Fusarium graminearum is the major causal agent of Fusarium head blight (FHB) disease in cereal crops worldwide. Infection with this fungal phytopathogen can regularly cause severe yield and quality losses and mycotoxin contamination in grains. In previous other studies, one research group report...

2-Fluraldehyde was converted into 2-(5-R-2-furyl)-1, 3-dioxanes; 5-R-2-cyanofurans where R = H, Br, I or NO2; bis(5-bromo-2-furyl-1,2-R diimine where R = ethyl or butyl; and 5-hydroxymethyl-2-furaldehyde. Furfuryl alcohol, obtained from 2-furaldehyde by the Cannizaro reaction, and 5-hydroxymethy...

Various classes of inhibitor of 2,3-oxido squalene cyclase have been synthesized and tested on rat liver and Saccharomyces cerevisiae microsomes, 3T3 fibroblast cultures, and various bacteria, fungi, and yeasts. The compounds include azasqualenes, azasqualanes, bis-azasqualenes, bis-azasqualanes...

New classes of squalene derivatives, rationally designed as inhibitors of 2,3-oxidosqualene (SO) cyclase, a key enzyme in sterol biosynthesis, were synthesized. These were: N-methylimine 7, aminalic hydroperoxide 8, N-methyloxaziridine 9 and N-methylamide 10.9 was synthesized by a new method, in...

Glutathione peroxidase (glutathione:hydrogen-peroxide oxidoreductase, EC 1.11.1.9) from rat liver was purified to at least 95% purity. A peptide of 16 amino acids, including the active-site selenocysteine (SeCys) residue, was isolated from a tryptic digest by reverse-phase HPLC and gel filtratio...

The STE4 and STE18 genes are required for haploid yeast cell mating. Sequencing of the cloned genes revealed that the STE4 polypeptide shows extensive homology to the β subunits of mammalian G proteins, while the STE18 polypeptide shows weak similarity to the γ subunit of transducin. Null muta...

The yeast pheromone response pathway involves the activation of a heterotrimeric G protein composed by SCGI (α) (also GPA1), STE4 (β), and STE18 (γ) subunits by the pheromone-activated receptors STE2 and STE3 in a and α cells, respectively. Upon exchange of bound GDP for GTP in the SCG1 subu...

In order to identify amino acid residues of Ste4p involved in receptor recognition and/or receptor-G protein coupling, we employed random in vitro mutagenesis and a genetic screening to isolate mutant Ste4p subunits with altered pheromone response. We generated a plasmid library containing rando...

A variety of hydrogen cyanide adducts of β-chloroaldimines using acetone cyanohydrin were prepared. The reactive behaviour of these α-amino-γ-chloronitriles towards bases was investigated with the aim to generate 1-aminocyclopropanecarbonitriles, which are precursors for the potentially plant...

Alzheimer's disease is a chronic neurodegenerative disease. Preparation of transdermal patches is a useful strategy for management of the disease. The transdermal patches bearing Rivastigmine tartarate were prepared using solvent casting method to provide good drug content uniformity. Trans...

Rheumatoid arthritis (RA) is considered a form of inflammatory autoimmune disease with unknown etiology, but environmental and genetic causes are sharing. T-cells, B-cells, synovial cells, osteoclast, and chondrocytes are the main cell types in RA pathophysiology. The present study aimed to inve...

BackgroundQuercetin is a well-known flavonoid, has pharmacokinetic interaction with ester drugs due to its capability of esterase inhibition in the gut and liver. However, the interaction between quercetin nanoparticles (NQC) and rivastigmine has not been reported. Hence, the present study was p...

A highly sensitive and cost-effective HPTLC method was developed for the determination of rivastigmine hydrogen tartarate (RIV) in bulk and capsules. Moreover, magnetic solid phase extraction procedure (MSPE) was performed for analysis of RIV in human plasma to preconcentrate RIV and decrease in...

IntroductionThe objective of the study was to assess adherence and persistence of patients treated with rivastigmine versus donepezil.

The electrochemical characterization and synthetic procedures of novel metallophthalocyanines (Co, Cu and Mn) 5, 6 and 7 fused eight N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide groups connected to ethylmercapto arms on peripherally positions were report...

This paper reports on the synthesis and characterization of new peripherally tetra-substituted metal-free (4), nickel(II) (5), zinc(II) (6), cobalt(II) (7), copper(II) (8), lead(II) (9) and octa-substituted zinc(II) (12) phthalocyanines containing (E)-4-(3-cinnamoylphenoxy) groups for the first ...

In this study, the synthesis and characterization of novel [1,2,3] triazole substituted phthalonitrile compound (3) and non-peripherally tetra 3-(2H-benzo[d][1,2,3]triazol-2-yl)-4-hydroxyphenethyl methacrylate substituted lead(II) (4), nickel(II) (5) and copper(II) (6) phthalocyanine derivatives...

Copper(II)phthalocyanine-incorporated metal organic framework (CuPc/MOF) composite material was synthesized for application as an electrocatalyst for hydrogen evolution reaction (HER). The composite exhibited excellent electroactivity compared to the unmodified MOF, as confirmed by the diffusion...

In this study, the phthalonitrile compound (3) and peripherally tetra substituted metal-free (4), lead(II) (5), nickel (II) (6) and cobalt(II) (7) phthalocyanines were synthesized for the first time. The characterization of the novel complexes was performed with FT-IR, 1H NMR, 13C NMR, UV–Vis a...

In this study novel peripherally tetra 4-phenylthiazole-2-thiol substituted metal-free phthalocyanine (4) and its zinc(II) (5), copper(II) (6) and cobalt(II) (7) derivatives were synthesized and characterized by a combination of various spectroscopic techniques such as FT-IR, 1H-NMR, UV–vis and...