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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

LAPACHOL

Cas:84-79-7

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)- Manufacturer/High quality/Best price/In stock

Cas:84-79-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

84-79-7 LAPACHOL

Cas:84-79-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 84-79-7 with competitive price

Cas:84-79-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)- 84-79-7

Cas:84-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

LAPACHOL CAS:84-79-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ster

LAPACHOL CAS:84-79-7

Cas:84-79-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

Cas:84-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Lapachol

Cas:84-79-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

lapachol

Cas:84-79-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Lapachol

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Lapachol

Cas:84-79-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

84-79-7

Cas:84-79-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Lapachol

Cas:84-79-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

LAPACHOL

Cas:84-79-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-hydroxy-3-(3-methylbut-2-enyl)-1,4-naphthoquinone

Cas:84-79-7

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Lapachol

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Lapachol L54791 5mg

Cas:84-79-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Lapachol

Cas:84-79-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Lapachol

Cas:84-79-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-hydroxy-3-(3-methylbut-2-enyl)-1,4-naphthoquinone

Cas:84-79-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

LAPACHOL

Cas:84-79-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

2-Hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione

Cas:84-79-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Lapachol CAS No.84-79-7

Cas:84-79-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

LAPACHOL

Cas:84-79-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)- cas 84-79-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

LAPACHOL

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

84-79-7

Cas:84-79-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. Prompt reaction, good quality and best service make us reliable and outstanding in this industry.Appearance:White to yellow powder Stor

lapachol manufacture

Cas:84-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

3,3-dimethyl acrylaldehyde
107-86-8

3,3-dimethyl acrylaldehyde

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With formic acid In ethanol; water at 200℃; under 155.149 - 155149 Torr; for 3h; chemoselective reaction;78%
With formic acid In ethanol; water at 200℃; for 3h;78%
isonaphthazarine
605-37-8

isonaphthazarine

isoprene
78-79-5

isoprene

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With oxalic acid In 1,4-dioxane at 100℃; for 6h;78%
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

prenyl bromide
870-63-3

prenyl bromide

A

Lapachol
84-79-7

Lapachol

B

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione
64469-16-5

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); triethylamine In 1,4-dioxane at 20℃; for 4h; Heck Reaction;A 61%
B 16%
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

prenyl bromide
870-63-3

prenyl bromide

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With triethylamine; sodium iodide In dimethyl sulfoxide at 20 - 70℃; for 7h; Inert atmosphere;60%
With tetrakis(triphenylphosphine) palladium(0); triethylamine In 1,4-dioxane at 20℃; for 4h; Heck Reaction;23%
With lead(II) bromide; aluminium In acetonitrile for 15h;20%
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

prenyl bromide
870-63-3

prenyl bromide

A

Lawsone 2-isopentenyl ether
42164-69-2

Lawsone 2-isopentenyl ether

B

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With triethylamine; sodium iodide In N,N-dimethyl-formamide at 40℃; for 72h;A 4.8%
B 58.2%
With lithium hydride In dimethyl sulfoxide 45 deg C, 5 h; 25 deg C, 10 h;A 30%
B 40%
With zinc In tetrahydrofuran at 55 - 60℃; for 3h; Further byproducts given;A 0.2
B 150 mg
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

3-methyl-2-buten-1-ol
556-82-1

3-methyl-2-buten-1-ol

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0); 1-Adamantanecarboxylic acid for 1h; Heating;43%
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

3-Methyl-1-butene
563-45-1

3-Methyl-1-butene

A

Lapachol
84-79-7

Lapachol

B

2-hydroxy-3-(3-methylbut-1-en-1-yl)naphthalene-1,4-dione
4042-39-1

2-hydroxy-3-(3-methylbut-1-en-1-yl)naphthalene-1,4-dione

Conditions
ConditionsYield
With copper diacetate; sodium acetate; palladium diacetate In tetrahydrofuran at 20℃; for 3h; Mechanism; Catalytic behavior;A 20%
B 33%
2-hydroxy-1,4-naphthoquinone silver salt
36417-25-1

2-hydroxy-1,4-naphthoquinone silver salt

prenyl bromide
870-63-3

prenyl bromide

A

Lawsone 2-isopentenyl ether
42164-69-2

Lawsone 2-isopentenyl ether

B

Lapachol
84-79-7

Lapachol

1,2,3,4-tetrahydroxynaphthalene
5690-26-6

1,2,3,4-tetrahydroxynaphthalene

3-methyl-2-buten-1-ol
556-82-1

3-methyl-2-buten-1-ol

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With 1,4-dioxane; oxalic acid und Behandeln des Reaktionsgemisches mit Luft;
2-acetyllapachol
57620-99-2

