Triethyl Phosphate supplier

Name
Triethyl phosphate
EINECS 201-114-5
CAS No. 78-40-0
Article Data295
CAS DataBase
Density 1.066 g/cm³
Solubility SOLUBLE
Melting Point -56.4 ºC
Formula C₆H₁₅O₄P
Boiling Point 219.3 ºC at 760 mmHg
Molecular Weight 182.156
Flash Point 115.6 ºC
Transport Information
Appearance colourless liquid with a mild odour
Safety 25
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Triethylphosphate;Phosphoric acid, triethyl ester;Triethoxyphosphine oxide;1-diethoxyphosphoryloxyethane;Ethyl phosphate ((EtO)3PO);Triethylfosfat [Czech];Tris(ethyl) phosphate;Phosphoric acid,esters,triethyl ester;Levagard TEP;Ethyl phosphate (VAN);TEP Triethyl phosphate;Triethyl phosphate (TEP);Triethyl Phosp;TEP;Triethyl phosphate(TEP);
PSA 54.57000
LogP 2.20400

Synthetic route

: 126-68-1
O,O,O-triethyl phosphorothioate

: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With pyridine; trifluoroacetic anhydride for 24h;	100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 20h;	100%
With ozone In dichloromethane at -75℃;	95%

: 2651-89-0
O,O,O-triethylselenophosphate

: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With pyridine; trifluoroacetic anhydride for 2h;	100%
With ozone In dichloromethane at -75℃;	94%
With Oxone In tetrahydrofuran; methanol Ambient temperature;	85%

: 64-17-5
ethanol

: 762-04-9
phosphonic acid diethyl ester

: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With iodosylbenzene In tetrahydrofuran for 24h; Heating;	100%
With tetraethylammonium iodide In acetonitrile at 25℃; electrosynthesis;	98.7%
With oxygen; copper dichloride at 50℃; for 5h; Product distribution; effect of the temp., the reagent ratio, the reaction time;	97%

: 64-17-5
ethanol

: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With phosphorous; oxygen; copper dichloride In benzene at 50℃;	98.2%
With phosphorous; oxygen; copper dichloride In benzene at 50℃; Product distribution; Mechanism; other alkylalcohols, var. concentrations of reagents;	98.2%
With trichlorophosphate In acetone at 10 - 30℃; under 10 Torr; for 4h;	97.7%

: 122-52-1
triethyl phosphite

A: 64-67-5
diethyl sulfate

B: 78-40-0
triethyl phosphate

C: 78-38-6
ethylphosphonic acid diethyl ester

Conditions

Conditions	Yield
With sulfur trioxide In dichloromethane at -78℃;	A 97% B 2% C 1%
With sulfur trioxide In dichloromethane at -78℃;	A 17% B 55% C 28%

...Expand

: 111-25-1
1-bromo-hexane

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 16165-66-5
diethyl hexylphosphonate

Conditions

Conditions	Yield
at 170℃; for 12h; Inert atmosphere; Dean-Stark;	A n/a B n/a C 95%

...Expand

: 64-17-5
ethanol

A: 1623-14-9
ethyl phosphate

B: 598-02-7
Diethyl phosphate

C: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With phosphorus; tetraethylammonium iodide In water; acetonitrile electrolysis;	A n/a B n/a C 84%

...Expand

: 866-23-9
diethyl (trichloromethyl)phosphonate

: 64-17-5
ethanol

: 762-04-9
phosphonic acid diethyl ester

A: 78-40-0
triethyl phosphate

B: 3167-62-2
diethyl (dichloromethyl)phosphonate

Conditions

Conditions	Yield
With triethylamine at 20℃;	A n/a B 84%

...Expand

: 67751-11-5
N,N,N',N'-Tetramethylharnstoff-diethylacetal

: 762-04-9
phosphonic acid diethyl ester

A: 78-40-0
triethyl phosphate

B: 124-40-3
dimethyl amine

C: 119949-72-3
diethyl phosphonate

Conditions

Conditions	Yield
at 80℃; under 400 Torr; reduced pressure;	A n/a B n/a C 83%

...Expand

: 6-Hydroxy-5-(triaethoxyphosphoranylidenamino)-5,6-dihydro-β-ionon

A: 78-40-0
triethyl phosphate

B: 5,6-epimino-5,6-dihydro-β-ionone

Conditions

Conditions	Yield
With ethanol In dichloromethane at 40℃; for 0.5h;	A n/a B 82%

: (4R*,5S*)-2,2,2-Triaethoxy-4,5-diphenyl-1,3,2λ5-oxazaphospholidin

A: 78-40-0
triethyl phosphate

trans-2,2-Diphenylaziridine: 25125-72-8
trans-2,2-Diphenylaziridine

Conditions

Conditions	Yield
With ethanol In dichloromethane at 40℃; for 0.5h;	A n/a B 82%

: 64-17-5
ethanol

(1,1,1-trichloromethyl)phosphonic acid diisopropyl ester: (1,1,1-trichloromethyl)phosphonic acid diisopropyl ester

