1,2-BUTANEDIOL supplier | CasNO.584-03-2

Name
1,2-Butanediol
EINECS
CAS No. 584-03-2
Article Data137
CAS DataBase
Density 1.001g/cm³
Solubility 100-1000g/L at 25℃
Melting Point -50 °C
Formula C4H10 O2
Boiling Point 191-192 °C747 mm Hg(lit.)
Molecular Weight 90.1222
Flash Point 93.3°C
Transport Information
Appearance clear colorless liquid
Safety Moderately toxic by ingestion. Combustible when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits acrid and irritating fumes.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (?à)-Butane-1,2-diol; 1,2-Butyleneglycol; 1,2-Dihydroxybutane; DL-1,2-Butanediol; NSC 24242
PSA 40.46000
LogP -0.25040

Synthetic route

: 59765-97-8
4-ethyl-2-methyl-1,3-dioxolane

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With water under 76.0051 - 760.051 Torr; Reflux;	98.5%

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

A: 67-56-1
methanol

B: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With (bis[(2-diisopropylphosphino)ethyl]amine)Mn(CO)2Br; hydrogen; sodium t-butanolate In tetrahydrofuran at 120℃; under 22502.3 Torr; for 26h; Schlenk technique; Glovebox; Autoclave;	A 74% B 97%
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); potassium carbonate In isopropyl alcohol at 140℃; Glovebox;	A 94 %Chromat. B 94%
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](bromo)(carbonyl)(hydride)iron(II); potassium tert-butylate; isopropyl alcohol In tetrahydrofuran at 140℃; for 18h; Catalytic behavior; Mechanism; Concentration; Solvent; Temperature; Reagent/catalyst; Time; Inert atmosphere; Schlenk technique; Green chemistry;	A 83 %Chromat. B 72%

: Trifluoro-acetic acid 1-(2,2,2-trifluoro-acetoxymethyl)-propyl ester

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With silica gel; triethylamine In diethyl ether; Petroleum ether Substitution; Detrifluoroacetylation;	96%

: 106-88-7
ethyloxirane

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With water In N,N-dimethyl-formamide at 110℃; for 20h;	92%
With water at 90℃; under 11251.1 Torr;	92.8%
With water at 90℃; under 11251.1 Torr;	92.7%

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With potassium tert-butylate; hydrogen; C16H18BrCoINO2 In dibutyl ether at 160℃; under 45004.5 Torr; for 20h; Sealed tube; Autoclave;	92%
With ammonium bromide; ethylenediamine at 80℃; for 5h; Microwave irradiation;	> 95 %Spectr.

: 600-15-7, 565-70-8
2-Hydroxybutanoic acid

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Autoclave; Sealed tube;	92%

: 106-98-9
1-butylene

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
Stage #1: 1-butylene With Oxone; potassium chloride In water; acetone at 30℃; for 12h; Large scale; Stage #2: With water; potassium hydroxide at 25 - 40℃; for 4h; pH=12; Large scale;	88%
With dihydrogen peroxide; tungsten(VI) oxide; acetic acid at 70℃;
With formic acid; dihydrogen peroxide at -17℃; beim anschliessenden Erwaermen mit wss. Natronlauge;

: 106-88-7
ethyloxirane

: 124-38-9
carbon dioxide

: 62-53-3
aniline

A: 101835-17-0
5-ethyl-3-phenyl-1,3-oxazolidine-2-one

B: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 110℃; under 3750.38 Torr; for 25h; Autoclave;	A 80% B n/a

...Expand

: 909878-64-4
meso-erythritol

A: 110-63-4
Butane-1,4-diol

B: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With hydrogen In 1,4-dioxane at 159.84℃; under 60006 Torr; for 24h; Autoclave;	A 12% B 79%
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 4h; Autoclave;

