1,12-Dodecanedioic acid supplier

Name
Dodecanedioic acid
EINECS 211-746-3
CAS No. 693-23-2
Article Data167
CAS DataBase
Density 1.066 g/cm³
Solubility < 0.1 g/L (20 °C) in water
Melting Point 127-129 °C(lit.)
Formula C₁₂H₂₂O₄
Boiling Point 394 °C at 760 mmHg
Molecular Weight 230.304
Flash Point 216.6 °C
Transport Information
Appearance white crystalline powder
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,10-Decanedicarboxylicacid;1,10-Dicarboxydecane;Corfree M 2;Decamethylenedicarboxylic acid;LCA 141;NSC 400242;SL-AH;n-Dodecane-a,w-dioic acid;n-Dodecanedioic acid;
PSA 74.60000
LogP 3.05660

Synthetic route

: 5675-51-4
1,12-dodecandiol

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With air; sodium nitrite In trifluoroacetic acid at 0 - 20℃; for 5h;	100%
With hydrogenchloride; calcium hypochlorite In tetrachloromethane; tert-butyl alcohol for 7h;	58%

: 22915-49-7
11-cyanoundecanoic acid methyl ester

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With hydrogenchloride; water for 2.5h; Reflux;	100%

: 95338-32-2, 13154-31-9
2-nitrocyclododecanone

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium carbonate In methanol for 10h; Ambient temperature;	92%
With Oxone; sodium hydroxide; disodium hydrogenphosphate; water 1.) MeOH, 70 deg C, 4 h, 2.) MeOH, r.t., 4 h; Yield given. Multistep reaction;

: 1,3-Dioxa-cyclopentadecane-4,15-dione

A: 505-95-3
12-hydroxydodecanoic acid

B: 5675-51-4
1,12-dodecandiol

C: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 6h;	A 85% B 8% C 6%
With sodium tetrahydroborate In tetrahydrofuran at 23℃; for 120h;	A 82% B 12% C n/a
With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 9h; Product distribution; influence of temperature, reaction time;	A 77% B 11% C 9%
With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 6h;	A 66% B 6% C 11%

...Expand

: 1501-82-2
cyclododecene

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With Oxone; 2-iodo-3,4,5,6-tetramethylbenzoic acid In water; acetonitrile for 24h;	85%
With tetrafluoroboric acid; iodomesitylene; 3-chloro-benzenecarboperoxoic acid In dichloromethane; water; acetonitrile at 50℃; for 10h; Inert atmosphere;	77 %Spectr.
With potassium peroxymonosulfate; iodobenzene In water; acetonitrile at 60℃; for 8h;	82 %Spectr.

: 118101-31-8
(1S,2S)-Cyclododecane-1,2-diol

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With potassium carbonate; stearic acid at 50℃; for 22.5h; electrolysis: nickel(III) oxide hydroxide electrode, 0.3 A;	84%

: 74824-56-9, 74867-43-9, 74867-44-0, 51100-54-0
dec-1-en-3-ol

: 201230-82-2
carbon monoxide

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With HeMaRaphos; water; toluene-4-sulfonic acid; palladium dichloride In tetrahydrofuran at 125℃; under 30003 Torr; for 24h; Autoclave; Green chemistry; regioselective reaction;	83%

: 1724-39-6
cyclododecanol

A: 693-23-2
1,12-dodecanedioic acid

B: 830-13-7
cyclododecanone

Conditions

Conditions	Yield
With oxygen; sodium nitrite In trifluoroacetic acid at 0 - 20℃; for 5h;	A 80% B 10%

: 73120-52-2
1,12-dimethoxydodecane

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With lithium nitrate In water; acetonitrile at 25℃; anodic oxidation;	78%

: 830-13-7
cyclododecanone

A: 947-05-7
oxacyclotridecan-2-one

B: 505-95-3
12-hydroxydodecanoic acid

C: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With maleic anhydride; dihydrogen peroxide In dichloromethane; acetic anhydride for 15h; Heating;	A 77% B n/a C n/a

