Thioacetamide supplier | CasNO.62-55-5

Name
Thioacetamide
EINECS 200-541-4
CAS No. 62-55-5
Article Data69
CAS DataBase
Density 1.07 g/cm³
Solubility 16.3 g/100 mL (25 °C) in water
Melting Point 108-112 °C(lit.)
Formula C₂H₅NS
Boiling Point 111.7 °C at 760 mmHg
Molecular Weight 75.1344
Flash Point 21.4 °C
Transport Information UN 2811
Appearance white solid
Safety 53-45-61-99
Risk Codes 45-22-36/38-52/53
Molecular Structure
Hazard Symbols T
Synonyms Acetamide,thio- (8CI);Acetimidic acid, thio- (7CI);Acetothioamide;Acetamide, thio-;Acetic acid, thiono-, amide;Acetimidic acid, thio-;
PSA 58.11000
LogP 0.99270

Synthetic route

: 60-35-5
acetamide

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With Lawessons reagent In tetrahydrofuran at 20℃; for 3h; Solvent;	93%
With Lawessons reagent In tetrahydrofuran at 20℃; for 0.166667h;	87%
With Lawessons reagent for 0.0333333h; microwave irradiation;	87%

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With aluminum oxide; diethyl dithiophosphate ammonium salt for 6h; Heating;	90%
Stage #1: acetonitrile With calcium hydride; tiolacetic acid at 50℃; for 1h; Stage #2: With water In ethyl acetate at 20℃;	80%
With diammonium sulfide In methanol at 80℃; for 0.25h; microwave irradiation;	53%

: 71-23-8
propan-1-ol

: 97893-05-5
dipropyl thioacetimidoylphosphite

A: 923-99-9
tri-n-propyl phosphite

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
In benzene	A 51% B 59.1%

...Expand

: 19172-47-5
Lawessons reagent

: 76-09-5
2,3-dimethyl-2,3-butane diol

A: 62-55-5
thioacetamide

B: 2-(4-Methoxyphenyl)-1,3,2-dioxaphosphorinane 2-sulfide

Conditions

Conditions	Yield
In acetonitrile for 4h; Heating;	A 13.3% B 54.5%

...Expand

: 107-21-1
ethylene glycol

: 92825-37-1, 88816-02-8
2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides

A: 62-55-5
thioacetamide

B: 2-(4-Phenoxy-phenyl)-[1,3,2]dioxaphospholane 2-sulfide

Conditions

Conditions	Yield
In acetonitrile for 4h; Ambient temperature;	A 53.3% B 12.3%

...Expand

: 97893-05-5
dipropyl thioacetimidoylphosphite

A: 20003-39-8
dipropyl phosphorochloridite

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With hydrogenchloride In benzene	A 37% B 53%

: 19172-47-5
Lawessons reagent

: 107-21-1
ethylene glycol

A: 62-55-5
thioacetamide

B: 2-(4-Methoxyphenyl)-1,3,2-dioxaphosphorinane 2-sulfide

C: 2,4-Bis-(4-methoxyphenyl)-2,4-dithiono-1,5-dioxa-3-thio-2,4-diphosphetane

Conditions

Conditions	Yield
In acetonitrile for 4h; Product distribution; Mechanism; Heating; other diols; also with p-phenoxyphenyl-(LR); variation of condition;	A 37.3% B 52% C 5.6%
In acetonitrile for 5h; Heating;	A 37.3% B 52% C 5.6%

...Expand

: 121-44-8
triethylamine

: 97893-05-5
dipropyl thioacetimidoylphosphite

A: 58498-86-5
diethyl-phosphoramidous acid dipropyl ester

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
In benzene at 55℃; for 0.333333h;	A 36.4% B 52%

...Expand

: 298-06-6
O,O-Diethyl hydrogen phosphorodithioate

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
In water at 80℃; for 6h;	45%

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 92825-37-1, 88816-02-8
2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides

