Product Name

  • Name

    Ethyl L-pyroglutamate

  • EINECS 230-480-9
  • CAS No. 7149-65-7
  • Article Data51
  • CAS DataBase
  • Density 1.161 g/cm3
  • Solubility
  • Melting Point 47-51 ºC
  • Formula C7H11 N O3
  • Boiling Point 176 ºC (12 mmHg)
  • Molecular Weight 157.169
  • Flash Point 142.9 °C
  • Transport Information
  • Appearance Colorless or yellowish oily liquid
  • Safety S26;S37/39
  • Risk Codes R36/37/38   
  • Molecular Structure Molecular Structure of 7149-65-7 (Ethyl L-pyroglutamate)
  • Hazard Symbols
  • Synonyms Proline,5-oxo-, ethyl ester, L- (7CI,8CI); (S)-(+)-Ethyl 2-pyrrolidone-5-carboxylate;Ethyl (2S)-5-oxopyrrolidine-2-carboxylate; Ethyl (S)-pyroglutamate; EthylL-2-oxo-5-pyrrolidinecarboxylate; Ethyl L-2-pyrrolidone-5-carboxylate; EthylL-pyroglutamate; Ethyl pyroglutamate; L-2-Ethoxycarbonyl-5-pyrrolidone;L-Pyroglutamic acid ethyl ester; NSC 166529; NSC 72279; Pyroglutamic acid ethylester
  • PSA 55.40000
  • LogP 0.15690

Synthetic route

ethanol
64-17-5

ethanol

(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone
14842-41-2

(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With potassium cyanide for 4h;100%
ethanol
64-17-5

ethanol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;99%
With thionyl chloride at 0℃; for 15h;99%
With thionyl chloride at -5 - 20℃; for 10h;98%
ethanol
64-17-5

ethanol

L-glutamic acid
56-86-0

L-glutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride Heating;95%
With thionyl chloride 1.) r. t., 1 h, 2.) reflux, 0.5 h;87%
With thionyl chloride 1) room temperature, 1 h; 2) reflux, 0.5 h;87%
ethyl iodide
75-03-6

ethyl iodide

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 0 - 20℃; for 6h;92%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 72h;
L-glutamic acid
56-86-0

L-glutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride In ethanol 1) 0 deg C; 2) 1 h, room temp., then 0.5 h reflux;84%
With thionyl chloride In ethanol; water
Multi-step reaction with 2 steps
1: 0.83 h / 220 - 290 °C / Autoclave; Large scale
2: toluene-4-sulfonic acid / methanol / -5 - 45 °C
View Scheme
ethanol
64-17-5

ethanol

(S)-5-oxopyrrolidine-2-carbonyl chloride
74936-93-9

(S)-5-oxopyrrolidine-2-carbonyl chloride

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
In dichloromethane for 0.0833333h; Heating;81%
L-glutamic acid diethyl ester
16450-41-2

L-glutamic acid diethyl ester

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
at 150℃; under 15.0015 Torr; Inert atmosphere;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-ethyl N-tert-butoxycarbonylpyroglutamate
144978-35-8, 144978-12-1

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃;100%
With dmap In dichloromethane at 20℃; for 6h;100%
With dmap In acetonitrile at 20℃; for 3h;98%
2-bromobenzaldehyde O-(phenylmethyl)oxime
902137-35-3

2-bromobenzaldehyde O-(phenylmethyl)oxime

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[2-(Benzyloxyimino-methyl)-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
902137-36-4

(S)-1-[2-(Benzyloxyimino-methyl)-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃;99%
2-bromobenzaldehyde O-(phenylmethyl)oxime
902137-35-3

2-bromobenzaldehyde O-(phenylmethyl)oxime

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-5-oxo-1-[2-[(E)-(phenylmethoxyimino)methyl]phenyl]proline ethyl ester
1032651-69-6

(S)-5-oxo-1-[2-[(E)-(phenylmethoxyimino)methyl]phenyl]proline ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h;99%
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
902137-32-0

methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[2-(Benzyloxyimino-methyl)-4-methoxycarbonyl-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
902137-42-2

(S)-1-[2-(Benzyloxyimino-methyl)-4-methoxycarbonyl-phenyl]-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃;98%
methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate
902137-32-0

methyl 4-bromo-3-[(phenylmethoxyimino)methyl]benzoate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-[4-(methoxycarbonyl)-2-[(E)-(phenylmethoxyimino)methyl]phenyl]-5-oxoproline ethyl ester
1032651-88-9

