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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,

L-Pyroglutamic acid ethyl ester

Cas:7149-65-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

L-Pyroglutamic acid ethyl ester 7149-65-7

Cas:7149-65-7

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality L-Pyroglutamic Acid Ethyl Ester supplier in China

Cas:7149-65-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 5-oxo-L-prolinate

Cas:7149-65-7

Min.Order:1

Negotiable

Type:Other

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

CHemwill -- Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Leader Biochemical Group

About Product Details

China Biggest factory Supply High Quality Ethyl L-pyroglutamate CAS 7149-65-7

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 7149-65-7 with competitive price

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact

Ethyl L-pyroglutamate CAS7149-65-7

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Ethyl L-pyroglutamate Synonyms: ETHYL L-PYROGLUTAMATE;ETHYL (S)-PYROGLUTAMATE;ETHYL (S)-2-PYRROLIDINONE-5-CARBOXYLATE;ETHYL (S)-(+)-2-PYRROLIDONE-5-CARBOXYLATE;ETHYL (S)-2-PYRROLIDONE-5-CARBOXYLATE;

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Proline, 5-oxo-,ethyl ester 7149-65-7

Cas:7149-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Ethyl L-pyroglutamate CAS:7149-65-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Ethyl L-pyroglutamate CAS:7149-65-7

Cas:7149-65-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

H-Pyr-Oet

Cas:7149-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:7149-65-7

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

L-Pyr- Ome

Cas:7149-65-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

H-Pyr-OEt

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Proline, 5-oxo-,ethyl ester

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality L-Pyroglutamic Acid Ethyl Ester

Cas:7149-65-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

7149-65-7

Cas:7149-65-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Ethyl L-Pyroglutamate CAS No.: 7149-65-7 Molecule Formula:C7H11NO3 Molecule Weight:157.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Ethyl L-Pyroglutamate on stock

Cas:7149-65-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

pGlu-OEt

Cas:7149-65-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

L-Pyr- Ome

Cas:7149-65-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethyl L-pyroglutamate

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

L-Pyr- Ome

Cas:7149-65-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

L-Pyr- Ome

Cas:7149-65-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

L-Proline, 5-oxo-,ethyl ester

Cas:7149-65-7

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

Pyr-Oet

Cas:7149-65-7

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Synthetic route

ethanol
64-17-5

ethanol

(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone
14842-41-2

(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With potassium cyanide for 4h;100%
ethanol
64-17-5

ethanol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;99%
With thionyl chloride at 0℃; for 15h;99%
With thionyl chloride at -5 - 20℃; for 10h;98%
ethanol
64-17-5

ethanol

L-glutamic acid
56-86-0

L-glutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride Heating;95%
With thionyl chloride 1.) r. t., 1 h, 2.) reflux, 0.5 h;87%
With thionyl chloride 1) room temperature, 1 h; 2) reflux, 0.5 h;87%
ethyl iodide
75-03-6

ethyl iodide

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 0 - 20℃; for 6h;92%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 72h;
L-glutamic acid
56-86-0

L-glutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride In ethanol 1) 0 deg C; 2) 1 h, room temp., then 0.5 h reflux;84%
With thionyl chloride In ethanol; water
Multi-step reaction with 2 steps
1: 0.83 h / 220 - 290 °C / Autoclave; Large scale
2: toluene-4-sulfonic acid / methanol / -5 - 45 °C
View Scheme
ethanol
64-17-5

ethanol

(S)-5-oxopyrrolidine-2-carbonyl chloride
74936-93-9

(S)-5-oxopyrrolidine-2-carbonyl chloride

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
In dichloromethane for 0.0833333h; Heating;81%
L-glutamic acid diethyl ester
16450-41-2

L-glutamic acid diethyl ester

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
at 150℃; under 15.0015 Torr; Inert atmosphere;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-ethyl N-tert-butoxycarbonylpyroglutamate
144978-35-8, 144978-12-1

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃;100%
With dmap In dichloromethane at 20℃; for 6h;100%
With dmap In acetonitrile at 20℃; for 3h;98%
2-bromobenzaldehyde O-(phenylmethyl)oxime
902137-35-3

2-bromobenzaldehyde O-(phenylmethyl)oxime

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[2-(Benzyloxyimino-methyl)-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
902137-36-4

(S)-1-[2-(Benzyloxyimino-methyl)-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃;99%
2-bromobenzaldehyde O-(phenylmethyl)oxime
902137-35-3

2-bromobenzaldehyde O-(phenylmethyl)oxime

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-5-oxo-1-[2-[(E)-(phenylmethoxyimino)methyl]phenyl]proline ethyl ester
1032651-69-6

(S)-5-oxo-1-[2-[(E)-(phenylmethoxyimino)methyl]phenyl]proline ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h;99%
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
902137-32-0

methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[2-(Benzyloxyimino-methyl)-4-methoxycarbonyl-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
902137-42-2

(S)-1-[2-(Benzyloxyimino-methyl)-4-methoxycarbonyl-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃;98%
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
902137-32-0

methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[4-(methoxycarbonyl)-2-[(E)-(phenylmethoxyimino)methyl]phenyl]-5-oxoproline ethyl ester
1032651-88-9

(S)-1-[4-(methoxycarbonyl)-2-[(E)-(phenylmethoxyimino)methyl]phenyl]-5-oxoproline ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h;98%
triethyloxonium fluoroborate
368-39-8

triethyloxonium fluoroborate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (2S)-5-ethoxy-3,4-dihydro-2H-pyrrole-2-carboxylate
76529-79-8

ethyl (2S)-5-ethoxy-3,4-dihydro-2H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 12h; regioselective reaction;97%
92%
In dichloromethane at 20℃; for 40h;92%
In chloroform at 5℃; for 4h;69%
In dichloromethane at 20℃; for 168h;56%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