A: 62-55-5
thioacetamide

B: 4,4,5,5-Tetramethyl-2-(4-phenoxy-phenyl)-[1,3,2]dioxaphospholane 2-sulfide

Conditions

Conditions	Yield
In acetonitrile for 4h; Ambient temperature;	A 35.3% B 41.6%

...Expand

: 19172-47-5
Lawessons reagent

: 57-55-6
propylene glycol

A: 62-55-5
thioacetamide

B: 2-(4-Methoxyphenyl)-4-methyl-1,3,2-dioxaphosphorinane 2-sulfide

C: 2,4-Bis-(4-methoxyphenyl)-2,4-dithiono-1,5-dioxa-3-thio-6-methyl-2,4-diphosphetane

Conditions

Conditions	Yield
In acetonitrile for 3h; Heating;	A 41.3% B 31.1% C 12.5%

...Expand

: 19172-47-5
Lawessons reagent

: 350680-89-6
bis-(3,5-dichloro-2-hydroxy-phenyl)-(4-nitro-phenyl)-methane

: 75-05-8
acetonitrile

A: 62-55-5
thioacetamide

B: 5,7,15,17-tetrachloro-10,12-bis-(4-methoxy-phenyl)-2-(4-nitro-phenyl)-9,13-dioxa-11-thia-10,12-diphospha-tricyclo[12.4.0.03,8]octadeca-1(14),3(8),4,6,15,17-hexaene 10,12-disulfide

Conditions

Conditions	Yield
for 12h; Heating;	A n/a B 37%

...Expand

: 110-63-4
Butane-1,4-diol

: 92825-37-1, 88816-02-8
2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides

A: 62-55-5
thioacetamide

B: 2-(4-Phenoxy-phenyl)-[1,3,2]dioxaphosphepane 2-sulfide

Conditions

Conditions	Yield
In acetonitrile for 2h; Heating;	A 29.3% B 8.13%

...Expand

: 19172-47-5
Lawessons reagent

: 110-63-4
Butane-1,4-diol

A: 62-55-5
thioacetamide

B: 2-(4-Methoxy-phenyl)-[1,3,2]dioxaphosphepane 2-sulfide

Conditions

Conditions	Yield
In acetonitrile for 4h; Heating;	A 18.6% B 26%

...Expand

: 19172-47-5
Lawessons reagent

: 107-21-1
ethylene glycol

A: 62-55-5
thioacetamide

B: 2,4-Bis-(4-methoxyphenyl)-2,4-dithiono-1,5-dioxa-3-thio-2,4-diphosphetane

Conditions

Conditions	Yield
In acetonitrile at 25℃; for 12h;	A 20% B 23%

...Expand

: 926-67-0
O-Ethyl thioacetate

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With ethanol; ammonia

: 631-61-8
ammonium acetate

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With aluminum sulfide at 240℃;

: 1000-84-6
O-ethyl acetimidate

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
With diethyl ether; hydrogen sulfide

: 64-17-5
ethanol

: 97893-04-4
diethyl thioacetimidoylphosphite

A: 62-55-5
thioacetamide

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
In benzene	A 2.5 g B 41.4 g

...Expand

: 3956-29-4
N-ethyl-thioacetamide

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
at 326.9℃; Kinetics; Thermodynamic data; log A, Ea; temperatures: 645.2 - 704.2 K;

: 3542-00-5
N-acetylthioacetamide

A: 463-51-4
Ketene

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
at 198.9 - 250.9℃; Kinetics; Arrhenius parameters;

: 21351-31-5
N-tert-butylethanethioamide

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
at 364.9 - 425.9℃; Kinetics; Arrhenius parameters;

: 2669-09-2
thioacetamide sulfoxide

A: 60-35-5
acetamide

B: 62-55-5
thioacetamide

C: 75-05-8
acetonitrile

Conditions

Conditions	Yield
With sodium NADH*4H2O In water-d2 at 37℃; for 24h; Yield given. Yields of byproduct given;
With sodium NADPH In water-d2 at 37℃; for 96h; Yield given. Yields of byproduct given;

...Expand

: 106814-55-5
O,O'-tetramethylene bis(hydrogen methylphosphonodithioate)

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
In tetrachloromethane Ambient temperature; investigation of intermediate, stability of the product, oligomerization;

: 2905-39-7
N-thioacetylpropanamide

A: 6004-44-0
prop-1-en-1-one

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
at 224.9℃; Rate constant; Thermodynamic data; Mechanism; Ea, var. temp.;

: 7647-01-0
hydrogenchloride

: 60-29-7
diethyl ether

: 637-51-4
isothiocyanatobenzene

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
bei Einw. von Saeuren;

