Nitenpyram is very effective in controlling Nilaparvata lugens (brown planthopper, BPH), and its resistance has been reported in field populations; however, the resistance mechanism remains unclear. In the present study, cross-resistance and resistance mechanisms in nitenpyram-resistant BPH were...

An efficient and direct aldol-type condensation of ethyl diazoacetate with trifluoromethyl ketones was developed in the presence of dialkyl zinc. A series of trifluoromethylated products were obtained in good to excellent yields (60–95%). A preliminary extension to a catalytic enantioselective ...

In this study, cobalt oxide doped nanoporous activated carbon (Co-NPAC) was synthesized and used as a heterogeneous catalyst for the Fenton oxidation of organic dye chemicals used in tannery process. The nanoporous activated carbon (NPAC) was prepared from rice husk by precarbonization followed ...

In this study we demonstrate that it is possible to ion exchange the small organic cations used to charge balance the dual-pendant sulfonate groups on the particular squaraine system under investigation with metal ions, although we also report that problems with low solubility in water may arise...

Publisher SummaryThe pyrimidine entity is one of the most prominent structures found in nucleic acid chemistry. Pyrimidine derivatives including uracil, thymine, cytosine, adenine, and guanine are fundamental building blocks for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Vitamin B1 ...

A description is given of Gobioecetes biwaensis n. g., n. sp. (Monogenea: Dactylogyridae) on the gills of a freshwater gobiid fish, Rhinogobius sp. BW Takahashi & Okazaki, 2002 from Lake Biwa, Shiga Prefecture and Rhinogobius sp. from Sento Imperial Palace, Kyoto Prefecture, Japan. This monogene...

A facile synthesis of (2S, 3R, 4S)-4-amino-5-cyclohexyl-1-morpholino-2, pentanediol (ACMP), the C-terminal compounds of renin inhibitor BW-175 is described.

(2S, 3R, 4S)-4-[L-N-[(2S)-3-ethylsulfonyl-2-(1-naphthylmethyl) propionyl]norleucyl]amino-5-cyclohexyl-1-morpholino-2,3-pentanediol(BW-175) was synthesized stereospecifically.

Single enantiomers of the new 5-methyl-3-aryloxazolidine-2,4-diones have been obtained either by an asymmetric synthesis using the chiral pool strategy or by a semipreparative resolution of the racemic compound by HPLC on an optically active stationary phase. The single enantiomers were assayed ...

Trifluoromethyl-β-amino alcohol 11 [(4S)-tert-butyl 4-amino-6,6,6-trifluoro-5-hydroxyhexanoate] was synthesized in five steps starting from Cbz-l-Glu-OH 5 where the key step involved the introduction of the trifluoromethyl (CF3) group to oxazolidinone 7, resulting in the formation of silyl ethe...

A series of 3-(2-aminocarbonyl-4-phenoxymethylphenyl)propanoic acid analogs were synthesized and evaluated for their EP3 antagonist activity in the presence of additive serum albumin. Several compounds were biologically evaluated for their in vivo efficacy with respect to the PGE2-induced uterin...

Four new acetylenes (1–4) and one new unsaturated ω-hydroxy fatty acid (5), together with 5 known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods. The new acetylenes are categorized as an unus...

Monoliths were prepared in 530 μm I.D. fused silica capillaries via in situ copolymerization of stearyl methacrylate (SMA) with a dimethacrylate cross-linker in the presence of a binary porogenic solvent containing tert.-butanol and 1,4-butanediol. Alkyl dimethacrylate cross-linkers other than ...

The first protocol for the asymmetric synthesis of 2,3,3,3-tetrafluoro-2-methyl-1-arylpropan-1-amines which function as fluorinated surrogates for α-isopropylbenzylamines in SAR-studies is presented herein. Crucial for the successful synthesis was the application of a recently developed direct ...

Four well-defined N-heterocyclic carbene-PdCl-[(2-Pyridyl)alkyl carboxylate] complexes have been conveniently synthesized through bridge-cleavage reactions of [Pd(μ-Cl)(Cl)(NHC)]2 with (2-pyridyl)alkyl carboxylic acids [2-(pyridin-2-yl)acetic acid and 3-(pyridin-2-yl)propanoic acid]. The new co...

Radiolabeled benzamides have been reported to be attractive agents for targeting malignant melanoma as they bind melanin and display high accumulation in melanoma cells. Herein, we report the synthesis and bioevaluation of a novel 68Ga-labeled benzamide as a potential PET agent for malignant mel...

The redox-active bis-chelate hexacoordinate ruthenium complex 2 Ru(ONO)2 comprising two redox-active 2,4,6,8-tetrakis(tert.-butyl)-9-hydroxyphenoxazin-1-one ligands 1 was synthesized by coupling ruthenium trichloride with 1 or its thallium salt. Reduction of 2 with zinc amalgam produces its radi...

The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male Fischer-344 rats after administration of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective serotonergic 5-HT2 agonist. rCMRglc was determined, using the ...

This study was aimed at exploring the role of 5-HT2/5-HT1C neurotransmission in male rat sexual behavior. The administration of the 5-HT2/5-HT1C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (1 mg/kg), suppressed sexual activity in most of the animals. The suppressive effect of DO...

In this study, lipase catalysis was successfully applied in synthesis of benzyl cinnamate through esterification of cinnamic acid with benzyl alcohol. Lipozyme TLIM was found to be more efficient for catalyzing this reaction than Novozym 435. In order to increase the yield of benzyl cinnamate, s...