p-Toluenesulfonamide supplier

Name
p-Toluenesulfonamide
EINECS 200-741-1
CAS No. 70-55-3
Article Data465
CAS DataBase
Density 1.271 g/cm³
Solubility 0.32 g/100ml (25 °C) in water
Melting Point 134-137 °C(lit.)
Formula C₇H₉NO₂S
Boiling Point 322.2 °C at 760 mmHg
Molecular Weight 171.22
Flash Point 148.6 °C
Transport Information
Appearance White crystalline powder
Safety 26-36
Risk Codes 36-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms p-Toluenesulfonamide(8CI);4-Methylbenzenesulfonamide;4-Methylphenylsulfonamide;4-Tolylsulfonamide;Benzenesulfonamide,4-methyl-;Plasticizer 15;Toluene-4-sulfonamide;Tolylsulfonamide;Topcizer 1S;Tosylamide;Uniplex 173;p-Methylbenzenesulfonamide;p-Tolylsulfonamide;p-Tosylamide;
PSA 68.54000
LogP 2.42350

Synthetic route

: 941-55-9
4-toluenesulfonyl azide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With C36H55N2Pd(2+)C7H7NO2S(2-); hydrogen In benzene-d6 at 75℃; for 12h; Temperature; Time;	100%
With iron(III) oxide; hydrazine hydrate In water at 120℃; for 1.5h; Inert atmosphere;	99%
With D-glucose; potassium hydroxide In water at 85℃; for 0.0833333h; Green chemistry; chemoselective reaction;	99%

: 78727-83-0
N-(p-tolylsulfonyl)diphenyltellurimide

: 88-89-1
2,4,6-Trinitrophenol

A: 70-55-3
toluene-4-sulfonamide

B: 107590-68-1
bis oxide

Conditions

Conditions	Yield
In diethyl ether; dichloromethane for 0.5h;	A 78% B 100%

...Expand

: N-(2,3-dimethylbut-2-enyl)-4-methylbenzenesulfonamide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; for 1h;	100%
With triethylsilane; trifluoroacetic acid In dichloromethane for 1h;	100%

: 603-35-0
triphenylphosphine

A: 70-55-3
toluene-4-sulfonamide

B: 1058-14-6
N-p-tolylsulfonylphosphine imide

Conditions

Conditions	Yield
With [(tris[2-{N-tetramethylguanidyl}ethyl]amine)CoII-[N-(p-toluenesulfonyl)imino](2-tert-butylsulfonyl)phenyliodinane](OTf)2 In acetone at -40℃; Kinetics; Reagent/catalyst; Time; Inert atmosphere;	A n/a B 100%

: 55962-05-5
[N-(p-tolylsulfonyl)imino]phenyliodinane

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With 1,3-dihydroisobenzofuran; manganese(ll) chloride In acetonitrile at 20℃; for 12h; Reagent/catalyst; Inert atmosphere;	100%
With iodine; benzene In dichloromethane at 20℃; for 24h; Mechanism; Inert atmosphere;	99%

: 319-89-1
tetrahydroxy-1,4-quinone

A: 1202-36-4
diphenyl telluride

B: 527-31-1
hexaketocyclohexane

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With N-(p-tolylsulfonyl)diphenyltellurimide In methanol for 0.5h; Ambient temperature;	A 97% B 88% C 99%

...Expand

: 32294-60-3
diphenyl ditelluride

: 62486-35-5
Te,Te-di(p-methoxyphenyl)-N-(p-tolylsulfonyl)tellurimide

A: 4456-34-2
bis(4-methoxyphenyl)telluride

B: 70-55-3
toluene-4-sulfonamide

C: 116161-54-7
N,N-bis(phenyltelluro)-p-toluenesulfonamide

Conditions

Conditions	Yield
In chloroform for 5h; Ambient temperature;	A 97% B 98% C 99%

...Expand

: 62486-35-5
Te,Te-di(p-methoxyphenyl)-N-(p-tolylsulfonyl)tellurimide

A: 4456-34-2
bis(4-methoxyphenyl)telluride

B: 70-55-3
toluene-4-sulfonamide

C: 116161-54-7
N,N-bis(phenyltelluro)-p-toluenesulfonamide

Conditions

Conditions	Yield
With diphenyl ditelluride In chloroform Ambient temperature;	A 97% B 98% C 99%