...Expand

: 4422-05-3
cis-1,2-cyclododecanediol

A: 3956-80-7
12-oxododecanoic acid

B: 693-23-2
1,12-dodecanedioic acid

C: 38279-34-4
dodecanedial

D: 3008-41-1
cyclododecane-1,2-dione

Conditions

Conditions	Yield
With Oxone; sodium ortho-iodobenzenesulfonate In acetonitrile at 70℃; for 1h;	A n/a B n/a C n/a D 72%

...Expand

: 294-62-2
cyclododecane

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With N-hydroxyphthalimide; bis(acetylacetonato)manganese(II); oxygen; acetic acid at 70℃; under 760.051 Torr; for 14h;	68%

: 108-94-1
cyclohexanone

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
Stage #1: cyclohexanone With dihydrogen peroxide In water at 25 - 30℃; for 0.25h; UV-irradiation; Stage #2: In water at 50℃; for 6h; Temperature; UV-irradiation;	67.1%
Multi-step reaction with 2 steps 1: H2O2; water 2: iron (II)-sulfate; aqueous sulfuric acid View Scheme
Multi-step reaction with 2 steps 1: H2O2; diethyl ether 2: iron (II)-sulfate heptahydrate; methanol View Scheme

: 505-95-3
12-hydroxydodecanoic acid

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With hydrogenchloride; calcium hypochlorite In tetrachloromethane; tert-butyl alcohol for 7h;	65%
With oleate hydratase from S. maltophilia In aq. buffer at 35℃; for 2h; pH=8; Enzymatic reaction;	46%
With chromium(VI) oxide; acetic acid

: 1486-75-5
(E)-Cyclododecen

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With jones reagent; osmium(VIII) oxide In water; acetone for 20h; Ambient temperature;	65%

: 74515-85-8
C48H88O16

A: 74-85-1
ethene

B: 693-23-2
1,12-dodecanedioic acid

C: 2177-96-0
12-oxo-tetradecanoic acid

D carbon monooxide, carbon dioxide, oxygen: carbon monooxide, carbon dioxide, oxygen

Conditions

Conditions	Yield
In n-heptane at 100℃; Product distribution; var. solvent, var. temp.;	A n/a B 60% C 12% D n/a

...Expand

: 3008-41-1
cyclododecane-1,2-dione

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In methanol; water for 2h; Ambient temperature;	47%

oligomeric diacyl peroxide: oligomeric diacyl peroxide

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide for 48h;	47%

: 2783-17-7
1,12-Diaminododecane

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
Pseudomonas K24	7%

: 26307-31-3
2-Acetoxycyclododecanone

A: 693-23-2
1,12-dodecanedioic acid

B: 19025-38-8, 140134-30-1
2-hydroxycyclododecanone

Conditions

Conditions	Yield
With potassium hydroxide In methanol	A 4.9 g B 3.1%
With potassium hydroxide In methanol Heating;	A 4.9 g B 3.1 g

: 111-24-0
1,5-dibromo-pentane

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With diethyl ether; magnesium bei der Einw. von Kohlendioxid auf das Reaktionsprodukt;

: 78-18-2
1-hydroxycyclohexyl 1-hydroperoxycyclohexyl peroxide

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With sulfuric acid; iron(II) sulfate
With methanol; iron(II) sulfate

: 78-18-2
1-hydroxycyclohexyl 1-hydroperoxycyclohexyl peroxide

A: 124-04-9
Adipic acid

B: 693-23-2
1,12-dodecanedioic acid

C: 108-94-1
cyclohexanone

D: 142-62-1
hexanoic acid

Conditions

Conditions	Yield
at 110 - 160℃;

...Expand

: 55311-11-0
dodec-6c-enedioic acid

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With 1,4-dioxane; platinum Hydrogenation;

: 106-14-9
12-Hydroxystearic acid

A: 123-99-9
azelaic acid

B: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With nitric acid
With ammonium vanadate bei Siedetemperatur;
With nitric acid

: 106-14-9
12-Hydroxystearic acid

A: 1852-04-6
undecanedioic acid

B: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With nitric acid
With ammonium vanadate; nitric acid
With nitric acid

