A monoanionic 2-(2′-phenolate)benzimidazole (HPBI−) stabilized in organometallic complex [Re(CO)2 (dppe)2](HPBI) (1) which was obtained by treating 2-(2′-hydroxyphenyl)benzimidazole (H2–PBI), 1,2-bis(diphenylphosphino)ethane (dppe), and Re2(CO)10, in toluene using a one-pot approach. Solid st...

AKR1C3 is a promising therapeutic target for castration-resistant prostate cancer. Herein, an evaluation of in-house library discovered substituted pyranopyrazole as a novel scaffold for AKR1C3 inhibitors. Preliminary SAR exploration identified its derivative 19d as the most promising compound w...

The FT-IR and FT-Raman spectra of 5-amino-1-(4-bromophenyl)-3-phenyl-1-H-pyrazole have been measured in the regions 4000–400 cm−1 and 3500–100 cm−1, respectively. The equilibrium geometry, bonding features and harmonic vibrational frequencies have been carried out with the help of DFT method. ...

A novel series of Schiff bases based on of 4-amino-5-(3,5-dimethoxy-phenyl)-4H-1,2,4-triazol-3-thiol scaffold was prepared by heating thiocarbohydrazide and 3,5,-dimethoxy benzoic acid at the temperature above its meting point, and subsequently, treating with substituted benzaldehydes. The chemi...

In the present work, the compound (4Z)-2-Phenyl-1-{(E)-[4-propan-2-yl) benzylidene]amino}-4-[(thiophen-2-yl)methylidene]-1H-imidazol-5(4H)-one} is studied experimentally and theoretically. The calculations have been performed to compute optimized geometry, atomic charges and thermodynamic proper...

New subphthalocyanines were synthesized by threatening 2-[4-({(1E)-[4-(dimethylamino)phenyl]methylene}amino)phenyl]ethanol 2 and 2-[4-({(1E)-[4-(diethylamino)phenyl]methylene}amino)phenyl]ethanol 3 with excess of boron subphthalocyanine chloride in toluene. The subphthalocyanines containing 2-[4...

Modulating inflammation by targeting IL-1β reduces recurrent athero-thrombotic cardiovascular events without lipid lowering. This presents an opportunity to explore other pathways associated with the IL-1β signaling cascade to modulate the inflammatory response post-myocardial infarction (MI)....

Polarized Raman spectra have been obtained from oriented single crystals of N-acetyl-l-tryptophan by use of a Raman microscope and 488.0 nm argon excitation. The crystal, of orthorhombic space group P212121, provides the relative Raman intensities Iaa, Ibb and Icc corresponding to the aa, bb and...

Sodium octanoate and N-acetyl-L-tryptophan (N-AcTrp) are widely used as stabilizers during pasteurization and storage of albumin products. However, as compared with N-AcTrp, N-acetyl-L-methionine (N-AcMet) is superior in protecting albumin exposed to light during storage. Here, we examine, wheth...

Three new dicopper(II) complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′-[3-(methylamino)-propyl]oxamide (H3chmpoxd) and end-capped with 1,10-phenanthroline (phen); 2,2’-diamino-4,4′-bithiazole (dabt); and 2,2’-bipyridine (bpy), namely [Cu2(chmpoxd)(H2O)(phen)](ClO4)⋅CH3CN (1), [Cu2(chmpo...

In recent years, the imine-bridged organics has been one of the hot spots in the field of photo-responsive materials. Herein, N-(5-chloro-2-hydroxyphenyl)-(3-hydroxyphenyl)-methalimine (CHPHPMI) was synthesized by a condensation reaction of 3-hydroxybenzaldehyde and 2-amino-4-chlorophen with for...

A new thiourea derivative, 1-benzoyl-3-(5-chloro-2-hydroxyphenyl)thiourea (bcht) has been synthesized from the reaction of 2-amino-4-chlorophenol with benzoyl isothiocyanate. The title compound has been characterized by elemental analyses, FT-IR, 13C, 1H NMR spectroscopy and the single crystal X...

Luminescent trivalent europium(III) complexes Eu(CHPB)3·(H2O)2 (C1), Eu(CHPB)3·neo (C2), Eu(CHPB)3·batho (C3), Eu(CHPB)3·phen (C4) and Eu(CHPB)3·bipy (C5) have been synthesized by involving a β-diketone ligand 1-(5-chloro-2-hydroxyphenyl)-1,3-butanedione (CHPB) and four ancillary ligands l...

Treatment of 7-bromo-5-(2′-chloro)phenyl-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one (1) with methyl or hexyl tosylate resulted in 7-bromo-5-(2′-chloro)phenyl-3-hydroxy-1-methyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one (2) and 7-bromo-5-(2′-chloro)phenyl-1-hexyl-1,2,4,5-tetrahydro-3H-1,4-b...

The chemical synthesis of RNA on solid phase has now become routine using labile protecting groups and mild deprotection methods. The great interest in antisense technology has sparked the development of P-chiral phosphorothioates and a large number of DNA analogues with modified sugars and/or b...

Xanthone derivatives have been shown to posses many biological properties. Some of them act within the central nervous system and show neuroprotective or antidepressant-like properties. Taking this into account we investigated antidepressant-like activity in mice and the possible mechanism of ac...

A variety of polycyclic aromatic hydrocarbons have been synthesized and structurally characterized in our laboratory. Phenanthrene derivatives were efficiently prepared in excellent yields and high purity via a two-step sequence. Heck coupling yielded the corresponding diarylethenes, followed by...

The standard (po = 0.1 MPa) molar enthalpies of formation, in the crystalline phase, of methyl 1H-indole-3-carboxylate and ethyl 1H-indole-2-carboxylate, at T = 298.15 K, were derived from measurements of the standard massic energies of combustion using a static bomb combustion calorimeter. The ...

The study has been carried out to evaluate the feasibility of synthesis of 1-methyl-, 2-methyl-, 1,2-dimethyl-, and 1-ethyl-2-methylphenanthrene through the annulation of the naphthalene system with the exploitation of the dicyanovinyl moiety of 2-naphthylalkylidenemalonodinitriles as an active ...

The substituted phenanthrene-9-carboxyaldehydes are very important intermediates for the syntheses of phenanthroindolizidine and phenanthroquinolizidine alkaloids. The novel title compound was prepared from the reaction of 5 steps starting from the condensation of 3-methoxyl-4-methyl-phenylaceti...