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HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:as request Port:any port

Griseofulvin

Cas:126-07-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

GUANGZHOU MEDCAN PHARMATECH LTD

superior quality and competitive price Appearance:A white or yellowish-white,microfine powder Storage:storage in ambient temperature Package:5-25kg/drum or bag Application:The drug binds to tubulin, interfering with microtubule function, thus inhibit

(+)-Griseofulvin

Cas:126-07-8

Min.Order:5 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Fast Delivery, Good Quality and reasonable price Professional Manufacturer, 28 years in pharmaceutical industry SGS audit supplier Appearance:A white or yellow white microfine powder Storage:room temperature Package:bag, tin, or drum Ap

GMP certified Griseofulvin manufacturer

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or yellowish-white microfine powder Storage:cool dry place Package:25kg/drum Application:medicine raw mater

Manufacturer high quality Griseofulvin Cas 126-07-8 with good price

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Fast delivery 99% Griseofulvin powder price cas:126-07-8

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $27.0 / 37.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Griseofulvin

Cas:126-07-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% (+)-Griseofulvin 126-07-8 GMP Manufacturer

Cas:126-07-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Griseofulvin

Cas:126-07-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

(+)-Griseofulvin in stock

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Griseofulvin

Cas:126-07-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Griseofulvin CAS NO: 126-07-8 Grade:Medical scientific research and export Molecular formula:C17H19ClO6 Molecular weight:354.7822 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Griseofulvin/cas:126-07-8/Raw material spot

Cas:126-07-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

(+)-Griseofulvin Basic information General description Physical and Chemical Properties Pharmacological effects Pharmacokinetics IndicationsAdverse reactions Precautions Drug Interactions Toxicity Pediatric medication Elde

TIANFU-CHEM CAS:126-07-8 (+)-Griseofulvin

Cas:126-07-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(+)-Griseofulvin

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 126-07-8 with best quality

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(+)-Griseofulvin/ LIDE PHARMA- Factory supply / Best price

Cas:126-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Griseofulvin Other Name Gris-peg, Grifulvin V CAS: 126-07-8 MF: C17H

Griseofulvin

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

Bodybuilding Raw Steroid Material Powder Griseofulvin CAS 126-07-8

Cas:126-07-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Griseofulvin Structure: Formula: C17H17ClO6 Molecular Weight : 352.77 Synonyms: 7-Chloro-2,4,6-trimethoxy-6-methyl-,(1S-trans)-Spiro(benzofuran-2(3H),1-(2)

Griseofulvin

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(+)-Griseofulvin 126-07-8

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply Griseofulvin CAS 126-07-8

Cas:126-07-8

Min.Order:100 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

(+)-Griseofulvin Other antibiotics

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $145.0 / 160.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(+)-Griseofulvin CAS: 126-07-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi

(+)-Griseofulvin CAS: 126-07-8

Cas:126-07-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(+)-Griseofulvin

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(+)-Griseofulvin

Cas:126-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Griseofulvin CAS 126-07-8 with Best Price

Cas:126-07-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

(+)-Griseofulvin in stock CAS NO.126-07-8

Cas:126-07-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(+)-Griseofulvin

Cas:126-07-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Griseofulvin

Cas:126-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products griseofulvin

Cas:126-07-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Synthetic route

2'-hydroxygriseofulvin
136616-32-5

2'-hydroxygriseofulvin

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
In tetrahydrofuran Ambient temperature;95%
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
469-54-5

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione

A

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
469-51-2, 469-52-3, 17818-12-1

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
With diethyl ether
methanol
67-56-1

methanol

A

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
469-51-2, 469-52-3, 17818-12-1

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
With hydrogenchloride

A

(-)-2',3'-dihydrodehydrogriseofulvin
86549-08-8, 86562-90-5

(-)-2',3'-dihydrodehydrogriseofulvin

B

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
With selenium(IV) oxide In tert-butyl alcohol for 10h; Heating;
Conditions
ConditionsYield
Product distribution; microbal transformation by seven streptomyces species;
(-)-dehydrogriseofulvin
3573-90-8

(-)-dehydrogriseofulvin

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
With 1,4-dihydronicotinamide adenine dinucleotide; pH 7.0 phosphate buffer; Streptomyces cinereocrocatus cell-free culture; NADPH In water; acetone at 28℃; for 5h; Product distribution; effect of NADH/NADPH ratio;
(+/-)-dehydrogriseofulvin
7776-77-4

(+/-)-dehydrogriseofulvin

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
In water; acetone at 28℃; for 72h; Streptomyces cinereocrocatus NRRL 3443;
Conditions
ConditionsYield
Product distribution; microbal transformation by seven streptomyces species;
norgriseofulvinic acid

norgriseofulvinic acid

A

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
469-51-2, 469-52-3, 17818-12-1