2-acetyllapachol

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With sodium carbonate
2-methoxylapachol
17241-45-1

2-methoxylapachol

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With sodium carbonate for 0.833333h; Heating;45 mg
2-chloro-3-(3-methylbut-2-enyl)naphthalene-1,4-dione
82214-83-3

2-chloro-3-(3-methylbut-2-enyl)naphthalene-1,4-dione

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With sodium hydroxide for 0.416667h; Heating;30 mg
3-Bromo-α-lapachone
79060-57-4

3-Bromo-α-lapachone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With acetic acid; zinc for 2h; Heating;10 mg
4-Bromo-iso-α-lapachone
79060-56-3

4-Bromo-iso-α-lapachone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With acetic acid; zinc for 2h; Heating;
4'-bromo-iso-β-lapachone
74693-34-8

4'-bromo-iso-β-lapachone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With zinc In acetic acid for 2h; Heating;40 mg
3-(2-methyl-2-buten-4-yl)-1,2-naphthalenedione
96964-75-9

3-(2-methyl-2-buten-4-yl)-1,2-naphthalenedione

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With sodium dithionite; potassium tert-butylate; oxygen 1.) benzene, 2 min, 2.) t-BuOH, 5 min.; Yield given. Multistep reaction;
1,2,4-triacetoxy-3-(3-methyl-but-2-enyl)-naphthalene
19336-09-5

1,2,4-triacetoxy-3-(3-methyl-but-2-enyl)-naphthalene

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane
3'-bromo-β-lapachone
41019-50-5

3'-bromo-β-lapachone

zinc dust

zinc dust

KOH-solution

KOH-solution

Lapachol
84-79-7

Lapachol

bromo-β-lapachone

bromo-β-lapachone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With zinc
chlorodihydrolapachol

chlorodihydrolapachol

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With potassium hydroxide
prenyl bromide
870-63-3

prenyl bromide

potassium-salt of 2-hydroxy-<1,4>naphthoquinone

potassium-salt of 2-hydroxy-<1,4>naphthoquinone

A

Lawsone 2-isopentenyl ether
42164-69-2

Lawsone 2-isopentenyl ether

B

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With acetone
2-hydroxy-1,4-naphthoquinone silver salt
36417-25-1

2-hydroxy-1,4-naphthoquinone silver salt

prenyl bromide
870-63-3

prenyl bromide

A

Lapachol
84-79-7

Lapachol

B

2-<γ.γ-dimethyl-allyloxy>-naphthoquinone-(1.4)

2-<γ.γ-dimethyl-allyloxy>-naphthoquinone-(1.4)

Conditions
ConditionsYield
With diethyl ether at 0℃;
1,2,3,4-tetrahydroxynaphthalene
5690-26-6

1,2,3,4-tetrahydroxynaphthalene

isoprene
78-79-5

isoprene

A

Lapachol
84-79-7

Lapachol

B

3-hydroxy-2-<2-methyl-buten-(2)-yl>-naphthoquinone-(1.4)

3-hydroxy-2-<2-methyl-buten-(2)-yl>-naphthoquinone-(1.4)

Conditions
ConditionsYield
With 1,4-dioxane; oxalic acid und Behandeln des Reaktionsgemisches mit Luft;
2-(3-Chloro-3-methylbutyl)-3-hydroxy-1,4-naphthoquinone
111479-51-7

2-(3-Chloro-3-methylbutyl)-3-hydroxy-1,4-naphthoquinone

diluted KOH-solution

diluted KOH-solution

A

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
4707-32-8

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

B

α-lapachone
4707-33-9

α-lapachone

C

Lapachol
84-79-7

Lapachol

D

oxydihydrolapachol

oxydihydrolapachol

2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

2-methyl-3-buten-2-ol
115-18-4

2-methyl-3-buten-2-ol

A

Lapachol
84-79-7

Lapachol

B

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione
64469-16-5

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0); 1-Adamantanecarboxylic acid Heating; Title compound not separated from byproducts.;
lapachol-1,4-di-O-β-D-glucopyranoside

lapachol-1,4-di-O-β-D-glucopyranoside

A

β-D-glucose
492-61-5

β-D-glucose

B

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
With β-cellulase; water at 37℃; for 48h; Enzymatic reaction;A n/a
B 25.2 mg
2-hydroxy-3-(2-methyl-2-buten-4-yl)naphthalene
96964-74-8

