1,2,3,4-Tetramethylbenzene supplier

Name
1,2,3,4-Tetramethylbenzene
EINECS 207-673-1
CAS No. 488-23-3
Article Data88
CAS DataBase
Density 0.838 g/mL at 25 °C(lit.)
Solubility Immiscible with water.
Melting Point 76-80 °C(lit.)
Formula C10H14
Boiling Point 204 °C at 760 mmHg
Molecular Weight 134.221
Flash Point 69.7 °C
Transport Information UN 1325 4
Appearance
Safety S26-S37
Risk Codes R11
Molecular Structure
Hazard Symbols F
Synonyms 1,2,3,4-Tetramethylbenzene;NSC 93932; Prehnitene; Prehnitol
PSA 0.00000
LogP 2.92020

Synthetic route

: 38108-82-6
1,2-bis(bromomethyl)-3,6-dimethylbenzene

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 5℃; Temperature; Reagent/catalyst; Inert atmosphere; Reflux;	97.3%
With tetrahydrofuran; lithium aluminium tetrahydride

: 95-93-2
1,2,4,5-tetramethylbenzene

: 75-36-5
acetyl chloride

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 527-53-7
1,2,3,5-Tetramethylbenzene

C: 2142-79-2
2,3,5,6-tetramethylacetophenone

Conditions

Conditions	Yield
With aluminium trichloride In tetrachloromethane 1.) 5 deg C, 1 h; 2.) 25 deg C, 1 h;	A 2.3% B 0.1% C 94.6%

...Expand

: 527-53-7
1,2,3,5-Tetramethylbenzene

: 108-24-7
acetic anhydride

A: 95-93-2
1,2,4,5-tetramethylbenzene

B: 488-23-3
1,2,3,4-Tetramethylbenzene

C: 2142-78-1
1-(2,3,4,6-tetramethyl-phenyl)-ethanone

D: 2142-79-2
2,3,5,6-tetramethylacetophenone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 50℃; for 0.5h; Further byproducts given;	A 1.8% B 1.9% C 92.8% D 2.2%

...Expand

: 95-93-2
1,2,4,5-tetramethylbenzene

: 108-24-7
acetic anhydride

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 2142-79-2
2,3,5,6-tetramethylacetophenone

C: 15517-58-5
1,1′-(2,3,5,6-tetramethyl-1,4-phenylene)bis(ethan-1-one)

Conditions

Conditions	Yield
aluminium trichloride In carbon disulfide 1.) 25 deg C, 1 h; 2.) 50 deg C, 3 h;	A 2.9% B 69.6% C 27.5%

...Expand

: 503-17-3
dimethylacetylene

Cp2TiCl2: Cp2TiCl2

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
Stage #1: Cp2TiCl2 With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: dimethylacetylene In tetrahydrofuran; hexane at -10℃; for 3h; Stage #3: With propyl cyanide In tetrahydrofuran; hexane at 50℃; for 1h;	53%

: 18611-39-7
1,2-Diisopropyliden-3,4-dichlor-cyclobutan

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 1124-20-5
2-(3-methylphenyl)propene

C: 76886-19-6
1-chloro-2-isopropyl-6-methylbenzene

Conditions

Conditions	Yield
at 250℃; for 2.5h;	A 51% B 11% C 30%

...Expand

: 18611-37-5
4-Chlor-2-chlormethylen-3-isopropyliden-1,1-dimethyl-cyclobutan

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 18611-39-7
1,2-Diisopropyliden-3,4-dichlor-cyclobutan

C: 76886-19-6
1-chloro-2-isopropyl-6-methylbenzene

Conditions

Conditions	Yield
at 300℃; for 2.5h; Mechanism; pyrolysis of halogen derivatives of dimethylenecyclobutane and methylenecyclobutene investigated;	A 48% B n/a C 2%

...Expand

: 18611-37-5
4-Chlor-2-chlormethylen-3-isopropyliden-1,1-dimethyl-cyclobutan

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 1124-20-5
2-(3-methylphenyl)propene