: 106-14-9
12-Hydroxystearic acid

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide; paraffin oil at 320℃;

: 24772-63-2
1,8-diiodooctane

: 996-82-7
sodium diethylmalonate

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With ethanol Erwaermen des Reaktionsgemisches mit wss.Natronlauge und Erhitzen des nach dem Ansaeuern erhaltenen Reaktionsprodukts auf 180grad;

: 4543-66-2
1,12-dodecanedinitrile

: 693-23-2
1,12-dodecanedioic acid

Conditions

Conditions	Yield
With sodium ethanolate

: 693-23-2
1,12-dodecanedioic acid

: 4834-98-4
1,12-dodecanedioyl dichloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide for 2h; Reflux;	100%
With thionyl chloride Heating;	95%
With thionyl chloride

: 67-56-1
methanol

: 693-23-2
1,12-dodecanedioic acid

: 1731-79-9
dodecanedioic acid dimethyl ester

Conditions

Conditions	Yield
With boron trifluoride at 65℃; for 0.333333h;	100%
With sulfuric acid for 24h; Reflux; Inert atmosphere;	100%
With sulfuric acid Heating;	99%

: 693-23-2
1,12-dodecanedioic acid

: 530-62-1
1,1'-carbonyldiimidazole

: 122236-61-7
1,12-Di-imidazol-1-yl-dodecane-1,12-dione

Conditions

Conditions	Yield
In neat (no solvent) for 2h;	100%
In N,N-dimethyl acetamide at 40℃;
In tetrahydrofuran for 24h; Ambient temperature;
In tetrahydrofuran

: 74124-79-1
di(succinimido) carbonate

: 693-23-2
1,12-dodecanedioic acid

: 75472-90-1
dodecanedioic acid bis(2,5-dioxopyrrolidin-1-yl) ester

Conditions

Conditions	Yield
With pyridine In acetonitrile at 20℃; for 7h;	100%
With pyridine In acetonitrile at 20℃; for 7h; Inert atmosphere;	100%
With pyridine In acetonitrile at 20℃; for 3h;	90%

: 105-38-4
vinyl propionate

: 693-23-2
1,12-dodecanedioic acid

: dodecandioic acid divinyl ester

Conditions

Conditions	Yield
With sulfuric acid; mercury(II) diacetate at 20 - 50℃; for 4h;	100%
With sulfuric acid; mercury(II) diacetate

: 693-23-2
1,12-dodecanedioic acid

: 38279-34-4
dodecanedial

Conditions

Conditions	Yield
With 9-borabicyclo[3.3.1]nonane dimer; lithium dihydrido borata-bicyclo[3.3.0]nonane In tetrahydrofuran for 1h; Ambient temperature;	99%
With hydrogen; 2,2-dimethylpropanoic anhydride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 80℃; under 22501.8 Torr; for 24h;	75%
With thexylchloroborane*methyl sulfide In dichloromethane for 0.25h; Ambient temperature;

: 112-92-5
1-octadecanol

: 693-23-2
1,12-dodecanedioic acid

: 42234-06-0
distearyl dodecanedioate

Conditions

Conditions	Yield
With 1-hexadecyl-3-sulfo-1H-imidazol-3-ium chloride In neat (no solvent) at 110℃; for 16h; Green chemistry;	99%

: 64-17-5
ethanol

: 693-23-2
1,12-dodecanedioic acid

: 10471-28-0
diethyl dodecanedioate

Conditions

Conditions	Yield
for 2h; Reflux; Acidic conditions;	98%
With sulfuric acid for 2h; Reflux;	98%
With hydrogenchloride decane-dicarboxylic acid-(1.10)-di--ester;

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 693-23-2
1,12-dodecanedioic acid

: 75472-90-1
dodecanedioic acid bis(2,5-dioxopyrrolidin-1-yl) ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h;	98%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dimethyl sulfoxide at 20℃;