: 762-04-9
phosphonic acid diethyl ester

A: 78-40-0
triethyl phosphate

B: 55696-11-2
dichloromethylphosphonic acid diisopropyl ester

Conditions

Conditions	Yield
With triethylamine at 20℃;	A n/a B 82%

...Expand

: 64-17-5
ethanol

: 53582-73-3
di-n-propyl trichloromethylphosphonate

: 762-04-9
phosphonic acid diethyl ester

A: 78-40-0
triethyl phosphate

B: 56973-22-9
O,O-di-n-propyl 1,1-dichloromethylphosphonate

Conditions

Conditions	Yield
With triethylamine at 20℃;	A n/a B 81%

...Expand

: 106-45-6
para-thiocresol

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 4143-38-8
thiophosphoric acid O,O'-diethyl ester S-p-tolyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; Reagent/catalyst;	A 12% B 81%

...Expand

: 615-41-8
2-iodochlorobenzene

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 28036-18-2
2-Chlorphenylphosphonsaeurediethylester

Conditions

Conditions	Yield
With Pd/C (30%) at 175℃; for 12h; Inert atmosphere; Dean-Stark;	A n/a B n/a C 80%

...Expand

: 64-17-5
ethanol

A: 78-40-0
triethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With phosphorous; CuCl2bpy3 In N,N-dimethyl-formamide at 50℃; Electrolysis;	A 79.3% B 5.4% C 15.3%
With phosphorous; CuCl2bpy3 In acetonitrile at 50℃; Electrolysis;	A 55% B 15.5% C 29.5%
With phosphorous; CuCl2bpy3 at 50℃; Electrolysis;	A 28.5% B 17.5% C 16%

...Expand

: 1474-78-8
triethyl phosphonoformate

A: 78-40-0
triethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

Conditions

Conditions	Yield
at 395℃; for 8h;	A 79% B 8%

: 64-17-5
ethanol

: 5887-93-4
trichloromethyl-phosphonic acid dibutyl ester

: 762-04-9
phosphonic acid diethyl ester

A: 78-40-0
triethyl phosphate

B: 66703-06-8
C9H19Cl2O3P

Conditions

Conditions	Yield
With triethylamine at 20℃;	A n/a B 79%

...Expand

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 762-04-9, 123-22-8
Diethyl phosphonate

Conditions

Conditions	Yield
With Oxone In tetrahydrofuran; methanol Ambient temperature;	A 78% B n/a

: 2-(bromo(phenyl)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 1080-32-6
O,O-diethyl benzylphosphonate

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 130℃; for 0.5h; Inert atmosphere;	A n/a B 76% C n/a

...Expand

: 1379148-12-5
diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 1379148-13-6
diethyl (7,13-dioxo-13,13a-dihydro-7H-benzo[de]indolo[2,1-a]isoquinolin-13a-yl)phosphonate

C: 1379148-15-8
diethyl 7-oxo-7H-benzo[de]indolo[2,1-a]isoquinolin-13-ylphosphate

D: 1379148-14-7
C27H31NO9P2

Conditions

Conditions	Yield
In toluene at 115℃; for 17h;	A n/a B 75% C 5% D 10 %Spectr.

...Expand

: 78-40-0
triethyl phosphate

: 33821-94-2
3-bromopropyltetrahydropyranylether

: 117144-98-6
[3-(Tetrahydro-pyran-3-yloxy)-propyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 175℃; for 5h;	100%

: 78-40-0
triethyl phosphate

: 154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline

: 154057-57-5
diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate

Conditions

Conditions	Yield
In toluene for 12h; Heating;	100%

: 78-40-0
triethyl phosphate

: zirconium(IV)

: zirconiumoxide ethylphosphate

Conditions

Conditions	Yield
In sulfuric acid precipitation of zirconiumoxide ethylphosphate from 3.6n H2SO4 solution, heating 12-15 hours;;	100%
In sulfuric acid precipitation of zirconiumoxide ethylphosphate from boiling heat;;
In sulfuric acid hydrolysis of a 0.1 mol Zr containing 6n H2SO4 solution with 375 ml (C2H5)3PO4 per mol ZrO2;; precipitation after heating for 5-6 hours;

: 78-40-0
triethyl phosphate

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 54965-29-6
6-(diethoxyphosphoryl)hexanoic acid ethyl ester

Conditions

Conditions	Yield
at 160℃; for 14h; Inert atmosphere;	100%

: 78-40-0
triethyl phosphate

: 823-78-9
meta-bromobenzyl bromide

: 128833-03-4
P-[(3-bromophenyl)methyl]phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 160℃; for 2h;	100%