C: 76886-19-6
1-chloro-2-isopropyl-6-methylbenzene

Conditions

Conditions	Yield
at 300℃; for 2.5h;	A 48% B 28% C 2%

...Expand

: 115-10-6
Dimethyl ether

: 106-42-3
para-xylene

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 700-12-9
pentamethylbenzene,

C: 87-85-4
Hexamethylbenzene

Conditions

Conditions	Yield
at 450℃; Leiten ueber Aluminiumoxyd-Siliciumdioxyd-Kontakte;

...Expand

: 95-93-2
1,2,4,5-tetramethylbenzene

: 527-53-7
1,2,3,5-Tetramethylbenzene

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With sulfuric acid at 85℃; Erhitzen der gebildeten 1.2.3.4-Tetramethyl-benzol-sulfonsaeure-(5) mit wss. H2SO4 auf 145grad;

: 700-12-9
pentamethylbenzene,

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 87-85-4
Hexamethylbenzene

Conditions

Conditions	Yield
With sulfuric acid Darstellung der Sulfonsaeure;

: 3982-67-0
ethylmesitylene

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 17851-27-3
1-ethyl-2,4,5-trimethylbenzene

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 559-64-8
sumaresinolic acid

A: 582-16-1
2,7-dimethylnaphthalene

B: 488-23-3
1,2,3,4-Tetramethylbenzene

C: 2131-43-3
1,2,5,6-tetramethylnaphthalene

D: 486-34-0
1,2,7-trimethylnaphthalene

Conditions

Conditions	Yield
at 310℃; under 12 Torr; anschliessendes Erhitzen mit Selen auf 340-350grad;

...Expand

: 90434-19-8
dibromo-m-xylene

: 74-88-4
methyl iodide

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With diethyl ether; sodium

: 41381-36-6
2-bromo-1,3,4-trimethyl-benzene

: 74-88-4
methyl iodide

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With sodium; benzene at 150℃; im Einschlussrohr;

: 95-63-6
1,2,4-Trimethylbenzene

A: 95-47-6
o-xylene

B: 106-42-3
para-xylene

C: 95-93-2
1,2,4,5-tetramethylbenzene

D: 488-23-3
1,2,3,4-Tetramethylbenzene

E: 527-53-7
1,2,3,5-Tetramethylbenzene

F: 108-38-3
m-xylene

Conditions

Conditions	Yield
With hydrogen; H Mordenite at 350℃; under 760 Torr; for 7h; Product distribution; variation of the catalyst;
With USY zeolite (spiltover hydrogen); hydrogen In gas at 200℃; for 0.333333h; Product distribution; effect of spiltover hydrogen on the stabilization of catalytic activity; also on illared montmorillonite;

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

A: 95-47-6
o-xylene

B: 106-42-3
para-xylene

C: 526-73-8
1,2,3-trimethylbenzene

D: 488-23-3
1,2,3,4-Tetramethylbenzene

E: 108-38-3
m-xylene

F: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With HY zeolite at 200℃; under 12.8 Torr; Product distribution; Rate constant; Equilibrium constant; kinetics, Ea, mechanism; var. temp.;

...Expand

: 34764-71-1
2',3',4',5'-tetramethylacetophenone

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With methoxybenzene; trifluoroacetic acid at 110℃; Rate constant;

: 74692-88-9
1,2,3,4-tetramethyl-[5-3H]benzene

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
With acetic acid; trifluoroacetic acid Rate constant; changes in Vol percent TFA in HOAc;

: Anthracene-9,10-dicarbonitrile; compound with 1,2,3,4-tetramethyl-benzene

A: 1217-45-4
9,10-Dicyanoanthracene

B: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
In acetonitrile Thermodynamic data; Rate constant; ΔG;

: 130563-79-0
Anthracene-2,6,9,10-tetracarbonitrile; compound with 1,2,3,4-tetramethyl-benzene

