Product Name

  • Name

    Tetrahydrothiophene

  • EINECS 203-728-9
  • CAS No. 110-01-0
  • Article Data153
  • CAS DataBase
  • Density 0.999 g/cm3
  • Solubility immiscible in water
  • Melting Point -96 °C
  • Formula C4H8S
  • Boiling Point 121.5 °C at 760 mmHg
  • Molecular Weight 88.1735
  • Flash Point 12.8 °C
  • Transport Information UN 2412
  • Appearance volatile, clear, colorless liquid with a strong unpleasant odor
  • Safety 16-23-36/37-61
  • Risk Codes 11-20/21/22-36/38-52/53
  • Molecular Structure Molecular Structure of 110-01-0 (Tetrahydrothiophene)
  • Hazard Symbols FlammableF; HarmfulXn
  • Synonyms NSC 5272;THT;Tetrahydrothiophen;Tetrahydrothiophene;Tetramethylene sulfide;Thiacyclopentane;Thilane;Thiolane;Thiophane;
  • PSA 25.30000
  • LogP 1.51340

Synthetic route

1-oxothiolane
1600-44-8

1-oxothiolane

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With N,N-dimethylthioformamide; sulfuric acid In acetone at 30℃; for 3h;100%
With benzo[1,3,2]dioxaborole In benzene-d6 at 20℃; for 0.25h;100%
With carbon monoxide; 1 wt% Au/TiO2; water In acetone at 60℃; under 7600.51 Torr; for 5h; Autoclave;99%
1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With sodium sulfide; N-benzyl-N,N,N-triethylammonium chloride In 1-methyl-pyrrolidin-2-one at 50 - 100℃; Solvent; Temperature; Reagent/catalyst; Concentration;98.8%
With sodium sulfide; N,N-dimethyl-formamide
With sodium sulfide; ethylene glycol
With sodium sulfide; ethanol
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With sodium sulfide In dimethyl sulfoxide at 150℃; for 0.333333h;95%
With sodiumsulfide nonahydrate Reflux;78%
With aluminum oxide; sulfide ion In toluene at 95℃; for 20h;44.7%
With ethanol; alkali sulfide
With sodium sulfide; ethanol
tetrahydrofuran
109-99-9

tetrahydrofuran

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With hydrogen sulfide; carbon monoxide at 370℃; for 6h; Ring cleavage; Dehydration;85%
With aluminum oxide; hydrogen sulfide at 400℃;
With aluminium oxide-chromium oxide; hydrogen sulfide at 300℃;
With aluminium oxide-chromium oxide; hydrogen sulfide at 265℃;
4-Mercapto-1-butanol
14970-83-3

4-Mercapto-1-butanol

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With 2,2,2-triphenyl-4,5-(2',2''-biphenyleno)-1,3,2-dioxyphospholane Ambient temperature;85%
With BNTP In dichloromethane at 40℃; for 24h;93 % Chromat.
With diethoxyltriphenylphosphorane In toluene at -25℃; for 6h; Yield given;
at 350℃; under 760.051 Torr; for 1h; Inert atmosphere; Flow reactor;
(tetrahydrothiophene)gold(I) chloride
39929-21-0

(tetrahydrothiophene)gold(I) chloride

{silver(I)2(μ-((CHPPh3)2)CO)2} diperchlorate*n acetone

{silver(I)2(μ-((CHPPh3)2)CO)2} diperchlorate*n acetone

A

thiophene
110-01-0

thiophene

B

{gold(I)2(μ-((CHPPh3)2)CO)2} diperchlorate*n acetone

{gold(I)2(μ-((CHPPh3)2)CO)2} diperchlorate*n acetone

Conditions
ConditionsYield
In dichloromethane byproducts: AgCl; addn. of solid Au compd. to the phosphonium salt in CH2Cl2 at room temp. and stirring for 3 h; filtn., concn. and addn. of diethyl ether; elem. anal.;A n/a
B 85%
hydrogenchloride
7647-01-0

hydrogenchloride

Cp(CO)2W(η(2)-DHTH)
121268-49-3

Cp(CO)2W(η(2)-DHTH)

triphenylphosphine
603-35-0

triphenylphosphine

A

thiophene
110-01-0

thiophene

B

CpW(CO)2(PPh3)Cl

CpW(CO)2(PPh3)Cl

Conditions
ConditionsYield
In dichloromethane addn. of HCl to the metal complex; color change from yellow to red; addn. of PPh3; stirring (15 min); removing solvent; extn. with CHCl3; removing solvent in vac. from the ext.;A n/a
B 81%
S-1-hexylthiolanium tetrafluoroborate
918945-49-0

