sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 97% |
Sertraline
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In propan-1-ol at 30℃; for 1h; Product distribution / selectivity; | 96% |
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride In octanol for 1h; Product distribution / selectivity; | 95% |
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride In propan-1-ol; water at 20 - 70℃; for 1h; pH=0; Product distribution / selectivity; | 90% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methoxypropyl acetate at 20 - 70℃; for 3h; Product distribution / selectivity; | 95% |
With N,N-dimethylacetamide hydrochloride In 4-methyl-2-pentanone at 20 - 80℃; for 1.5h; Product distribution / selectivity; | 94% |
With N,N-dimethylacetamide hydrochloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity; | 90% |
sertraline adipate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 86% |
(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate
sertraline hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water Industrial scale; | 85% |
With hydrogenchloride In acetonitrile at 0 - 15℃; for 0.5 - 1h; Product distribution / selectivity; | 82.6% |
With hydrogenchloride In tert-Amyl alcohol at 25 - 30℃; for 8h; pH=2.0; Product distribution / selectivity; |
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: C17H17Cl2N*C5H9NO4 With sodium hydroxide In water; toluene at 80℃; for 3h; Stage #2: With hydrogenchloride In ethanol pH=1.0; Heating; | 83.68% |
sertraline phthalate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; 4-methyl-2-pentanone at 25 - 70℃; for 3h; Product distribution / selectivity; | 79% |
sertraline 4-methylbenzoate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 79% |
sertraline salicylate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 73% |
sertraline hydrochloride
Conditions | Yield |
---|---|
Purification / work up; | 46% |
hydrogenchloride
(1S,4S)-sertraline*(S)-mandelic acid
sertraline hydrochloride
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 20℃; pH=1 - 2; Heating / reflux; |
1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate With sodium hydroxide In water; ethyl acetate pH=2; Stage #2: With hydrogenchloride In isopropyl alcohol pH=2; |
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol; toluene at 20 - 60℃; pH=1 - 2; Conversion of starting material; | |
With hydrogenchloride In water at 20 - 25℃; for 1h; pH=1 - 2; | |
With hydrogenchloride In isopropyl alcohol; toluene at 0 - 60℃; for 0.25 - 0.333333h; pH=1 - 2; Conversion of starting material; | |
With hydrogenchloride In isopropyl alcohol at 15 - 50℃; for 0.5h; pH=1 - 2; Conversion of starting material; |
Conditions | Yield |
---|---|
Stage #1: acetic acid; Sertraline In water at 5 - 25℃; for 1.33333h; Stage #2: With hydrogenchloride In water at 5 - 15℃; for 1.25h; |
A
trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
B
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water Product distribution / selectivity; | |
With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | |
With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity; |
N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine
B
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 6h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; | |
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; platinum on carbon In methanol at 25 - 35℃; for 0.5h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; | |
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; N,N-dimethylacetamide hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 4h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; |
(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme |
α-naphthol
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: chiral HPLC / Resolution of racemate 2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: chiral HPLC / Resolution of racemate 2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 3.2: 40 h / -40 °C / Inert atmosphere 4.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 5.2: 0 - 20 °C / Inert atmosphere 6.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 7.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere 2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere 2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme |
1,2-dichloro-benzene
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: [RuBArF(p-cymene)(S,S)-MsDPEN]; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 2: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme |
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 20℃; for 6h; Inert atmosphere; optical yield given as %ee; | 500 mg |
With hydrogenchloride In acetic acid methyl ester at 20℃; for 6h; | 500 mg |
(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 2.2: 40 h / -40 °C / Inert atmosphere 3.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 4.2: 0 - 20 °C / Inert atmosphere 5.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 6.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(1S,4S)-1-(benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 1.2: 40 h / -40 °C / Inert atmosphere 2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 5.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 3.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 2: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