: 167354-12-3
(2R)-1-(benzyloxy)-2-butanol

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol	79%

: 62214-39-5
(2S)-but-3-ene-1,2-diol

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
In palladium-carbon; ethanol	68%

: 64244-53-7
<(2-tetrahydropyranoyloxy)methyl>oxirane

: 75-16-1
methylmagnesium bromide

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
Stage #1: <(2-tetrahydropyranoyloxy)methyl>oxirane; methylmagnesium bromide With copper(I) bromide In tetrahydrofuran at -10℃; for 1h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In methanol at 20℃;	64%

: 56-81-5
glycerol

A: 57-55-6
propylene glycol

B: 110-63-4
Butane-1,4-diol

C: 513-85-9
2.3-butanediol

D: 584-03-2
1,2-dihydroxybutane

E: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen at 212℃; under 51716.2 Torr; Product distribution / selectivity;	A 60% B n/a C n/a D n/a E n/a

...Expand

: 124-38-9
carbon dioxide

: 201230-82-2
carbon monoxide

A: 67-56-1
methanol

B: 71-23-8
propan-1-ol

C: 57-55-6
propylene glycol

D: 626-95-9
1,4-Pentanediol

E: 111-29-5
1 ,5-pentanediol

F: 110-63-4
Butane-1,4-diol

G: 60-29-7
diethyl ether

H: 34557-54-5
methane

I: 64-17-5
ethanol

J: 6032-29-7
(+/-)-2-pentanol

K: 18826-95-4, 107-88-0
1.3-butanediol

L: 5343-92-0
1,2-pentanediol

M: 74-84-0
ethane

N: 74-98-6
propane

O: 115-10-6
Dimethyl ether

P: 540-67-0
ethyl methyl ether

Q: 78-83-1
2-methyl-propan-1-ol

R: 584-02-1
2-pentanol

S: 71-41-0
pentan-1-ol

T: 3174-67-2
1,3-pentanediol

U: 79-20-9
acetic acid methyl ester

V: 67-63-0
isopropyl alcohol

W: 78-92-2, 15892-23-6
iso-butanol

X: 75-65-0
tert-butyl alcohol

Y: 71-36-3
butan-1-ol

Z: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With hydrogen; Cu/Co/Al at 260 - 320℃; under 45004.5 - 75007.5 Torr; Conversion of starting material;	A 57.5% B n/a C n/a D n/a E n/a F n/a G n/a H n/a I 28.5% J n/a K n/a L n/a M n/a N n/a O n/a P n/a Q n/a R n/a S n/a T n/a U n/a V n/a W n/a X n/a Y n/a Z n/a
With hydrogen; Cu/ZnO/Al2O3 at 285 - 300℃; under 45004.5 - 67506.8 Torr; Conversion of starting material;	A 57.5% B n/a C n/a D n/a E n/a F n/a G n/a H n/a I 28.5% J n/a K n/a L n/a M n/a N n/a O n/a P n/a Q n/a R n/a S n/a T n/a U n/a V n/a W n/a X n/a Y n/a Z n/a