L-1-<(Ethoxycarbonyl)methyl>-5-oxoprolin-ethylester
100462-35-9

L-1-<(Ethoxycarbonyl)methyl>-5-oxoprolin-ethylester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;97%
With sodium hydride 1.) benzene, r.t., 30 min; 50-60 deg C, 10 min, 2.) r.t., 2 h; Yield given. Multistep reaction;
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-Pyroglutaminol
17342-08-4

(S)-Pyroglutaminol

Conditions
ConditionsYield
With potassium borohydride; lithium chloride In tetrahydrofuran at -15 - 20℃; for 2h; Reagent/catalyst;95%
With lithium borohydride In tetrahydrofuran at 20℃; for 48h;90%
With sodium tetrahydroborate In ethanol83%
phosgene
75-44-5

phosgene

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

L-1-(chlorocarbonyl)proline ethyl ester
86050-92-2

L-1-(chlorocarbonyl)proline ethyl ester

Conditions
ConditionsYield
In chloroform at 5 - 40℃; for 29h;95%
benzyl bromide
100-39-0

benzyl bromide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-(+)-1-(benzyl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
137641-62-4

(S)-(+)-1-(benzyl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;95%
With sodium hydride 1) THF, mineral oil, 0.25 h, 2) THF, mineral oil, room temperature, 2 h; Yield given. Multistep reaction;
With potassium tert-butylate In tetrahydrofuran; water; ethyl acetate
With tert-BuOK In tetrahydrofuran; water; ethyl acetate
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 24.5h;
methyl chloroformate
79-22-1

methyl chloroformate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl N-methoxycarbonyl-L-pyroglutamate
261177-52-0

ethyl N-methoxycarbonyl-L-pyroglutamate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h;95%
allyl bromide
106-95-6

allyl bromide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-allyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
115445-33-5

(S)-1-allyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;94%
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran sonication (ultrasonic cleaning bath);81%
With sodium hydride In tetrahydrofuran at 20℃;80%
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonic bath;78%
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonication;43%
1,3-dibromopropene
627-15-6

1,3-dibromopropene

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-(3-bromo-2-propenyl)-5-oxoproline ethyl ester

1-(3-bromo-2-propenyl)-5-oxoproline ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;93%
carbon monoxide
201230-82-2

carbon monoxide

2-(2-iodophenyl)acetonitrile
40400-15-5

2-(2-iodophenyl)acetonitrile

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-ethyl 10-cyano-5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3-carboxylate
1075683-99-6

(S)-ethyl 10-cyano-5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3-carboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;93%
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate
80442-95-1

ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With Lawessons reagent In toluene for 1h; Heating;92%
With Lawessons reagent In tetrahydrofuran Ambient temperature;90%
With Lawessons reagent In tetrahydrofuran at 20℃; for 1h;90%
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

methyl iodide
74-88-4

methyl iodide

1-methyl-L-pyroglutamic acid ethyl ester

1-methyl-L-pyroglutamic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;92%
With sodium hydride Yield given. Multistep reaction;
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #1: ethyl (S)-pyroglutamate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.25h;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 96h;
carbon monoxide
201230-82-2

carbon monoxide

ethyl 2-(2-iodophenyl)acetate
90794-29-9

ethyl 2-(2-iodophenyl)acetate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-diethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3,10-dicarboxylate
1075683-90-7

(S)-diethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3,10-dicarboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;92%
2-carbomethoxyaniline
134-20-3

2-carbomethoxyaniline

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

9-oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ethyl ester
866925-48-6

9-oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane for 3h; Heating;91%
carbon monoxide
201230-82-2

carbon monoxide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 2-(3,4-methylenedioxy-6-iodophenyl)acetate

ethyl 2-(3,4-methylenedioxy-6-iodophenyl)acetate

(S)-diethyl 5-oxo-5,7,8,9-tetrahydro-[1,3]dioxolo[4,5-g]pyrrolo[1,2-b]isoquinoline-7,10-dicarboxylate
1075683-97-4

(S)-diethyl 5-oxo-5,7,8,9-tetrahydro-[1,3]dioxolo[4,5-g]pyrrolo[1,2-b]isoquinoline-7,10-dicarboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;90%
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-phenyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

1-phenyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;89%
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 3-(2,5-dioxo-1-phenyl-imidazolidin-4-yl)propanoate

ethyl 3-(2,5-dioxo-1-phenyl-imidazolidin-4-yl)propanoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 16h;89%
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(2S)-ethyl 1-Phenylcarbamoyl-5-oxopyrrolidine-2-carboxylate

(2S)-ethyl 1-Phenylcarbamoyl-5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
With sodium hydride In diethyl ether at 20℃; for 1h;89%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (S)-N-(ethoxycarbonyl)pyroglutamate
125048-82-0

ethyl (S)-N-(ethoxycarbonyl)pyroglutamate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h;88%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-benzyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

1-benzyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;87%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 3-(1-benzyl-2,5-dioxo-imidazolidin-4-yl)propanoate

ethyl 3-(1-benzyl-2,5-dioxo-imidazolidin-4-yl)propanoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 16h;87%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-(9H-fluoren-9-ylmethyl) 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate

1-(9H-fluoren-9-ylmethyl) 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere;
87%
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere;
87%
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.25h; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 16h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; water
83%

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