...Expand

: 52867-19-3
diphenyl-N-(p-toluenesulfonyl)selenimide

: 108-98-5
thiophenol

A: 1132-39-4
diphenylselenide

B: 70-55-3
toluene-4-sulfonamide

C: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
In chloroform for 0.25h; Product distribution; Ambient temperature;	A 96% B 99% C 97%

...Expand

: 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide

: 108-98-5
thiophenol

A: 1842-38-2
dibenzyl selenide

B: 70-55-3
toluene-4-sulfonamide

C: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
In chloroform for 0.166667h; Product distribution; Ambient temperature;	A 98% B 99% C 97%

...Expand

: 52867-19-3
diphenyl-N-(p-toluenesulfonyl)selenimide

: 100-53-8
phenylmethanethiol

A: 150-60-7
dibenzyl disulphide

B: 1132-39-4
diphenylselenide

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
In chloroform for 0.666667h; Product distribution; Ambient temperature;	A 98% B 97% C 99%

...Expand

: 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide

: 100-53-8
phenylmethanethiol

A: 150-60-7
dibenzyl disulphide

B: 1842-38-2
dibenzyl selenide

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
In chloroform for 0.333333h; Product distribution; Ambient temperature;	A 98% B 99% C 98%

...Expand

: 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide

: 102-08-9
N,N-diphenylthiourea

A: 1842-38-2
dibenzyl selenide

B: 70-55-3
toluene-4-sulfonamide

C: 622-16-2
1,3-Diphenylcarbodiimide

Conditions

Conditions	Yield
In methanol for 0.5h; Mechanism; Ambient temperature;	A 99% B 98% C 76%

...Expand

: 106-45-6
para-thiocresol

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
Stage #1: para-thiocresol With dihydrogen peroxide; zirconium(IV) chloride In acetonitrile at 25℃; Stage #2: With pyridine; ammonia In acetonitrile at 25℃; for 0.0333333h; chemoselective reaction;	99%
Stage #1: para-thiocresol With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; Stage #2: With pyridine; ammonia In water; acetonitrile at 25℃; for 0.0333333h;	97%
With tert.-butylhydroperoxide; ammonium hydroxide; iodine In water; acetonitrile at 100℃; for 16h;	86%

: 4917-56-0
N-formyl-N-tosylamide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In dichloromethane; water at 40℃; for 10h; Schlenk technique;	99%

: 98-59-9
p-toluenesulfonyl chloride

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With ammonia; sodium hydrogencarbonate In water; acetone at 25℃; Schotten-Baumann Reaction; Flow reactor; Combinatorial reaction / High throughput screening (HTS);	98%
With sodium isocyanate In water for 0.166667h; Reflux;	97%
With ammonium hydroxide In tetrahydrofuran at 0 - 20℃;	96%

: 319-89-1
tetrahydroxy-1,4-quinone

A: 118-76-3
rhodizonic acid

B: 4456-34-2
bis(4-methoxyphenyl)telluride

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With Te,Te-di(p-methoxyphenyl)-N-(p-tolylsulfonyl)tellurimide In methanol for 0.25h; Ambient temperature;	A 89% B 98% C 98%

...Expand

: 355-80-6
2,2,3,3,4,4,5,5-octafluoropentan-1-ol

: 80920-02-1
Sb,Sb,Sb-tripropyl-N-(p-tolylsulfonyl)stibine imide

A: 70-55-3
toluene-4-sulfonamide

B: 80927-38-4
bis(octafluoropentaloxy)tripropylantimony

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 35 - 37℃;	A 98% B 83%

...Expand

: 32294-60-3
diphenyl ditelluride

: 78727-83-0
N-(p-tolylsulfonyl)diphenyltellurimide

A: 1202-36-4
diphenyl telluride

B: 70-55-3
toluene-4-sulfonamide

C: 116161-54-7
N,N-bis(phenyltelluro)-p-toluenesulfonamide

Conditions

Conditions	Yield
In chloroform Ambient temperature;	A 95% B 96% C 98%

...Expand

: 13150-76-0
N-[(4-methylphenyl)sulfonyl]-S,S-diphenyl-sulfilimine

A: 139-66-2
diphenyl sulfide

B: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With sodium tetrahydroborate; meso-tetraphenylporphyrin iron(III) chloride In ethanol; benzene at 25℃; for 0.1h;	A 98% B n/a