S-1-hexylthiolanium tetrafluoroborate

potassium selenocyanate
3425-46-5

potassium selenocyanate

A

thiophene
110-01-0

thiophene

B

n-hexyl selenocyanate
60669-47-8

n-hexyl selenocyanate

Conditions
ConditionsYield
In ethanol at 80℃; for 24h;A n/a
B 73%
S-methylthiolanium cation
45377-03-5

S-methylthiolanium cation

A

thiophene
110-01-0

thiophene

B

methane
34557-54-5

methane

C

methane-d3
676-80-2

methane-d3

D

n-butyl methyl sulfide
628-29-5

n-butyl methyl sulfide

Conditions
ConditionsYield
With diclazuril; water-d2; mercury; zinc; Ni(I)-F430 pentamethyl ester In N,N-dimethyl-formamide at 25℃; Kinetics; reductive cleavage of methyl sulphonium salts, deuterated methane formation;A 67%
B 70%
C n/a
D 30%
S-methylthiolanium cation
45377-03-5

S-methylthiolanium cation

A

thiophene
110-01-0

thiophene

B

methane
34557-54-5

methane

C

n-butyl methyl sulfide
628-29-5

n-butyl methyl sulfide

Conditions
ConditionsYield
With hydrogenchloride; water; mercury; zinc; Ni(I)-F430 pentamethyl ester In N,N-dimethyl-formamide at 25℃; Kinetics; reductive cleavage of methyl sulphonium salts, CH4 formation;A 67%
B 70%
C 30%
pyrrolidine
123-75-1

pyrrolidine

CpV(CO)3(tetrahydrothiophene)
111635-23-5

CpV(CO)3(tetrahydrothiophene)

A

thiophene
110-01-0

thiophene

(C5H5)V(CO)3(C4H8NH)
111635-24-6

(C5H5)V(CO)3(C4H8NH)

Conditions
ConditionsYield
In toluene soln. concd. to a small vol., addn. of hexane and cooling the soln. to -30°C yields crystals; elem. anal.;A n/a
B 57.8%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

CpV(CO)3(tetrahydrothiophene)
111635-23-5

CpV(CO)3(tetrahydrothiophene)

A

thiophene
110-01-0

thiophene

tetracarbonylcyclopentadienylvanadium
12108-04-2

tetracarbonylcyclopentadienylvanadium

cis-(η5-C5H5)V(CO)2*bipyridine
99620-52-7

cis-(η5-C5H5)V(CO)2*bipyridine

Conditions
ConditionsYield
In toluene soln. allowed to stand at room temp. overnight; elem. anal.;A n/a
B n/a
C 48.9%
potassium thioacyanate
333-20-0

potassium thioacyanate

S-methylthiolanium fluorosulphate

S-methylthiolanium fluorosulphate

A

thiophene
110-01-0

thiophene

B

methyl thiocyanate
556-64-9

methyl thiocyanate

C

erucin
4430-36-8

erucin

D

4-(methylthio)butyl thiocyanate
41756-12-1

4-(methylthio)butyl thiocyanate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70℃; for 7h; Yields of byproduct given;A n/a
B n/a
C n/a
D 45%
1-oxothiolane
1600-44-8