...Expand

: 124-38-9
carbon dioxide

: 201230-82-2
carbon monoxide

A: 67-56-1
methanol

B: 71-23-8
propan-1-ol

C: 57-55-6
propylene glycol

D: 626-95-9
1,4-Pentanediol

E: 111-29-5
1 ,5-pentanediol

F: 110-63-4
Butane-1,4-diol

G: 60-29-7
diethyl ether

H: 64-17-5
ethanol

I: 6032-29-7
(+/-)-2-pentanol

J: 18826-95-4, 107-88-0
1.3-butanediol

K: 5343-92-0
1,2-pentanediol

L: 115-10-6
Dimethyl ether

M: 540-67-0
ethyl methyl ether

N: 78-83-1
2-methyl-propan-1-ol

O: 584-02-1
2-pentanol

P: 71-41-0
pentan-1-ol

Q: 3174-67-2
1,3-pentanediol

R: 79-20-9
acetic acid methyl ester

S: 67-63-0
isopropyl alcohol

T: 78-92-2, 15892-23-6
iso-butanol

U: 75-65-0
tert-butyl alcohol

V: 71-36-3
butan-1-ol

W: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With hydrogen; Zn/Cr/K at 350 - 420℃; under 75007.5 - 135014 Torr; Conversion of starting material;	A 57.5% B n/a C n/a D n/a E n/a F n/a G n/a H 28.5% I n/a J n/a K n/a L n/a M n/a N n/a O n/a P n/a Q n/a R n/a S n/a T n/a U n/a V n/a W n/a

...Expand

: 56-81-5
glycerol

A: 57-55-6
propylene glycol

B: 107-21-1
ethylene glycol

C: 513-85-9
2.3-butanediol

D: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; HC-1 catalyst at 193 - 216℃; under 82745.9 Torr; Product distribution / selectivity;	A 56% B 4.37% C n/a D n/a

...Expand

cellulose: cellulose

A: 57-55-6
propylene glycol

B: 50-70-4
D-sorbitol

C: 107-21-1
ethylene glycol

D: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With phosphotungstic acid; ruthenium-carbon composite; hydrogen In water at 250℃; under 45004.5 Torr; for 0.833333h; Autoclave;	A 5.5% B 12.4% C 53.1% D 6.2%

...Expand

: 13814-27-2
1,2-butanediol diacetate

A: 55378-41-1
1-hydroxy-2-acetoxybutane

B: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
1,3-disubstituted tetraalkyldistannoxane (X = Y = Cl) In methanol; chloroform for 120h; Ambient temperature;	A 53% B 22%

: 56-81-5
glycerol

A: 57-55-6
propylene glycol

B: 513-85-9
2.3-butanediol

C: 584-03-2
1,2-dihydroxybutane

D: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen at 209 - 213℃; under 51716.2 - 82745.9 Torr; Product distribution / selectivity;	A 51% B n/a C n/a D n/a

...Expand

: 106-98-9
1-butylene

A: 86943-35-3
(+/-)-2-hydroxybutanal

B: 123-38-6
propionaldehyde

C: 5077-67-8
1-Hydroxy-2-butanone

D: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With air; dihydrogen peroxide for 0.5h; Product distribution; Kinetics; Further Variations:; reaction time; Oxidation; UV-irradiation;	A 7% B 50.6% C 24.2% D 18.2%

...Expand

cellulose: cellulose

A: 57-55-6
propylene glycol

B: 107-21-1
ethylene glycol

C: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With Rh/C; hydrogen; ortho-tungstic acid; copper(II) sulfate In water at 245℃; under 45004.5 Torr; for 0.5h; Autoclave;	A 7.4% B 50% C 6.7%
With phosphotungstic acid; platinum on activated charcoal; hydrogen In water at 250℃; under 45004.5 Torr; for 0.833333h; Autoclave;	A 12.8% B 23.2% C 6%
With hydrogen In water at 219.84℃; under 31503.2 - 48754.9 Torr; for 8h; Autoclave;

...Expand

: 56-81-5
glycerol

A: 67-56-1
methanol

B: 849585-22-4
LACTIC ACID

C: 57-55-6
propylene glycol

D: 64-17-5
ethanol

E: 107-21-1
ethylene glycol

F: 513-85-9
2.3-butanediol

G: 584-03-2
1,2-dihydroxybutane

H: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; solid catalyst similar to the “G” catalyst disclosed in U.S. Pat. No. 6,479,713 or the “HC-1” catalyst available from Sud Chemie (Louisville, Ky.) In water at 154 - 229℃; under 62059.4 - 82745.9 Torr; Product distribution / selectivity;	A 0.6% B 0.7% C 47.3% D 0.1% E 2.1% F n/a G n/a H n/a

