A novel and efficient In(OTf)3 and HOAc cooperatively catalyzed hydration of 1-haloalkynes is described. This method provides ready access to α-chloromethyl ketones, α-bromomethyl ketones and α-iodomethyl ketones in moderate to high yields from simple, inexpensive starting materials. A broad ...

The first-ever Diels-Alder reactions of 3-alkenyl indoles with a conjugated alkynyl ketone are reported. These reactions proceed in an atom-economic manner without a catalyst and give various substituted 1-acetyl carbazoles in moderate to excellent yields. These products can be converted to 1-hy...

The huge waste sulfuric acid from isobutane/butene alkylation, which contains acid soluble oil and can lead environment pollution and waste of resources, is difficult to deal with. For the treatment of alkylation waste sulfuric acid, the process convert waste sulfuric acid into dilute sulfuric a...

Efficient encapsulation of paraquat and diquat herbicides by 4-sulfonatocalix[n]arene (n = 4, 6, 8) in water have been examined by Benesi Hilderbrandt equation which explicit 1:1 complexation of 4-sulfonatocalix[n]arene with paraquat and diquat. The binding constants have been calculated and 4-s...

A new integrable hierarchy related to a 4 × 4 matrix isospectral problem is proposed, in which the semi-discrete version of the coupled KdV system is the first member. Subsequently the N-fold Darboux transformation for the second member in the obtained hierarchy is constructed. As applications,...

Complex formation of mixed palladium (II) chloro-hydroxo and palladium(II) bromo-hydroxo complexes have been investigated employing spectrophotometry at 25 °C and an ionic strength of 1.0 M. Hyperquad Simulation and Speciation (HySS) was employed to determine the ideal titration conditions and ...

A novel metal-organic framework {[Zn2L2(bibp)2]·H2O}n (L = N,N′-bis(4-carbozylbenzyl)-4-aminotoluene)(MOF 1) was synthesized and characterized, the structure presenting an 8-fold interpenetrating diamondoid networks with [4+4] mode, which exhibits high thermostability and two kinds of intertwi...

A facile synthetic method for N-alkylated substituted benzochalcogenadiazoles is described. When treated with Meerwein salt, the 4-nitrobenzochalcogenadiazoles have undergone an N-alkylation to afford the expected salts as a mixture of two N1/N3 isomers in toluene. The regioselectivity of the al...

Monomeric, N-heterocyclic (NHC) carbene/carboxylato/gold(I) complex [Au(RS-pyrrld)(IPr)] (RS-Hpyrrld = RS-2-pyrrolidone-5-carboxylic acid; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) (1, 0.01 mmol) in a mixed solvent of 1,4-dioxane : water (4 : 1 v/v) showed high activity in the cata...

Thirteen amido functionalized N-heterocyclic carbene ligands were synthesized via a simple synthetic procedure. The synthesized ligands were characterized by NMR, FAB-MS and single crystal X-ray analysis, unanimously confirming the proposed structures. Subsequent complexation with a palladium pr...

A series of N-aryl (2a,b) or benzyl (2c,d) substituted piperidoimidazolinium salts and their palladium complexes (3a-d) were prepared and characterized by 1H, 13C NMR, IR spectroscopy and elemental analysis. The crystal structures of 3a and 3c have been determined by X-ray crystallography. Therm...

WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl)piperazinyl)ethyl))-N-(2-pyridinyl)cyclohexanecarboxamide] 1 and its O-desmethyl derivative DWAY 2 are well-known high affinity 5-HT1A receptor antagonists, which when labeled with carbon-11 (β+; t1/2 = 20.4 min) in the carbonyl group are effective radiol...

The vibrational structure of solid 3-fluoroisonicotinic acid, as measured by IR absorption and Raman spectra in the 4000–50 cm−1 region and aided by B3LYP/6-311++G(d,p) and NBO calculations has been analyzed. While anomalous spectral behavior similar to that in pyridine-carboxylic acids has bee...

Fluorinated imide, N-acetyl-2,6-difluorobenzamide (C6H3F2-2,6)C(O)NHC(O)Me 2, could be obtained through one-pot reaction of NiMe2(PMe3)3 with 2,6-difluorobenzamide (C6H3F2-2,6)C(O)NH2 1 in CO atmosphere. A postulated reaction mechanism via N–H bond cleavage and carbonylative reductive eliminati...

Arteflene 4 reacts with FeCl2.4H2O in acetonitrile or with hemin / N-acetylcysteine (heme Fe(II)) in acetonitrile to produce the diol 5 and the enone 6. Treatment of arteflene with ZnAcOH, a model of NADH dehydrogenase, results in the formation of the diol 5 in 80% yield. The formation of the en...

Arteflene is a synthetic endoperoxide antimalarial. Its peroxide bridge undergoes iron(II)-mediated reduction in vitro which yields a carbon-centered cyclohexyl radical and a mixture of cis- and trans-α,β-unsaturated ketones (enones). The enones are biliary metabolites in rats and therefore su...

The series of 6-benzhydryl-4-methyl-2-(1H-benzoimidazol-2-yl)phenol derivatives (HL) and their zinc complexes (ZnL2) were synthesized and fully characterized. Single-crystal X-ray diffraction studies were conducted on representative complexes (C1 and C4), which revealed a distorted tetrahedral g...

Three novel compounds constructed with HL, namely [CoL2]n (1), [CuL2]n (2) and [CuL2]n (3) (HL = 4-benzoimidazol-1-yl-methyl benzoic acid) have been synthesized and characterized by elemental analysis, FT-IR, XRD, TGA, and single crystal X-ray diffraction. Besides the coordinated bonds, strong C...

The thermodynamics of the adsorption of phosphamidon on antimony(V) phosphate cation exchanger has been studied at 30, 45 and 50°C and the thermodynamic equilibrium constant (K0), standard free energy change (ΔG°), enthalpy change (ΔH°) and entropy change (ΔS°) have been calculated to pre...

In this work, the effect of vanadium loading as an active phase, cesium and antimony as promoters for the performance of Ti-phosphate-supported vanadium(v) oxide catalysts by experiment design method has been investigated. To find out the effects of parameters on the selectivity to phtalic anhyd...