1-oxothiolane

1-ethenyl-4-methylbenzene
622-97-9

1-ethenyl-4-methylbenzene

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

A

thiophene
110-01-0

thiophene

B

ethyl 2,2-difluoro-4-oxo-4-(p-tolyl)butanoate

ethyl 2,2-difluoro-4-oxo-4-(p-tolyl)butanoate

Conditions
ConditionsYield
With potassium dihydrogenphosphate; fac-tris(2-phenylpyridinato-N,C2')iridium(III) at 20℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;A n/a
B 33%
thiophene
188290-36-0

thiophene

A

thiophene
110-01-0

thiophene

B

2,5-dihydro-thiophene
1708-32-3

2,5-dihydro-thiophene

Conditions
ConditionsYield
With biphenyl; tetraethylammonium perchlorate In water; N,N-dimethyl-formamide electrolysis in a separated cell, the operating electrode was mercury, the reference electrode was the saturated calomel electrode, initial current was 150 mA;A 19.7%
B 24%
With biphenyl; tetraethylammonium perchlorate In water; N,N-dimethyl-formamide electrolysis in a separated cell, the operating electrode was mercury, the reference electrode was the saturated calomel electrode, initial current was 150 mA;A 19.7%
B 24%
With biphenyl; tetraethylammonium perchlorate In water; N,N-dimethyl-formamide Product distribution; electrolysis in a separated cell, the operating electrode was mercury, the reference electrode was the saturated calomel electrode, initial current 150 mA; other solvent;A 19.7%
B 24%
1,1,2,3,4,5-hexahydro-1-<<(4-methylphenyl)sulfonyl>imino>tiophene
13553-70-3

1,1,2,3,4,5-hexahydro-1-<<(4-methylphenyl)sulfonyl>imino>tiophene

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With 1,4-dibromo-butane; zinc at 150℃; for 2h;20%
With dimethylsilicon dichloride; zinc Ambient temperature;
thiophene
188290-36-0

thiophene

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With 10% Ru/MgO; hydrogen at 200℃; under 38002.6 Torr; for 24h;11%
With rhenium heptasulfide at 250℃; under 220652 Torr; Hydrogenation;
With methanol; palladium on activated charcoal; sulfuric acid Hydrogenation;
2,5-dihydro-thiophene
1708-32-3

2,5-dihydro-thiophene

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With palladium on activated charcoal; ethanol Hydrogenation;
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With ethanol; alkali sulfide
Butane-1,4-diol
110-63-4

Butane-1,4-diol

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
With aluminum oxide; hydrogen sulfide at 400℃;
With hydrogen sulfide at 230 - 250℃; for 0.00138889h; Reagent/catalyst; Temperature; Flow reactor;
1-(4-hydroxy-butyl)-tetrahydro-thiophenium; bromide

1-(4-hydroxy-butyl)-tetrahydro-thiophenium; bromide

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
beim Erhitzen;
thiophene
188290-36-0

thiophene

A

thiophene
110-01-0

thiophene

B

trans-2-Butene
624-64-6

trans-2-Butene

C

Isobutane
75-28-5

Isobutane

D

Dibutyl sulfide
544-40-1

Dibutyl sulfide

E

2-methylpropan-2-thiol
75-66-1

2-methylpropan-2-thiol

F

isobutene
115-11-7

isobutene

Conditions
ConditionsYield
aluminum oxide; cobalt molybdenum In n-heptane at 290℃; under 21280 Torr; Product distribution; Mechanism; effect of temperature, pressure and contact time;
thiophene
188290-36-0

thiophene

A

thiophene
110-01-0

thiophene

B

1-butylene
106-98-9

1-butylene

C

(Z)-2-Butene
590-18-1

(Z)-2-Butene

D

trans-2-Butene
624-64-6

trans-2-Butene

E

buta-1,3-diene
106-99-0

buta-1,3-diene

F

n-butane
106-97-8

n-butane

Conditions
ConditionsYield
With hydrogen sulfide; hydrogen; aluminum oxide; molybdenum at 399.9℃; Product distribution; other catalysts; conversion of thiophene, product selectivities;
thiophene
188290-36-0

thiophene

A

thiophene
110-01-0

thiophene

B

1-butylene
106-98-9

1-butylene

C

butene-2
107-01-7

butene-2

D

n-butane
106-97-8

n-butane

Conditions
ConditionsYield
With aluminum oxide; cobalt molybdenum; hydrogen sulfide; hydrogen at 300℃; rate of thiophene disappearance as a function of the actual H2S at various temperatures;
1,4-Butanedithiol
1191-08-8

