1. ISO 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:as request Port:any port
superior quality and competitive price Appearance:A white or yellowish-white,microfine powder Storage:storage in ambient temperature Package:5-25kg/drum or bag Application:The drug binds to tubulin, interfering with microtubule function, thus inhibit
Cas:126-07-8
Min.Order:5 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryFast Delivery, Good Quality and reasonable price Professional Manufacturer, 28 years in pharmaceutical industry SGS audit supplier Appearance:A white or yellow white microfine powder Storage:room temperature Package:bag, tin, or drum Ap
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Min.Order:1 Kilogram
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or yellowish-white microfine powder Storage:cool dry place Package:25kg/drum Application:medicine raw mater
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Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:126-07-8
Min.Order:1 Kilogram
FOB Price: $27.0 / 37.0
Type:Manufacturers
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Cas:126-07-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:126-07-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
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Name:Griseofulvin CAS NO: 126-07-8 Grade:Medical scientific research and export Molecular formula:C17H19ClO6 Molecular weight:354.7822 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da
Cas:126-07-8
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiry(+)-Griseofulvin Basic information General description Physical and Chemical Properties Pharmacological effects Pharmacokinetics IndicationsAdverse reactions Precautions Drug Interactions Toxicity Pediatric medication Elde
Cas:126-07-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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Min.Order:1 Kilogram
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:126-07-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Griseofulvin Other Name Gris-peg, Grifulvin V CAS: 126-07-8 MF: C17H
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
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Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Griseofulvin Structure: Formula: C17H17ClO6 Molecular Weight : 352.77 Synonyms: 7-Chloro-2,4,6-trimethoxy-6-methyl-,(1S-trans)-Spiro(benzofuran-2(3H),1-(2)
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
Negotiable
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Cas:126-07-8
Min.Order:10 Gram
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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Min.Order:100 Kilogram
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Type:Lab/Research institutions
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Cas:126-07-8
Min.Order:1 Kilogram
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Type:Trading Company
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Min.Order:1 Gram
Negotiable
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Min.Order:1 Kilogram
Negotiable
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
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Min.Order:10 Gram
Negotiable
Type:Trading Company
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Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
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Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Conditions | Yield |
---|---|
In tetrahydrofuran Ambient temperature; | 95% |
diazomethane
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
A
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
B
griseofulvin
Conditions | Yield |
---|---|
With diethyl ether |
methanol
A
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
B
griseofulvin
Conditions | Yield |
---|---|
With hydrogenchloride |
sodium methylate
(+)-epigriseofulvin
griseofulvin
(-)-dihydrogriseofulvin
A
(-)-2',3'-dihydrodehydrogriseofulvin
B
griseofulvin
Conditions | Yield |
---|---|
With selenium(IV) oxide In tert-butyl alcohol for 10h; Heating; |
(-)-dehydrogriseofulvin
A
(-)-griseofulvin
B
griseofulvin
Conditions | Yield |
---|---|
Product distribution; microbal transformation by seven streptomyces species; |
Conditions | Yield |
---|---|
With 1,4-dihydronicotinamide adenine dinucleotide; pH 7.0 phosphate buffer; Streptomyces cinereocrocatus cell-free culture; NADPH In water; acetone at 28℃; for 5h; Product distribution; effect of NADH/NADPH ratio; |
Conditions | Yield |
---|---|
In water; acetone at 28℃; for 72h; Streptomyces cinereocrocatus NRRL 3443; |
(+/-)-dehydrogriseofulvin
A
(-)-griseofulvin
B
griseofulvin
Conditions | Yield |
---|---|
Product distribution; microbal transformation by seven streptomyces species; |
diazomethane
A
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)
B
griseofulvin
Conditions | Yield |
---|---|
With diethyl ether |
hydrogenchloride
methanol
