Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,
Cas:7149-65-7
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:7149-65-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:7149-65-7
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:7149-65-7
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:7149-65-7
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryAbout Product Details
Cas:7149-65-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 5.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:7149-65-7
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:7149-65-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact
Cas:7149-65-7
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Trading Company
inquiryName: Ethyl L-pyroglutamate Synonyms: ETHYL L-PYROGLUTAMATE;ETHYL (S)-PYROGLUTAMATE;ETHYL (S)-2-PYRROLIDINONE-5-CARBOXYLATE;ETHYL (S)-(+)-2-PYRROLIDONE-5-CARBOXYLATE;ETHYL (S)-2-PYRROLIDONE-5-CARBOXYLATE;
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:7149-65-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryEthyl L-pyroglutamate CAS:7149-65-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
Cas:7149-65-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:7149-65-7
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:7149-65-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:7149-65-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o
Product name: Ethyl L-Pyroglutamate CAS No.: 7149-65-7 Molecule Formula:C7H11NO3 Molecule Weight:157.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:7149-65-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
ethanol
(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone
ethyl (S)-pyroglutamate
Conditions | Yield |
---|---|
With potassium cyanide for 4h; | 100% |
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; | 99% |
With thionyl chloride at 0℃; for 15h; | 99% |
With thionyl chloride at -5 - 20℃; for 10h; | 98% |
Conditions | Yield |
---|---|
With thionyl chloride Heating; | 95% |
With thionyl chloride 1.) r. t., 1 h, 2.) reflux, 0.5 h; | 87% |
With thionyl chloride 1) room temperature, 1 h; 2) reflux, 0.5 h; | 87% |
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 0 - 20℃; for 6h; | 92% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 72h; |
Conditions | Yield |
---|---|
With thionyl chloride In ethanol 1) 0 deg C; 2) 1 h, room temp., then 0.5 h reflux; | 84% |
With thionyl chloride In ethanol; water | |
Multi-step reaction with 2 steps 1: 0.83 h / 220 - 290 °C / Autoclave; Large scale 2: toluene-4-sulfonic acid / methanol / -5 - 45 °C View Scheme |
ethanol
(S)-5-oxopyrrolidine-2-carbonyl chloride
ethyl (S)-pyroglutamate
Conditions | Yield |
---|---|
In dichloromethane for 0.0833333h; Heating; | 81% |
L-glutamic acid diethyl ester
ethyl (S)-pyroglutamate
Conditions | Yield |
---|---|
at 150℃; under 15.0015 Torr; Inert atmosphere; |
di-tert-butyl dicarbonate
ethyl (S)-pyroglutamate
(S)-ethyl N-tert-butoxycarbonylpyroglutamate
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; | 100% |
With dmap In dichloromethane at 20℃; for 6h; | 100% |
With dmap In acetonitrile at 20℃; for 3h; | 98% |
2-bromobenzaldehyde O-(phenylmethyl)oxime
ethyl (S)-pyroglutamate
(S)-1-[2-(Benzyloxyimino-methyl)-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; | 99% |
2-bromobenzaldehyde O-(phenylmethyl)oxime
ethyl (S)-pyroglutamate
(S)-5-oxo-1-[2-[(E)-(phenylmethoxyimino)methyl]phenyl]proline ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h; | 99% |
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
ethyl (S)-pyroglutamate
(S)-1-[2-(Benzyloxyimino-methyl)-4-methoxycarbonyl-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; | 98% |
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
ethyl (S)-pyroglutamate
(S)-1-[4-(methoxycarbonyl)-2-[(E)-(phenylmethoxyimino)methyl]phenyl]-5-oxoproline ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h; | 98% |
triethyloxonium fluoroborate
ethyl (S)-pyroglutamate
ethyl (2S)-5-ethoxy-3,4-dihydro-2H-pyrrole-2-carboxylate
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 12h; regioselective reaction; | 97% |
92% | |
In dichloromethane at 20℃; for 40h; | 92% |
In chloroform at 5℃; for 4h; | 69% |
In dichloromethane at 20℃; for 168h; | 56% |