: 24698-06-4
C19H16N2O4S2

A: 952-97-6
4-nitrophenyl phenyl sulfide

B: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With 1-Benzyl-1,4-dihydronicotinamide; meso-tetraphenylporphyrin iron(III) chloride In benzene at 25℃; for 0.1h; NaBH4;	A 98% B n/a
In neat (no solvent) at 300℃; for 2h;

: 78727-83-0
N-(p-tolylsulfonyl)diphenyltellurimide

A: 1202-36-4
diphenyl telluride

B: 70-55-3
toluene-4-sulfonamide

C: 116161-54-7
N,N-bis(phenyltelluro)-p-toluenesulfonamide

Conditions

Conditions	Yield
With diphenyl ditelluride In chloroform Ambient temperature;	A 95% B 96% C 98%

...Expand

: 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide

: 17356-08-0
thiourea

A: 420-04-2
CYANAMID

B: 1842-38-2
dibenzyl selenide

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
In methanol for 0.5h; Mechanism; Ambient temperature;	A 72% B 98% C 98%

...Expand

: 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide

: 2227-79-4
benzenecarbothioamide

A: 1842-38-2
dibenzyl selenide

B: 70-55-3
toluene-4-sulfonamide

C: 100-47-0
benzonitrile

Conditions

Conditions	Yield
In methanol for 0.5h; Mechanism; Ambient temperature;	A 98% B 98% C 81%

...Expand

: C25H22NO2S2(1+)*ClO4(1-)

A: 127-63-9
diphenyl sulphone

B: S,S,S-triphenyloxosulfonium perchlorate

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water for 1h; Ambient temperature;	A 20% B 77% C 98%

...Expand

: 103-19-5
di(p-tolyl) disulfide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
Stage #1: di(p-tolyl) disulfide With dihydrogen peroxide; zirconium(IV) chloride In acetonitrile at 25℃; Stage #2: With pyridine; ammonia In acetonitrile at 25℃; for 0.0166667h; chemoselective reaction;	98%

: 78388-16-6
N-(9-phenyl-9-fluorenyl)toluenesulfonamide

: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With chlorotriisopropylsilane; trifluoroacetic acid In dichloromethane for 0.25h;	98%

: 91-01-0
1,1-Diphenylmethanol

A: 574-42-5
benzhydryl ether

B: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With N-sulfinyl-p-toluenesulfonamide In diethyl ether at 25℃; for 20h;	A 94% B 97%

: 599-67-7
1,1-diphenylethanol

A: 530-48-3
1,1-Diphenylethylene

B: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
In toluene for 20h; Heating;	A 507 mg B 97%

: N-(p-tolylsulfonyl)(diacetylmethyl)-o-nitrophenylsulfimide

A: 70-55-3
toluene-4-sulfonamide

B: 112128-28-6
diacetylmethyl o-nitrophenyl sulfoxide

Conditions

Conditions	Yield
With sulfuric acid for 2h; Heating;	A 97% B 62%

: 24424-99-5
di-tert-butyl dicarbonate

: 70-55-3
toluene-4-sulfonamide

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dmap; triethylamine In 1,2-dichloro-ethane at 20℃;	100%
With dmap; triethylamine In dichloromethane at 20℃;	98%
With N,N,N',N'-tetramethylguanidinium acetate at 20℃; for 0.5h; Neat (no solvent);	94%

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 70-55-3
toluene-4-sulfonamide