...Expand

: 7647-01-0
hydrogenchloride

: 60-29-7
diethyl ether

: 637-53-6
thioacetanilide

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
bei Einw. von Saeuren;

...Expand

: 7783-06-4
hydrogen sulfide

: 75-05-8
acetonitrile

: 62-55-5
thioacetamide

Conditions

Conditions	Yield
at 80℃; under 6251820 Torr;

: 7647-01-0
hydrogenchloride

: 60-29-7
diethyl ether

: 636-04-4
N-Phenylbenzothioamide

: 75-05-8
acetonitrile

A: 93-98-1
N-phenyl benzoyl amide

B: 62-55-5
thioacetamide

Conditions

Conditions	Yield
bei Einw. von Saeuren;

...Expand

: 62-55-5
thioacetamide

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 50834-78-1
methyl 4-(2-methyl-1,3-thiazol-4-yl)phenyl ether

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	100%
In ethylene glycol at 20℃; for 0.0833333h;	97%
With 1,3-di-n-butyl-imidazolium tetrafluoroborate at 20℃; for 0.25h;	96%

: 60965-26-6
2-Bromo-2',4'-dimethoxyacetophenone

: 62-55-5
thioacetamide

: 448908-41-6
4-(2,4-dimethoxy-phenyl)-2-methyl-thiazole

Conditions

Conditions	Yield
In ethanol for 2h; Heating / reflux;	100%

: 62-55-5
thioacetamide

: 13051-49-5
5-Acetoxy-3-chloropentan-2-one

: 866561-40-2
acetic acid 2-(2,4-dimethylthiazol-5-yl)-ethyl ester

Conditions

Conditions	Yield
at 110 - 120℃; for 0.5h;	100%
at 110 - 120℃; for 0.5h;	100%
at 110 - 120℃; for 0.5h;	100%

: 890023-15-1
3-chloro-1,6,6-trimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 62-55-5
thioacetamide

: 890023-16-2
1-amino-5,8,8-trimethyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 4h; Heating / reflux;	100%

: nickel(II) chloride hexahydrate

: 62-55-5
thioacetamide

A: nickel(II) sulfide

B: trinickel tetrasulfide

C: nickel disulfide

D: nickel(II) hydroxide

Conditions

Conditions	Yield
With ammonium hydroxide; ammonium chloride In water NiCl2*6H2O dissolved in distilled water with NH4OH and NH4Cl buffer soln. adjusted the pH to 9.9 at 60°C;	A 0% B 100% C 0% D 0%
With ammonium hydroxide; ammonium chloride In water NiCl2*6H2O dissolved in distilled water with NH4OH and NH4Cl buffer soln. adjusted the pH to 9.9 at 70°C;	A 0% B 100% C 0% D 0%
With sodium hydroxide In water NiCl2*6H2O dissolved in distilled water with NaOH, thioacetamide added at 40°C, quickly mixed, boiled at 100°C for 1 h, refluxed at 60-80°C for 12 h; filtered, washed, dried at 120°C;	A 0% B 0% C 100% D 0%

...Expand

: 278172-59-1
methyltriphenylbismuthonium tetrafluoroborate

: 62-55-5
thioacetamide

A: 277306-39-5
1-(methylthio)ethyleneiminium tetrafluoroborate

B: 603-33-8
triphenylbismuthane

Conditions

Conditions	Yield
In chloroform-d1 mixt. (Ph3BiMe)(BF4), thioacetamide, and CDCl3 was allowed to react at room temp. for 1 min; detn. by NMR;	A 100% B 100%

...Expand

: 1167412-36-3
1-(4-fluorophenyl)-3-(phenylsulfanyl)prop-2-yn-1-ol

: 62-55-5
thioacetamide

: 1167412-46-5
4-(4-fluorobenzyl)-2-methyl-5-(phenylsulfanyl)-thiazole

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; scandium tris(trifluoromethanesulfonate) In nitromethane; water for 0.166667h; Reflux; regioselective reaction;	100%

