Semicarbazide hydrochloride supplier

Name
Semicarbazide hydrochloride
EINECS 209-247-0
CAS No. 563-41-7
Article Data15
CAS DataBase
Density 1.286g/cm3
Solubility 100 g/L (15 °C) in water
Melting Point 175-177 °C (dec.)(lit.)
Formula CH₅N₃O^.HCl
Boiling Point 235.3 °C at 760 mmHg
Molecular Weight 111.531
Flash Point 96.1 °C
Transport Information UN 2811 6.1/PG 3
Appearance White solid
Safety 24/25-22-45-53
Risk Codes 22-40-36/38-25-45-23/24/25
Molecular Structure
Hazard Symbols Xn, T
Synonyms Hydrazinecarboxamide,monohydrochloride (9CI);Semicarbazide, monohydrochloride (8CI);Aminoureahydrochloride;Hydrazinecarboxamide, hydrochloride;Semicarbazide chloride;
PSA 81.14000
LogP 1.12190

Synthetic route

: 1574-10-3
benzaldehyde semicarbazone

: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; water

: 7647-01-0
hydrogenchloride

: 39130-96-6
thiazolidine-2,4-dione-2-semicarbazone

A: 2295-31-0
2,4-thiazolidinedion

B: 563-41-7
semicarbazide hydrochloride

...Expand

: 7647-01-0
hydrogenchloride

: 2,6-dimethyl-6-semicarbazido-hept-2-en-4-one semicarbazone

A: 504-20-1
phorone

B: 563-41-7
semicarbazide hydrochloride

...Expand

: 7647-01-0
hydrogenchloride

: 10153-17-0
2-carbamothioyl-N-phenylhydrazine carboxamide

A: 603-54-3
N,N-diphenylurea

B: 563-41-7
semicarbazide hydrochloride

C 2-imino-1.3.4-thiodiazolone-(5): 2-imino-1.3.4-thiodiazolone-(5)

...Expand

: 590-28-3
potassium cyanate

hydrazine sulfate: hydrazine sulfate

: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With water; sodium carbonate at 50 - 60℃; in mehreren Stufen;

: 745076-15-7
C17H17N3O2S

A: 10424-68-7
1,1'-(sulfonylbis(4,1-phenylene))bis(ethan-1-one)

B: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid at 20℃; for 168h;

: 745076-14-6
C18H20N6O2S

A: 10424-68-7
1,1'-(sulfonylbis(4,1-phenylene))bis(ethan-1-one)

B: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid at 20℃; for 168h;

: 745076-16-8
C18H20N6OS2

A: 10424-68-7
1,1'-(sulfonylbis(4,1-phenylene))bis(ethan-1-one)

B: 563-41-7
semicarbazide hydrochloride

C: 79-19-6
thiosemicarbazide

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid at 20℃; for 168h;

...Expand

: 38132-39-7
methyl benzoylformate semicarbazone

A: 15206-55-0
methyl 2-oxo-2-phenylacetate

B: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
In water at 30℃; pH=5.00; Equilibrium constant;

: 590-28-3
potassium cyanate

: 10034-93-2
hydrazinium sulfate

: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium carbonate; acetone In water byproducts: hydrazodicarbonamide; addn. of aq. KOCN to warm (50-60°C) aq. soln. of hydrazine sulfate and Na2CO3; mixt. allowed to stand for 1 d; filtration of hydrazodicarbonamide; addn. of acetone; acetone semicarbazone extd. with ethanol and heated with concd. HCl;
With Na2CO3; benzaldehyde; HCl In water addn. of aq. KOCN to a warm (50-60°C) aq. soln. of hydrazine sulfate and Na2CO3; allow to stand for 1 d; addn. of benzaldehyde; benzaldehyde semicarbazone heated with concd. HCl; extn. of free benzaldehyde with benzene or toluene;
With Na2CO3; acetone; HCl In water
With Na2CO3; benzaldehyde; HCl In water

: 28787-22-6
4-carbamimidoyl semicarbazide; dihydrochloride

: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium ethanolate the intermediate 4-(4,6-dihydroxy-pyrimidyl-(2))-semicarbazide hydrochloride is decomposed with concd. HCl;

: Mn(2+)*2CH6N3O(1+)*4Cl(1-)=Mn(CH6N3O)2Cl4

A: 563-41-7
semicarbazide hydrochloride

B: manganese(ll) chloride

Conditions

Conditions	Yield
decompn. at 135°C;
decompn. at 135°C;

: 59-87-0
nitrofurazone

: 563-41-7
semicarbazide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 25℃; for 12h;