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 80721-78-4
2,6,9,10-tetracyanoanthracene

Conditions

Conditions	Yield
In acetonitrile Thermodynamic data; Rate constant; ΔG;

: 66312-03-6
2,3,4,5-Tetramethyltetracyclo<4.4.0.02,4.03,5>deca-7,9-dien-1,6-dicarbonsaeureanhydrid

A: 85-44-9
phthalic anhydride

B: 488-23-3
1,2,3,4-Tetramethylbenzene

C: 3031-15-0
1,2,3,4-tetramethylnaphthalene

D: 80673-73-0
3,9b-Dihydro-9b-hydroxy-1,2,3a-trimethyl-3-methylencyclopenta<2>benzopyran-5(3aH)-on

E: 80684-79-3
3,4,5,6,9,10,11,12-Octamethylpentacyclo<6.4.2.02,7.03,6.09,12>tetradeca-4,10,13-trien-2,7-dicarbonsaeureanhydrid

Conditions

Conditions	Yield
at 145℃; for 0.833333h; Product distribution;

...Expand

: 95-93-2
1,2,4,5-tetramethylbenzene

: 75-36-5
acetyl chloride

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 2142-79-2
2,3,5,6-tetramethylacetophenone

Conditions

Conditions	Yield
aluminium trichloride In carbon disulfide at 25℃; for 1h; Product distribution; other acetylation agent, other solvents, other conditions, further tetramethylbenzenes;

...Expand

: 527-53-7
1,2,3,5-Tetramethylbenzene

: 34764-71-1
2',3',4',5'-tetramethylacetophenone

A: 95-93-2
1,2,4,5-tetramethylbenzene

B: 488-23-3
1,2,3,4-Tetramethylbenzene

C: 2142-78-1
1-(2,3,4,6-tetramethyl-phenyl)-ethanone

D: 2142-79-2
2,3,5,6-tetramethylacetophenone

Conditions

Conditions	Yield
With aluminium trichloride In nitromethane at 20℃; for 15h; Product distribution; Mechanism; further solvent, methyl substituted acetophenones, with or without methyl substituted benzenes;	A 29.6 % Chromat. B 4.6 % Chromat. C 0.9 % Chromat. D 16.2 % Chromat.

...Expand

: C23H23(1+)

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 12257-35-1
9-fluorenyl carbocation

Conditions

Conditions	Yield
In various solvent(s) at -20℃; Rate constant; Equilibrium constant;

: 3726-45-2
1R,2c,3t,4t-tetramethylcyclohexane

selenium: selenium

: 488-23-3
1,2,3,4-Tetramethylbenzene

Conditions

Conditions	Yield
at 400℃;

: 95-93-2
1,2,4,5-tetramethylbenzene

aluminium halide: aluminium halide

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 527-53-7
1,2,3,5-Tetramethylbenzene

Conditions

Conditions	Yield
at 26.9℃; Zusammensetzung des Gleichgewichtsgemisches;

...Expand

: 95-93-2
1,2,4,5-tetramethylbenzene

aluminium oxide silicon dioxide: aluminium oxide silicon dioxide

A: 488-23-3
1,2,3,4-Tetramethylbenzene

B: 527-53-7
1,2,3,5-Tetramethylbenzene

Conditions

Conditions	Yield
at 426.9℃; Zusammensetzung des Gleichgewichtsgemisches;

...Expand

: 16957-70-3
2-methylpent-2-enoic acid

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 3-ethyl-2,4,5,6,7-pentamethyl-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
Stage #1: 2-methylpent-2-enoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25℃; for 2h; Inert atmosphere; Stage #2: With aluminum (III) chloride In dichloromethane at 8℃; Inert atmosphere; Stage #3: 1,2,3,4-Tetramethylbenzene In dichloromethane at 25℃; for 4h; Inert atmosphere;	100%

: 621-23-8
1,2,3-trimethoxybenzene

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 2,4,6-trimethoxy-2',3',4',5'-tetramethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid at 50℃; for 18h; Inert atmosphere; Sealed tube;	98%