2-hydroxy-3-(2-methyl-2-buten-4-yl)naphthalene

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / CuCl, O2 / acetonitrile / 0.33 h / 5 - 10 °C
2: 1.) aq. Na2S2O4, 2.) t-BuOK, O2 / 1.) benzene, 2 min, 2.) t-BuOH, 5 min.
View Scheme
2-Hydroxy-1,4-naphthoquinone
83-72-7

2-Hydroxy-1,4-naphthoquinone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3 / acetone / 40 h / Heating
2: 70 mg / zinc dust / tetrahydrofuran / 24 h
3: 45 mg / aq.Na2CO3 / 0.83 h / Heating
View Scheme
2-chloro-1,4-naphthoquinone
1010-60-2

2-chloro-1,4-naphthoquinone

Lapachol
84-79-7

Lapachol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 300 mg / zinc dust / tetrahydrofuran / 4 h
2: 30 mg / 1percent aq.NaOH / 0.42 h / Heating
View Scheme
Lapachol
84-79-7

Lapachol

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
4707-32-8

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃;100%
With sulfuric acid at 0 - 20℃;100%
With sulfuric acid99%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

Lapachol
84-79-7

Lapachol

lapachol laurate

lapachol laurate

Conditions
ConditionsYield
With lutidine In dichloromethane at 0℃; for 0.0833333h;100%
With lutidine In dichloromethane at 0℃;100%
With triethylamine In diethyl ether at 20℃; for 0.5h;
Lapachol
84-79-7

Lapachol

2-hydroxy-3-(3-methyl-butyl)-5,6,7,8-tetrahydro-[1,4]naphthoquinone

2-hydroxy-3-(3-methyl-butyl)-5,6,7,8-tetrahydro-[1,4]naphthoquinone

Conditions
ConditionsYield
With 10% palladium on activated carbon; hydrogen; acetic acid under 2844.39 Torr; for 6h;100%
With palladium 10% on activated carbon; hydrogen; acetic acid under 2844.39 Torr; for 6h;
Lapachol
84-79-7

Lapachol

acetyl chloride
75-36-5

acetyl chloride

2-acetyllapachol
57620-99-2

2-acetyllapachol

Conditions
ConditionsYield
With lutidine In dichloromethane at 0℃; for 0.0833333h;99.7%
With lutidine In dichloromethane at 0℃;99%
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;80%
With triethylamine In diethyl ether at 20℃; for 0.5h;
Lapachol
84-79-7

Lapachol

di(4-bromophenyl) selenide
33834-56-9

di(4-bromophenyl) selenide

3-((4-bromophenyl)selanyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

3-((4-bromophenyl)selanyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

Conditions
ConditionsYield
With iodine; dimethyl sulfoxide at 50℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry;99%
Lapachol
84-79-7

Lapachol

2-hydroxy-3-isopentylnaphthalene-1,4-dione
3343-38-2

2-hydroxy-3-isopentylnaphthalene-1,4-dione

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal under 3750.3 Torr; for 2h; Heating;98%
With 10% palladium on activated carbon; hydrogen In ethanol under 1551.49 Torr; for 0.25h;90%
With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 20℃; for 12h;83%
mer-[(1,4-bis(diphenylphosphino)butane)aquatrichlororuthenium(III)]
243643-58-5

mer-[(1,4-bis(diphenylphosphino)butane)aquatrichlororuthenium(III)]

Lapachol
84-79-7

Lapachol

RuCl2(lapachol)(1,4-bis(diphenylphosphine)butane)
1615718-36-9

RuCl2(lapachol)(1,4-bis(diphenylphosphine)butane)

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane for 24h; Reflux; Inert atmosphere;98%
dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer

dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer

Lapachol
84-79-7

Lapachol

chlorido[(3-(3-methylbut-2-enyl)-2-oxo-κO)-[1,4]-naphthoquinonato-κO](η6-pentamethylcyclopentadienyl)rhodium(III)
1429209-71-1

chlorido[(3-(3-methylbut-2-enyl)-2-oxo-κO)-[1,4]-naphthoquinonato-κO](η6-pentamethylcyclopentadienyl)rhodium(III)

Conditions
ConditionsYield
With sodium methylate In methanol; dichloromethane at 20℃; for 24h; Inert atmosphere;96%
Lapachol
84-79-7

Lapachol

4-chlorobenzoyl chloride
586-75-4

4-chlorobenzoyl chloride

4-bromo-benzoic acid 3-(3-methyl-but-2-enyl)-1,4-dioxo-1,4-dihydro-naphthalen-2-yl ester

4-bromo-benzoic acid 3-(3-methyl-but-2-enyl)-1,4-dioxo-1,4-dihydro-naphthalen-2-yl ester

