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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(S)-1-(Benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:32159-21-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:20

(S)-1-(Benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid

Cas:32159-21-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-Benzyloxycarbonyl-L-pyroglutamic acid

Cas:32159-21-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 32159-21-0 with competitive price

Cas:32159-21-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Cbz-Pyr-OH CAS No. 32159-21-0 Synonyms Cbz-L-Pyroglutamic acid Purity 98.0% min Molecular Formula C13H13NO5 Molecular Weight 263.25 Appearance: white powder

Cbz-Pyr-OH

Cas:32159-21-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Z-PYR-OH

Cas:32159-21-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)- 32159-21-0

Cas:32159-21-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Z-PYR-OHCAS:32159-21-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, st

Z-PYR-OHCAS:32159-21-0

Cas:32159-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

CBZ-L-Pyroglutamic acid manufacturer

Cas:32159-21-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Z-Pyr-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity N-cbz-L-pyroglutamic acid crystalline

Cas:32159-21-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used for APIs Transportation: as per yo

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Carbobenzoxy-L-pyroglutamicacid

Cas:32159-21-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

CBZ-L-Pyroglutamic acid;Z-Pyr-OH.99%

Cas:32159-21-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Z-PYR-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

Cbz-Pyr-OH

Cas:32159-21-0

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Cbz-L-pyroglutamic acid

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(S)-1-(Benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cbz-Pyr-Oh cas no. 32159-21-0 98%

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Research Peptide Biotechnology Co., Ltd.

High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Z-Pyr-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

N-cbz-L-pyroglutamic acid crystalline

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Z-PYR-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Z-PYR-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GL Biochem (Shanghai) Ltd.

Application:Intermidates

Z-Pyr-OH

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(phenylmethyl) ester, (2S)-

Cas:32159-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

sodium carbonate
497-19-8

sodium carbonate

benzyl chloroformate
501-53-1

benzyl chloroformate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
In 1,4-dioxane; sodium hydroxide87%
benzyl chloroformate
501-53-1

benzyl chloroformate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
With triethylamine In acetonitrile for 1h; Ambient temperature;20%
With 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; acetonitrile; methyloxirane 1.) r.t., 15 min, 2.) 1 h; Yield given. Multistep reaction;
N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
With N-cyclohexyl-cyclohexanamine; dicyclohexyl-carbodiimide 1.) THF, 0 deg C; Multistep reaction;
Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: DCC / tetrahydrofuran / 0 °C
2: dicyclohexylamine (DCHA) / tetrahydrofuran / 0 °C
View Scheme
N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
With N-cyclohexyl-cyclohexanamine In tetrahydrofuran at 0℃; Yield given;
2-bromothiophene
1003-09-4

2-bromothiophene

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-4-Benzyloxycarbonylamino-5-oxo-5-thiophen-2-yl-pentanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-5-thiophen-2-yl-pentanoic acid

B

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

C

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 40℃; for 2h;
Stage #2: N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #3: With citric acid In tetrahydrofuran at -78 - 20℃; Title compound not separated from byproducts;
1-bromo-butane
109-65-9

1-bromo-butane

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-4-Benzyloxycarbonylamino-5-oxo-nonanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-nonanoic acid

B

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

C

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: 1-bromo-butane With magnesium In tetrahydrofuran at 40℃; for 2h;
Stage #2: N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #3: With citric acid In tetrahydrofuran at -78 - 20℃; Title compound not separated from byproducts;
3-methoxyphenyl bromide
2398-37-0

3-methoxyphenyl bromide

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-4-Benzyloxycarbonylamino-5-(3-methoxy-phenyl)-5-oxo-pentanoic acid

(S)-4-Benzyloxycarbonylamino-5-(3-methoxy-phenyl)-5-oxo-pentanoic acid

B

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

C

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: 3-methoxyphenyl bromide With magnesium In tetrahydrofuran at 40℃; for 2h;
Stage #2: N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #3: With citric acid In tetrahydrofuran at -78 - 20℃; Title compound not separated from byproducts;
1-bromo-hexane
111-25-1