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
With diethyl ether
hydrogenchloride
7647-01-0

hydrogenchloride

methanol
67-56-1

methanol

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
469-54-5

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione

A

griseofulvin
126-07-8

griseofulvin

B

isogriseofulvin

isogriseofulvin

diethyl ether
60-29-7

diethyl ether

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
469-54-5

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione

A

griseofulvin
126-07-8

griseofulvin

B

isogriseofulvin

isogriseofulvin

chloroglucinol dimethyl ether
18113-21-8

chloroglucinol dimethyl ether

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 93 percent / pyridine
2: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating
3: 73 percent / diisopropylazodicarboxylate, tributylphosphine
4: 78 percent / LHMDS / tetrahydrofuran / -78 °C
5: 95 percent / MsN3, Et3N
6: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
7: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
8: tetrahydrofuran / Ambient temperature
9: 100 percent / TFA
10: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
11: 49 percent / NaOMe / methanol / Ambient temperature
12: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
3'-chloro-2'-hydroxy-4',6'-dimethoxyacetophenone
81325-85-1

3'-chloro-2'-hydroxy-4',6'-dimethoxyacetophenone

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 73 percent / diisopropylazodicarboxylate, tributylphosphine
2: 78 percent / LHMDS / tetrahydrofuran / -78 °C
3: 95 percent / MsN3, Et3N
4: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
5: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
6: tetrahydrofuran / Ambient temperature
7: 100 percent / TFA
8: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
9: 49 percent / NaOMe / methanol / Ambient temperature
10: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
Acetic acid 2-chloro-3,5-dimethoxy-phenyl ester
131939-10-1

Acetic acid 2-chloro-3,5-dimethoxy-phenyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating
2: 73 percent / diisopropylazodicarboxylate, tributylphosphine
3: 78 percent / LHMDS / tetrahydrofuran / -78 °C
4: 95 percent / MsN3, Et3N
5: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
6: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
7: tetrahydrofuran / Ambient temperature
8: 100 percent / TFA
9: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
10: 49 percent / NaOMe / methanol / Ambient temperature
11: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
1-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-ethanone
136616-28-9

1-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-ethanone

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 78 percent / LHMDS / tetrahydrofuran / -78 °C
2: 95 percent / MsN3, Et3N
3: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
4: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
5: tetrahydrofuran / Ambient temperature
6: 100 percent / TFA
7: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
8: 49 percent / NaOMe / methanol / Ambient temperature
9: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-3-oxo-propionic acid methyl ester
136616-29-0

3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-3-oxo-propionic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 95 percent / MsN3, Et3N
2: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
3: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
4: tetrahydrofuran / Ambient temperature
5: 100 percent / TFA
6: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
7: 49 percent / NaOMe / methanol / Ambient temperature
8: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
(R)-7-Chloro-4,6-dimethoxy-2-((E)-(R)-1-methyl-but-2-enyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
136616-31-4

(R)-7-Chloro-4,6-dimethoxy-2-((E)-(R)-1-methyl-but-2-enyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
2: tetrahydrofuran / Ambient temperature
3: 100 percent / TFA
4: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
5: 49 percent / NaOMe / methanol / Ambient temperature
6: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
(R)-7-Chloro-4,6-dimethoxy-2-((S)-1-methyl-2-oxo-ethyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
136642-41-6

(R)-7-Chloro-4,6-dimethoxy-2-((S)-1-methyl-2-oxo-ethyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / Ambient temperature
2: 100 percent / TFA
3: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
4: 49 percent / NaOMe / methanol / Ambient temperature
5: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
(R)-7-Chloro-4,6-dimethoxy-2-((R)-1-methyl-3-oxo-butyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
136734-91-3

(R)-7-Chloro-4,6-dimethoxy-2-((R)-1-methyl-3-oxo-butyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 49 percent / NaOMe / methanol / Ambient temperature
2: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-2-diazo-3-oxo-propionic acid methyl ester
136616-30-3

3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-2-diazo-3-oxo-propionic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating
2: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
3: tetrahydrofuran / Ambient temperature
4: 100 percent / TFA
5: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
6: 49 percent / NaOMe / methanol / Ambient temperature
7: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
(R)-2-((Z)-(R)-3-Carboxy-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
136642-44-9, 136642-45-0

(R)-2-((Z)-(R)-3-Carboxy-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
2: 49 percent / NaOMe / methanol / Ambient temperature
3: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
(R)-2-((Z)-(R)-3-tert-Butoxycarbonyl-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
136642-42-7, 136642-43-8