1,4-Butanedithiol

thiophene
110-01-0

thiophene

Conditions
ConditionsYield
Al(III)-montmorillonite at 175℃; for 1h;66 % Chromat.
With hydrogen at 350℃; under 760.051 Torr; for 1h; Flow reactor;
4-Mercapto-1-butanol
14970-83-3

4-Mercapto-1-butanol

diethoxyltriphenylphosphorane
86852-11-1, 18509-25-6

diethoxyltriphenylphosphorane

A

thiophene
110-01-0

thiophene

B

4-(ethylthio)-1-butanol
18721-62-5

4-(ethylthio)-1-butanol

Conditions
ConditionsYield
In toluene at 25℃;A 65 % Spectr.
B 35 % Spectr.
3-buten-1-thiol
5954-70-1

3-buten-1-thiol

A

thiophene
110-01-0

thiophene

B

2-methyl-thietane
17837-41-1

2-methyl-thietane

Conditions
ConditionsYield
In cyclohexane at 80℃; Yield given. Yields of byproduct given;
thiophene
110-01-0

thiophene

thiophene
188290-36-0

thiophene

Conditions
ConditionsYield
MTB-4A catalyst at 230℃; under 413.729 Torr; Product distribution / selectivity; Inert atmosphere;100%
at 500℃; Product distribution; gas phase pyrolysis;10%
beim Durchleiten durch ein dunkelrotgluehendes Glasrohr;
thiophene
110-01-0

thiophene

1-oxothiolane
1600-44-8

1-oxothiolane

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; tetrabutylammomium bromide In dichloromethane; water for 0.25h; Ambient temperature;100%
With water; silica gel; magnesium monoperoxyphthalate hexahydrate In dichloromethane for 1h; Ambient temperature;100%
With bromine; silica gel In dichloromethane for 0.833333h; Ambient temperature;100%
thiophene
110-01-0

thiophene

sulfolane
126-33-0

sulfolane

Conditions
ConditionsYield
With silica gel; magnesium monoperoxyphthalate hexahydrate In dichloromethane for 0.833333h; Heating;100%
With sodium tungstate (VI) dihydrate; dihydrogen peroxide In methanol; water at 40℃;100%
With selenium(IV) oxide; dihydrogen peroxide In water; ethyl acetate chemoselective reaction;99%
thiophene
110-01-0

thiophene

4-iodobutanoic acid
7425-27-6

4-iodobutanoic acid

C8H15O2S(1+)*BF4(1-)

C8H15O2S(1+)*BF4(1-)

Conditions
ConditionsYield
With silver tetrafluoroborate In acetonitrile for 72h; Ambient temperature;100%
thiophene
110-01-0

thiophene

5-iodopentanoic acid
19448-36-3

5-iodopentanoic acid

C9H17O2S(1+)*BF4(1-)

C9H17O2S(1+)*BF4(1-)

Conditions
ConditionsYield
With silver tetrafluoroborate In acetonitrile for 72h; Ambient temperature;100%
thiophene
110-01-0

thiophene

6-iodohexanoic acid
4224-63-9

6-iodohexanoic acid

C10H19O2S(1+)*BF4(1-)

C10H19O2S(1+)*BF4(1-)

Conditions
ConditionsYield
With silver tetrafluoroborate In acetonitrile for 72h; Ambient temperature;100%
thiophene
110-01-0

thiophene

7-iodoheptanoic acid
88019-89-0

7-iodoheptanoic acid

C11H21O2S(1+)*BF4(1-)

C11H21O2S(1+)*BF4(1-)

Conditions
ConditionsYield
With silver tetrafluoroborate In acetonitrile for 72h; Ambient temperature;100%
thiophene
110-01-0

thiophene

8-iodo-1-octanoic acid
1795-61-5

8-iodo-1-octanoic acid

C12H23O2S(1+)*BF4(1-)

C12H23O2S(1+)*BF4(1-)