(S)-1-[4-(methoxycarbonyl)-2-[(E)-(phenylmethoxyimino)methyl]phenyl]-5-oxoproline ethyl ester

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 8h;98%
triethyloxonium fluoroborate
368-39-8

triethyloxonium fluoroborate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (2S)-5-ethoxy-3,4-dihydro-2H-pyrrole-2-carboxylate
76529-79-8

ethyl (2S)-5-ethoxy-3,4-dihydro-2H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 12h; regioselective reaction;97%
92%
In dichloromethane at 20℃; for 40h;92%
In chloroform at 5℃; for 4h;69%
In dichloromethane at 20℃; for 168h;56%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

L-1-<(Ethoxycarbonyl)methyl>-5-oxoprolin-ethylester
100462-35-9

L-1-<(Ethoxycarbonyl)methyl>-5-oxoprolin-ethylester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;97%
With sodium hydride 1.) benzene, r.t., 30 min; 50-60 deg C, 10 min, 2.) r.t., 2 h; Yield given. Multistep reaction;
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-Pyroglutaminol
17342-08-4

(S)-Pyroglutaminol

Conditions
ConditionsYield
With potassium borohydride; lithium chloride In tetrahydrofuran at -15 - 20℃; for 2h; Reagent/catalyst;95%
With lithium borohydride In tetrahydrofuran at 20℃; for 48h;90%
With sodium tetrahydroborate In ethanol83%
phosgene
75-44-5

phosgene

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

L-1-(chlorocarbonyl)proline ethyl ester
86050-92-2

L-1-(chlorocarbonyl)proline ethyl ester

Conditions
ConditionsYield
In chloroform at 5 - 40℃; for 29h;95%
benzyl bromide
100-39-0

benzyl bromide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-(+)-1-(benzyl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
137641-62-4

(S)-(+)-1-(benzyl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;95%
With sodium hydride 1) THF, mineral oil, 0.25 h, 2) THF, mineral oil, room temperature, 2 h; Yield given. Multistep reaction;
With potassium tert-butylate In tetrahydrofuran; water; ethyl acetate
With tert-BuOK In tetrahydrofuran; water; ethyl acetate
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 24.5h;
methyl chloroformate
79-22-1

methyl chloroformate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl N-methoxycarbonyl-L-pyroglutamate
261177-52-0

ethyl N-methoxycarbonyl-L-pyroglutamate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h;95%
allyl bromide
106-95-6

allyl bromide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-1-allyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
115445-33-5

(S)-1-allyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;94%
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran sonication (ultrasonic cleaning bath);81%
With sodium hydride In tetrahydrofuran at 20℃;80%
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonic bath;78%
With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran Ambient temperature; sonication;43%
1,3-dibromopropene
627-15-6

1,3-dibromopropene

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-(3-bromo-2-propenyl)-5-oxoproline ethyl ester

1-(3-bromo-2-propenyl)-5-oxoproline ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;93%
carbon monoxide
201230-82-2

carbon monoxide

2-(2-iodophenyl)acetonitrile
40400-15-5

2-(2-iodophenyl)acetonitrile

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-ethyl 10-cyano-5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3-carboxylate
1075683-99-6

(S)-ethyl 10-cyano-5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3-carboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;93%
...Expand
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate
80442-95-1

ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With Lawessons reagent In toluene for 1h; Heating;92%
With Lawessons reagent In tetrahydrofuran Ambient temperature;90%
With Lawessons reagent In tetrahydrofuran at 20℃; for 1h;90%
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

methyl iodide
74-88-4

methyl iodide

1-methyl-L-pyroglutamic acid ethyl ester

1-methyl-L-pyroglutamic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin at 0℃; 20-30 min;92%
With sodium hydride Yield given. Multistep reaction;
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #1: ethyl (S)-pyroglutamate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.25h;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 96h;
carbon monoxide
201230-82-2

carbon monoxide

ethyl 2-(2-iodophenyl)acetate
90794-29-9

ethyl 2-(2-iodophenyl)acetate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(S)-diethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3,10-dicarboxylate
1075683-90-7

(S)-diethyl 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-b]isoquinoline-3,10-dicarboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;92%
...Expand
2-carbomethoxyaniline
134-20-3

