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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(Trifluoromethyl)-2-Pyridinamine supplier in China

Cas:183610-70-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-(Trifluoromethyl)-2-Pyridinamine

Cas:183610-70-0

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Amino-3-Trifluoromethylpyridine

Cas:183610-70-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Amino-3-trifluoromethylpyridine

Cas:183610-70-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 183610-70-0 with competitive price

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2-Pyridinamine,3-(trifluoromethyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:183610-70-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $85.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Amino-3-(trifluoromethyl)pyridine CAS:183610-70-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qua

2-Amino-3-(trifluoromethyl)pyridine CAS:183610-70-0

Cas:183610-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,

Factory Price 2-Amino-3-(trifluoromethyl)pyridine Cas 183610-70-0

Cas:183610-70-0

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Pyridinamine,3-(trifluoromethyl)-

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-(Trifluoromethyl)-2-Pyridinamine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Amino-3-trifluoromethyl pyridine/High quality/Best price

Cas:183610-70-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(trifluoromethyl)-2-pyridinamine CAS NO.183610-70-0

Cas:183610-70-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:In Room Temperature Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Transportation:as your request Port:Shanghai; Ningb

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Henan Tianfu Chemical Co., Ltd.

3-(TRIFLUOROMETHYL)-2-PYRIDINAMINE; 3-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE; 2-AMINO-3-(TRIFLUOROMETHYL) PYRIDINE; 3-(Trifluoromethyl)pyridin-2-amine; 3-(TrifluoroMethyl)1-2 -pyridinaMine; 3-(TrifluoroMethyl)-2-pyridiMine; 2-PyridinaMine, 3-(trifluoroM

3-Trifluoromethyl-pyridin-2-ylamine

Cas:183610-70-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Amino-3-(trifluoromethyl)pyridine Chemical Properties Melting point 70-72°C Boiling point 203.2±35.0 °C(Predicted) density 1.368±0.06 g/cm3(Predicted) storage temp. Room temperature. pka 4.18±0.36(Pre

2-Amino-3-trifluoromethylpyridine

Cas:183610-70-0

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-Amino-3-trifluoromethylpyridine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Amino-3-(trifluoromethyl)pyridine

Cas:183610-70-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-fluoro-3-trifluoromethylpyridine
65753-52-8

2-fluoro-3-trifluoromethylpyridine

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

Conditions
ConditionsYield
With ammonia In water at 130℃; under 22502.3 Torr; for 10h; Temperature;95%
(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine
911112-72-6

(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: (4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine With sulfuric acid at 5 - 23℃; for 0.5h;
Stage #2: With sodium hydroxide In water at 0℃;
92%
2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

Conditions
ConditionsYield
With ammonia In water at 175℃; for 24h;71%
With ammonia In water at 175℃; for 72h;
Multi-step reaction with 2 steps
1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave
2: ammonia / water / 10 h / 130 °C / 22502.3 Torr
View Scheme
methanol
67-56-1

methanol

8-Trifluoromethyl-tetrazolo[1,5-a]pyridine
143812-76-4

8-Trifluoromethyl-tetrazolo[1,5-a]pyridine

A

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

B

2-methoxy-4-trifluoromethyl-1H-1,3-diazepine
177211-80-2

2-methoxy-4-trifluoromethyl-1H-1,3-diazepine

Conditions
ConditionsYield
In 1,4-dioxane at 25℃; for 1.33333h; Irradiation;A 5%
B 47%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

5-bromo-3-(trifluoromethyl)pyridin-2-amine
79456-34-1

5-bromo-3-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With N-Bromosuccinimide In acetonitrile at 0 - 20℃;99%
With N-Bromosuccinimide In acetonitrile at 5 - 23℃; for 1h;98%
With N-Bromosuccinimide In acetonitrile at 20℃;93%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

5-iodo-3-(trifluoromethyl)pyridin-2-amine

5-iodo-3-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With N-iodo-succinimide; acetic acid at 0 - 20℃; for 90h;89%
Stage #1: 2-amino-3-trifluoromethylpyridine With N-iodo-succinimide; acetic acid at 0 - 20℃;
Stage #2: With sodium hydrogencarbonate In water Cooling with ice;
76%
With N-iodo-succinimide76%
With N-iodo-succinimide In acetic acid at 0 - 20℃;76%
With N-iodo-succinimide In N,N-dimethyl-formamide at 20℃;70%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

5-chloro-3-(trifluoromethyl)pyridin-2-amine
79456-33-0

5-chloro-3-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;
cyclohexanone
108-94-1

cyclohexanone

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With iodine; oxygen In 1,1,2,2-tetrachloroethane at 160℃; for 24h; Green chemistry;88%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

C6H5F3N2O

C6H5F3N2O

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In acetone at 0 - 20℃; for 12.5h;81%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

5-nitro-3-(trifluoromethyl)pyridin-2-amine
1121056-94-7

5-nitro-3-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With sulfuric acid; nitric acid In water at 0 - 50℃; for 3.25h;75%
2-chloro-5-(1-chloroethyl)pyridine