sertraline hydrochloride
Sertraline
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene for 0.25h; pH=> 10; | 93% |
With sodium hydroxide In water; ethyl acetate | 77% |
With ammonium hydroxide In water pH=10; | |
With sodium hydroxide In water | |
With potassium carbonate In water at 20℃; | 10.9 g |
carbonochloridic acid, chloromethyl ester
sertraline hydrochloride
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 4.5h; | 88% |
di-tert-butyl dicarbonate
sertraline hydrochloride
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 2.33333h; Inert atmosphere; | 86% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With chlorosulfonic acid; trifluoroacetic acid at 20℃; for 16h; | 72% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 65% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; | 61% |
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: sertraline hydrochloride With chlorosulfonic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With thionyl chloride In dichloromethane at 20℃; for 16h; Stage #3: With ammonia; trifluoroacetic acid more than 3 stages; | 58% |
sertraline hydrochloride
(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Conditions | Yield |
---|---|
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h; Stage #2: With sodium hydroxide In dichloromethane; water | 35% |
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h; Stage #2: With sodium hydroxide In dichloromethane; water | 35% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With iodine In ethanol |
acetic acid
sertraline hydrochloride
sertraline hydrochloride acetic acid solvate
Conditions | Yield |
---|---|
at 20 - 60℃; for 16h; |
sertraline hydrochloride
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; potassium nitrate; trifluoroacetic acid at 0℃; for 1.5h; |
The Sertraline hydrochloride with the cas number 79559-97-0, is also called (1)(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride; (2) Adjuvin ; (3) Atruline ; (4) Gladem ; (5) Serad ; (6) Sertraline HCl ; (7) Sertraline hydrochloride ; (8) Tatig ; (9) Tresleen ; (10) Zoloft ; (11)1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S-cis)- . It belongs to the following product categories:(1)Pharmaceutical Intermediates; (2)Active PharmaceuticalIngredients; (3)APIs; (4)Inhibitors; (5)Intermediates & Fine Chemicals; (6)Pharmaceuticals; (7)Serotonin receptor
Properties of Sertraline hydrochloride are: (1)ACD/LogP: 4.81 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 1.77 ; (4)ACD/LogD (pH 7.4): 2.77 ; (5)ACD/BCF (pH 5.5): 2.41 ; (6)ACD/BCF (pH 7.4): 24.52 ; (7)ACD/KOC (pH 5.5): 8.89 ; (8)ACD/KOC (pH 7.4): 90.64 ; (9)#H bond acceptors: 1 ; (10)#H bond donors: 1 ; (11)#Freely Rotating Bonds: 2 ; (12)Polar Surface Area: 3.24Å2 ; (13)Flash Point: 205.6 °C ; (14)Enthalpy of Vaporization: 66.96 kJ/mol; (15)Boiling Point: 416.3 °C at 760 mmHg ; (16)Vapour Pressure: 3.85E-07 mmHg at 25°C
The Sertraline hydrochloride appears to be white or white-like crystalline powder. The Sertraline hydrochloride is mainly used for treatment with depression and obsessive-compulsive disorder. Usage and dosage: The usual dose is 50mg, once a day. Dose can be increased according to patient's condition within weeks, the maximum amount can reach 200mg/day. Please pay attention to using this medicine, because it can cause the following adverse effects: slight xerocheilia, nausea, indigestion, liquid stools and diarrhea. A few patients may show tremor, sweating, defering male ejaculation. Serum transaminase occasionally asymptomatically increase.
You can still convert the following datas into molecular structure :
1. SMILES: Cl.Clc1ccc(cc1Cl)[C@H]3c2c(cccc2)[C@@H](NC)CC3
2. InChI: InChI=1/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
The Sertraline hydrochloride toxic data can be showed in the following sheet.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 2857ug/kg (2.857mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Shinkei Seishin Yakuri. Neuropsychopharmacology. Vol. 19, Pg. 395, 1997. |
mouse | LDLo | intraperitoneal | 56mg/kg (56mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) | Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998. |
mouse | LDLo | oral | 336mg/kg (336mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: FOOD INTAKE (ANIMAL) | Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998. |
rat | LDLo | intraperitoneal | 56mg/kg (56mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) | Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998. |
rat | LDLo | oral | 840mg/kg (840mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998. |
women | TDLo | oral | 7mg/kg/2W-I (7mg/kg) | BEHAVIORAL: HEADACHE MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Journal of Clinical Psychiatry. Vol. 54, Pg. 432, 1993. |
women | TDLo | oral | 7mg/kg/7D-I (7mg/kg) | BEHAVIORAL: EXCITEMENT | Journal of Clinical Psychiatry. Vol. 54, Pg. 321, 1993. |
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