ethyl bromoacetate
ethyl (S)-pyroglutamate
L-1-<(Ethoxycarbonyl)methyl>-5-oxoprolin-ethylester
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min; | 97% |
With sodium hydride 1.) benzene, r.t., 30 min; 50-60 deg C, 10 min, 2.) r.t., 2 h; Yield given. Multistep reaction; |
ethyl (S)-pyroglutamate
(S)-Pyroglutaminol
Conditions | Yield |
---|---|
With potassium borohydride; lithium chloride In tetrahydrofuran at -15 - 20℃; for 2h; Reagent/catalyst; | 95% |
With lithium borohydride In tetrahydrofuran at 20℃; for 48h; | 90% |
With sodium tetrahydroborate In ethanol | 83% |
phosgene
ethyl (S)-pyroglutamate
L-1-(chlorocarbonyl)proline ethyl ester
Conditions | Yield |
---|---|
In chloroform at 5 - 40℃; for 29h; | 95% |
benzyl bromide
ethyl (S)-pyroglutamate
(S)-(+)-1-(benzyl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min; | 95% |
With sodium hydride 1) THF, mineral oil, 0.25 h, 2) THF, mineral oil, room temperature, 2 h; Yield given. Multistep reaction; | |
With potassium tert-butylate In tetrahydrofuran; water; ethyl acetate | |
With tert-BuOK In tetrahydrofuran; water; ethyl acetate | |
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 24.5h; |
methyl chloroformate
ethyl (S)-pyroglutamate
ethyl N-methoxycarbonyl-L-pyroglutamate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h; | 95% |
allyl bromide
ethyl (S)-pyroglutamate
(S)-1-allyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min; | 94% |
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran sonication (ultrasonic cleaning bath); | 81% |
With sodium hydride In tetrahydrofuran at 20℃; | 80% |
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonic bath; | 78% |
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonication; | 43% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min; | 93% |
carbon monoxide
2-(2-iodophenyl)acetonitrile
ethyl (S)-pyroglutamate
(S)-ethyl 10-cyano-5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3-carboxylate
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave; | 93% |
ethyl (S)-pyroglutamate
ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate
Conditions | Yield |
---|---|
With Lawessons reagent In toluene for 1h; Heating; | 92% |
With Lawessons reagent In tetrahydrofuran Ambient temperature; | 90% |
With Lawessons reagent In tetrahydrofuran at 20℃; for 1h; | 90% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min; | 92% |
With sodium hydride Yield given. Multistep reaction; | |
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; | |
Stage #1: ethyl (S)-pyroglutamate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.25h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 96h; |
carbon monoxide
ethyl 2-(2-iodophenyl)acetate
ethyl (S)-pyroglutamate
(S)-diethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3,10-dicarboxylate
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave; | 92% |
2-carbomethoxyaniline
ethyl (S)-pyroglutamate
9-oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With trichlorophosphate In 1,2-dichloro-ethane for 3h; Heating; | 91% |
carbon monoxide
ethyl (S)-pyroglutamate
(S)-diethyl 5-oxo-5,7,8,9-tetrahydro-[1,3]dioxolo[4,5-g]pyrrolo[1,2-b]isoquinoline-7,10-dicarboxylate
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave; | 90% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; | 89% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; for 16h; | 89% |
Conditions | Yield |
---|---|
With sodium hydride In diethyl ether at 20℃; for 1h; | 89% |
chloroformic acid ethyl ester
ethyl (S)-pyroglutamate
ethyl (S)-N-(ethoxycarbonyl)pyroglutamate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h; | 88% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; | 87% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; for 16h; | 87% |
(fluorenylmethoxy)carbonyl chloride
ethyl (S)-pyroglutamate
Conditions | Yield |
---|---|
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere; | 87% |
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere; | 87% |
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.25h; Inert atmosphere; Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 16h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water | 83% |
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