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
A
griseofulvin
diazomethane
diethyl ether
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
A
griseofulvin
chloroglucinol dimethyl ether
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 93 percent / pyridine 2: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating 3: 73 percent / diisopropylazodicarboxylate, tributylphosphine 4: 78 percent / LHMDS / tetrahydrofuran / -78 °C 5: 95 percent / MsN3, Et3N 6: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 7: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 8: tetrahydrofuran / Ambient temperature 9: 100 percent / TFA 10: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 11: 49 percent / NaOMe / methanol / Ambient temperature 12: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
3'-chloro-2'-hydroxy-4',6'-dimethoxyacetophenone
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 73 percent / diisopropylazodicarboxylate, tributylphosphine 2: 78 percent / LHMDS / tetrahydrofuran / -78 °C 3: 95 percent / MsN3, Et3N 4: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 5: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 6: tetrahydrofuran / Ambient temperature 7: 100 percent / TFA 8: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 9: 49 percent / NaOMe / methanol / Ambient temperature 10: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
Acetic acid 2-chloro-3,5-dimethoxy-phenyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating 2: 73 percent / diisopropylazodicarboxylate, tributylphosphine 3: 78 percent / LHMDS / tetrahydrofuran / -78 °C 4: 95 percent / MsN3, Et3N 5: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 6: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 7: tetrahydrofuran / Ambient temperature 8: 100 percent / TFA 9: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 10: 49 percent / NaOMe / methanol / Ambient temperature 11: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
1-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-ethanone
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 78 percent / LHMDS / tetrahydrofuran / -78 °C 2: 95 percent / MsN3, Et3N 3: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 4: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 5: tetrahydrofuran / Ambient temperature 6: 100 percent / TFA 7: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 8: 49 percent / NaOMe / methanol / Ambient temperature 9: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-3-oxo-propionic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 95 percent / MsN3, Et3N 2: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 3: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 4: tetrahydrofuran / Ambient temperature 5: 100 percent / TFA 6: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 7: 49 percent / NaOMe / methanol / Ambient temperature 8: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
(R)-7-Chloro-4,6-dimethoxy-2-((E)-(R)-1-methyl-but-2-enyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 2: tetrahydrofuran / Ambient temperature 3: 100 percent / TFA 4: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 5: 49 percent / NaOMe / methanol / Ambient temperature 6: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
(R)-7-Chloro-4,6-dimethoxy-2-((S)-1-methyl-2-oxo-ethyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: tetrahydrofuran / Ambient temperature 2: 100 percent / TFA 3: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 4: 49 percent / NaOMe / methanol / Ambient temperature 5: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
(R)-7-Chloro-4,6-dimethoxy-2-((R)-1-methyl-3-oxo-butyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 49 percent / NaOMe / methanol / Ambient temperature 2: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-2-diazo-3-oxo-propionic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 62 percent / 5 mol percent of rhodium pivalate 2(piv)4> / benzene / 1 h / Heating 2: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH 3: tetrahydrofuran / Ambient temperature 4: 100 percent / TFA 5: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 6: 49 percent / NaOMe / methanol / Ambient temperature 7: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
(R)-2-((Z)-(R)-3-Carboxy-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 2: 49 percent / NaOMe / methanol / Ambient temperature 3: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
(R)-2-((Z)-(R)-3-tert-Butoxycarbonyl-1-methyl-but-2-enyl)-7-chloro-4,6-dimethoxy-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
griseofulvin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / TFA 2: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h 3: 49 percent / NaOMe / methanol / Ambient temperature 4: 95 percent / tetrahydrofuran / Ambient temperature View Scheme |
griseofulvin
(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione
Conditions | Yield |
---|---|
With iodine; magnesium In diethyl ether; toluene Sonication; | 99% |
