The aim of this study was to assess the adverse effects of synthetic progestin norgestrel (NGT) on the reproduction of zebrafish by measuring the egg production, histology and transcriptional expression profiles along the hypothalamic-pituitary-gonadal (HPG) axis in adult zebrafish. After a pre-...

Synthetic hormones in wastewater effluents released into the aquatic environments may interfere with the normal endocrine systems of fish in receiving streams. Norgestrel (NGT) is a synthetic progestin widely used in oral contraceptives and frequently detected in wastewater effluents. In this st...

The fungal linoleate diol synthase (LDS) family contains over twenty characterized 8-, 9-, and 10-dioxygenases (DOX), usually fused to catalytically competent cytochromes P450. Crystal structures are not available, but indirect evidence suggests that linoleic acid enters the active site of 8R-DO...

New chiral dioxidomolybdenum(VI) complexes with tridentate Schiff base ligands obtained by monocondensation of 1R,2S(−)-norephedrine with salicylaldehyde and its derivatives were synthesized. The complexes were characterized by elemental analysis and by their IR, CD, UV–vis, one- (1H) and two-d...

A sensitive method has been developed for the determination of bismuth in urine using continuous flow hydride generation and atomic fluorescence spectrometry (HG AFS). The conditions for bismuth hydride generation as well as some instrumental parameters were optimized using univariate methodolog...

Hydride generation (HG) of bismuth was accomplished in non-aqueous media by using solid reductant of potassium borohydride (KBH4) as a derivation reagent. The riched micelle phase of surfactant Triton X-114 was used as the non-aqueous media for the chemical vapor generation (CVG), and atomic flu...

Between 2008 and 2011, four polar bears (Ursus maritimus) from the Greenland population swam and/or drifted on ice to Iceland where they arrived in very poor body condition. Body fat resources in these animals were only between 0% and 10% of the body weight (usually 25%). Here we studied the lip...

In order to study the effect of the double bonds geometry of linolenic acid (18:3 n-3) on its biological activities, (9Z,12Z,15E)- and (9E,12Z,15Z)-octadecatrienoic acids, found in many refined vegetable oils, were made by total synthesis. Synthesis of 18:3 Δ9c, 12c, 15t involves a Wittig react...

trans-4-Hydroxy-2-nonenal (HNE) is an aldehyde end-product of lipid peroxidation in biological systems which is capable of producing a range of powerful biological effects. We wish to describe a sensitive and selective strategy for the determination of HNE in biological samples. The method is ba...

Saturated and mono- and di-unsaturated aldehydes (C5C10) were converted into their 2,4-dinitrophenylhydrazones. The separation of nanogram amounts of these hydrazones was performed by high-performance liquid chromatography with C18 reversed-phase columns in an isocratic elution. Separation of ...

1.1. A participate enzyme fraction and an acetone powder preparation from cucumber fruits cleaved 9- and 13-hydroperoxyoctadecadienoic acids to form volatile aldehydes and oxoacid fragments.2.2. From the 9-hydroperoxide, the major volatile fragments were cis-3-nonenal and trans-2-nonenal using p...

Incubation of rat aorta and intestine in vitro with dl-α-methylbenzyl-[1-14C]-linoleamide (MBLA) results in the fairly selective formation of radioactive cholesterol esters and a radioactive complex between MBLA and free cholesterol. A much wider range of lipids is labelled after incubating liv...

Noberastine (NOB), a new histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. To evaluate the efficacy and safety of NOB in ragweed seasonal allergic rhinitis, 250 eligible patients were randomized to one of four parallel, double-blind treatment groups: NOB, 10, 2...

The double-ionization energies of the eight chlorofluoroethane molecules have been measured by double-charge-transfer spectrometry. Several peaks were observed in most of the spectra giving information about the energies required to populate electronically excited states (or groups of states) of...

The differences in the dynamic behaviour of 1,1,2-trichlorotrifluoroethane over fluorinated alumina or chromia catalysts at moderate temperatures are significant. Alumina-based catalysts favour the isomerization of CCl2FCClF2 followed by the dismutation of CCl3CF3 so formed. Fluorinated chromias...

Dismutation and isomerization of trichlorotrifluoroethanes have been investigated on a Cr2O3/C catalyst which is used for industrial fluorination of chlorofluoroethanes by hydrogen fluoride. Transformation of CCl2F-CClF2 shows a rapid dismutation into the other halocarbons and a slow isomerizati...

Ultraviolet absorption cross-sections of three chlorofluoroethanes (CH3CF2Cl - HCFC 142b, CH3CFCl2 - HCFC 141b and CF3CHCl2 - HCFC 123) are measured with uncertainties of 2%. These compounds are photodissociated in the stratosphere. But, as shown by a one-dimensional model calculation, a s...

A [36Cl] radiotracer study of the behaviour of 1,1,2-trichlorotrifluoroethane on β-aluminium(III) fluoride at elevated temperature indicates that the isomerisation of CCl2FCClF2 to CCl3CF3 occurs by an intramolecular process. Isomerisation is followed by dismutation of CCl3CF3 to give CCl2FCF3 ...

To search for effective and selective inhibitors of carboxylesterase (CaE), a series of 7-hydroxy-7-polyfluoroalkyl-4,7-dihydroazolo[5,1-c][1,2,4]triazines has been synthesized. Their inhibitory activity against acetylcholinesterase, butyrylcholinesterase, and CaE were investigated using the met...

Alkylation of 1H-6-methyl-3-phenyl-pyrazolo[5,1-c][1,2,4]triazole and 1H-7-ethoxycarbonyl-6-methyl-3-phenyl-pyrazolo[5,1-c][1,2,4]triazole using different alkylating agents leads regioselectively to 1-N-alkylated products. The hydrolysis–decarboxylation of 1,6-dimethyl-7-ethoxycarbonyl-pyrazolo...