The structure of koumine, an indole alkaloid from Gelsemium elegans Benth., was determined by a X-ray crystallographic study.

Crude alkaloidal extraction from Gelsemium elegans Benth. produces analgesic property. However, its clinical utility has been obstructed by its narrow therapeutic index. Here, we investigated the potential of koumine, a monomer of Gelsemium alkaloids, to reduce both inflammatory and neuropathic ...

Three monomers of G. elegans indole alkaloids (gelsemine, koumine and humantenmine) were simultaneously detected in porcine plasma for the first time with the development and validation of a sensitive and reliable LC-ESI-MS/MS method. Using a gradient mobile phase at a constant flow rate of 0.2 ...

Gelsemine, the principal active alkaloid from Gelsemium sempervirens Ait., and koumine, the most dominant alkaloids from Gelsemium elegans Benth., produced antinociception in a variety of rodent models of painful hypersensitivity. The present study explored the molecular mechanisms underlying ge...

Formal synthesis of (±)-kopsinine (1) and its related alkaloids 2–4 was accomplished using a high-yield reaction (11 → 12) effected with a base.

The structure of 17-α-hydroxy-Δ14,15-kopsinine has been confirmed by a detailed NMR analysis. A bisindole alkaloid was obtained from the leaf extract of Kopsia teoi and its structure established by spectral methods.

Chiral diether-mediated asymmetric aminolithiation of indolylpropenoate with lithium amide in toluene at −78 °C for 15 min gave, after aqueous ammonium chloride quench, the corresponding conjugate addition product with 97% ee in 89% yield. If hydrogen chloride in methanol was selected as a quen...

Bullatine A (BLA), a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. The mechanism underlying the effects was examined in the present study. The effect of BLA on extracellular ATP induced cell death/apoptosis and pro-inflammat...

Ethnopharmacological relevanceBullatine A, a C20-diterpenoid alkaloid and one of the major effective ingredients in Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao), can block pain hypersensitivity in a variety of rodent models through expression of spinal microglial dynorphin A.

Quantitative and concurrent determinations of penicillic acid and patulin have been achieved after separation of these compounds, as their trimethylsilyl derivatives, by gas-liquid chromatography with electron-capture detection and a column of 10% of DC-200 plus 15% of QF-1 on Gas-Chrom Q; the m...

A rapid, simple and economical method using a limited amount of organic solvent is described for the determination of patulin in apple juice. The sample was extracted with ethyl acetate and the extract was cleaned up by extraction with sodium carbonate solution. Patulin was then determined by re...

Organic binder is a significant substitution of the bentonite in iron ore pelletizing process, reducing the exploitation of clay resource and improving the quality of pellets. Fulvic acid is one of the important functional groups of modified humic acid (MHA) binder which is invented by the autho...

Carbon dioxide capture/release reactions using magnetite, Fe3O4, and hematite, Fe2O3, as sorbents were studied. Kinetics of mechanically activated chemical reactions between iron oxides and CO2 was investigated as a function of CO2 pressure and planetary ball mill process parameters. It was foun...

Heterogeneous photodegradation of 2,6-dimethylphenol (2,6-DMP) in the natural iron oxide (NIO) system with oxalic acid under UV irradiation was investigated. The NIO was characterized by X-ray diffraction (XRD), X-ray fluorescence and Brunauer–Emmett–Teller (BET) methods. The XRD pattern of NI...

Volcanic soils are a potential source of abundant and low-cost adsorbent materials. Allophane and iron oxides are the main inorganic constituents of Andisols, soils derived from volcanic-ashes abundant in the central and southern continental Chilean territory. The present study aimed to elucidat...

The contamination of groundwater with arsenic is a serious health issue in many parts of the world. Although iron has been shown to be effective at removal of arsenic from water, there has been no research to assess the feasibility of using natural iron oxide minerals for water treatment. The su...

The phosphorus (P) fraction distribution and formation mechanism in the supernatant after P adsorption onto iron oxides and iron oxide–humic acid (HA) complexes were analyzed using the ultrafiltration method in this study. With an initial P concentration of 20 mg/L (I = 0.01 mol/L and pH = 7), ...

The contamination of groundwater with arsenic is a serious health issue in many parts of the world. Although iron has been shown to be effective at removal of arsenic from water, there has been no research to assess the feasibility of using natural iron oxide minerals for water treatment. The su...

The use of natural products is essential in the processing of iron oxide ores by flotation. It is the purpose of this review to trace the historic development of the use of some natural products in the processing of iron oxide ores. The reagents used for floating either iron oxides or activated ...

Solar disinfection (SODIS) is a well-accepted intervention method, leading to an improvement in contaminated water sources. In this work, we attempted to further enhance the bacterial inactivation process during light exposure. By means of iron oxide addition, we generated a film on the inner su...