2-carbomethoxyaniline

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

9-oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ethyl ester
866925-48-6

9-oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane for 3h; Heating;91%
carbon monoxide
201230-82-2

carbon monoxide

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 2-(3,4-methylenedioxy-6-iodophenyl)acetate

ethyl 2-(3,4-methylenedioxy-6-iodophenyl)acetate

(S)-diethyl 5-oxo-5,7,8,9-tetrahydro-[1,3]dioxolo[4,5-g]pyrrolo[1,2-b]isoquinoline-7,10-dicarboxylate
1075683-97-4

(S)-diethyl 5-oxo-5,7,8,9-tetrahydro-[1,3]dioxolo[4,5-g]pyrrolo[1,2-b]isoquinoline-7,10-dicarboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; triphenylphosphine In tetrahydrofuran at 80℃; under 10343.2 Torr; for 24h; Autoclave;90%
...Expand
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-phenyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

1-phenyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;89%
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 3-(2,5-dioxo-1-phenyl-imidazolidin-4-yl)propanoate

ethyl 3-(2,5-dioxo-1-phenyl-imidazolidin-4-yl)propanoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 16h;89%
phenyl isocyanate
103-71-9

phenyl isocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

(2S)-ethyl 1-Phenylcarbamoyl-5-oxopyrrolidine-2-carboxylate

(2S)-ethyl 1-Phenylcarbamoyl-5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
With sodium hydride In diethyl ether at 20℃; for 1h;89%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl (S)-N-(ethoxycarbonyl)pyroglutamate
125048-82-0

ethyl (S)-N-(ethoxycarbonyl)pyroglutamate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 8h;88%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-benzyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

1-benzyl-2,7-dioxo-[1,3]diazepane-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;87%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

ethyl 3-(1-benzyl-2,5-dioxo-imidazolidin-4-yl)propanoate

ethyl 3-(1-benzyl-2,5-dioxo-imidazolidin-4-yl)propanoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 16h;87%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

1-(9H-fluoren-9-ylmethyl) 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate

1-(9H-fluoren-9-ylmethyl) 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere;		87%
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 20h; Inert atmosphere;		87%
Stage #1: ethyl (S)-pyroglutamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.25h; Inert atmosphere;
Stage #2: (fluorenylmethoxy)carbonyl chloride In tetrahydrofuran at -78 - 20℃; for 16h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; water		83%

Ethyl L-pyroglutamate Chemical Properties

Molecular Formula: C7H11NO3
Molar mass: 157.178 g/mol
EINECS: 230-480-9
Density: 1.161 g/cm3
Flash Point: 142.9 °C
Index of Refraction: 1.466
Boiling Point: 312.7 °C at 760 mmHg
Vapour Pressure: 0.000519 mmHg at 25°C
Melting point: 54-56 °C
Storage temp: 0-6°C
Appearance: White to cream low melting solid
Product categories: pharmacetical;Pyroglutamic acid [Pyr, pGu];Chiral and Miscellaneous Reagents;Heterocycles
Structure of Ethyl L-pyroglutamate (7149-65-7):
        
XLogP3-AA: -0.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Systematic Name: Ethyl (2S)-5-oxopyrrolidine-2-carboxylate 
SMILES: O=C(OCC)[C@H]1NC(=O)CC1 
InChI: InChI=1/C7H11NO3/c1-2-11-7(10)5-3-4-6(9)8-5/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1 
InChIKey: QYJOOVQLTTVTJY-YFKPBYRVBB 
Std. InChI: InChI=1S/C7H11NO3/c1-2-11-7(10)5-3-4-6(9)8-5/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1 
Std. InChIKey: QYJOOVQLTTVTJY-YFKPBYRVSA-N

Ethyl L-pyroglutamate Toxicity Data With Reference

Carcinogenicity of Ethyl L-pyroglutamate (7149-65-7) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. And its toxicological properties have not been fully investigated.

Ethyl L-pyroglutamate Safety Profile

Hazard Codes: Xi
Risk Statements:
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection

Ethyl L-pyroglutamate Specification

 Ethyl L-pyroglutamate (7149-65-7) also can be called (S)-5-Oxoproline ethyl ester ; Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate ; Ethyl 5-oxo-2-pyrrolidinecarboxylate ; Aclaplastin ;L-Pyroglutamic acid ethyl ester.It is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should  flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.Notes to physician: Treat supportively and symptomatically.
In addition, Ethyl L-pyroglutamate (7149-65-7) is not compatible with strong oxidizing agents,strong bases, and you must not take it with incompatible materials.And also prevent it to broken down into hazardous decomposition products: oxides of nitrogen,carbon dioxide,carbon monoxide.

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