(R)-2-((Z)-(R)-3-tert-Butoxycarbonyl-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

griseofulvin
126-07-8

griseofulvin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / TFA
2: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
3: 49 percent / NaOMe / methanol / Ambient temperature
4: 95 percent / tetrahydrofuran / Ambient temperature
View Scheme
griseofulvin
126-07-8

griseofulvin

(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione
7634-11-9, 5128-41-6

(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione

Conditions
ConditionsYield
With iodine; magnesium In diethyl ether; toluene Sonication;99%
With magnesium iodide In diethyl ether; toluene at 80℃;98%
With iodine; magnesium In diethyl ether; toluene at 80℃; for 3h;81%
griseofulvin
126-07-8

griseofulvin

C17H15(2)H2ClO6

C17H15(2)H2ClO6

Conditions
ConditionsYield
With tetrakis(tetrabutylammonium)decatungstate(VI); 2,4,6-Triisopropylthiophenol; water-d2 In acetonitrile Irradiation;99%
griseofulvin
126-07-8

griseofulvin

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-ol)

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-ol)

Conditions
ConditionsYield
With sodium tetrahydroborate; cerium(III) chloride In methanol at -40℃;98%
griseofulvin
126-07-8

griseofulvin

phenylboronic acid
98-80-6

phenylboronic acid

(2S,6′R)-2′,4,6-trimethoxy-6′-methyl-7-phenyl-3H-spiro[benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione

(2S,6′R)-2′,4,6-trimethoxy-6′-methyl-7-phenyl-3H-spiro[benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 3-(dicyclohexylphosphino)-2-(2,6-dimethoxyphenyl)-1-methyl-1H-indole In 1,4-dioxane at 120℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Sealed tube; Inert atmosphere;98%
griseofulvin
126-07-8

griseofulvin

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-oxime)
13215-39-9, 13215-54-8

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-oxime)

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol; dimethyl sulfoxide at 75℃; for 24h;95%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 6h; Reflux;93%
With hydroxylamine
With hydroxylamine hydrochloride; sodium acetate In ethanol; dimethyl sulfoxide
With hydroxylamine hydrochloride; sodium methylate In dimethyl sulfoxide Reflux;
griseofulvin
126-07-8

griseofulvin

(2S,6′R)-(+)-7-deuterio-2′,4,6-trimethoxy-6′-methyl-3H-spiro[1-benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione

(2S,6′R)-(+)-7-deuterio-2′,4,6-trimethoxy-6′-methyl-3H-spiro[1-benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 1-deuteriodiphenylmethanol; 3-(2,6-dibenzhydryl-4-methylphenyl)-4,5-dimethyl-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate In toluene at 90℃; for 16h; Inert atmosphere;95%
griseofulvin
126-07-8

griseofulvin

griseofulvic acid
1158186-19-6

griseofulvic acid

Conditions
ConditionsYield
With sulfuric acid In acetic acid at 80℃; for 0.75h;93%
With sulfuric acid; acetic acid
With sulfuric acid; acetic acid In water
2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

griseofulvin
126-07-8

griseofulvin

(2S,6'R)-2',4,6-trimethoxy-6'-methyl-7-(o-tolyl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

(2S,6'R)-2',4,6-trimethoxy-6'-methyl-7-(o-tolyl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

Conditions
ConditionsYield
With potassium phosphate monohydrate; 3,6-di-tert-butyl-9-(2-(dicyclohexylphosphanyl)phenyl)-9H-carbazole; palladium diacetate In 1,4-dioxane at 120℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere;93%
griseofulvin
126-07-8

griseofulvin

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
469-54-5

(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate In water; acetonitrile for 6h; Reflux;91%
With ethanol; sulfuric acid; water
With sodium hydroxide; ethanol; water
With sulfuric acid In water; acetic acid
griseofulvin
126-07-8

griseofulvin

(2S,2'S,4'S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohexan-4'-ol)
1158186-26-5

(2S,2'S,4'S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohexan-4'-ol)

Conditions
ConditionsYield
With platinum on carbon; hydrogen In methanol at 20℃; for 12h;86%
thiosemicarbazide
79-19-6

thiosemicarbazide

griseofulvin
126-07-8

griseofulvin

4'-thiosemicarbazonegriseofulvin
1343483-15-7

4'-thiosemicarbazonegriseofulvin

Conditions
ConditionsYield
With acetic acid In methanol for 72h; Reflux;85.4%
griseofulvin
126-07-8

griseofulvin

griseofulvic acid

griseofulvic acid

Conditions
ConditionsYield
With sulfuric acid; acetic acid at 100℃;81%
copper(II) choride dihydrate

copper(II) choride dihydrate

griseofulvin
126-07-8

griseofulvin

C34H34Cl2CuO12(2+)*2Cl(1-)

C34H34Cl2CuO12(2+)*2Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;71%
zinc(II) chloride dihydrate

zinc(II) chloride dihydrate

griseofulvin
126-07-8

griseofulvin

C17H17Cl2O6Zn(1+)*Cl(1-)