: 17639-64-4
N-p-toluenesulfonylpyrrole

Conditions

Conditions	Yield
With phosphorus pentoxide In toluene at 110℃; for 0.333333h;	100%
With scandium tris(trifluoromethanesulfonate) In 1,4-dioxane at 100℃; for 0.666667h; Clauson-Kaas condensation;	95%
With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 2h;	90%

: 56234-52-7
1,8-bis(p-toluenesulfonyloxy)-3,6-bis(p-toluenesulfonyl)-3,6-diazaoctane

: 70-55-3
toluene-4-sulfonamide

: 52667-89-7
N,N',N-tris(p-toluenesulfonyl)-1,4,7-triazacyclononane

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 240h; Cyclization; Heating;	100%
With potassium carbonate In acetonitrile for 144h; Heating;	97%

: 100-52-7
benzaldehyde

: 70-55-3
toluene-4-sulfonamide

: 98-83-9
isopropenylbenzene

: 258851-74-0
N-(1,3-diphenylbut-3-en-1-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; ytterbium(III) triflate In tetrahydrofuran; dichloromethane at 20℃; for 1h;	100%
With trimethylsilyl trifluoromethanesulfonate; ytterbium(III) triflate In tetrahydrofuran; dichloromethane at 20℃; for 1h;	92%
With trimethylsilyl trifluoromethanesulfonate; ytterbium(III) triflate In tetrahydrofuran; dichloromethane at 20℃; for 1h; Condensation; imino ene reaction;	90%

...Expand

: 70-55-3
toluene-4-sulfonamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: N,N-Dimethyl-N'-<(4-methylphenyl)sulfonyl>formamidine

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Heating;	100%

: 7632-57-7
diphenylmethylenecyclopropene

: 70-55-3
toluene-4-sulfonamide

: N,N-bis-(2-benzhydryl-allyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With palladium diacetate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In toluene at 110℃; for 3h;	100%

: 28228-81-1
bis(p-methoxyphenyl)methylenecyclopropane

: 70-55-3
toluene-4-sulfonamide

: N,N-bis-{2-[bis-(4-methoxy-phenyl)-methyl]-allyl}-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With palladium diacetate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In toluene at 115℃; for 3h;	100%

: 70-55-3
toluene-4-sulfonamide

: methylheptylmethylenecyclopropane

: 4-methyl-N,N-bis-[2-(1-methyl-octyl)-allyl]-benzenesulfonamide

Conditions

Conditions	Yield
With palladium diacetate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In toluene at 110℃; for 8h;	100%

: 70-55-3
toluene-4-sulfonamide

: 88284-48-4
2-(trimethylsilyl)phenyl trifluoromethanesulfonate

: 4703-19-9
N,N-diphenyl-p-toluenesulfonamide

Conditions

Conditions	Yield
With cesium fluoride In acetonitrile at 20℃; for 24h;	100%

: 1125-88-8
benzaldehyde dimethyl acetal

: 70-55-3
toluene-4-sulfonamide

: 51608-60-7
N-(benzylidene)-p-methylbenzenesulfonamide

Conditions

Conditions	Yield
at 170℃;	100%
at 170℃;	95%
at 180℃; for 0.75h;	91%
at 120 - 130℃; for 4h;	82%
at 150℃; for 2h;

: 459-57-4
4-fluorobenzaldehyde

: 70-55-3
toluene-4-sulfonamide

: 193675-43-3
N-(4-fluorobenzylidene)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With Amberlyst(R) 15 ion-exchange resin In toluene for 16h; Inert atmosphere; Reflux; Molecular sieve;	100%
With amberlyst 15 In toluene for 16h; Heating; Molecular sieve;	98%
With Amberlyst 15 In toluene for 12h; Molecular sieve; Reflux; Dean-Stark;	98%

: 1203-68-5
2-Phenylbenzaldehyde

: 70-55-3
toluene-4-sulfonamide

: 1292302-62-5
N-(2-phenylbenzylidene)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With boron trichloride - methyl sulfide complex In toluene at 20℃; for 7.5h;	100%
With copper diacetate In toluene Reflux;	97%
With tetraethoxy orthosilicate Heating;	47%

