In this study, novel beta and alpha tetra-[4-oxy-3-methoxybenzoic acid]-substituted Co(II), Zn(II) and Cu(II) phthalocyanines were prepared by the cyclotetramerization of the new phthalonitriles (1)/(2) and the corresponding divalent metal salts. The compounds were characterized by spectral data...

The triazol compound 3-methyl-4-(3-morpholinopropyl)-1H-1,2,4-triazol-5(4H)-one (3), phthalonitrile compound 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phthalonitrile (5), peripherally tetra substituted zinc(II) (6) and copper(II) (7) phthalocyanines and their wat...

The synthesis of zinc(II), cobalt(II), copper(II) and indium(III)(OAc) phthalocyanines carrying four 4-(4-octylpiperazin-1-yl)phenoxy moieties in peripheral/non-peripheral positions were performed by the cyclotetramerization of compounds 4-[4-(4-octylpiperazin-1-yl)phenoxy]phthalonitrile or 3-[4...

The cold-induced expression system in Escherichia coli is useful and we have applied this system to prepare the coelenterazine-utilizing luciferases including Renilla luciferase (RLase), a red-shifted variant of Renilla luciferase (RLase-547), the catalytic domain of Oplophorus luciferase (19kOL...

Coelenterazine is a widespread bioluminescent substrate for a diverse set of marine species. Moreover, its imidazopyrazinone core is present in eight phyla of bioluminescent organisms. Given their very attractive intrinsic properties, these bioluminescent systems have been used in bioimaging, ph...

Imidazopyrazinone is a typical scaffold present in marine bioluminescence, in which thermal energy is converted into excitation energy in an enzyme-catalyzed reaction. In fact, the imidazopyrazinone scaffold is a common link among organisms of eight phyla. The characterization of the light emiss...

The synthesis, characterization, photophysical and mesomorphism of new hydrogen bonded (H-bonded) bent shaped mesogens derived from 1, 5-bis (4-hydroxyphenyl) penta-1, 4-dien-3-one are reported. The H-bonded bent shaped mesogens are formed by the complexation of 1: 2 molar ratio of 1, 5-bis (4-h...

25B-NBOMe and 25C-NBOMe are potent 5-HT2A receptor agonists that have been associated with inducing hallucinogenic effects in drug users and severe intoxications. This paper describes the identification of their metabolites in rat and human urine by liquid chromatography (LC)-high resolution (HR...

Bacterial degradation of 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) has been previously reported, however, its degradation enzyme system has not been characterized. In this study, a DDE-degrading bacterium, Janibacter sp. TYM3221, was isolated and characterized. Transformation of DDE was...

Cytoplasmic membrane proteins ExbB and ExbD of the Escherichia coli TonB system couple cytoplasmic membrane protonmotive force (pmf) to TonB. TonB transmits this energy to high-affinity outer membrane active transporters. ExbD is proposed to catalyze TonB conformational changes during energy tra...

Experimental studies were conducted by thermogravimetric analyzer and drop tube furnace to clarify the co-combustion and NO formation characteristics of semi-coke and bituminous coal. The same experiments were carried out on the blend of anthracite and bituminous coal for comparison. Results ind...

Aim/objectiveIndia accounts for the highest tuberculosis burden in the world, and abdominal tuberculosis has been an endemic surgical and gastroenterological problem. Aim of this study is to present our two decades experience on abdominal (gastrointestinal) tuberculosis.

BackgroundBefore total body computed tomography scan, an initial rapid imaging assessment should be conducted in the trauma bay. It generally includes a chest x-ray, pelvic x-ray, and an extended focused ultrasonography assessment for trauma. This initial imaging assessment has been poorly descr...

(3-Pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines were prepared via cyclization of diallylaminoquinolines and 4-chloro-N-quinolinylbutanamides, respectively, as novel synthetic intermediates en route to N-functionalized 3-, 5-, 6- and 8-aminoquinolines with potential biological activity. (...

The kinetics and oxidation of 4-methylthiophenyl acetic acid by acidified potassium dichromate was studied spectro photometrically at constant ionic strength 0.01mol/dm3. The reaction exhibits 2:1 stoichiometry. The first order dependence of the reaction on [K2Cr2O7]o was noticed and less than u...

The objective of this experiment was to test the effect of a Met analog, 2-hydroxy-4-methylthio-butanoic acid (HMTBa), on ruminal fermentation and microbial protein synthesis, nutrient digestibility, urinary N losses, and performance of dairy cows. Eight multiparous lactating Holstein dairy cows...

ABSTRACTThe d-isomer of Met cannot be used directly by the mammary gland in dairy cows; instead, it is transformed into l-Met, the proteogenic isomer, in the liver and other extramammary tissues. It remains unclear whether different Met forms and a Met hydroxy analog, 2-hydroxy-4-(methylthio)but...

ABSTRACT2-Hydroxy-4-(methylthio)butanoate (HMTBa) is a methionine analog that has been observed to attenuate biohydrogenation (BH)-induced milk fat depression (MFD), possibly through reducing the shift to altered BH pathways. It has also been suggested that HMTBa increases microbial protein synt...

Two diaryl ether regioisomers of pyridine were prepared through the CuI/TMEDA/Cs2CO3-catalyzed reaction of 2,4-dibromopyridine with phenol derivatives under nitrogen atmosphere. The dipolar solvent DMSO gave 4-isomer as the major product whereas less polar toluene resulted in 2-isomer as a major...

Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Here we report the synthesis and biological evaluation of a new series of α,γ-diketo acids (DKAs) as NS5B polymerase inhibitors. We initiated structure–activity relationship (SAR) optimization aroun...