2-Amino-3-(trifluoromethyl)pyridine supplier

Name
2-Amino-3-(trifluoromethyl)pyridine
EINECS
CAS No. 183610-70-0
Article Data7
CAS DataBase
Density 1.368 g/cm³
Solubility
Melting Point 70-72 °C
Formula C₆H₅F₃N₂
Boiling Point 203.2 °C at 760 mmHg
Molecular Weight 162.114
Flash Point 76.7 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes Xi:Irritant;
Molecular Structure
Hazard Symbols Xi
Synonyms (3-Trifluoromethylpyridin-2-yl)amine;3-(Trifluoromethyl)-2-pyridinamine;
PSA 38.91000
LogP 2.26380

Synthetic route

: 65753-52-8
2-fluoro-3-trifluoromethylpyridine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
With ammonia In water at 130℃; under 22502.3 Torr; for 10h; Temperature;	95%

: 911112-72-6
(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
Stage #1: (4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine With sulfuric acid at 5 - 23℃; for 0.5h; Stage #2: With sodium hydroxide In water at 0℃;	92%

: 65753-47-1
2-chloro-3-trifluoromethyl-pyridine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
With ammonia In water at 175℃; for 24h;	71%
With ammonia In water at 175℃; for 72h;
Multi-step reaction with 2 steps 1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave 2: ammonia / water / 10 h / 130 °C / 22502.3 Torr View Scheme

: 67-56-1
methanol

: 143812-76-4
8-Trifluoromethyl-tetrazolo[1,5-a]pyridine

A: 183610-70-0
2-amino-3-trifluoromethylpyridine

B: 177211-80-2
2-methoxy-4-trifluoromethyl-1H-1,3-diazepine

Conditions

Conditions	Yield
In 1,4-dioxane at 25℃; for 1.33333h; Irradiation;	A 5% B 47%

...Expand

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 0 - 20℃;	99%
With N-Bromosuccinimide In acetonitrile at 5 - 23℃; for 1h;	98%
With N-Bromosuccinimide In acetonitrile at 20℃;	93%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 5-iodo-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-iodo-succinimide; acetic acid at 0 - 20℃; for 90h;	89%
Stage #1: 2-amino-3-trifluoromethylpyridine With N-iodo-succinimide; acetic acid at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In water Cooling with ice;	76%
With N-iodo-succinimide	76%
With N-iodo-succinimide In acetic acid at 0 - 20℃;	76%
With N-iodo-succinimide In N,N-dimethyl-formamide at 20℃;	70%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 79456-33-0
5-chloro-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;	88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;	88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;

: 108-94-1
cyclohexanone

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine; oxygen In 1,1,2,2-tetrachloroethane at 160℃; for 24h; Green chemistry;	88%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: C6H5F3N2O

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In acetone at 0 - 20℃; for 12.5h;	81%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1121056-94-7
5-nitro-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water at 0 - 50℃; for 3.25h;	75%

: 2-chloro-5-(1-chloroethyl)pyridine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1-[1-(6-chloro-3-pyridyl)ethyl]-3-(trifluoromethyl)pyridin-2-imine

Conditions

Conditions	Yield
With sodium iodide In acetonitrile at 82℃; for 72h;	75%

: 816-40-0
1-Bromo-2-butanone

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1167570-72-0
2-ethyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium iodide In ethanol Heating / reflux;	74%

: 7425-63-0
methyl 3-bromo-2-oxopropanoate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1206972-73-7
8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 3h;	72%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 22245-83-6
3-(trifluoromethyl)pyridine-2-(1H)-one

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 70℃; for 1h;	69%

: 18020-59-2
methyl 3-hydroxy-2-methylidene-3-phenylpropionate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 3-(benzyl)-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol Reflux;	67%

: 108-94-1
cyclohexanone

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 4-(trifluoromethyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sulfur In neat (no solvent) at 110℃; for 16h; Inert atmosphere; regioselective reaction;	65%

: 1-(3-(methoxymethoxy)phenyl)prop-2-yn-1-yl acetate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 3-(3-(methoxymethoxy)phenyl)-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With copper acetylacetonate; N-ethyl-N,N-diisopropylamine; 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine In methanol at 20℃; for 6h; Inert atmosphere; regioselective reaction;	61%

: 1210909-06-0
2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanoic acid

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: N-(3-(trifluoromethyl)pyridin-2-yl)-2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanamide

Conditions

Conditions	Yield
Stage #1: 2-(4-((2-(trifluoromethyl)pyridin-4-yl)amino)phenyl)propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h; Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃;	59%