: 50-00-0
formaldehyd

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 55743-69-6
5,6-bis(bromomethyl)-1,2,3,4-tetramethylbenzene

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 100℃; for 8h;	97%
With sulfuric acid; acetic acid; sodium bromide for 3h; Heating;	6%
With hydrogen bromide; acetic acid

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 54509-71-6
1-iodo-2,3,4,5-tetramethylbenzene

Conditions

Conditions	Yield
With sulfuric acid; iodine; nitric acid In acetic acid at 50 - 55℃; for 5h;	97%
With iodine; Selectfluor In acetonitrile at 55 - 65℃; for 1h;	85%

: chloro(1,5-cyclooctadiene)iridium(I) dimer

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 16836-95-6
silver(I) 4-methylbenzenesulfonate

: 75751-43-8
[Ir(C6H2(CH3)4)((CHCHC2H4)2)](1+)*OSO2C6H4CH3(1-)=[Ir(C6H2(CH3)4)((CHCHC2H4)2)]OSO2C6H4CH3

Conditions

Conditions	Yield
In ethanol; dichloromethane; acetone (N2); silver tosylate treated with acetone/EtOH/C6H2(CH3)4, treated with Ir complex/CH2Cl2, stirred for 14 h at room temp.; filtered, concd., Et2O added, decanted, dried (vac.), recrystd. from CH2Cl2/Et2O/pentane and CH2Cl2/Et2O; elem. anal.;	97%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 75-36-5
acetyl chloride

A: 95-93-2
1,2,4,5-tetramethylbenzene

B: 34764-71-1
2',3',4',5'-tetramethylacetophenone

Conditions

Conditions	Yield
aluminium trichloride In carbon disulfide at 25℃; for 3h;	A 2.9% B 96.4%
With aluminium trichloride In carbon disulfide at 25℃; for 3h;	A 4.2% B 91.8%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 19219-82-0
1,2,3,4-tetramethyl-2,5-dichlorobenzene

Conditions

Conditions	Yield
With benzyl(trimethyl)ammonium tetrachloroiodate In acetic acid for 20h; Ambient temperature;	96%
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid at 90℃; for 2.5h;	33%
With 1,3-dichloro-5,5-dimethylhydantoin In acetic acid at 90℃; for 2.5h;	33%
With aluminium trichloride; sulfuryl dichloride

: 488-23-3
1,2,3,4-Tetramethylbenzene

A: 40101-36-8
1-Bromo-2,3,4,5-tetramethylbenzene

B: 36321-73-0
1,2-dibromo-3,4,5,6-tetramethylbenzene

Conditions

Conditions	Yield
With benzyltrimethylazanium tribroman-2-uide; zinc(II) chloride In acetic acid for 2h; Ambient temperature;	A 96% B 85%

: 80-59-1
Tiglic acid

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 163842-93-1
2,3,4,5,6,7-tetramethylindane-1-one

Conditions

Conditions	Yield
Stage #1: Tiglic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 12h; Inert atmosphere; Stage #2: 1,2,3,4-Tetramethylbenzene With aluminum (III) chloride In dichloromethane at 8 - 25℃; for 4h; Inert atmosphere;	96%

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 75-36-5
acetyl chloride

A: 2142-79-2
2,3,5,6-tetramethylacetophenone

B: 34764-71-1
2',3',4',5'-tetramethylacetophenone

Conditions

Conditions	Yield
With aluminium trichloride In chloroform at 25℃; for 1h;	A 4.1% B 95.3%

...Expand

: 50-00-0
formaldehyd

: 488-23-3
1,2,3,4-Tetramethylbenzene

: mono(bromomethyl)prehnitene

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 80℃; for 3h;	95%

: 381-98-6
trifluoromethyacrylic acid

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 1219921-42-2
2-trifluoromethyl-3-(4',5',6',7'-tetramethylphenyl)-1-indanone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 0 - 20℃; Friedel Crafts reaction;	95%