: 78-40-0
triethyl phosphate

: 3001-72-7
DBN

: 1,5-diazabicyclo[4.3.0]-5-nonenium diethylphosphate

Conditions

Conditions	Yield
Stage #1: triethyl phosphate With diethylamine at 125℃; for 30h; Stage #2: DBN	99.7%

: 78-40-0
triethyl phosphate

: 109-89-7
diethylamine

: 5802-75-5
diethylammonium diethylphosphate

Conditions

Conditions	Yield
at 125℃; for 30h;	99.7%

: 848906-02-5
1,2,3,4-tetramethylimidazolium methyl carbonate

: 78-40-0
triethyl phosphate

: 1,2,3,4-tetramethylimidazolium diethylphosphate

Conditions

Conditions	Yield
Stage #1: triethyl phosphate With diethylamine at 125℃; for 30h; Stage #2: 1,2,3,4-tetramethylimidazolium methyl carbonate In methanol Reagent/catalyst;	99.5%

: 78-40-0
triethyl phosphate

: 109-89-7
diethylamine

: 5802-76-6
diethyl triethylammonium phosphate

Conditions

Conditions	Yield
at 125℃; for 30h;	99.5%

: 616-47-7
1-methyl-1H-imidazole

: 78-40-0
triethyl phosphate

: 3-ethyl-1-methylimidazol-3-ium diethyl phosphate

Conditions

Conditions	Yield
In water at 130℃; for 14h;	99%
at 100℃; for 36h;	97.3%
at 140℃; Inert atmosphere;

: 78-40-0
triethyl phosphate

: 877-88-3
3,5-dimethoxybenzyl bromide

: 108957-75-1
diethyl 3,5-dimethoxybenzylphosphonate

Conditions

Conditions	Yield
at 160℃; for 4h;	99%
at 120℃; for 10h;	95%
at 160℃; for 4h;	95%

: 78-40-0
triethyl phosphate

: 17162-77-5
β-ethoxyvinyldichlorophosphine

: ((2-ethoxyvinyl)-bis(phosphonato)phosphine)

Conditions

Conditions	Yield
In toluene Michaelis-Arbuzov Synthesis; Schlenk technique; Inert atmosphere;	99%

: 78-40-0
triethyl phosphate

: 74-88-4
methyl iodide

: 683-08-9
Diethyl methylphosphonate

Conditions

Conditions	Yield
at 60℃; for 4h;	99%

: 78-40-0
triethyl phosphate

: 1,2,3,4-tetramethylimidazolinium methyl carbonate

: 1,2,3,4-tetramethylimidazolinium diethyl phosphate salt

Conditions

Conditions	Yield
In methanol at 120℃; under 7500.75 Torr; for 36h;	99%

: 78-40-0
triethyl phosphate

: monomethyl carbonate N-picoline salt

: diethyl phosphate N-picoline salt

Conditions

Conditions	Yield
In methanol at 80℃; under 15001.5 Torr; for 48h;	98.7%

: 78-40-0
triethyl phosphate

: N-methylpyrrollium monomethyl carbonate salt

: diethyl phosphate N-methylpyrrollium salt

Conditions

Conditions	Yield
In methanol at 130℃; under 7500.75 Torr; for 36h;	98.7%

: 67-56-1
methanol

: 78-40-0
triethyl phosphate

: triethyl hydrazine monomethyl methyl carbonate

: diethyl phosphate methyl triethyl hydrazine

Conditions

Conditions	Yield
at 100℃; under 7500.75 Torr; for 36h;	98.2%

...Expand

: 78-40-0
triethyl phosphate

: 839-90-7
1,3,5-tris(2-hydroxyethyl)-S-triazine-2,4,6-trione

: C15H27N3O11P2

Conditions

Conditions	Yield
With sodium carbonate at 78 - 200℃; Temperature;	98.07%

: 78-40-0
triethyl phosphate

: 93345-12-1
4-(3,4-Dichloro-benzenesulfonylamino)-benzenesulfonyl azide

: 93345-13-2
C18H23Cl2N2O7PS2

Conditions

Conditions	Yield
In toluene at 0℃;	98%

: 78-40-0
triethyl phosphate

: 939-26-4
2-bromomethylnaphthyl bromide

: 57277-25-5
(naphthalen-2-ylmethyl)phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 140℃; for 12h;	98%

: 78-40-0
triethyl phosphate

: 60792-57-6
3-methyl-1-oxo-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile

: 121105-88-2
5-ethyl-3-methyl-1-oxo-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate for 1h; Heating;	98%