...Expand

: 50-70-4
D-sorbitol

A: 106-69-4
hexane-1,2,6-triol

B: 140946-33-4
1,4,5-hexanetriol

C: 20221-50-5, 24211-51-6, 122923-46-0, 5581-21-5
1,2,5,6-hexanetetrol

D: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With propylene glycol; hydrogen; copper In water at 210℃; under 93089.1 Torr; Concentration;	A 5.51% B 26.54% C 46.12% D 10.26%

...Expand

: 56-81-5
glycerol

A: 57-55-6
propylene glycol

B: 513-85-9
2.3-butanediol

C: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen at 202℃; under 82745.9 Torr; Product distribution / selectivity;	A 43% B n/a C n/a
With sodium hydroxide; hydrogen; solid catalyst similar to the "G" catalyst disclosed in US 6,479,713 or the "HC-1" catalyst available from Sd Chemie (Louisville, KY) at 154 - 229℃; under 62059.4 - 82745.9 Torr; Product distribution / selectivity;	A 33.2% B n/a C n/a
With sodium hydroxide; hydrogen at 196℃; under 82745.9 Torr; Product distribution / selectivity;	A 27% B n/a C n/a
With sodium hydroxide; hydrogen; solid catalyst similar to the “G” catalyst disclosed in U.S. Pat. No. 6,479,713 or the “HC-1” catalyst available from Sud Chemie (Louisville, Ky.) In water at 150 - 210℃; under 51716.2 Torr; Product distribution / selectivity;	A 10% B n/a C n/a
With sodium hydroxide; hydrogen; Süd Chemie HC-1 catalyst In water at 159 - 212℃; under 96435 Torr; Product distribution / selectivity;

...Expand

cellulose: cellulose

A: 57-55-6
propylene glycol

B: 2319-57-5, 2418-52-2, 6968-16-7, 7493-90-5, 7541-59-5
1,2,3,4-butanetetrol

C: 107-21-1
ethylene glycol

D: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With ruthenium-carbon composite; hydrogen In water at 215℃; under 39003.9 Torr; for 1.5h; Catalytic behavior; Reagent/catalyst; Autoclave;	A 9.6% B 9% C 40.6% D 7.8%

...Expand

: 56-81-5
glycerol

A: 849585-22-4
LACTIC ACID

B: 57-55-6
propylene glycol

C: 64-17-5
ethanol

D: 107-21-1
ethylene glycol

E: 513-85-9
2.3-butanediol

F: 584-03-2
1,2-dihydroxybutane

G: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; solid catalyst similar to the “G” catalyst disclosed in U.S. Pat. No. 6,479,713 or the “HC-1” catalyst available from Sud Chemie (Louisville, Ky.) In water at 178 - 198℃; under 62059.4 Torr; Product distribution / selectivity;	A 1% B 38% C 0.1% D 1.6% E n/a F n/a G n/a

...Expand

: 497-06-3
3,4-butenediol

: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With hydrogen; 5%-palladium/activated carbon In ethanol at 20℃; under 2625.26 Torr; for 16h;	37%

: 50-99-7
D-glucose

A: 57-55-6
propylene glycol

B: 107-21-1
ethylene glycol

C: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With palladium on activated charcoal; water; zinc at 250℃; for 0.5h; Temperature;	A 33.3% B 7.1% C 7.6%
With 5% active carbon-supported ruthenium; hydrogen; ortho-tungstic acid; sodium hydroxide In water; glycerol at 200℃; under 37503.8 Torr; for 4h;

...Expand

: 56-81-5
glycerol

A: 67-56-1
methanol

B: 849585-22-4
LACTIC ACID

C: 57-55-6
propylene glycol

D: 107-21-1
ethylene glycol

E: 513-85-9
2.3-butanediol

F: 584-03-2
1,2-dihydroxybutane

G: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; solid catalyst similar to the “G” catalyst disclosed in U.S. Pat. No. 6,479,713 or the “HC-1” catalyst available from Sud Chemie (Louisville, Ky.) In water at 185 - 205℃; under 82745.9 Torr; Product distribution / selectivity;	A 0.7% B 0.5% C 33.2% D 1.5% E n/a F n/a G n/a