: 15687-27-1
ibuprofen

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 2-(4-isobutylphenyl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions

Conditions	Yield
Stage #1: ibuprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h; Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 36h;	59%

: tert-butyl 4-(10-bromo-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: tert-butyl 4-(2-oxo-10-{[3-(trifluoromethyl)pyridin-2-yl]amino}-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With potassium phosphate; t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate In tert-butyl alcohol at 110℃; Inert atmosphere;	58%

: 32025-65-3
3-methoxyphenylglyoxal

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1167571-66-5
2-chloro-3-(3-methoxyphenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Stage #1: 3-methoxyphenylglyoxal; 2-amino-3-trifluoromethylpyridine In dichloromethane for 1h; Heating / reflux; Stage #2: With thionyl chloride In tetrachloromethane for 0.5h; Heating / reflux; Stage #3: With potassium carbonate In water	56%

: 15484-46-5
methyl 2-hydroxymethylacrylate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 3-methyl-9-(trifluoromethyl)-2H-pyrido[1,2-a]pyrimidin-2-one

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol Reflux;	52%

: 78-95-5
chloroacetone

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1167570-71-9
2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium iodide In ethanol Heating / reflux;	51%

: 16169-88-3, 84681-19-6, 116119-86-9, 116182-55-9
1-phenylprop-2-ynyl acetate

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 2-methyl-3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With copper acetylacetonate; N-ethyl-N,N-diisopropylamine; 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine In methanol at 20℃; for 18h; Inert atmosphere; regioselective reaction;	50%

: N-((3-bromo-5-methylphenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: N-((3-methyl-5-((3-(trifluoromethyl)pyridin-2-yl)amino)-phenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Inert atmosphere;	50%

: 5104-49-4
fluorobiprofen

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 2-(2-fluoro-(1,1'-biphenyl)-4-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions

Conditions	Yield
Stage #1: fluorobiprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h; Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 72h;	45%

: 122-78-1
phenylacetaldehyde

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 3-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sulfur In cyclohexane; dimethyl sulfoxide at 120℃; for 1h; Sealed tube;	41%

: 53716-49-7
2-(6-chloro-carbazol-2-yl)-propionic acid

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 2-(6-chloro-9H-carbazol-2-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)propanamide

Conditions

Conditions	Yield
Stage #1: 2-(6-chloro-carbazol-2-yl)-propionic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h; Stage #2: 2-amino-3-trifluoromethylpyridine In acetonitrile at 20℃; for 36h;	41%

: 14508-49-7
2-chloropyrazin

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: C10H7F3N4

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Inert atmosphere;	29%

2-Amino-3-(trifluoromethyl)pyridine Specification

The 2-Amino-3-(trifluoromethyl)pyridine is an organic compound with the formula C₆H₅F₃N₂. The systematic name of this chemical is 3-(trifluoromethyl)pyridin-2-amine. With the CAS registry number 183610-70-0, it is also named as 2-Pyridinamine, 3-(trifluoromethyl)-. The product's categories are Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Amines; Pyridines. Additionally, this chemical should be stored at room temperature.

The other characteristics of 2-Amino-3-(trifluoromethyl)pyridine can be summarized as: (1)ACD/LogP: 2.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.07; (4)ACD/LogD (pH 7.4): 2.09; (5)ACD/BCF (pH 5.5): 21.82; (6)ACD/BCF (pH 7.4): 22.84; (7)ACD/KOC (pH 5.5): 312.05; (8)ACD/KOC (pH 7.4): 326.63; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 16.13 Å²; (13)Index of Refraction: 1.478; (14)Molar Refractivity: 33.56 cm³; (15)Molar Volume: 118.4 cm³; (16)Polarizability: 13.3×10^-24 cm³; (17)Surface Tension: 33.2 dyne/cm; (18)Density: 1.368 g/cm³; (19)Flash Point: 76.7 °C; (20)Enthalpy of Vaporization: 43.95 kJ/mol; (21)Boiling Point: 203.2 °C at 760 mmHg; (22)Vapour Pressure: 0.28 mmHg at 25°C

People can use the following data to convert to the molecule structure.
1. SMILES:FC(F)(F)c1cccnc1N
2. InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
3. InChIKey:YWOWJQMFMXHLQD-UHFFFAOYAV
4. Std. InChI:InChI=1S/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
5. Std. InChIKey:YWOWJQMFMXHLQD-UHFFFAOYSA-N

Product Name

2-Amino-3-(trifluoromethyl)pyridine

Synthetic route

2-Amino-3-(trifluoromethyl)pyridine Specification

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