: 62-55-5
thioacetamide

: 87154-68-5
3-chloro-4-(bromoacetyl)nitrobenzene

: 3-chloro-4-(2-methyl-thiazol-4-yl)-aniline

Conditions

Conditions	Yield
Stage #1: thioacetamide; 3-chloro-4-(bromoacetyl)nitrobenzene In ethanol at 85℃; for 1h; Stage #2: With hydrogenchloride; tin(II) chloride dihdyrate In ethanol; water for 1h; Reflux; Stage #3: With potassium hydroxide In ethanol; water at 0℃;	100%

: 62-55-5
thioacetamide

: 70-11-1
α-bromoacetophenone

: 1826-16-0
2-methyl-4-phenylthiazole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 1h; Hantzsch Thiazole Synthesis; Sealed tube;	99%
With tert-butylammonium hexafluorophosphate(V) In methanol at 20℃; for 0.25h;	95%
With 1,3-di-n-butyl-imidazolium tetrafluoroborate at 20℃; for 0.166667h;	94%

: 62-55-5
thioacetamide

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 39541-91-8
2-methyl-4-(3-nitrophenyl)-thiazole

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	99%
In ethanol for 1.5h; Heating;	83%

: 615-43-0
2-iodophenylamine

: 62-55-5
thioacetamide

: 120-75-2
2-Methylbenzothiazole

Conditions

Conditions	Yield
With calcium oxide; palladium; triphenylphosphine In N,N-dimethyl-formamide at 60℃; for 3h; Product distribution; molar ratio of each component, 1,1'-bis(diphenylphosphino)ferrocene (dppf) ligand, reation time;	99%
With calcium oxide; palladium; triphenylphosphine In N,N-dimethyl-formamide at 60℃; for 3h;	99 % Chromat.

: 62-55-5
thioacetamide

: 78367-93-8
2-[2-Bromo-3-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione

: 78367-98-3
2-{4-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-2-methyl-thiazol-5-ylmethyl}-isoindole-1,3-dione

Conditions

Conditions	Yield
With sulfur dioxide In N,N-dimethyl-formamide for 1h; Heating;	99%

: 62-55-5
thioacetamide

: 267244-45-1
(2S,3S,4S)-N-benzoyl-4-(bromoacetyl)-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethylpyrrolidine

: 267244-46-2
(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-(2'-methylthiazol-4'-yl)pyrrolidine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Condensation; Heating;	99%
With sodium hydrogencarbonate In ethanol for 2h; Heating;	99%

: 39065-54-8
2-phenyl-5-cyanopyridine

: 62-55-5
thioacetamide

: 478541-13-8
6-phenyl-thionicotinamide

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 98℃; for 20h;	99%

: tin (IV) chloride pentahydrate

: 62-55-5
thioacetamide

: tin disulfide

Conditions

Conditions	Yield
In water at 160℃; for 12h; High pressure; Autoclave;	99%
With layryl mercaptane In ethane-1,2-diol Sonication; thioacetamide in ethanediol heated to 65°C,, then SnCl4 in ethanediol and lauryl mercaptane added; sonicated for 0.5 h; mixt. injected into thioacetamide within 40 min; cooled down to room temp.; EtOH added; centrifuged; washed 3 times with EtOH;
With cetyltrimethylammonium bromide In ethanol High Pressure; cetyltrimethylammonium bromide, SnCl4*5H2O and thioacetamide added into Schlenk flask; sealed by Teflon screw cap; heated at 40, 80 or 120°C for 2, 4, 6, 8 or 10 h under inert atm.; allowed to cool naturally to room temp.; filtered out, washed with water for sseveral times; dispersed in Et2O/EtOH (1:1) via sonication, centrifuged; dried overnight under high vac. at40°C;

: 2-bromo-1-(2-bromo-5-(trifluoromethyl)phenyl)ethanone

: 62-55-5
thioacetamide

: 4-(2-bromo-5-(trifluoromethyl)phenyl)-2-methylthiazole

Conditions

Conditions	Yield
In ethanol at 80℃; for 12h; Sealed tube;	99%

: 62-55-5
thioacetamide

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 365427-24-3
4-(3-methoxyphenyl)-2-methylthiazole

Conditions

Conditions	Yield
In toluene for 24h; Heating / reflux;	98.5%
In ethanol at 80℃; for 1h;	90%
In ethanol at 80℃; for 1h;	90%