: 563-41-7
semicarbazide hydrochloride

: 104-55-2
3-phenyl-propenal

: 3839-82-5
cinnamaldehyde semicarbazone

Conditions

Conditions	Yield
With acetic acid In water for 0.5h; Reflux;	100%
With aluminum oxide In water; tert-butyl alcohol for 0.0833333h;	90%
With ethanol
In ethanol

: 5353-96-8
6,7-benzoisatin

: 563-41-7
semicarbazide hydrochloride

: 110536-39-5, 110536-40-8
syn-Benzisatin-3-semicarbazone

Conditions

Conditions	Yield
With hydrogenchloride 1.) aq. EtOH, reflux, 25 min, 2.) EtOH, room temp.;	100%

: 5588-87-4
1H-benzo[e]indole-1,2(3H)-dione

: 563-41-7
semicarbazide hydrochloride

: 110536-33-9
C13H10N4O2

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	100%

: 563-41-7
semicarbazide hydrochloride

: 148840-19-1
(E)-2-formyl-3-(furan-2-yl)acrylonitrile

: C9H8N4O2

Conditions

Conditions	Yield
With pyridine for 0.25h; Ambient temperature;	100%

: 563-41-7
semicarbazide hydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 6292-71-3, 120445-53-6
4-methoxybenzaldehyde semicarbazone

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	100%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol at 20℃; for 0.25h; Stage #2: 4-methoxy-benzaldehyde In ethanol at 20℃;	93%
With hydroxylamine hydrochloride; potassium carbonate for 0.025h; microwave irradiation;	90%

: 563-41-7
semicarbazide hydrochloride

: 191398-65-9
1-{4-[4-mono(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone

: 1-{4-[4-mono(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone-N-aminocarbonylsemicarbazone

Conditions

Conditions	Yield
With sodium acetate In ethanol Heating;	100%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol for 0.25h; Heating; Stage #2: 1-{4-[4-mono(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone With hydrogenchloride Heating;	98%

: 563-41-7
semicarbazide hydrochloride

: 199865-07-1
1-{4-[3,5-di(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone

: 1-{4-[3,5-di(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone-N-aminocarbonylsemicarbazone

Conditions

Conditions	Yield
With sodium acetate In ethanol Heating;	100%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol for 0.25h; Heating; Stage #2: 1-{4-[3,5-di(4-acetylphenoxymethyl)benzyloxy]phenyl}-1-ethanone With hydrogenchloride Heating;	96%

: 1006876-04-5
4-[(2,2-diethoxy)acetyl]methyl benzoate

: 563-41-7
semicarbazide hydrochloride

: 1006876-05-6
methyl 4-(3-oxo-2,3-dihydro-1,2,4-triazin-6-yl)benzoate

Conditions

Conditions	Yield
Stage #1: 4-[(2,2-diethoxy)acetyl]methyl benzoate; semicarbazide hydrochloride With N-ethyl-N,N-diisopropylamine In methanol; 1,2-dichloro-ethane at 95℃; for 5h; Stage #2: With acetic acid In water Heating / reflux;	100%
Stage #1: 4-[(2,2-diethoxy)acetyl]methyl benzoate; semicarbazide hydrochloride With N-ethyl-N,N-diisopropylamine In methanol; 1,2-dichloro-ethane at 95℃; for 5h; Stage #2: With acetic acid In water Heating / reflux;	100%

: 563-41-7
semicarbazide hydrochloride

: 930-33-6
2,4-dihydro-1,2,4-triazol-3-one

Conditions

Conditions	Yield
With trimethyl orthoformate In methanol; toluene	100%

: 563-41-7
semicarbazide hydrochloride

: 6630-33-7
ortho-bromobenzaldehyde

: 351980-45-5
1-(2-bromobenzylidene)semicarbazide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	100%
With sodium acetate In water

: 563-41-7
semicarbazide hydrochloride

: 591-31-1
3-methoxy-benzaldehyde

: 2-[(3-methoxyphenyl)methylene]hydrazinecarboxamide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	100%
With sodium acetate In ethanol; water Heating;
In 1,4-dioxane for 0.5h; Reflux;
With sodium acetate
With sodium acetate In methanol; water at 20℃; for 0.5h;

: 852519-81-4
3-(3-Hydroxy-17-oxo-estra-1,3,5(10)-trien-15β-yl)-N-(5-methyl-thiazol-2-yl)-propionamide

: 563-41-7
semicarbazide hydrochloride

: 3-{(13S,15R)-3-hydroxy-17-[(E)-N-urea-imino]-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-15-yl}-N-(5-methylthiazol-2-yl)propanamide

Conditions

Conditions	Yield
With sodium acetate In tetrahydrofuran; ethanol at 70℃; for 5h;	100%

