Three mononuclear copper(II) complexes (C1–C3) containing the ligand 2-(2-aminomethyl)pyridine (aep) and some modifications of it were designed to get insights on the influence of pendant second sphere groups (thiophene and benzene) on their physicochemical and catalytic properties. Complexes C...

Electrochemical oxidation of 3,5-di-tert-butylcatechol (1) has been studied in ethanol/water mixtures by means of cyclic voltammetry and controlled-potential coulometry. The results revealed that 3,5-di-tert-butyl-1,2-benenzoquinone (2) derived from oxidation of 3,5-di-tert-butylcatechol partici...

The functionalization of 3,5-di-tert-butylcatechol with a group CH2X in the 6th position (where the group X has the additional heteroatoms) was performed in order to prepare new functionalized 3,5-di-tert-butylcatechols of the common type (6-(CH2-X)-3,5-Cat)H2, where X is methoxy group (catechol...

The asymmetric reduction of achiral β-dialkyl-aminopropiophenones with LAH partly decomposed with (−)-menthol has been studied. The effects of the LAH/(−)-menthol ratio, the temperature, and the dialkylamino residue on the optical yield were investigated, and the absolute configurations of the ...

Irradiation of β-aminopropiophenones 1 leads to the formation of 2-aminocyclopropanols 2 which can undergo oxidative ring opening to give enaminones 3. The regioselectivity of cyclopropanol formation of the α-benzyl substituted 1 is determined by the preferred charge transfer interaction betwe...

The reduction by LAH of α-asymmetric-β-amino propiophenones is stereospecific and affords the erythro amino-alcohols as predominant diastereomers. The configurations of these amino-alcohols have been assigned by correlation of IR and NMR spectra, from which their preferred conformations have b...

In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic analysis. EGFR kinase inhibitory potencies...

The aim of this study was to clarify the restricted rotation around the CH2N bond of the compounds, 5-(2-(p-chlorophenylbenzimidazol-1-yl-methyl)-4-(o-methylphenyl)-2,4-dihydro-[1,2,4]-triazole-3 thione [1], 4-(o-florophenyl)- [2], 4-(o-chlorophenyl)- [3] and 4-(o-bromophenyl)- [4], which are so...

Complexes [Pd(Cl)(μ-Cl)(P(CCFc)R2)]2 (Fc = (η5-C5H4)(η5-C5H5); 6e, R = tBu; 6f, R = cC6H11) and [PdCl2(P(CCFc)R2)2] (7a, R = C6H5; 7b, R = 2-MeC6H4; 7c, R = 2,4,6-Me3C6H2; 7d, R = cC4H3O; 7e, R = tBu; 7f, R = cC6H11) are accessible by the reaction of P(CCFc)R2 (3a–f) with either [PdCl2(cod)]...

The aim of present study was to develop and validate a rapid, sensitive, inexpensive and reliable method for the detection of trace levels of acetaldehyde in peritoneal dialysis fluids (PDFs) by 2,4-dinitrophenylhydrazine (DNPH) derivatization and extraction. Separation and analysis of acetaldeh...

An off-line optimization technique based on soft modeling methods has been used to determine the optimum conditions for the separation of eight carbonyl-2,4-dinitrophenylhydrazones by gas chromatography equipped with a nitrogen–phosphorous detector. In this method theoretical simulations of pea...

Aldehyde-2,4-dinitrophenylhydrazones exist as (E)- and (Z)-geometrical isomers, and adventitious isomerization during sample preparation can cause analytical errors. Purified alkenal-2,4-dinitrophenylhydrazone derivatives comprise only the (E)-isomer. However, partial isomerization to the (Z)-is...

The most widely used method for qualitative and quantitative analysis of carbonyl compounds is the 2,4-dinitrophenylhydrazine method through the formation of 2,4-dinitrophenylhydrazone derivatives. However, this method may cause an analytical error because 2,4-dinitrophenylhydrazones have both E...

The quantitative analysis of ketones using DNPH is usually conducted in the presence of an acid catalyst. However, this method may cause an analytical error because 2,4-dinitrophenylhydrazones have both E- and Z-stereoisomers. Purified ketone-2,4-dinitrophenylhydrazone comprised only the E-isome...

1. Bioluminescence was measured in cells transferred from a light/dark cycle of 12: 12hr to constant darkness.2. Gonyaulax responded strongly and specifically to 5-methoxytryptamine and its analogue, N,N-dimethyl-5-methoxytryptamine. The reaction threshold for 5-methoxytryptamine was as low as 2...

We have tested by [35S]-GTPγS binding the intrinsic activity of three full agonists (serotonin, 5-methoxytryptamine and 5-methoxy-2-methyl-N,N-dimethyltryptamine) on rat 5-HT6 receptors cloned in HEK-293 cells, using the scintillation proximity assay.Serotonin and 5-methoxytryptamine are solubl...

The reaction of 5-amino-2,3-dicyano-1,4-naphthoquinone (1) with arylamines gave 5-amino-8-arylamino- (2), 5,8-bis(arylamino)- (3), and 5-hydroxy-8-arylamino-2,3-dicyano-1,4-naphthoquinone (4) together with 5-amino-2-arylamino-3-cyano- (5) and 5-amino-2-cyano-3-aryl-amino-1,4-naphthoquinone (6). ...

The utility of carbon paste modified with 2,3-dicyano 1,4-naphthoquinone (CYNQ) for the voltammetric determination of Ag(I) is demonstrated. The method is based on the formation of Ag(I) complex with CYNQ by accumulation from the aqueous solution to the electrode surface without an applied poten...

Molecular complexes of 2,3-dicyano-1,4-naphthoquinone with various aromatic anilines were studied spectrophotometrically in dichloromethane solvent at different temperatures. All these complexes show a new broad charge-transfer band in the visible region of the electromagnetic spectrum. All the ...

The electron donor–acceptor (EDA) interaction between 2,3-dicyano-1,4-naphthoquinone (DCNQ) and 3,4-dimethylaniline (3,4-DMA) is studied in chloroform, dichloromethane and 1:1 (v/v) mixture of chloroform and dichloromethane. The rate of formation of the product was measured as a function of tim...