With magnesium iodide In diethyl ether; toluene at 80℃; | 98% |
With iodine; magnesium In diethyl ether; toluene at 80℃; for 3h; | 81% |
griseofulvin
Conditions | Yield |
---|---|
With tetrakis(tetrabutylammonium)decatungstate(VI); 2,4,6-Triisopropylthiophenol; water-d2 In acetonitrile Irradiation; | 99% |
griseofulvin
Conditions | Yield |
---|---|
With sodium tetrahydroborate; cerium(III) chloride In methanol at -40℃; | 98% |
Conditions | Yield |
---|---|
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 3-(dicyclohexylphosphino)-2-(2,6-dimethoxyphenyl)-1-methyl-1H-indole In 1,4-dioxane at 120℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Sealed tube; Inert atmosphere; | 98% |
griseofulvin
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-oxime)
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium acetate In ethanol; dimethyl sulfoxide at 75℃; for 24h; | 95% |
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 6h; Reflux; | 93% |
With hydroxylamine | |
With hydroxylamine hydrochloride; sodium acetate In ethanol; dimethyl sulfoxide | |
With hydroxylamine hydrochloride; sodium methylate In dimethyl sulfoxide Reflux; |
griseofulvin
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); 1-deuteriodiphenylmethanol; 3-(2,6-dibenzhydryl-4-methylphenyl)-4,5-dimethyl-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate In toluene at 90℃; for 16h; Inert atmosphere; | 95% |
griseofulvin
griseofulvic acid
Conditions | Yield |
---|---|
With sulfuric acid In acetic acid at 80℃; for 0.75h; | 93% |
With sulfuric acid; acetic acid | |
With sulfuric acid; acetic acid In water |
2-Methylphenylboronic acid
griseofulvin
Conditions | Yield |
---|---|
With potassium phosphate monohydrate; 3,6-di-tert-butyl-9-(2-(dicyclohexylphosphanyl)phenyl)-9H-carbazole; palladium diacetate In 1,4-dioxane at 120℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; | 93% |
griseofulvin
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione
Conditions | Yield |
---|---|
With ammonium cerium (IV) nitrate In water; acetonitrile for 6h; Reflux; | 91% |
With ethanol; sulfuric acid; water | |
With sodium hydroxide; ethanol; water | |
With sulfuric acid In water; acetic acid |
griseofulvin
(2S,2'S,4'S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohexan-4'-ol)
Conditions | Yield |
---|---|
With platinum on carbon; hydrogen In methanol at 20℃; for 12h; | 86% |
Conditions | Yield |
---|---|
With acetic acid In methanol for 72h; Reflux; | 85.4% |
griseofulvin
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid at 100℃; | 81% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 71% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 71% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 65% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 64% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 62% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 60% |
ethanethiol
griseofulvin
A
d-4'-demethoxy-4'-(ethylthio)isogriseofulvin
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane for 0.666667h; Ambient temperature; | A 27% B 52% |
N,N-phenylbistrifluoromethane-sulfonimide
griseofulvin
Conditions | Yield |
---|---|
Stage #1: griseofulvin With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 20℃; for 12h; Inert atmosphere; | 47% |
griseofulvin
Conditions | Yield |
---|---|
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; sodium hydrogencarbonate In acetonitrile at 20℃; Irradiation; | 36% |
griseofulvin
(2S,6'R)-(7-chloro-4,6-dimethoxy-5-nitro-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)
Conditions | Yield |
---|---|
With nitric acid; acetic anhydride at 0 - 20℃; | 33% |
With nitric acid In acetic acid |
griseofulvin
(2S,5’R)-7-chloro-6-hydroxy-3’,4-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1,3-dione
Conditions | Yield |
---|---|
With pyridine; 18-crown-6 ether; potassium iodide at 20 - 120℃; for 9h; | 32% |
With pyridine; 18-crown-6 ether; potassium iodide at 80℃; for 9h; | 32% |
With lithium iodide In pyridine at 115℃; for 16h; | 29% |
griseofulvin
Conditions | Yield |
---|---|
With Selectfluor In acetonitrile at 0 - 50℃; for 28h; | A 10% B 23% |
1,1-dimethylhydrazine
griseofulvin
(2S,6'R, E)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-on-4'-dimethylhydrazine)
Conditions | Yield |
---|---|
With acetic acid In water; toluene at 50℃; for 24h; | 19% |
griseofulvin
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(3'-iodo-2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)
Conditions | Yield |
---|---|
With N-iodo-succinimide; triethylsilyl trifluoromethyl sulfonate In dichloromethane at 20℃; Inert atmosphere; Cooling with ice; | 19% |
methanol
sodium methylate
griseofulvin
A
O-methylorcinol
B
3-chloro-4,6-dimethoxysalicylic acid
methanol
sodium ethanolate
griseofulvin
(+)-epigriseofulvin
Conditions | Yield |
---|---|
es erfolgt partielle Umwandlung; |
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