...Expand

: 56-81-5
glycerol

A: 849585-22-4
LACTIC ACID

B: 57-55-6
propylene glycol

C: 107-21-1
ethylene glycol

D: 513-85-9
2.3-butanediol

E: 584-03-2
1,2-dihydroxybutane

F: 1825-14-5, 3950-21-8, 36402-52-5, 42075-32-1, 72345-23-4, 625-69-4
pentane-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen at 177 - 228℃; under 62059.4 - 82745.9 Torr; Product distribution / selectivity;	A 0.5% B 33.2% C 1.5% D n/a E n/a F n/a

...Expand

: 1034-39-5
dibromotriphenylphosphorane

: 584-03-2
1,2-dihydroxybutane

: 4-ethyl-2,2,2-triphenyl-1,3,2λ5-dioxaphospholane

Conditions

Conditions	Yield
With triethylamine In toluene Cyclization;	99%

: 110-87-2
3,4-dihydro-2H-pyran

: 584-03-2
1,2-dihydroxybutane

: 78791-18-1
1-OTHP-2-BuOH

Conditions

Conditions	Yield
With ruthenium(III) acetate at 20℃; for 8h;	99%

: [Ti(N-phenylsalicylideneimine(-H))2(O-i-Pr)2]

: 584-03-2
1,2-dihydroxybutane

: 943433-23-6
[Ti(N-phenylsalicylideneimine(-H))2(OCH2CH(C2H5)O)]

Conditions

Conditions	Yield
In benzene byproducts: (CH3)2CHOH; under unhydrous atm., soln. of ligand added to soln. of Ti compd. (3.06:3.01), refluxed, monitored by isopropanol liberated; concd., crystd., elem. anal.;	99%

: 124-38-9
carbon dioxide

: 584-03-2
1,2-dihydroxybutane

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

Conditions

Conditions	Yield
With 2-Cyanopyridine; cerium(IV) oxide at 139.84℃; under 37503.8 Torr; for 1h; Autoclave;	99%
With 1,10-Phenanthroline; calcium carbide; zinc trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 180℃; under 37503.8 Torr; for 24h; Autoclave; Glovebox; Sealed tube;	82%
Stage #1: carbon dioxide With 1-butyl-3-methyl-1H-imidazol-3-iumhydrogencarbonate at 25℃; under 760.051 Torr; for 6h; Stage #2: 1,2-dihydroxybutane at 25℃; under 760.051 Torr; for 12h;	40.4%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-methyl-but-3-yn-2-ol In N,N-dimethyl-formamide at 120℃; under 22502.3 Torr; for 10h; Autoclave;	99 %Chromat.
With tetraethylammonium iodide In acetonitrile at 20℃; under 760.051 Torr; Electrolysis;	47.6 %Chromat.

: 616-38-6
carbonic acid dimethyl ester

: 584-03-2
1,2-dihydroxybutane

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

Conditions

Conditions	Yield
In neat (no solvent) at 110℃; for 24h; Temperature; Green chemistry;	99%
With zinc(II) trifluoroacetate hydrate; 1,3-bis(imidazol-1-ylmethyl)benzene for 9h; Reagent/catalyst; Reflux;
With tetrabutylammomium bromide at 180℃; under 8250.83 Torr; for 0.05h; Flow reactor;
With sodium methylate In methanol at 64 - 90℃;

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 4282-31-9
Thiophene-2,5-dicarboxylic acid

: zinc(II) nitrate hexahydrate

: 584-03-2
1,2-dihydroxybutane

: [Zn12(thiophene-2,5-dicarboxylic acid)6(1,2-butanediol)6(1,4-diaza-bicyclo[2.2.2]octane)3]

