The reaction of 1-N-benzylindazole (1) and 2-N-benzylindazole (1a) with Na2PdCl4 in MeOH afforded the NN coordinated complexes Pd(1)2Cl2 (2) as the only trans-isomer and Pd(1a)2Cl2 (2a) as the 1:1 mixture of cis and trans isomers. Direct palladation of 1 and 1a using Pd(OAc)2 in AcOH led to the ...

An experimentally simple, efficient, and inexpensive catalyst system was developed for the N-arylation of imidazole, indole, pyrrole, alkyl alcohol amines, and alkyl amines with aryl iodides and bromides. The reaction proceeds in water-ethanol media at 120 °C for 12 h with Cu2O as the catalyst,...

N,N-bis((1H-pyrazol-1-yl)methyl)(cyclohexyl)methanamine (LA), N,N-bis((1H-pyrazol-1-yl)methyl)-2,6-diethylbenzenamine (LB), N,N-bis((1H-pyrazol-1-yl)methyl)-4-bromobenzenamine (LC), N,N-bis((1H-pyrazol-1-yl)methyl)cyclohexanamine (LD), N,N-bis((1H-pyrazol-1-yl)methyl)(furan-2-yl)methanamine (LE)...

Long carbon chain alkanediols are used in the production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)], however these substrates possess high toxicity towards bacterial cells. This study demonstrated the effective utilisation of a long carbon chain alkanediol, namely 1,8-octane...

Topical ocular drug delivery has always been a challenge for pharmaceutical technology scientists. In the last two decades, many nano-systems have been studied to find ways to overcome the typical problems of topical ocular therapy, such as difficult corneal penetration and poor drug availabilit...

3-Hydroxyalkanoic acids (3HA) are precious precursors for synthesis of value added chemicals. According to their carbon chain lengths, 3HA can be divided into two groups: short-chain-length (SCL) 3HA consisting of 3–5 carbon atoms and medium-chain-length (MCL) 3HA containing 6–14 carbon atoms....

The three dimensional solubility parameters defined by Hansen are based on dispersion forces between structural units, interaction between polar groups and hydrogen bonding. For polar polymers such as poly(3-hydroxyalkanoates), P(3HA), this approach was used to obtain the three coordinates of a ...

Poly(vinyl chloride) (PVC) is a well-known polymer with low thermal stability. With the aim to improve the physical properties of PVC, biopolyesters were investigated for the plasticizing and thermal effects in PVC. In this study, polymeric medium-chain-length poly(3-hydroxyalkanoates) (mcl-PHA)...

Comamonas testosteroni has been studied for its ability to synthesize and accumulate medium chain length poly(3-hydroxyalkanoates) (mcl-PHAs) during cultivation on vegetable oils available in the local market. Castor seed oil, coconut oil, mustard oil, cotton seed oil, groundnut oil, olive oil a...

The Guaymas basin (Gulf of California) provides a particularly interesting extreme environment. Temperatures ranged from 3°C to 11°C at the organic-rich sediment surface and increased with depth, ranging from 59.7°C to 150°C from 20 cm to 30 cm. After either acidic or alkaline hydrolysis of ...

Films of bacterial poly(3-hydroxyoctanoate) (PHO) (Mn = 85 000) pure or blended with racemic poly[(R,S)-lactic acid] (PLA50) of low molecular weight (Mn = 1100) were prepared by solvent casting techniques and incubated in buffer solutions at 37°C and at different pH. Changes in weight, molecula...

A Schottky diode has been constructed from chemically synthesised copolymer of cyclohexyl and hexyl substituted thiophene units, and various metals such as In, Ag, Al, Sn, etc. The polymer film was deposited on SnO2 coated glass substrate using spin casting technique. The electrical properties o...

The synthesis and characterisation of head to tail regioregular poly(3-pentoxythiophene), poly(3-cyclohexylthiophene) and three mixed alkoxy/cyclohexyl 3-substituted thiophene copolymers with a head to tail arrangement of adjacent rings is presented together with a comparative study of their pho...

Polythiophenes substituted with hexyl, cyclohexyl and methyl at the 3 position, and poly(3,4-dihexylthiophene) were synthesized. The properties of the polymers were characterized for conductivity, electroactivity, mechanical and thermal stability using NMR, gel permeation chromatography, cyclic ...

The purpose of this study was to synthetize the focused library of 34 new piperazinamides of 3-methyl- and 3,3-dimethyl-(2,5-dioxopyrrolidin-1-yl)propanoic or butanoic acids as potential new hybrid anticonvulsants. These hybrid molecules join the chemical fragments of well-known antiepileptic dr...

Methods are presented to synthesize and characterize [propyl-3H] trefentanil 3 and [propenyl-3H] naloxonazine 6.

The role of CD36 in oxidised low-density lipoprotein (oxLDL) mediated cell death was examined by down regulating the receptor level with the macrophage generated antioxidant 7,8‐dihydroneopterin. Down regulation of CD36 protein levels in human monocyte derived macrophages by 7,8-dihydroneopteri...

ContextKnee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.

Flavones have been studied for their activities via benzodiazepine site on the type-A γ-aminobutyric acid (GABAA) receptors, for which knowledge on structure–efficacy relationships has been rather limited in comparison to that on structure–affinity relationships. The present study focused on ...

Falcipain-2 is a papain family cysteine protease and an emerging antimalarial drug target. A pseudo-tripeptide scaffold I was designed using in silico screening tools and the three dimensional structures of falcipain-2, falcipain-3, and papain. This scaffold was investigated at four positions, T...