1-bromo-hexane

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-4-Benzyloxycarbonylamino-5-oxo-undecanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-undecanoic acid

B

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

C

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: 1-bromo-hexane With magnesium In tetrahydrofuran at 40℃; for 2h;
Stage #2: N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #3: With citric acid In tetrahydrofuran at -78 - 20℃; Title compound not separated from byproducts;
phenylmagnesium chloride
100-59-4

phenylmagnesium chloride

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

B

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

C

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: phenylmagnesium chloride; N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #2: With citric acid In tetrahydrofuran
phenyllithium
591-51-5

phenyllithium

N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

(S)-2-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

(S)-2-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

B

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

C

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

D

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: phenyllithium; N-(benzyloxycarbonyl)-L-glutamic acid anhydride In tetrahydrofuran at -78℃; for 4h;
Stage #2: With citric acid In tetrahydrofuran
N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

A

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

B

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: N-(benzyloxycarbonyl)-L-glutamic acid anhydride With tert-butylmagnesium chloride In tetrahydrofuran at -78℃; for 4h;
Stage #2: With citric acid In tetrahydrofuran
Stage #1: N-(benzyloxycarbonyl)-L-glutamic acid anhydride With phenylzinc chloride In tetrahydrofuran at -78℃; for 2h;
Stage #2: With citric acid In tetrahydrofuran
N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

Ph3MgLi

Ph3MgLi

A

(S)-2-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

(S)-2-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

B

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

(S)-4-Benzyloxycarbonylamino-5-oxo-5-phenyl-pentanoic acid

C

N-benzyloxycarbonyl-L-glutamic acid
1155-62-0

N-benzyloxycarbonyl-L-glutamic acid

D

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Conditions
ConditionsYield
Stage #1: N-(benzyloxycarbonyl)-L-glutamic acid anhydride; Ph3MgLi In tetrahydrofuran at -78 - 20℃;
Stage #2: With citric acid In tetrahydrofuran
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

methyl iodide
74-88-4

methyl iodide

(5S)-N-(benzyloxycarbonyl)-5-methoxycarbonyl-2-pyrrolidinone
75857-94-2

(5S)-N-(benzyloxycarbonyl)-5-methoxycarbonyl-2-pyrrolidinone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane98%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 6.5h; Heating / reflux;98%
(2R,4'R,8'R)-α-tocopheramine
3398-70-7

(2R,4'R,8'R)-α-tocopheramine

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

A

vitamin E amine pyroglutamate conjugate

vitamin E amine pyroglutamate conjugate

B

N-methylmorpholine hydrochloride
3651-67-0

N-methylmorpholine hydrochloride

Conditions
ConditionsYield
Stage #1: Cbz-L-pGlu-OH With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at 0 - 20℃; for 2h;
Stage #2: (2R,4'R,8'R)-α-tocopheramine With triethylamine In tetrahydrofuran at 0℃;
A 98%
B n/a
VESA-PEG-NH2

VESA-PEG-NH2

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

A

Reaxys ID: 11380187

Reaxys ID: 11380187

B

N-methylmorpholine hydrochloride
3651-67-0

N-methylmorpholine hydrochloride

Conditions
ConditionsYield
Stage #1: Cbz-L-pGlu-OH With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at 0 - 20℃; for 2h;
Stage #2: VESA-PEG-NH2 With triethylamine In tetrahydrofuran; water at 0℃;
A 98%
B n/a
tryptamine
61-54-1

tryptamine

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

(S)-2-[2-(1H-Indol-3-yl)-ethylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

(S)-2-[2-(1H-Indol-3-yl)-ethylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran Heating;90%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

benzyl chloride
100-44-7

benzyl chloride

dibenzyl (2S)-5-oxotetrahydro-1H-pyrrole-1,2-dicarboxylate
71389-33-8

dibenzyl (2S)-5-oxotetrahydro-1H-pyrrole-1,2-dicarboxylate

Conditions
ConditionsYield
With triethylamine In acetone for 72h; Heating;85%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Z-Glp-NH2