Conditions
ConditionsYield
With silver tetrafluoroborate In acetonitrile for 72h; Ambient temperature;100%
thiophene
110-01-0

thiophene

12-iodododecan-1-oic acid
71736-19-1

12-iodododecan-1-oic acid

1-(11-Carboxy-undecyl)-tetrahydro-thiophenium; perchlorate

1-(11-Carboxy-undecyl)-tetrahydro-thiophenium; perchlorate

Conditions
ConditionsYield
With silver perchlorate In acetonitrile for 72h; Ambient temperature;100%
With silver perchlorate In acetonitrile
thiophene
110-01-0

thiophene

(2E,4E)-1-bromo-2,4-pentadecadiene-6,9-diyne
74448-20-7

(2E,4E)-1-bromo-2,4-pentadecadiene-6,9-diyne

(E,E)-2,4-pentadecadien-6,9-diyn-1-yl tetrahydrothiophenium bromide
81019-26-3

(E,E)-2,4-pentadecadien-6,9-diyn-1-yl tetrahydrothiophenium bromide

Conditions
ConditionsYield
In methanol; water for 1h; Ambient temperature;100%
In methanol; water for 0.666667h; Ambient temperature;
thiophene
110-01-0

thiophene

Phenyl-(2-methylprop-1-enyl)iodonium tetrafluoroborate

Phenyl-(2-methylprop-1-enyl)iodonium tetrafluoroborate

C8H15S(1+)*BF4(1-)

C8H15S(1+)*BF4(1-)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 25℃; for 3h;100%
thiophene
110-01-0

thiophene

Phenoxyacetyl iodide
79929-43-4

Phenoxyacetyl iodide

C12H15IO2S

C12H15IO2S

Conditions
ConditionsYield
In neat (no solvent) at 20℃; Green chemistry;100%
thiophene
110-01-0

thiophene

2,2-Dimethylpropanoyl iodide
61915-52-4

2,2-Dimethylpropanoyl iodide

C9H17IOS

C9H17IOS

Conditions
ConditionsYield
In neat (no solvent) at 20℃; Green chemistry;100%
thiophene
110-01-0

thiophene

Ta2Cl6(μ-C4Et4)

Ta2Cl6(μ-C4Et4)

[Ta2Cl6(μ-C4Et4)tetrahydrothiophene]

[Ta2Cl6(μ-C4Et4)tetrahydrothiophene]

Conditions
ConditionsYield
In toluene at 20℃; for 0.0833333h; Inert atmosphere;100%
thiophene
110-01-0

thiophene

(η6-toluene)bis(η1-pentafluorophenyl)cobalt(II)
60528-58-7

(η6-toluene)bis(η1-pentafluorophenyl)cobalt(II)

bis(pentafluorophenyl)bis(tetrahydrothiophene)cobalt(II)
86197-37-7

bis(pentafluorophenyl)bis(tetrahydrothiophene)cobalt(II)

Conditions
ConditionsYield
In dichloromethane tetrahydrothiophene was added to a soln. of Co complex under N2; evapn.; washing with pentane, drying in vac. for 5 min; elem. anal.;99%
thiophene
110-01-0

thiophene

(η(5)-C5H4C(O)CH2OCH3)Mn(CO)3
175875-75-9

(η(5)-C5H4C(O)CH2OCH3)Mn(CO)3

(η(5)-C5H4C(O)CH2OCH3)Mn(CO)2(tetrahydrothiophene)
185259-76-1

(η(5)-C5H4C(O)CH2OCH3)Mn(CO)2(tetrahydrothiophene)

Conditions
ConditionsYield
In cyclohexane byproducts: CO; Irradiation (UV/VIS); irradiation of mixt. of Mn-complex and tetrathiophene soln. (350 nm light source, 46 min, IR monitoring); filtration (Celite), solvent removal (vac.), chromy. (SiO2, 8% EtOAc-C6H6), evapn.; elem. anal.;99%
In n-heptane Kinetics; Ar-atmosphere; at least 10 times excess of C4H8S; not isolated; detd. by UV-VIS spectroscopy;
thiophene
110-01-0

thiophene

fac-[Re(CO)3(THF)((Ph2C4HN)2N)]
1192803-69-2

fac-[Re(CO)3(THF)((Ph2C4HN)2N)]

fac-[Re(CO)3(tetrahydrothiophene)((Ph2C4HN)2N)]
1192803-75-0

fac-[Re(CO)3(tetrahydrothiophene)((Ph2C4HN)2N)]