: 563-41-7
semicarbazide hydrochloride

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1-(4-(methylthio)benzylidene)semicarbazide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	100%

: 563-41-7
semicarbazide hydrochloride

: 587-04-2
3-Chlorobenzaldehyde

: 2-[(3-fluorophenyl)methylene]hydrazinecarboxamide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	99.2%
With sodium acetate In ethanol; water for 0.0194444h; Microwave irradiation;	89.1%
With acetic acid In ethanol Reflux;	77%

: 479-87-8
3-hydroxy-6,7-dimethoxy-3H-isobenzofuran-1-one

: 563-41-7
semicarbazide hydrochloride

: 26342-00-7
6-<(semicarbazono)methyl>-2,3-dimethoxybenzoic acid

Conditions

Conditions	Yield
With pyridine at 42℃; for 6h;	99%

: 563-41-7
semicarbazide hydrochloride

: 88973-46-0
6-Oxo-trans,trans-2,4-hexadienoic acid

: 88973-54-0
Semicarbazone l'acide formyl-5 pentadiene-2,4 oique

Conditions

Conditions	Yield
With sodium acetate In ethanol; water Ambient temperature;	99%

: 3132-99-8
m-bromobenzoic aldehyde

: 563-41-7
semicarbazide hydrochloride

: 38407-30-6
1-(3-bromobenzylidene)semicarbazide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	99%
With sodium acetate In ethanol; water for 0.0166667h; Microwave irradiation;	94.2%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol at 20℃; for 0.25h; Stage #2: m-bromobenzoic aldehyde In ethanol at 20℃;	85%

: 563-41-7
semicarbazide hydrochloride

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 99847-76-4
1-(1-(3-bromophenyl)ethylidene)semicarbazide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	99%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol at 20℃; for 0.25h; Stage #2: 1-(3-Bromophenyl)ethanone In ethanol at 20℃;	91%
Stage #1: semicarbazide hydrochloride With sodium acetate In ethanol for 0.75h; Heating; Stage #2: 1-(3-Bromophenyl)ethanone In ethanol for 1h; Heating;

: 563-41-7
semicarbazide hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 3862-85-9
2-[(4-fluorophenyl)methylene]hydrazinecarboxamide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	99%
With sodium acetate In ethanol; water for 0.0208333h; Microwave irradiation;	90.7%
With hydrogenchloride In ethanol at 20℃; for 3h;	84%

: 563-41-7
semicarbazide hydrochloride

: 119-67-5
o-carboxybenzaldehyde

: 347309-96-0
2-((2-carbamoylhydrazono)methyl)benzoic acid

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	99%
With sodium acetate In water

: 563-41-7
semicarbazide hydrochloride

: 121-33-5
vanillin

: 16742-60-2, 120445-66-1
vanillin semicarbazone

Conditions

Conditions	Yield
With acetic acid In ethanol for 1.5h; Reflux;	98%
With sodium acetate In ethanol; water at 20℃;	94%
With hydrogenchloride In ethanol; water at 20℃;	81%

: 815-68-9
3-acetylpentane-2,4-dione

: 563-41-7
semicarbazide hydrochloride

: 31705-88-1
3,5-dimethylpyrazole hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 48h; Ambient temperature;	98%

: 563-41-7
semicarbazide hydrochloride

: 112055-19-3
tris-dimorpholinomethyl s-triazine

: 112055-23-9
C9H12N12O3

Conditions

Conditions	Yield
In water at 100℃; for 0.25h;	98%

: 563-41-7
semicarbazide hydrochloride

: 5896-17-3
2-(phenylmethoxy)benzaldehyde

: o-benzyloxybenzaldehyde semicarbazone

Conditions

Conditions	Yield
With sodium acetate In ethanol	98%

: 563-41-7
semicarbazide hydrochloride

: 403-42-9
1-(4-fluorophenyl)ethanone

: 326-33-0
4-fluoroacetophenone semicarbazone

Conditions

Conditions	Yield
With sodium acetate In methanol; water	98%
With sodium acetate In methanol; water at 20℃;	98%
Stage #1: semicarbazide hydrochloride With potassium acetate In ethanol at 1℃; for 1h; Reflux; Stage #2: 1-(4-fluorophenyl)ethanone In ethanol Reflux;	87%

: 771-03-9
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

: 563-41-7
semicarbazide hydrochloride

: 54107-20-9
3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one semicarbazone

Conditions

Conditions	Yield
With sodium acetate In acetic acid 1.) r.t., 2 h, 2.) reflux;	98%

