulfonyl chloride

: 34535-98-3
D,L-cis-phenylcyclopropylamine

: N-phenyl-N-cyclopropylpyridine-2-sulfonamide

Conditions

Conditions	Yield
	95%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 1055306-88-1
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055307-43-1
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Conditions

Conditions	Yield
With 15-crown-5; sodium hydride In tetrahydrofuran at 20℃; for 1h;	95%
With 15-crown-5; sodium hydride In tetrahydrofuran at 0℃; for 0.5h;	95%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 27652-35-3
(E)-2-styrylaniline

: (E)-N-(2-styrylphenyl)pyridine-2-sulfonamide

Conditions

Conditions	Yield
With pyridine at 0 - 25℃; for 2h;	95%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 111-27-3
hexan-1-ol

: Pyridine-2-sulfonic acid hexyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	94%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: N-(α-Methylbenzyl)pyridine-2-sulfonamide

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether at 0℃; for 1.5h;	94%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 1301109-78-3
C18H28N2O6S

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h;	94%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 106-49-0
p-toluidine

: N-(p-tolyl)pyridine-2-sulfonamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	94%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 95-69-2
4-chloro-2-methylbenzeneamine

: N-(4-chloro-2-methylphenyl)pyridine-2-sulfonamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	94%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 687-47-8
(S)-Ethyl lactate

: 123455-83-4
(S)-2-(Pyridine-2-sulfonyloxy)-propionic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	93%

: 66715-65-9
pyridine-2-sulfonyl chloride

: 6627-72-1
rac-endo-borneol

: 123455-85-6
Pyridine-2-sulfonic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	93%

Pyridin-2-sulfonyl chloride Specification

The IUPAC name of Pyridin-2-sulfonyl chloride is pyridine-2-sulfonyl chloride. With the CAS registry number 66715-65-9, it is also named as 2-Pyridylsulfonyl chloride. In addition, its molecular formula is C₅H₄ClNO₂S and its molecular weight is 177.60876.

The other characteristics of Pyridin-2-sulfonyl chloride can be summarized as: (1)ACD/LogP: 1.23; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.227; (4)ACD/LogD (pH 7.4): 1.227; (5)ACD/BCF (pH 5.5): 5.045; (6)ACD/BCF (pH 7.4): 5.045; (7)ACD/KOC (pH 5.5): 110.843; (8)ACD/KOC (pH 7.4): 110.843; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 55.41 Å²; (13)Index of Refraction: 1.553; (14)Molar Refractivity: 38.2 cm³; (15)Molar Volume: 119.313 cm³; (16)Polarizability: 15.143×10^-24cm³; (17)Surface Tension: 50.296 dyne/cm; (18)Density: 1.489 g/cm³; (19)Flash Point: 125.657 °C; (20)Enthalpy of Vaporization: 50.213 kJ/mol; (21)Boiling Point: 284.162 °C at 760 mmHg; (22)Vapour Pressure: 0.005 mmHg at 25 °C.

People can use the following data to convert to the molecule structure.
(1)SMILES: c1ccnc(c1)S(=O)(=O)Cl
(2)InChI: InChI=1/C5H4ClNO2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H
(3)InChIKey: JQJOGAGLBDBMLU-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C5H4ClNO2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H
(5)Std. InChIKey: JQJOGAGLBDBMLU-UHFFFAOYSA-N

Product Name

PYRIDINE-2-SULFONYL CHLORIDE

Synthetic route

Pyridin-2-sulfonyl chloride Specification

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