: 70-55-3
toluene-4-sulfonamide

: 110046-51-0
hept-6-en-1-yl 4-methylbenzenesulfonate

: 1353723-21-3
N-(hept-6-en-1-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 15h; Inert atmosphere; Reflux;	100%

: 1469876-14-9
3-(trifluoromethyl)dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate

: 70-55-3
toluene-4-sulfonamide

: 1469876-08-1
9-tosyl-2-(trifluoromethyl)-9H-carbazole

Conditions

Conditions	Yield
With copper diacetate; sodium carbonate In ethylene glycol; isopropyl alcohol at 90℃; for 16h; Inert atmosphere;	100%
With copper diacetate; sodium carbonate; ethylene glycol In isopropyl alcohol at 85℃; for 16h; Ullmann Condensation; Inert atmosphere;	55%
With copper diacetate; sodium carbonate In ethylene glycol; isopropyl alcohol for 16h; Inert atmosphere; Reflux; Green chemistry;

: 189999-35-7
[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate

: 70-55-3
toluene-4-sulfonamide

: 3165-71-7
9-tosyl-9H-carbazole

Conditions

Conditions	Yield
With copper diacetate; sodium carbonate In ethylene glycol; isopropyl alcohol at 90℃; for 16h; Inert atmosphere;	100%
With copper diacetate; sodium carbonate; ethylene glycol In isopropyl alcohol at 85℃; for 16h; Ullmann Condensation; Inert atmosphere;	60%
With copper diacetate; sodium carbonate In ethylene glycol; isopropyl alcohol for 16h; Inert atmosphere; Reflux; Green chemistry;

: 124-19-6
nonan-1-al

: 70-55-3
toluene-4-sulfonamide

: N-octylidene-p-toluenesulfonamide

Conditions

Conditions	Yield
With anthranilic acid In dichloromethane at 60℃; for 24h; Molecular sieve;	100%

: 51410-45-8
estragole oxide

: 70-55-3
toluene-4-sulfonamide

: N-(2-hydroxy-3-(4-methoxyphenyl)propyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 6h;	100%
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 5h;	98%

: 3095-95-2
diethylphosphonoacetic acid

: 70-55-3
toluene-4-sulfonamide

: 2-(diethoxyphosphoryl)-N-(p-toluenesulfonyl)ethanamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 71h; Inert atmosphere;	100%

: 4373-13-1
4-methyl-1,2-dihydronaphthalene

: 100-52-7
benzaldehyde

: 70-55-3
toluene-4-sulfonamide

: N-(2-(3,4-dihydronaphthalen-1-yl)-1-phenylethyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; ytterbium(III) triflate In tetrahydrofuran; dichloromethane at 20℃; for 0.0166667h;	100%

...Expand

: 70-55-3
toluene-4-sulfonamide

: N-d2-p-toluenesulfonamide

Conditions

Conditions	Yield
With deuteromethanol for 5h; Sealed tube; Inert atmosphere;	100%

: 1829-26-1
1-acetoxy-1,2-benziodoxol-3-one

: 70-55-3
toluene-4-sulfonamide

: Zhdankin’s reagent

Conditions

Conditions	Yield
Stage #1: 1-acetoxy-1,2-benziodoxol-3-one With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: toluene-4-sulfonamide In dichloromethane at 20℃; for 3h; Inert atmosphere;	100%

: 13513-82-1
1-(2-methoxyphenyl)ethanol

: 70-55-3
toluene-4-sulfonamide

A: 93027-83-9
N-(1-(2-methoxyphenyl)ethyl)-4-methylbenzenesulfonamide

B: 859312-83-7
di[1-(2-methoxyphenyl)ethyl]ether

Conditions

Conditions	Yield
With acidic mesoporous zeolite β-catalyst In 1,2-dichloro-ethane at 80℃; for 6h; Sealed tube; Inert atmosphere;	A 100% B n/a

...Expand

: 32293-73-5
α-methyl-4-(methylthio)benzenemethanol

: 70-55-3
toluene-4-sulfonamide

A: 1-(4-methylthiophenyl)-1-(p-toluenesulfonamido)ethane

B: C18H22OS2

Conditions

Conditions	Yield
With acidic mesoporous zeolite β-catalyst In 1,2-dichloro-ethane at 80℃; for 6h; Sealed tube; Inert atmosphere;	A 100% B n/a