: 563-41-7
semicarbazide hydrochloride

: 168279-57-0
3-methylthio-5,6,7,8-tetrahydro benzothiophene-4-one

: 6,7-Dihydro-3-(methylthio)benzothiophen-4(5H)-one semicarbazone

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 15h; Heating;	98%

: 563-41-7
semicarbazide hydrochloride

: 74974-54-2
2-chloro-1,1,1-trimethoxyethane

: 252742-72-6
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions

Conditions	Yield
In methanol at 20℃; for 72h;	98%
In methanol at 20℃;	62%
In methanol at 20℃; for 72h;
In methanol at 20℃; for 144h;
In methanol at 20℃; for 3h;

: 7310-95-4
2-Hydroxy-5-methylisophthalaldehyde

: 563-41-7
semicarbazide hydrochloride

: 300731-04-8
2,2'-[(2-hydroxy-5-methyl-1,3-phenylene)bis(methanylidene)]bis(hydrazine-1-carboxamide)

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃; for 0.0833333h; Sonication; Green chemistry;	98%
With sodium carbonate In ethanol for 2h; Heating;	76.4%
Stage #1: semicarbazide hydrochloride In methanol for 1h; Stage #2: 2-Hydroxy-5-methylisophthalaldehyde In methanol for 6h; Reflux;	76%

: 563-41-7
semicarbazide hydrochloride

: 389086-29-7
1-[(2R,6R,8R,10S,13R)-13-hydroxy-10-(2'-hydroxyethyl)-13-methyl-1,7,9-trioxadispiro[5.1.5.2]pentadec-2-yl]-2-propanone

: 1-[(2R,6R,8R,10S,13R)-13-hydroxy-10-(2'-hydroxyethyl)-13-methyl-1,7,9-trioxadispiro[5.1.5.2]pentadec-2-yl]-2-propanone semicarbazone

Conditions

Conditions	Yield
With sodium acetate In ethanol for 8h;	98%

Semicarbazide hydrochloride Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 12 ,1976,p. 209.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

Semicarbazide hydrochloride Specification

The IUPAC name of Semicarbazide hydrochloride is aminourea hydrochloride. With the CAS registry number 563-41-7, it is also named as Carbamylhydrazine hydrochloride. The product's categories are bases & related reagents; inhibitors; nucleotides. It is white solid which is soluble in water, soluble in ethanol and ether. In addition, this chemical should be sealed in the container and placed in the cool and dry aera.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -2.75; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2.75; (4)ACD/LogD (pH 7.4): -2.75; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 1; (12)Flash Point: 96.1 °C; (13)Enthalpy of Vaporization: 48.17 kJ/mol; (14)Boiling Point: 235.3 °C at 760 mmHg; (15)Vapour Pressure: 0.0407 mmHg at 25°C; (16)Tautomer Count: 3; (17)Exact Mass: 111.01994; (18)Topological Polar Surface Area: 81.1; (19)Heavy Atom Count: 6; (20)Complexity: 42.2.

Preparation of Semicarbazide hydrochloride: The condensation of hydrazine hydrate and urea to get semicarbazide solution which is acidified by hydrochloric acid. Then we can get the product after cold crystallization by water.

Uses of Semicarbazide hydrochloride: It is used as intermediate of medicine and pesticide, such as used in the production of nitrofurazone, nitrofurantoin drugs. And it is also used as analytical reagent and chromatography reagent. Additionlly, it can react with 3-methyl-butan-2-one to obtain 3-methyl-butan-2-one semicarbazone. This reaction needs reagent potassium acetate and water.

When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed, so people should not breathe dust. And it is also irritating to eyes and skin, so people must avoid contact with skin and eyes. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Avoid exposure - obtain special instructions before use.

People can use the following data to convert to the molecule structure.
1. SMILES:Cl.O=C(N)NN
2. InChI:InChI=1/CH5N3O.ClH/c2-1(5)4-3;/h3H2,(H3,2,4,5);1H

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	145mg/kg (145mg/kg)		Farmakologiya i Toksikologiya Vol. 24, Pg. 623, 1961.
mouse	LD50	oral	225mg/kg (225mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 686, 1960.
mouse	LD50	subcutaneous	167mg/kg (167mg/kg)		Acta Biologica et Medica Germanica. Vol. 21, Pg. 635, 1968.
rabbit	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT	Farmakologiya i Toksikologiya Vol. 24, Pg. 623, 1961.
rat	LD	intraperitoneal	> 98mg/kg (98mg/kg)	VASCULAR: STRICTIRA; CJAMGES OM VESSE;S	Toxicology and Applied Pharmacology. Vol. 155, Pg. 237, 1999.
rat	LDLo	oral	10mg/kg (10mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 44, 1953.

Product Name

Semicarbazide hydrochloride

Synthetic route

Semicarbazide hydrochloride Consensus Reports

Semicarbazide hydrochloride Specification

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