Z-Glp-NH2

Conditions
ConditionsYield
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In 1,4-dioxane 4-16 h;84%
1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)-5-oxotetrahydro-1H-pyrrole-1-carboxylate
958637-27-9

benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)-5-oxotetrahydro-1H-pyrrole-1-carboxylate

Conditions
ConditionsYield
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In dichloromethane at 40 - 50℃; for 0.333333h;
Stage #2: Cbz-L-pGlu-OH In dichloromethane at 20℃; for 2h; Further stages.;
84%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate
81470-51-1

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

Conditions
ConditionsYield
With perchloric acid In water at 20℃; for 16h;79%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

N-methyl-m-toluidine
696-44-6

N-methyl-m-toluidine

benzyl (2S)-2-[methyl(m-tolyl)carbamoyl]-5-oxopyrrolidine-1-carboxylate

benzyl (2S)-2-[methyl(m-tolyl)carbamoyl]-5-oxopyrrolidine-1-carboxylate

Conditions
ConditionsYield
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 20℃; for 12h;75%
8-amino quinoline
578-66-5

8-amino quinoline

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

C22H19N3O4

C22H19N3O4

Conditions
ConditionsYield
Stage #1: Cbz-L-pGlu-OH With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0 - 20℃; for 1.5h;
Stage #2: 8-amino quinoline In tetrahydrofuran at 20℃; for 6h;
74%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

4-methoxy-aniline
104-94-9

4-methoxy-aniline

(S)-2-(4-Methoxy-phenylcarbamoyl)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester
339994-37-5

(S)-2-(4-Methoxy-phenylcarbamoyl)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine; chloroformic acid ethyl ester In ethyl acetate at -15 - 20℃; for 50h;68%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Ala2-PheCH3, HBr
90427-75-1

Ala2-PheCH3, HBr

Z-Glp-Ala2-PheCH3
88576-78-7

Z-Glp-Ala2-PheCH3

Conditions
ConditionsYield
With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran67%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

isobutene
115-11-7

isobutene

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate
81470-51-1

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane67%
Stage #1: Cbz-L-pGlu-OH; isobutene With sulfuric acid In dichloromethane at 20℃; Cooling with ice;
Stage #2: With sodium carbonate In dichloromethane; water
67%
With sulfuric acid In dichloromethane at 20℃; Cooling with ice;67%
With sulfuric acid In dichloromethane at 20℃; Cooling with ice;67%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

L-glutamic acid dibenzyl ester 4-toluenesulfonate
2791-84-6

L-glutamic acid dibenzyl ester 4-toluenesulfonate

Z-pGlu-Glu(OBzl)-OBzl
122389-55-3

Z-pGlu-Glu(OBzl)-OBzl

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane63%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

benzyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate
153870-19-0

benzyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: Cbz-L-pGlu-OH With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -10℃;
Stage #2: With sodium tetrahydroborate In methanol at 0℃;
61%
Multi-step reaction with 2 steps
1: N-methyl morpholine / tetrahydrofuran / 0.08 h / -5 °C
2: NaBH4 / tetrahydrofuran
View Scheme
L-histidine methyl ester
95384-14-8

L-histidine methyl ester

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

N-Z-L-pyroglutamyl-L-histidine methyl ester

N-Z-L-pyroglutamyl-L-histidine methyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide; acetonitrile 1h at -10 deg C, then 12h at 4 deg C;55%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

benzyl bromide
100-39-0

benzyl bromide

dibenzyl (2S)-5-oxotetrahydro-1H-pyrrole-1,2-dicarboxylate
71389-33-8

dibenzyl (2S)-5-oxotetrahydro-1H-pyrrole-1,2-dicarboxylate

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 18h; Ambient temperature;51%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

3-chloro-benzenecarboperoxoic acid
937-14-4

3-chloro-benzenecarboperoxoic acid

(R)-2-(3-Chloro-benzoyloxy)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester
130654-55-6

(R)-2-(3-Chloro-benzoyloxy)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In chloroform at 25℃; for 1h;42%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Ala3-PheCH3, HBr
90427-76-2

Ala3-PheCH3, HBr

Z-Glp-Ala3-PheCH3
88576-80-1

Z-Glp-Ala3-PheCH3

Conditions
ConditionsYield
With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran40%
BOC-glycine
4530-20-5