C17H17Cl2O6Zn(1+)*Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;71%
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

griseofulvin
126-07-8

griseofulvin

C34H34Cl2CoO12(2+)*2Cl(1-)

C34H34Cl2CoO12(2+)*2Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;65%
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

griseofulvin
126-07-8

griseofulvin

C34H34Cl2NiO12(2+)*2Cl(1-)

C34H34Cl2NiO12(2+)*2Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;64%
manganese(II) chloride dihydrate

manganese(II) chloride dihydrate

griseofulvin
126-07-8

griseofulvin

C34H34Cl2MnO12(2+)*2Cl(1-)

C34H34Cl2MnO12(2+)*2Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;62%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

griseofulvin
126-07-8

griseofulvin

C34H34Cl2FeO12(3+)*3Cl(1-)

C34H34Cl2FeO12(3+)*3Cl(1-)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;60%
ethanethiol
75-08-1

ethanethiol

griseofulvin
126-07-8

griseofulvin

A

d-4'-demethoxy-4'-(ethylthio)isogriseofulvin
187884-76-0

d-4'-demethoxy-4'-(ethylthio)isogriseofulvin

B

d-2'-demethoxy-2'-(ethylthio)griseofulvin

d-2'-demethoxy-2'-(ethylthio)griseofulvin

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane for 0.666667h; Ambient temperature;A 27%
B 52%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

griseofulvin
126-07-8

griseofulvin

(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3-oxo-3H-spiro[benzofuran-2,1'-cyclohexane]-2',4'-dien-4'-yl trifluoromethanesulfonate

(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3-oxo-3H-spiro[benzofuran-2,1'-cyclohexane]-2',4'-dien-4'-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: griseofulvin With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 20℃; for 12h; Inert atmosphere;
47%
(1-diazo-2-ethoxy-2-oxoethyl)(2-(2-ethoxy-2-oxoethoxy)carbonylphenyl)iodonium trifluoromethanesulfonate

(1-diazo-2-ethoxy-2-oxoethyl)(2-(2-ethoxy-2-oxoethoxy)carbonylphenyl)iodonium trifluoromethanesulfonate

griseofulvin
126-07-8

griseofulvin

C21H21ClN2O8

C21H21ClN2O8

Conditions
ConditionsYield
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; sodium hydrogencarbonate In acetonitrile at 20℃; Irradiation;36%
griseofulvin
126-07-8

griseofulvin

(2S,6'R)-(7-chloro-4,6-dimethoxy-5-nitro-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)
148929-55-9

(2S,6'R)-(7-chloro-4,6-dimethoxy-5-nitro-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

Conditions
ConditionsYield
With nitric acid; acetic anhydride at 0 - 20℃;33%
With nitric acid In acetic acid
griseofulvin
126-07-8

griseofulvin

(2S,5’R)-7-chloro-6-hydroxy-3’,4-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1,3-dione
20168-89-2, 20168-88-1

(2S,5’R)-7-chloro-6-hydroxy-3’,4-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1,3-dione

Conditions
ConditionsYield
With pyridine; 18-crown-6 ether; potassium iodide at 20 - 120℃; for 9h;32%
With pyridine; 18-crown-6 ether; potassium iodide at 80℃; for 9h;32%
With lithium iodide In pyridine at 115℃; for 16h;29%
griseofulvin
126-07-8

griseofulvin

A

(2S,6'R)-7-chloro-5-fluoro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

(2S,6'R)-7-chloro-5-fluoro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

B

C16H14ClFO6

C16H14ClFO6

Conditions
ConditionsYield
With Selectfluor In acetonitrile at 0 - 50℃; for 28h;A 10%
B 23%
1,1-dimethylhydrazine
57-14-7

1,1-dimethylhydrazine

griseofulvin
126-07-8

griseofulvin

(2S,6'R, E)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-dimethylhydrazine)
1158186-28-7

(2S,6'R, E)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-dimethylhydrazine)

Conditions
ConditionsYield
With acetic acid In water; toluene at 50℃; for 24h;19%
griseofulvin
126-07-8

griseofulvin

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(3'-iodo-2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)
888042-10-2

(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(3'-iodo-2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

Conditions
ConditionsYield
With N-iodo-succinimide; triethylsilyl trifluoromethyl sulfonate In dichloromethane at 20℃; Inert atmosphere; Cooling with ice;19%
methanol
67-56-1

methanol

sodium methylate
124-41-4

sodium methylate

griseofulvin
126-07-8

griseofulvin

A

O-methylorcinol
3209-13-0

O-methylorcinol

B

3-chloro-4,6-dimethoxysalicylic acid
3187-20-0

3-chloro-4,6-dimethoxysalicylic acid

Conditions
ConditionsYield
es erfolgt partielle Umwandlung;
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