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 14202-27-8, 51830-12-7, 67315-16-6, 70095-87-3, 70494-79-0, 139686-29-6, 139686-31-0, 139686-32-1
(+/-) methyl (4,5)-trans-epoxy-(2E)-hexenoate

: methyl (4,5)-anti-4-(2',3',4',5'-tetramethylphenyl)-5-hydroxy-2(E)-hexenoate

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at -78 - -20℃; for 2h;	94%

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 88946-78-5
bis[dichloro-(η(6)-1,2,3,4-tetramethylbenzene)ruthenium]

Conditions

Conditions	Yield
In neat (no solvent) Ru-complex was stirred in excess refluxing arene under N2 for 24 h; soln. was cooled, ppt. collected, washed with hexane;	94%

: 358-23-6
trifluoromethylsulfonic anhydride

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 1193-82-4
racemic methyl phenyl sulfoxide

: 1402011-74-8
S-methyl-S-phenyl-2,3,4,5-tetramethylphenyl sulfonium triflate

Conditions

Conditions	Yield
In diethyl ether at 0 - 5℃; Inert atmosphere;	93.67%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 1193-82-4
racemic methyl phenyl sulfoxide

: 1025373-45-8
trifluoromethanesulfonic acid anhydride

: 1402011-74-8
S-methyl-S-phenyl-2,3,4,5-tetramethylphenyl sulfonium triflate

Conditions

Conditions	Yield
In diethyl ether at 0 - 5℃; Inert atmosphere;	93.67%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 108-24-7
acetic anhydride

A: 15517-58-5
1,1′-(2,3,5,6-tetramethyl-1,4-phenylene)bis(ethan-1-one)

B: 34764-71-1
2',3',4',5'-tetramethylacetophenone

C: 69313-51-5
1,3-diacetyl-2,4,5,6-tetramethylbenzene

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 50℃; for 2h;	A 5.4% B 90.6% C 2.8%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 117965-56-7
2,3-bis(bromomethyl)-1,4-bis(dibromomethyl)benzene

Conditions

Conditions	Yield
With bromine In tetrachloromethane for 1h; Heating; Irradiation;	90%

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 814-68-6
acryloyl chloride

: 711-43-3
4,5,6,7-tetramethyl-1H-indan-1-one

Conditions

Conditions	Yield
With aluminium trichloride Cyclization; acylation; Heating;	90%

: 358-23-6
trifluoromethylsulfonic anhydride

: 24824-93-9
chloromethyl p-tolyl sulfoxide

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 1374153-80-6
(chloromethyl)(2,3,4,5-tetramethylphenyl)(p-tolyl)sulfonium triflate

Conditions

Conditions	Yield
In diethyl ether at 0 - 5℃; Inert atmosphere;	89.74%

...Expand

: 24824-93-9
chloromethyl p-tolyl sulfoxide

: 488-23-3
1,2,3,4-Tetramethylbenzene

: (chloromethyl)(2,3,4,5-tetramethylphenyl)(p-tolyl)sulfonium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: chloromethyl p-tolyl sulfoxide; 1,2,3,4-Tetramethylbenzene With trifluoromethylsulfonic anhydride In diethyl ether at -60℃; for 4h; Stage #2: With tetrafluoroboric acid In diethyl ether for 0.5h;	89%

: 358-23-6
trifluoromethylsulfonic anhydride

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 54234-79-6, 67529-46-8, 109120-75-4, 21865-07-6
propyl phenyl sulfoxide

: S-phenyl-S-propyl-2,3,4,5-tetramethylphenylsulfonium triflate

Conditions

Conditions	Yield
In diethyl ether at -78℃; for 2h; Inert atmosphere;	89%

...Expand

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 36321-73-0
1,2-dibromo-3,4,5,6-tetramethylbenzene