: potassium [14C]formate

: 78-40-0
triethyl phosphate

: 41279-20-3
ethyl <1-14C>formate

Conditions

Conditions	Yield
for 0.333333h; microwave irradiation;	98%

: 78-40-0
triethyl phosphate

: 811-73-4
trimethylstannyl iodide

: O,O'-diethyl-O''-trimethylstannyl phosphate

Conditions

Conditions	Yield
In further solvent(s) byproducts: C2H5I; to (EtO)3PO Me3SnI added, stirred at 85°C; volatiles removed, residue crystalized; elem. anal.;	98%
In 1,4-dioxane Kinetics; byproducts: C2H5I; (EtO)3PO and Me3SnI in dioxane mixad, 85°C, sealed tube; not isolated, detected by NMR;

: 78-40-0
triethyl phosphate

: 1493-13-6
trifluorormethanesulfonic acid

: triethoxy(hydroxy)phosphonium trifluoromethanesulfonate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	98%

: 895550-03-5
2-(bromomethyl)-3-methylbenzo[b]thiophene

: 78-40-0
triethyl phosphate

: 957059-39-1
(3-methylbenzo[b]thiophen-2-ylmethyl)phosphonic acid diethyl ester

Conditions

Conditions	Yield
In toluene for 18h; Arbuzov reaction; Reflux;	98%

: 78-40-0
triethyl phosphate

: 62601-06-3
sodium 1-(13)C-propionate

: 78217-95-5
Propanoic-1-13C Acid Ethyl Ester

Conditions

Conditions	Yield
1.) reflux, 3.5 h;	97%
for 3.5h; Heating;	97%

Triethyl Phosphate History

Triethyl phosphate was firstly studied by a French chemist named Jean Louis Lassaigne in the early 1800s.

Triethyl Phosphate Specification

1. Introduction of Triethyl Phosphate
Triethyl Phosphate, its synonyms are Phosphoric acid, triethyl ester; Tris(ethyl) phosphate; Triethylfosfat; TEP; Triethoxyphosphine oxide; Ethyl phosphate. Triethyl phosphate is a colorless liquid.

2. Properties of Triethyl Phosphate
Water Solubility: soluble
Density: 1.066 g/cm3
Flash Point: 115.6 °C
Enthalpy of Vaporization: 43.72 kJ/mol
Boiling Point: 219.3 °C at 760 mmHg
Vapor pressure: 1 mm Hg ( 40 °C)
Melting Point: -56 °C
Vapour Pressure of Triethyl Phosphate (CAS NO.78-40-0): 0.177 mmHg at 25 °C
Classification Code: Mutation data; Reproductive Effect; Skin / Eye Irritant
Product Categories: Organics;Functional Materials;Phosphates (Plasticizer);Plasticizer

3. Structure Descriptors of Triethyl Phosphate
Canonical SMILES: P(OCC)(OCC)(OCC)=O
InChI: InChI=1/C6H15O4P/c1-4-8-11(7,9-5-2)10-6-3/h4-6H2,1-3H3

4. Toxicity of Triethyl Phosphate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	800mg/kg (800mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.
guinea pig	LD50	oral	1600mg/kg (1600mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.
guinea pig	LD50	skin	> 20mL/kg (20mL/kg)		National Technical Information Service. Vol. OTS0528351,
mouse	LC	inhalation	> 44300ug/m3/4 (44.3mg/m3)		"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.
mouse	LD50	intraperitoneal	485mg/kg (485mg/kg)		Therapie. Vol. 15, Pg. 237, 1960.
mouse	LD50	oral	1180mg/kg (1180mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.
rat	LCLo	inhalation	28000ppm/6H (28000ppm)		American Industrial Hygiene Association Journal. Vol. 34, Pg. 286, 1973.
rat	LD50	intraperitoneal	800mg/kg (800mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.
rat	LD50	oral	1165mg/kg (1165mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.
rat	LDLo	intravenous	1gm/kg (1000mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Nature. Vol. 179, Pg. 154, 1957.

5. Safety Information of Triethyl Phosphate
Hazard Codes:

Xn
Risk Statements: 22
R22: Harmful if swallowed.
Safety Statements: 25
S25: Avoid contact with eyes.
WGK Germany: 1
RTECS of Triethyl Phosphate: TC7900000

6. Use of Triethyl Phosphate
Triethyl Phosphate, its primary uses are as an industrial catalyst, a polymer resin modifier, and a plasticizer (eg. for unsaturated polyesters). In smaller scale it is used as a solvent for eg. cellulose acetate, flame retardant, an intermediate for pesticides and other chemicals, stabilizer for peroxides, a strength agent for rubber and plastic including vinyl polymers and unsaturated polyesters, etc. It is is also a common intermediate in the manufacture of pesticides. Triethyl phosphate is also a common intermediate in the manufacture of pesticides.

Product Name

Triethyl phosphate

Synthetic route

Triethyl Phosphate History

Triethyl Phosphate Specification

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