Conditions
ConditionsYield
With lutidine In dichloromethane at 0℃; for 0.0833333h;95.7%
Lapachol
84-79-7

Lapachol

α-lapachone
4707-33-9

α-lapachone

Conditions
ConditionsYield
With hydrogenchloride; acetic acid95%
With hydrogenchloride; acetic acid In water95%
With hydrogenchloride In water at 80℃; for 4h;85%
Lapachol
84-79-7

Lapachol

3'-bromo-β-lapachone
41019-50-5

3'-bromo-β-lapachone

Conditions
ConditionsYield
With bromine In dichloromethane for 24h;95%
With bromine; acetic acid Behandeln des Reaktionsprodukts mit Wasser;
With chloroform; bromine Behandeln des Reaktionsprodukts mit Alkohol;
Lapachol
84-79-7

Lapachol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

C21H18N2O
875845-30-0

C21H18N2O

Conditions
ConditionsYield
With sodium acetate; acetic acid at 90 - 95℃;95%
1-methyl-1-nitrosourea
684-93-5

1-methyl-1-nitrosourea

Lapachol
84-79-7

Lapachol

2-methoxylapachol
17241-45-1

2-methoxylapachol

Conditions
ConditionsYield
With potassium hydroxide at 0℃; Inert atmosphere;95%
Lapachol
84-79-7

Lapachol

(E)-4-(1,4-dihydro-2-hydroxy-1,4-dioxonaphthalen-3-yl)-2-methylbut-2-enal

(E)-4-(1,4-dihydro-2-hydroxy-1,4-dioxonaphthalen-3-yl)-2-methylbut-2-enal

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane Reflux;95%
isoniazid
54-85-3

isoniazid

Lapachol
84-79-7

Lapachol

1-N-isonicotinoyl-hydrazone-[2-hydroxy-3-(3-methyl-2-butenyl)]-1,4-naphthoquinone

1-N-isonicotinoyl-hydrazone-[2-hydroxy-3-(3-methyl-2-butenyl)]-1,4-naphthoquinone

Conditions
ConditionsYield
With triethylamine In water at 20℃; for 48h;95%
isoniazid
54-85-3

isoniazid

Lapachol
84-79-7

Lapachol

1-N'-(4-hydroxy-3-(3-methylbut-2-enyl)-2-oxonaphthalen-1(2H)-ylidene)isonicotinohydrazide

1-N'-(4-hydroxy-3-(3-methylbut-2-enyl)-2-oxonaphthalen-1(2H)-ylidene)isonicotinohydrazide

Conditions
ConditionsYield
Stage #1: isoniazid; Lapachol With triethylamine In water at 20℃; for 48h;
Stage #2: With acetic acid In water
95%
cis-[RuCl2(triphenylphospine)2(1,10-phenantroline)]
159700-02-4, 21627-33-8

cis-[RuCl2(triphenylphospine)2(1,10-phenantroline)]

Lapachol
84-79-7

Lapachol

hexafluorophosphate

hexafluorophosphate

[Ru(lapachol)(triphenylphospine)2(1,10-phenantroline)]PF6

[Ru(lapachol)(triphenylphospine)2(1,10-phenantroline)]PF6

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane for 72h; Reflux; Inert atmosphere;94%
Di-n-butyl selenide
14835-66-6

Di-n-butyl selenide

Lapachol
84-79-7

Lapachol

3-(butylselanyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

3-(butylselanyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

Conditions
ConditionsYield
With iodine; dimethyl sulfoxide at 50℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry;94%
Lapachol
84-79-7

Lapachol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

3-(3-methylbut-2-enyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl methanesulfonate
1376687-04-5

3-(3-methylbut-2-enyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl methanesulfonate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 0 - 20℃; for 48h;93.7%
Lapachol
84-79-7

Lapachol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

C21H28O3Si

C21H28O3Si

Conditions
ConditionsYield
With lutidine In dichloromethane at 0℃;93%
diphenyl diselenide
1666-13-3

diphenyl diselenide

Lapachol
84-79-7

Lapachol

2,2-dimethyl-3-(phenylselanyl)-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

2,2-dimethyl-3-(phenylselanyl)-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

Conditions
ConditionsYield
With tert-butylammonium hexafluorophosphate(V) In acetonitrile at 20℃; for 1h; Reagent/catalyst; Solvent; Time; Electrolysis; Green chemistry;93%
With iodine; dimethyl sulfoxide In neat (no solvent) at 50℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry; regioselective reaction;65%
With iodine; dimethyl sulfoxide at 50℃; for 0.166667h; Microwave irradiation;
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