2-chloro-5-(1-chloroethyl)pyridine

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

1-[1-(6-chloro-3-pyridyl)ethyl]-3-(trifluoromethyl)pyridin-2-imine

1-[1-(6-chloro-3-pyridyl)ethyl]-3-(trifluoromethyl)pyridin-2-imine

Conditions
ConditionsYield
With sodium iodide In acetonitrile at 82℃; for 72h;75%
1-Bromo-2-butanone
816-40-0

1-Bromo-2-butanone

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-ethyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine
1167570-72-0

2-ethyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium iodide In ethanol Heating / reflux;74%
methyl 3-bromo-2-oxopropanoate
7425-63-0

methyl 3-bromo-2-oxopropanoate

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester
1206972-73-7

8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60℃; for 3h;72%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite In water at 70℃; for 1h;69%
methyl 3-hydroxy-2-methylidene-3-phenylpropionate
18020-59-2

methyl 3-hydroxy-2-methylidene-3-phenylpropionate

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(benzyl)-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

3-(benzyl)-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol Reflux;67%
cyclohexanone
108-94-1

cyclohexanone

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

4-(trifluoromethyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine

4-(trifluoromethyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With sulfur In neat (no solvent) at 110℃; for 16h; Inert atmosphere; regioselective reaction;65%
1-(3-(methoxymethoxy)phenyl)prop-2-yn-1-yl acetate

1-(3-(methoxymethoxy)phenyl)prop-2-yn-1-yl acetate

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(3-(methoxymethoxy)phenyl)-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

3-(3-(methoxymethoxy)phenyl)-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With copper acetylacetonate; N-ethyl-N,N-diisopropylamine; 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine In methanol at 20℃; for 6h; Inert atmosphere; regioselective reaction;61%
2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanoic acid
1210909-06-0

2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanoic acid

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

N-(3-(trifluoromethyl)pyridin-2-yl)-2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanamide

N-(3-(trifluoromethyl)pyridin-2-yl)-2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanamide

Conditions
ConditionsYield
Stage #1: 2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h;
Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃;
59%
ibuprofen
15687-27-1

ibuprofen

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-(4-isobutylphenyl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

2-(4-isobutylphenyl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions
ConditionsYield
Stage #1: ibuprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h;
Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 36h;
59%
tert-butyl 4-(10-bromo-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

tert-butyl 4-(10-bromo-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

tert-butyl 4-(2-oxo-10-{[3-(trifluoromethyl)pyridin-2-yl]amino}-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

tert-butyl 4-(2-oxo-10-{[3-(trifluoromethyl)pyridin-2-yl]amino}-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate; t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate In tert-butyl alcohol at 110℃; Inert atmosphere;58%
3-methoxyphenylglyoxal
32025-65-3

3-methoxyphenylglyoxal

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-chloro-3-(3-methoxyphenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine
1167571-66-5

2-chloro-3-(3-methoxyphenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
Stage #1: 3-methoxyphenylglyoxal; 2-amino-3-trifluoromethylpyridine In dichloromethane for 1h; Heating / reflux;
Stage #2: With thionyl chloride In tetrachloromethane for 0.5h; Heating / reflux;
Stage #3: With potassium carbonate In water
56%
methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-methyl-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

3-methyl-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol Reflux;52%
chloroacetone
78-95-5

chloroacetone

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine
1167570-71-9

2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium iodide In ethanol Heating / reflux;51%
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-methyl-3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

2-methyl-3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With copper acetylacetonate; N-ethyl-N,N-diisopropylamine; 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine In methanol at 20℃; for 18h; Inert atmosphere; regioselective reaction;50%
N-((3-bromo-5-methylphenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

N-((3-bromo-5-methylphenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

N-((3-methyl-5-((3-(trifluoromethyl)pyridin-2-yl)amino)-phenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

N-((3-methyl-5-((3-(trifluoromethyl)pyridin-2-yl)amino)-phenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Inert atmosphere;50%
fluorobiprofen
5104-49-4

fluorobiprofen

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-(2-fluoro-(1,1'-biphenyl)-4-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

2-(2-fluoro-(1,1'-biphenyl)-4-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h;
Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 72h;
45%
phenylacetaldehyde
122-78-1

phenylacetaldehyde

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With sulfur In cyclohexane; dimethyl sulfoxide at 120℃; for 1h; Sealed tube;41%
2-(6-chloro-carbazol-2-yl)-propionic acid
53716-49-7

2-(6-chloro-carbazol-2-yl)-propionic acid

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

2-(6-chloro-9H-carbazol-2-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

2-(6-chloro-9H-carbazol-2-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions
ConditionsYield
Stage #1: 2-(6-chloro-carbazol-2-yl)-propionic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h;
Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 36h;
41%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

C10H7F3N4

C10H7F3N4

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Inert atmosphere;29%

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