: 693-23-2
1,12-dodecanedioic acid

: 75-59-2
tetramethyl ammoniumhydroxide

: bis(tetramethylammonium) dodecanedioate

Conditions

Conditions	Yield
In methanol at 21℃; for 48h;	98%

: 693-23-2
1,12-dodecanedioic acid

: 106-91-2
2,3-Epoxypropyl methacrylate

: 1,12-bis[2-hydroxy-3-methacryloyloxypropyl] dodecanedioate

Conditions

Conditions	Yield
With triphenylphosphine at 90℃; for 3h;	98%

: 693-23-2
1,12-dodecanedioic acid

: 5675-51-4
1,12-dodecandiol

Conditions

Conditions	Yield
With tricarbonyl(η(4)-cycloocta-1,5-diene)iron; phenylsilane In tetrahydrofuran at 20℃; for 24h; UV-irradiation; Inert atmosphere; chemoselective reaction;	97%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;	91%
Multi-step reaction with 2 steps 1: sulfuric acid / Heating 2: LiAlH4 / diethyl ether / 0 °C View Scheme
Stage #1: 1,12-dodecanedioic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 2℃; for 0.25h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at 2℃;

: 693-23-2
1,12-dodecanedioic acid

: 115-11-7
isobutene

: 234081-98-2
1,10-decanedicarboxylic acid mono-tert-butyl ester

Conditions

Conditions	Yield
With graphene-ferric oxide composite nanomaterial In dichloromethane for 4h; Solvent; Reagent/catalyst; Cooling with ice;	95.3%
With graphene/ferric oxide composite nanomaterial In dichloromethane; di-isopropyl ether for 4h; Solvent; Cooling with ice;

: 120-93-4
imidazolidone

: 693-23-2
1,12-dodecanedioic acid

poly[N,N-(1,10-decanedicarboxyl)-2-imidazolidone], Mw 22000, Mn 8100, DP 34; monomer(s): 1,10-decanedicarboxylic acid; 2-imidazolidone: poly[N,N-(1,10-decanedicarboxyl)-2-imidazolidone], Mw 22000, Mn 8100, DP 34; monomer(s): 1,10-decanedicarboxylic acid; 2-imidazolidone

Conditions

Conditions	Yield
With 3,5-bis-trifluromethylphenylboronic acid In 1,3,5-trimethyl-benzene for 24h; Heating;	95%

: 693-23-2
1,12-dodecanedioic acid

: 62-53-3
aniline

: 190966-17-7
N1,N12-diphenyldodecane-1,12-diamine

Conditions

Conditions	Yield
With tris(2,4-pentanedionato)ruthenium(III); methanesulfonic acid; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In 1,4-dioxane at 220℃; under 7500.75 Torr; for 42h; Solvent; Autoclave; Inert atmosphere;	95%

: 693-23-2
1,12-dodecanedioic acid

: 11-amino-N-(strychnin-2-yl)undecanoic acid amide

: N1,N12-Bis[N-(strychnine-2-yl)undecanoic Acid Amide-11-yl]dodecanediamide

Conditions

Conditions	Yield
Stage #1: 1,12-dodecanedioic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h; Inert atmosphere; Cooling with ice; Stage #2: 11-amino-N-(strychnin-2-yl)undecanoic acid amide In dichloromethane at 20℃; for 14h; Inert atmosphere; Cooling with ice;	93%

: 27574-41-0
tri-n-butylbenzylammonium hydroxide

: 693-23-2
1,12-dodecanedioic acid

: benzyl(tributyl)azanium dodecanedioic acetate

Conditions

Conditions	Yield
at 20℃; for 12h;	90.55%

: 693-23-2
1,12-dodecanedioic acid

: 122-39-4
diphenylamine

A: 11-(acridin-9-yl)undecan-1-oic acid

B: 1,10-bis(acridin-9-yl)decane

Conditions

Conditions	Yield
With zinc(II) chloride at 230℃; for 20h; Condensation;	A 90% B 3%
With zinc(II) chloride at 230℃; for 40h; Condensation;	A 12% B 61%

