An acid proteinase of granulomatous tissues in rats with carrageenin-induced inflammation released kinin from T-kininogen. The kinin isolated by n-butanol extraction was separated by reverse-phase high-performance liquid chromatography into T-kinin and a T-kinin derivative. From determination of...

High-pressure liquid chromatography capable of resolving all known vitamin D metabolites and a sensitive competitive binding protein assay specific for 1α,25-dihydroxyvitamin D3 were used to assay the blood of rats dosed with ethanol, 1α-hydroxyvitamin D3, 24R-hydroxy-25-fluorovitamin D3, or 1...

The alteration in the biologic activity of the vitamin D3 molecule resulting from the replacement of a hydrogen atom with a fluorine atom is a subject of fundamental interest. To investigate this problem we synthesized 3β -fluorovitamin D3 6 and its hydrogen analog, 3-deoxyvitarnin D3 7, and te...

We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3β, 22-diol-3β-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3β-acetate 3 and (E) 22-dehydrocholest-5-en-3β-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixt...

The molecular characterization of castor oil ethoxylates (CASEOs) was studied by reverse-phase liquid chromatography (RPLC) mass spectrometry (MS) and multistage mass spectrometry (MSn). The developed RPLC method allowed the separation of the various CASEO components, and especially, the baselin...

As the global need for drugs getting increases, the necessity of novel and effective drugs are the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The present study deals about the synthesis of precursors 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl) pyrim...

A novel effective method is reported for the preparation of 1-amino-1H-pyrazole-4-carboxylic acid derivatives by Fe(II)-catalyzed rearrangement of isoxazoles having (2,4-dinitrophenylhydrazono)methyl substituent at C4. The reaction proceeds smoothly for both E and Z isomers of 4-(hydrazonomethyl...

Three series of 3,7-bis(arylazo)-6-methyl-2-phenyl-1H-imidazo-[1,2-b]pyrazoles were prepared starting from N-aryl 2-oxo-2-phenylethanehydrazonoyl bromides and 5-amino-4-arylazo-3-methyl pyrazoles. The acid dissociation constants pK and pK∗ in both the ground and excited states, respectively, wer...

A simple, green and environmentally benign procedure was developed for the one pot synthesis of 3-methyl-1,4-diphenyl-1,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidine-6-one/thiones using catalytic amount of phthalimide-N-sulfonic acid (PISA) in 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) ionic ...

Publisher SummaryThis chapter deals with the chemistry of 4 and 5-aminoimidazoles, the compounds of recently recognized biological importance. In most living systems, 5-amino-1-(β-D-ribofuranosyl)-imidazole-5’-monophosphate (AIR) is an intermediate in the de novo biosynthesis of purine ribonuc...

The experimental data on the viscosity and thermal conductivity (TC) of ethylene glycol (EG)-based hybrid nanofluids (HyNFs) dispersed with a SiC–CuO/C nanocomposite (NC) is reported for the first time. The rheological behavior and dynamic viscosity have been analyzed with a computer controlled...

This study investigated the transdermal permeability of baicalin, a hydrophobic and readily hydrolyzed drug, delivered by glyceryl monooleate (GMO)-based cubic phase gel (CPG) mediated with Transcotol® P (TP, diethylene glycol monoethyl ether). A range of CPGs was produced by varying GMO, water,...

By means of an experiment a concentration technique of organic micropollutants in raw water has been developed. This technique is based on the continuous pump, from the river bed, of an unchanging flow of 2 l/h on various solid supports (activated carbon, XAD-2 resins). By means of solvent extra...

Copolymers based on d,l-lactide (D,L-LA) and ethylene brassylate, with EB molar contents ranging from 3 to 39%, were synthesized by ring-opening polymerization at 130 °C using triphenyl bismuth. The poly (D,L-LA-co-EB) presented a random distribution of sequences (R→1), resulting in a fully am...

Ring opening copolymerization of ethylene brassylate (EB) and δ-valerolactone (δ-VL) with various feeding ratios catalyzed by triphenyl bismuth was performed to prepare poly(ethylene brassylate-co-δ-valerolactone) copolyesters. The reactivity ratios of EB and δ-VL were firstly determined to ...

High-molecular-weight poly(ethylene brassylate-co-ε-caprolactone) copolyesters within a wide composition range were prepared via triphenyl bismuth catalyzed copolymerization of ethylene brassylate (EB) and ε-caprolactone (ε-CL) in bulk. Microstructural analysis of the resulting copolyesters d...

Poly(ethylene brassylate), a novel inexpensive biodegradable polyester, has been reinforced with cellulose nanocrystals (CNCs) with the aim of improving its thermal stability and mechanical properties. The composites have been characterized through calorimetry, tensile tests, thermogravimetry an...

Special proton-gradient-transfer acid complexes (PGTACs) in which the bonded protons are not equivalent and have gradients in transfer ability, acidity, and reactivity were reported. The acidity gradient of the protons gave the PGTACs excellent catalytic activity and selectivity in the esterific...

Geranyl acetate (1) was oxidized thermally and photochemically using (mcpba, H2O2) respectively to obtain (E)-5-(3, 3-dimethyloxiran-2-yl)-3-methylpent-2-enyl acetate (2) and 3-(2-(3, 3-dimethyloxiran-2-yl) ethyl)-3-methyloxiran-2-yl) methyl acetate (3). On the other hand, photooxygenation of 1 ...

The mixed-ligand complex [Cr(dpt)(ida)]ClO4·2H2O (dpt=di(3-aminopropyl)amine, H2ida=iminodiacetic acid) adopts a structure in which the ligands are tridentate and coordinate facially, with the imino nitrogen trans to the dpt secondary amine. Thus the preference of iminodiacetate for facial coor...