BOC-glycine

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

N-Boc-O-benzyl-L-threonine
15260-10-3

N-Boc-O-benzyl-L-threonine

Boc-Arg(Tos)-OH
13836-37-8

Boc-Arg(Tos)-OH

BOC-O-benzyl-L-serine
23680-31-1

BOC-O-benzyl-L-serine

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

Boc-Asp(O-cyclohexyl)-OH
73821-95-1

Boc-Asp(O-cyclohexyl)-OH

Boc-cysteine(4-Me-Bn)
61925-77-7

Boc-cysteine(4-Me-Bn)

Boc-(S)-Lys(2-Cl-Z)-OH
54613-99-9

Boc-(S)-Lys(2-Cl-Z)-OH

Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan
47355-10-2

Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan

N(α)-t-butoxycarbonyl-N(ϖ)-benzyloxymethyl-L-histidine
83468-83-1

N(α)-t-butoxycarbonyl-N(ϖ)-benzyloxymethyl-L-histidine

rerdused μ-conotoxin SIIIA

rerdused μ-conotoxin SIIIA

Conditions
ConditionsYield
Stage #1: Boc-cysteine(4-Me-Bn) With benzotriazol-1-ol In 1-methyl-pyrrolidin-2-one Automated synthesizer;
Stage #2: With trifluoroacetic acid
Stage #3: BOC-glycine; L-N-Boc-Ala; N-Boc-O-benzyl-L-threonine; Boc-Arg(Tos)-OH; BOC-O-benzyl-L-serine; Cbz-L-pGlu-OH; Boc-Asp(O-cyclohexyl)-OH; Boc-cysteine(4-Me-Bn); Boc-(S)-Lys(2-Cl-Z)-OH; Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan; N(α)-t-butoxycarbonyl-N(ϖ)-benzyloxymethyl-L-histidine
22%
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide
4510-09-2

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

Conditions
ConditionsYield
With hydrazine hydrate
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

benzylamine
100-46-9

benzylamine

N'-benzyl-N-benzyloxycarbonyl-L-glutamine
64153-27-1

N'-benzyl-N-benzyloxycarbonyl-L-glutamine

acetic acid tert-butyl ester
540-88-5

acetic acid tert-butyl ester

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate
81470-51-1

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

Conditions
ConditionsYield
With perchloric acid Yield given. Multistep reaction;
With perchloric acid Ambient temperature; Yield given;
diethyl 1-aminoethylphosphonate
54788-35-1

diethyl 1-aminoethylphosphonate

Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

(S)-2-[1-(Diethoxy-phosphoryl)-ethylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

(S)-2-[1-(Diethoxy-phosphoryl)-ethylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6.5h;
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

L-tryptophan ethyl ester hydrochloride
2899-28-7, 6519-67-1, 61535-49-7, 67557-18-0, 68401-14-9

L-tryptophan ethyl ester hydrochloride

N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester
87694-59-5

N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester

Conditions
ConditionsYield
With chloroformic acid ethyl ester; triethylamine 1.) THF, 0 deg C, 30 min, 2.) r.t., 3 h; Yield given. Multistep reaction;
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyllysyl-serine methyl ester
84983-67-5

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyllysyl-serine methyl ester

Z-Pyr-Ala-Lys(Z)-Ser-OMe
84983-68-6

Z-Pyr-Ala-Lys(Z)-Ser-OMe

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; methoxybenzene; trifluoroacetic acid 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C; Yield given. Multistep reaction;
Cbz-L-pGlu-OH
32159-21-0

Cbz-L-pGlu-OH

HCl.H-Leu-Gly-NH2
38173-66-9

HCl.H-Leu-Gly-NH2

(Z)--Leu-Gly-NH2
39705-62-9

(Z)--Leu-Gly-NH2

Conditions
ConditionsYield
With 4-methyl-morpholine; triethylamine; isobutyl chloroformate 1.) THF, -20 deg C, 10 min, 2.) THF, DMF, H2O, RT, 1 h; Yield given. Multistep reaction;

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