...Expand

: 4553-62-2
2-methylglutaronitrile

: 693-23-2
1,12-dodecanedioic acid

A: 29553-51-3
3-methyl-piperidine-2,6-dione

B: 4543-66-2
1,12-dodecanedinitrile

Conditions

Conditions	Yield
With aluminum (III) chloride at 200℃; for 5h;	A 88% B 81%

...Expand

: 112-72-1
1-Tetradecanol

: 693-23-2
1,12-dodecanedioic acid

: 42234-02-6
dimyristyl dodecanedioate

Conditions

Conditions	Yield
With 1-hexadecyl-3-sulfo-1H-imidazol-3-ium chloride In neat (no solvent) at 110℃; for 16h; Green chemistry;	88%

: 693-23-2
1,12-dodecanedioic acid

: (S)-2-Amino-6-benzyloxycarbonylamino-hexanoic acid ethyl ester; compound with toluene-4-sulfonic acid

: Dodecanedioyl-Lys(Z)-OEt

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran; chloroform; N,N-dimethyl-formamide 1.) 0 deg C, 4 h, 2. ) room temp., 2 days;	87%

: 763111-47-3
4-[4’’-fluoro-3’’-(piperazine-1’’’-carbonyl)benzyl]-2H-phthalazin-1-one

: 693-23-2
1,12-dodecanedioic acid

: 12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanoic acid

Conditions

Conditions	Yield
Stage #1: 1,12-dodecanedioic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 4-[4’’-fluoro-3’’-(piperazine-1’’’-carbonyl)benzyl]-2H-phthalazin-1-one In N,N-dimethyl-formamide at 20℃; for 16h;	87%

: 693-23-2
1,12-dodecanedioic acid

: 190579-30-7
3β-hydroxy-14β,16β-O-(4-methoxybenzylidene)card-20(22)-enolide

: 190579-38-5
hydrogen 14β,16β-O-(4-methoxybenzylidene)card-20(22)-enolide-3β-yl 1,10-decanedicarboxylate

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride for 4h; Ambient temperature;	86%

: 693-23-2
1,12-dodecanedioic acid

: 66280-55-5
diperoxydodecanedioic acid

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide at 15 - 20℃; for 5h;	85%
With dihydrogen peroxide In sulfuric acid at 20℃; for 4h;	49%
With sulfuric acid; dihydrogen peroxide

1,12-Dodecanedioic acid Chemical Properties

IUPAC Name: Dodecanedioic acid
Synonyms of Dodecanedioic acid (CAS NO.693-23-2): 1,10-Decanedicarboxylic acid ; 1,10-Dicarboxydecane ; 1,12-Dodecanedioic acid ; Decamethylenedicarboxylic acid ; EINECS 211-746-3 ; HSDB 5745 ; NSC 400242
CAS NO: 693-23-2
Molecular Formula of Dodecanedioic acid (CAS NO.693-23-2): C₁₂H₂₂O₄
Molecular Weight: 230.3007
Molecular Structure:

Product Categories: Industrial/Fine Chemicals ; alpha,omega-Alkanedicarboxylic Acids ; alpha,omega-Bifunctional Alkanes ; Monofunctional & alpha,omega-Bifunctional Alkanes
Melting Point: 127-129 °C
Polar Surface Area: 52.6 Å²
Index of Refraction: 1.474
Molar Refractivity: 60.77 cm³
Molar Volume: 215.8 cm³
Surface Tension: 43.1 dyne/cm
Density of Dodecanedioic acid (CAS NO.693-23-2): 1.066 g/cm³
Flash Point: 216.6 °C
Enthalpy of Vaporization: 70.68 kJ/mol
Boiling Point: 394 °C at 760 mmHg
Vapour Pressure: 2.63E-07 mmHg at 25°C

1,12-Dodecanedioic acid Uses

Dodecanedioic acid (CAS NO.693-23-2) is mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitor, surfactant, and engineering plastics.

1,12-Dodecanedioic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
HS Code: 29171990

1,12-Dodecanedioic acid Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

Dodecanedioic acid

Synthetic route

1,12-Dodecanedioic acid Chemical Properties

1,12-Dodecanedioic acid Uses

1,12-Dodecanedioic acid Safety Profile

1,12-Dodecanedioic acid Specification

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