Conditions
ConditionsYield
In thiophene dissolving of Re(CO)3(THF)(N(C4HNPh2)2) in THT; pentane vapor diffusion; crystn.;99%
thiophene
110-01-0

thiophene

trifluoromethanesulfonic acid 2-fluoroethyl ester
95353-04-1

trifluoromethanesulfonic acid 2-fluoroethyl ester

1-(2-fluoroethyl)tetrahydro-1H-thiophen-1-ium trifluoromethanesulfonate

1-(2-fluoroethyl)tetrahydro-1H-thiophen-1-ium trifluoromethanesulfonate

Conditions
ConditionsYield
In neat (no solvent) at 60℃; for 15h; Inert atmosphere; Sealed tube;99%
thiophene
110-01-0

thiophene

trichloro(tetrahydrothiophene)gold(III)
29991-21-7

trichloro(tetrahydrothiophene)gold(III)

(tetrahydrothiophene)gold(I) chloride
39929-21-0

(tetrahydrothiophene)gold(I) chloride

Conditions
ConditionsYield
In ethanol; water98.9%
thiophene
110-01-0

thiophene

allyl bromide
106-95-6

allyl bromide

1-allyl-tetrahydrothiophenium bromide
66713-38-0

1-allyl-tetrahydrothiophenium bromide

Conditions
ConditionsYield
In methanol at 25℃; for 22h;98.5%
In methanol at 20℃; for 16h;95%
In dichloromethane at 20℃; for 168h;86%
thiophene
110-01-0

thiophene

2,3-Dimethyl-2-butene
563-79-1

2,3-Dimethyl-2-butene

A

di(p-tolyl) disulfide
103-19-5

di(p-tolyl) disulfide

B

1-(2,3-Dimethyl-but-2-enyl)-tetrahydro-thiophenium; perchlorate

1-(2,3-Dimethyl-but-2-enyl)-tetrahydro-thiophenium; perchlorate

Conditions
ConditionsYield
With p-methylbenzenesulfenyl chloride; lithium perchlorate In nitromethane at 20℃; for 10h;A n/a
B 98%
thiophene
110-01-0

thiophene

p-Xylylene dichloride
623-25-6

p-Xylylene dichloride

p-phenylenedimethylene-1,1-bis(tetrahydrothiophen-1-ium)dichloride

p-phenylenedimethylene-1,1-bis(tetrahydrothiophen-1-ium)dichloride

Conditions
ConditionsYield
In methanol at 20℃; for 90h; Inert atmosphere;98%
In methanol for 60h; Ambient temperature;91%
In methanol Heating;80%
thiophene
110-01-0

thiophene

cadmium bis(trimethylsilyl)amide

cadmium bis(trimethylsilyl)amide

(1,1';3',1''-terphenyl)-2'-ol
2432-11-3

(1,1';3',1''-terphenyl)-2'-ol

Cd(C6H3(C6H5)2O)2(C4H8S)2
206071-18-3

Cd(C6H3(C6H5)2O)2(C4H8S)2

Conditions
ConditionsYield
In thiophene Ar; stirring (room temp., 1 h); crystn. on cooling (-20°C, 2 d), drying (vac., 20 min); elem. anal.;98%
thiophene
110-01-0

thiophene

ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

ethyl 3-oxo-3-phenyl-2-(tetrahydrothiophen-2-yl)propanoate

ethyl 3-oxo-3-phenyl-2-(tetrahydrothiophen-2-yl)propanoate

Conditions
ConditionsYield
With diiron nonacarbonyl; di-tert-butyl peroxide for 1h; Reflux;98%
thiophene
110-01-0

thiophene

[Pt(7,8-benzo[h]quinolinyl)(pentafluorophenyl)(acetone)]
1403765-89-8

[Pt(7,8-benzo[h]quinolinyl)(pentafluorophenyl)(acetone)]

[Pt(C6F5)(bzq)(tht)]
1446102-34-6

[Pt(C6F5)(bzq)(tht)]