: 5743-04-4
cadmium(II) acetate dihydrate

: 62-55-5
thioacetamide

: cadmium(II) sulphide

Conditions

Conditions	Yield
In further solvent(s) Sonication; Cd salt and thioacetamide slowly dissolved 1-ethyl-3-methylimidazolium ethyl sulfate under stirring at room temp., sonicated for 60 min; centrifuged, washed 3 times (H2O, EtOH), dried at 50°C for 24 h;	98.2%
In water Sonication; Cd salt and thioacetamide slowly dissolved in H2O/1-ethyl-3-methylimidazolium ethyl sulfate (1:1) under stirring at room temp., sonicated for 60min; centrifuged, washed 3 times (H2O, EtOH), dried at 50°C for 24 h;	89.8%
In water Sonication; Cd salt and thioacetamide slowly dissolved in H2O under stirring at roomtemp., sonicated for 60 min; centrifuged, washed 3 times (H2O, EtOH), dried at 50°C for 24 h;	82%

: 62-55-5
thioacetamide

: 78367-95-0
2-[2-Bromo-3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione

: 78367-97-2
2-{4-[4-Chloro-2-(2-chlorobenzoyl)phenyl-2-methyl]-5-thiazolyl-methyl}-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With sulfur dioxide In N,N-dimethyl-formamide for 1h; Heating;	98%
With sulfur dioxide In methanol; dichloromethane; N,N-dimethyl-formamide

: 598-79-8
2-Chloroacrylic acid

: 62-55-5
thioacetamide

: 116077-22-6
S-(2-Carboxy-2-chlorethyl)thioacetamid-hydrochlorid

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile for 4h; Ambient temperature;	98%

: 16490-68-9
2-chloroacrylamide

: 62-55-5
thioacetamide

: 116077-26-0
S-<2-Carbamoyl-2-chlorethyl>thioacetamid-hydrochlorid

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile for 1h; Ambient temperature;	98%

: 62-55-5
thioacetamide

: 33027-12-2
o-bromoacetylbenzophenone

: 4-(2-benzoylphenyl)-2-methylthiazole

Conditions

Conditions	Yield
In 1,4-dioxane Ambient temperature;	98%

: 1835-02-5
2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

: 62-55-5
thioacetamide

: 256950-42-2
4-(3,4-dimethoxyphenyl)-2-methylthiazole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 65℃; for 8h;	98%
In ethanol for 2h; Reflux; Inert atmosphere;	87%
In N,N-dimethyl-formamide for 4h; Inert atmosphere; Reflux;	82%

: 875639-57-9
2-bromo-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

: 62-55-5
thioacetamide

: 1046793-78-5
4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methylthiazole

Conditions

Conditions	Yield
In tetrahydrofuran for 6h; Heating / reflux;	98%

: 1192167-42-2
4-(1-hydroxy-1,3-diphenylprop-2-ynyl)benzonitrile

: 62-55-5
thioacetamide

: 1242072-86-1
4-((2-methyl-5-phenylthiazol-4-yl)methyl)benzonitrile

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,2-dichloro-ethane at 100℃; for 23h; Inert atmosphere; regioselective reaction;	98%

: 1522-13-0
1,1,3-triphenylprop-2-yn-1-ol

: 62-55-5
thioacetamide

: 1242072-82-7
4-benzhydryl-2-methyl-5-phenylthiazole

Conditions

Conditions	Yield
With 5 wtpercent H-USY zeolite In 1,2-dichloro-ethane at 100℃; for 16h; Concentration;	98%
With toluene-4-sulfonic acid In 1,2-dichloro-ethane at 100℃; for 5h; Inert atmosphere; regioselective reaction;	90%

: 62698-34-4
1-(4-chlorophenyl)-1,3-diphenylprop-2-yn-1-ol

: 62-55-5
thioacetamide

: 1242072-84-9
4-((4-chlorophenyl)(phenyl)methyl)-2-methyl-5-phenylthiazole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,2-dichloro-ethane at 100℃; for 2.5h; Inert atmosphere; regioselective reaction;	98%

: 938-10-3
phenylsulfonyl azide

: 62-55-5
thioacetamide

: 4392-36-3
N-benzenesulfonylacetamidine

Conditions

Conditions	Yield
In ethanol for 1h; Temperature; Solvent; Reflux; chemoselective reaction;	98%
In ethanol for 1h; Temperature; Reflux;	98%