...Expand

: 885-77-8
4,4'-dimethylbenzhydrol

: 70-55-3
toluene-4-sulfonamide

A: 37858-01-8
bis[bis(p-tolyl)methyl] ether

B: 1581274-94-3
C22H23NO2S

Conditions

Conditions	Yield
With acidic mesoporous zeolite β-catalyst In 1,2-dichloro-ethane at 80℃; for 6h; Sealed tube; Inert atmosphere;	A n/a B 100%

...Expand

: 2373-89-9
4,4'-dimethoxychalcone

: 70-55-3
toluene-4-sulfonamide

: 2-bromo-1-(4'-methoxyphenyl)-3-(4-methoxyphenyl)-3-(p-toluenesulfonamido)propan-1-one

Conditions

Conditions	Yield
With N-Bromosuccinimide; aluminium In dichloromethane at 25℃; for 0.166667h; regioselective reaction;	99.8%
With N-Bromosuccinimide; silicon In dichloromethane at 25℃; for 1h; Aerobic conditions; stereoselective reaction;	98%
With N-Bromosuccinimide; copper In dichloromethane at 25℃; for 1h; stereoselective reaction;	97.5%
With N-Bromosuccinimide; potassium iodide In dichloromethane at 25℃; for 2h; Aerobic conditions; regioselective reaction;	97%

p-Toluenesulfonamide Chemical Properties

IUPAC Name: 4-Methylbenzenesulfonamide
Molecular Formula: C₇H₉NO₂S
Molecular Weight: 171.21 g/mol
SMILES: O=S(=O)(c1ccc(cc1)C)N Copy
InChI: InChI=1/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)
EINECS: 200-741-1
Classification Code: Drug / Therapeutic Agent; Mutation data
Product Categories: SULFONAMIDE; FINE Chemical & INTERMEDIATES; Organic Building Blocks; Sulfonamides / Sulfinamides; Sulfur Compounds
Melting Point: 134-137 °C(lit.)
Water Solubility: 0.32 g/100 mL (25 °C)
Index of Refraction: 1.564
Molar Refractivity: 43.81 cm³
Molar Volume: 134.6 cm³Surface Tension: 46.3 dyne/cm
Density: 1.271 g/cm³
Flash Point: 148.6 °C
Enthalpy of Vaporization: 56.4 kJ/mol
Boiling Point: 322.2 °C at 760 mmHg
Vapour Pressure of p-Toluenesulfonamide (CAS NO.70-55-3): 0.000285 mmHg at 25 °C

p-Toluenesulfonamide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	75mg/kg (75mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
guinea pig	LDLo	subcutaneous	2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.
mouse	LD50	intraperitoneal	250mg/kg (250mg/kg)		National Technical Information Service. Vol. AD691-490,

p-Toluenesulfonamide Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

p-Toluenesulfonamide Safety Profile

Poison by ingestion and intraperitoneal routes. Mutation data reported. Used as a fungicide. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36-20/21/22
R36:Irritating to eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 1
RTECS: XT5075000
PackingGroup of p-Toluenesulfonamide (CAS NO.70-55-3): III

p-Toluenesulfonamide Specification

p-Toluenesulfonamide (CAS NO.70-55-3), its Synonyms are 4-Toluenesulfonamide ; 4-Methylbenzenesulfonamide ; 4-Toluenesulfonic acid, amide ; Benzenesulfonamide, 4-methyl- ; Toluene-4-sulfonamide ; Toluene-p-sulphonamide ; Tolylsulfonamide ; para-Toluenesulfonamide . It is white crystalline powder.

Product Name

p-Toluenesulfonamide

Synthetic route

p-Toluenesulfonamide Chemical Properties

p-Toluenesulfonamide Toxicity Data With Reference

p-Toluenesulfonamide Consensus Reports

p-Toluenesulfonamide Safety Profile

p-Toluenesulfonamide Specification

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