Lapachol
84-79-7

Lapachol

2-((7-chloroquinolin-4- yl)oxy)-3-(3-methylbut-2- en- 1-yl)naphthalene-1,4- dione

2-((7-chloroquinolin-4- yl)oxy)-3-(3-methylbut-2- en- 1-yl)naphthalene-1,4- dione

Conditions
ConditionsYield
Stage #1: Lapachol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 4,7-dichloroquinoline In N,N-dimethyl-formamide at 120℃; for 24h;
93%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Lapachol
84-79-7

Lapachol

chlorido[(3-(3-methylbut-2-enyl)-2-oxo-κO)-[1,4]-naphthoquinonato-κO](η6-p-cymene)ruthenium(II)
1429209-69-7

chlorido[(3-(3-methylbut-2-enyl)-2-oxo-κO)-[1,4]-naphthoquinonato-κO](η6-p-cymene)ruthenium(II)

Conditions
ConditionsYield
With sodium methylate In methanol; dichloromethane at 20℃; for 4.5h; Inert atmosphere;92%
Lapachol
84-79-7

Lapachol

dimethyl sulfate
77-78-1

dimethyl sulfate

2-methoxylapachol
17241-45-1

2-methoxylapachol

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 3h;91%
With potassium carbonate In acetone at 20℃; for 2h;88%
With sodium hydroxide at 70 - 80℃; for 1h;139 mg
With potassium carbonate In acetone
With potassium carbonate In acetone at 20℃;
Lapachol
84-79-7

Lapachol

3-hydroxy-4-(hydroxyimino)-2-(3-methylbut-2-enylnaphtalen-1(4H)-one)

3-hydroxy-4-(hydroxyimino)-2-(3-methylbut-2-enylnaphtalen-1(4H)-one)

Conditions
ConditionsYield
With sodium hydroxide; hydroxylamine hydrochloride for 2h;91%
Lapachol
84-79-7

Lapachol

2-bis[3,5bis(trifluoromethyl)phenyl]diselane
1787-80-0

2-bis[3,5bis(trifluoromethyl)phenyl]diselane

2,2-dimethyl-3-(naphthalen-1-ylselanyl)-3,4-dihydro-2Hbenzo[h]chromene-5,6-dione

2,2-dimethyl-3-(naphthalen-1-ylselanyl)-3,4-dihydro-2Hbenzo[h]chromene-5,6-dione

Conditions
ConditionsYield
With tert-butylammonium hexafluorophosphate(V) In acetonitrile at 20℃; for 1h; Electrolysis; Green chemistry;91%
Lapachol
84-79-7

Lapachol

2,3-dihydro-3-[(3-methylbut-2-enyl)-1,4-naphthoquinon-2-yloxy]-3-(3-methylbut-2-enyl)-2-oxo-1,4-naphthoquinone
855637-05-7

2,3-dihydro-3-[(3-methylbut-2-enyl)-1,4-naphthoquinon-2-yloxy]-3-(3-methylbut-2-enyl)-2-oxo-1,4-naphthoquinone

Conditions
ConditionsYield
With lead dioxide In acetic acid Heating;90%
With lead dioxide; acetic acid90%
With lead dioxide; acetic acid Heating;
Lapachol
84-79-7

Lapachol

(E)-2-hydroxy-3-(4-hydroxy-3-methylbut-2-enyl)-naphthalene-1,4-dione
523-34-2

(E)-2-hydroxy-3-(4-hydroxy-3-methylbut-2-enyl)-naphthalene-1,4-dione

Conditions
ConditionsYield
With tert.-butylhydroperoxide; selenium(IV) oxide; salicylic acid In dichloromethane at 0 - 20℃; for 2h;90%
Multi-step reaction with 2 steps
1: selenium(IV) oxide / 1,4-dioxane / Reflux
2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
View Scheme
Lapachol
84-79-7

Lapachol

A

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
4707-32-8

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

B

α-lapachone

α-lapachone

Conditions
ConditionsYield
With zinc(II) chloride In dichloromethane at 42℃; for 4h; Reagent/catalyst; Temperature;A n/a
B 90%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

cobalt(II) acetate dihydrate

cobalt(II) acetate dihydrate

Lapachol
84-79-7

Lapachol

[Co(lapachol)2(1,10-phenanthroline)]

[Co(lapachol)2(1,10-phenanthroline)]

Conditions
ConditionsYield
Stage #1: Lapachol With potassium hydroxide In methanol for 1h;
Stage #2: 1,10-Phenanthroline; cobalt(II) acetate dihydrate In methanol at 20℃; for 3h;
89.3%

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