: 62-55-5
thioacetamide

: 624-90-8, 1516-70-7
Methanesulfonyl azide

: 30924-67-5
N-(methylsulfonyl)acetimidamide

Conditions

Conditions	Yield
In ethanol for 1h; Solvent; Temperature; Reflux; chemoselective reaction;	98%
In water at 20℃; for 15h; Solvent; Temperature;	63%

: methyl 4-(2-bromoacetyl)cubane-1-carboxylate

: 62-55-5
thioacetamide

: methyl 4-(2-methylthiazol-4-yl)cubane-1-carboxylate

Conditions

Conditions	Yield
In methanol at 20 - 70℃; for 2h; Inert atmosphere;	98%

Thioacetamide Chemical Properties

The molecular structure of thioacetamide (CAS NO.62-55-5):

IUPAC Name: ethanethioamide
Empirical Formula: C₂H₅NS
Molecular Weight: 75.1328
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 0
Index of Refraction: 1.543
Molar Refractivity: 22.13 cm³
Molar Volume: 70.2 cm³
Surface Tension: 50.6 dyne/cm
Density: 1.07 g/cm³
Flash Point: 21.4 °C
Enthalpy of Vaporization: 35.03 kJ/mol
Boiling Point: 111.7 °C at 760 mmHg
Vapour Pressure: 22.5 mmHg at 25°C
EINECS: 200-541-4
Melting Point: 108-112 °C(lit.)
Product Categories: Sulphur Derivatives
Storage Temp: Store at RT
Water Solubility: 16.3 g/100 mL (25 ºC)
Merck: 14,9319
BRN: 506006
Stability: Stability Incompatible with water, mineral acids
Conditions to Avoid: Incompatible materials
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) and ammonia (NH3), hydrogen sulfide, sulfur oxides (SOx), including sulfur oxide and sulfur dioxide.
Hazardous Polymerization: Will not occur

Thioacetamide Production

Thioacetamide is prepared by treating acetamide with phosphorus pentasulfide as shown in the following idealized reaction:
CH₃C(O)NH₂+ 1/4 P₄S₁₀ → CH₃C(S)NH₂ + 1/4 P₄S₆O₄

Thioacetamide Toxicity Data With Reference

1.	mmo-smc 19,900 µmol/L	MGGEAE Molecular and General Genetics. 174 (1979),39.
2.	otr-rat:emb 30 mg/L	JJIND8 JNCI, Journal of the National Cancer Institute. 67 (1981),1303.
3.	orl-rat TDLo:7350 mg/kg/40W-C:CAR	JJIND8 JNCI, Journal of the National Cancer Institute. 79 (1987),1047.
4.	orl-rat TD:5140 mg/kg/47W-C:ETA,TER	JPBAA7 Journal of Pathology and Bacteriology. 72 (1956),415.
5.	orl-rat LD50:301 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 27 (1974),380.
6.	ipr-mus LD50:300 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
7.	scu-mus LDLo:2000 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 12 (1904),447.

Thioacetamide Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See also SULFIDES and MERCAPTANS.
Hazard Codes: Toxic T
Risk Statements 45-22-36/38-52/53
R45:May cause cancer.
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 53-45-61-99
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: 2811
WGK Germany: 3
RTECS: AC8925000
F: 10
HS Code 29309070

Thioacetamide Specification

Thioacetamide , with CAS number of 62-55-5, can be called ethanethioamide ; Acetamide, thio- ; Acetic acid, thiono-, amide ; Acetimidic acid, thio- ; Acetimidic acid, thio- (7CI) . Thioacetamide (CAS NO.62-55-5) is a white solid, can be used as the production of catalysts, stabilizers, inhibitor, electroplating additives, photographic drugs, pesticides, dyeing auxiliary and ore dressing agent. Also used as a polymer curing agent, crosslinking agent, rubber additives and pharmaceutical raw materials. The production methods of Thioacetamide (CAS NO.62-55-5) is acetonitrile and hydrogen sulfide reaction or to acetamide with phosphorus pentasulfide reaction.

Product Name

Thioacetamide

Synthetic route

Thioacetamide Chemical Properties

Thioacetamide Production

Thioacetamide Toxicity Data With Reference

Thioacetamide Safety Profile

Thioacetamide Specification

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