Conditions
ConditionsYield
In acetone at 0℃; for 0.0333333h; Inert atmosphere;98%
thiophene
110-01-0

thiophene

dimethylcarbamoyl iodide
13358-75-3

dimethylcarbamoyl iodide

C7H14INOS

C7H14INOS

Conditions
ConditionsYield
In neat (no solvent) at 20℃; Green chemistry;98%
thiophene
110-01-0

thiophene

hydrogen tetrachloroaurate(III) tetrahydrate

hydrogen tetrachloroaurate(III) tetrahydrate

(tetrahydrothiophene)gold(I) chloride
39929-21-0

(tetrahydrothiophene)gold(I) chloride

Conditions
ConditionsYield
In ethanol; water at 20℃; for 0.5h;98%
In ethanol at 20℃; for 1h; Inert atmosphere; Schlenk technique;98%
In ethanol; water65%
thiophene
110-01-0

thiophene

1,1,1,-trichloroethoxysulfonylazide
1186018-19-8

1,1,1,-trichloroethoxysulfonylazide

C6H10Cl3NO3S2

C6H10Cl3NO3S2

Conditions
ConditionsYield
With iron(III) acetylacetonate In dichloromethane at 20℃; under 2100.21 Torr; for 0.833333h; Flow reactor; UV-irradiation;98%

Tetrahydrothiophene Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

Tetrahydrothiophene Specification

The Tetrahydrothiophene, with the CAS registry number 110-01-0 and EINECS registry number 203-728-9, is also known as Thiophane. And the molecular formula of this chemical is C4H8S. It is the saturated analog of thiophene. Besides, it is a volatile, clear, colorless liquid with a strong unpleasant odor,and stability Highly flammable,vapour-air mixtures explosive in some proportions; note low flash point and fairly wide explosion limit range. Heavier than air, so potentially explosive mixtures may travel considerable distances to source of ignition .It is used as a solvent and to make other chemicals.

The physical properties of Tetrahydrothiophene are as following:
 (1)ACD/LogP: 1.34; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.34; (4)ACD/LogD (pH 7.4): 1.34; (5)ACD/BCF (pH 5.5): 6.1; (6)ACD/BCF (pH 7.4): 6.1; (7)ACD/KOC (pH 5.5): 127.03; (8)ACD/KOC (pH 7.4): 127.03; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 25.3 Å2; (13)Index of Refraction: 1.515; (14)Molar Refractivity: 26.6 cm3; (15)Molar Volume: 88.1 cm3; (16)Polarizability: 10.54×10-24cm3; (17)Surface Tension: 35.7 dyne/cm; (18)Density: 0.999 g/cm3; (19)Flash Point: 12.8 °C; (20)Enthalpy of Vaporization: 34.66 kJ/mol; (21)Boiling Point: 121.5 °C at 760 mmHg; (22)Vapour Pressure: 17.5 mmHg at 25°C.

Preparation and uses of Tetrahydrothiophene:
It can be prepared by 1,4-dibromobutane and sodium sulfide in the solvent alcohol. It is occasionally used as an odorant in natural gas because of its smell. It is also used as a solvent, as an insecticide, and as a moth repellant. It is an intermediate in the preparation of the solvent sulfolane, which is produced by the oxidation of tetrahydrothiophene. In addition, it is also used as an electrolyte for lithium batteries.

Safety information of Tetrahydrothiophene:
You should be cautious while dealing with this chemical. It is a kind of highly flammable chemical which irritates eyes and skin. It is also harmful by inhalation, in contact with skin and if swallowed. Besides, it is harmful to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. Therefore, you had better take the following instructions: Wear suitable protective clothing and gloves; Keep away from food, drink and animal feeding stuffs; Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer); Avoid release to the environment. Refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: S1CCCC1
(2)InChI: InChI=1/C4H8S/c1-2-4-5-3-1/h1-4H2
(3)InChIKey: RAOIDOHSFRTOEL-UHFFFAOYAY

The toxicity data of Tetrahydrothiophene is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC50 inhalation 27gm/m3/2H (27000mg/m3)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1088, 1986.
rat LD50 oral 1750mg/kg (1750mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0555157,

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