Conditions

Conditions	Yield
With bromine; iodine In dichloromethane for 3h;	88%
With bromine; zinc(II) chloride In acetic acid at 20℃; for 14h;	85%
With bromine; zinc(II) chloride In acetic acid at 20℃; for 14h;	85%

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 5503-82-2
1,2-diiodo-3,4,5,6-tetramethylbenzene

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h;	88%
With sulfuric acid; iodine; periodic acid In water; acetic acid at 50 - 55℃; Suzuki iodination;	83%
With iodine; Selectfluor In acetonitrile at 55 - 65℃; for 2.5h;	67%
With sulfuric acid; iodine; periodic acid In acetic acid
With sulfuric acid; iodine; periodic acid In acetic acid

: 96-48-0
4-butanolide

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 147792-79-8
4-(2,3,4,5-Tetramethylphenyl)buttersaeure

Conditions

Conditions	Yield
With aluminium trichloride at 60℃; for 2h;	88%

: 35660-94-7
(E)-2-methylbut-2-enoyl chloride

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 163842-93-1
2,3,4,5,6,7-tetramethylindane-1-one

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide Heating;	88%
With aluminium trichloride Cyclization; acylation; Heating;	87%
Stage #1: (E)-2-methylbut-2-enoyl chloride With aluminum (III) chloride In dichloromethane Inert atmosphere; Stage #2: 1,2,3,4-Tetramethylbenzene In dichloromethane at 25℃; for 4h; Inert atmosphere;	77.25 g

: 488-23-3
1,2,3,4-Tetramethylbenzene

: 42887-62-7
2,3,4,5-tetramethyl-1-nitrobenzene

Conditions

Conditions	Yield
With silver nitrate; boron trifluoride In acetonitrile at 25℃; for 8h;	86%
With silver nitrate; boron trifluoride In acetonitrile at 25℃; for 5h; competitive nitration benzene, relative rate;
With nitric acid

1,2,3,4-Tetramethylbenzene Chemical Properties

Molecular Formula of 1,2,3,4-Tetramethylbenzene (CAS NO.488-23-3): C₁₀H₁₄
Molecular Weight: 134.22 g/mol
EINECS: 202-465-7
Flashing point: 69.7 °C
Index of Refraction: 1.5190
Density: 0.838 g/mL at 25 °C(lit.)
Boiling Point: 0.838 g/mL at 25 °C(lit.)
Melting point: 76-80 °C(lit.)
Structure of 1,2,3,4-Tetramethylbenzene (CAS NO.488-23-3):

IUPAC Name: 1,2,3,4-Tetramethylbenzene

1,2,3,4-Tetramethylbenzene Toxicity Data With Reference

1.		skn-rbt 100 mg/24H MLD		DCTODJ Drug and Chemical Toxicology. 1 (1978),219.
2.		orl-rat LD50:6408 mg/kg		DCTODJ Drug and Chemical Toxicology. 1 (1978),219.

1,2,3,4-Tetramethylbenzene Consensus Reports

Reported in EPA TSCA Inventory.

1,2,3,4-Tetramethylbenzene Safety Profile

Mildly toxic by ingestion. A skin irritant. A flammable material. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of 1,2,3,4-Tetramethylbenzene (CAS NO.488-23-3): F
Risk Statements:
R11:Highly flammable.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37:Wear suitable gloves.
RIDADR UN 1325 4.1/PG 2
WGK Germany 1
RTECS DC0500000

1,2,3,4-Tetramethylbenzene Specification

1,2,3,4-Tetramethylbenzene , its cas register number is 488-23-3. It also can be called Prehnitene ; and Benzene, 1,2,3,4-tetramethyl- .

Product Name

1,2,3,4-Tetramethylbenzene

Synthetic route

1,2,3,4-Tetramethylbenzene Chemical Properties

1,2,3,4-Tetramethylbenzene Toxicity Data With Reference

1,2,3,4-Tetramethylbenzene Consensus Reports

1,2,3,4-Tetramethylbenzene Safety Profile

1,2,3,4-Tetramethylbenzene Specification

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