Conditions

Conditions	Yield
Stage #1: 1,4-diaza-bicyclo[2.2.2]octane; Thiophene-2,5-dicarboxylic acid; zinc(II) nitrate hexahydrate In N,N-dimethyl-formamide for 1h; Stage #2: 1,2-dihydroxybutane In N,N-dimethyl-formamide at 130℃; for 48h; Sealed tube;	99%

...Expand

: (C9H6NO)B(OCH(CH3)2)2

: 584-03-2
1,2-dihydroxybutane

: 185610-99-5
(C9H6NO)B(OCH2CH(C2H5)O)

Conditions

Conditions	Yield
In benzene refluxing (10 h); recrystn. (benzene/CH2Cl2); elem. anal.;	98.95%

: 67-64-1
acetone

: 584-03-2
1,2-dihydroxybutane

: 4-Ethyl-2,2-dimethyl-[1,3]dioxolane

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate at 20℃; for 2h;	98%

: 62-53-3
aniline

: 584-03-2
1,2-dihydroxybutane

: 114010-10-5
1-(phenylamino)-butan-2-ol

Conditions

Conditions	Yield
With C29H44IrN5P2; potassium tert-butylate In diethylene glycol dimethyl ether at 130℃; for 20h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Glovebox;	98%

: 201230-82-2
carbon monoxide

: 584-03-2
1,2-dihydroxybutane

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

Conditions

Conditions	Yield
With N-chloro-succinimide; (neocuproine)Pd(OAc)2; sodium acetate In acetonitrile at 55℃; under 760.051 Torr; for 24h; Molecular sieve;	97%
With air; potassium iodide; palladium(II) iodide In ISOPROPYLAMIDE at 100℃; under 15201 Torr; for 15h; Autoclave;	94%
With oxygen; potassium iodide; palladium(II) iodide In N,N-dimethyl acetamide at 100℃; under 15201 Torr; for 15h;	94%
With triethylamine; copper dichloride 1.) THF, 30 kg/cm2, 80 deg C, 4h, 2.) room temp, 18 h, 1 atm; Yield given. Multistep reaction;
With oxygen; sodium carbonate; copper dichloride In acetonitrile at 100℃; under 22502.3 Torr; for 3h; Autoclave;

: 58479-61-1
tert-butylchlorodiphenylsilane

: 584-03-2
1,2-dihydroxybutane

: 1-(tert-butyl-diphenyl-silanyloxy)-butan-2-ol

Conditions

Conditions	Yield
With 4-methylpyridine-1-oxide In dichloromethane at 20℃; Molecular sieve; regioselective reaction;	97%

: 124-38-9
carbon dioxide

: 115-19-5
2-methyl-but-3-yn-2-ol

: 584-03-2
1,2-dihydroxybutane

A: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

B: 115-22-0
3-Hydroxy-3-methyl-2-butanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride In acetonitrile at 80℃; under 7500.75 Torr; for 24h; Autoclave; Sealed tube; chemoselective reaction;	A 97% B 65 %Chromat.
Stage #1: carbon dioxide; 2-methyl-but-3-yn-2-ol With C15H18N2O2 In acetonitrile at 25℃; under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Stage #2: 1,2-dihydroxybutane With 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine In acetonitrile at 25℃; for 24h; Inert atmosphere; Schlenk technique;	A 89 %Spectr. B n/a

...Expand

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: zinc(II) nitrate hexahydrate

: 121-91-5
isophthalic acid

: 584-03-2
1,2-dihydroxybutane

: 12Zn(2+)*6C8H4O4(2-)*3C6H12N2*6C4H8O2(2-)

Conditions

Conditions	Yield
Stage #1: 1,4-diaza-bicyclo[2.2.2]octane; zinc(II) nitrate hexahydrate; isophthalic acid In N,N-dimethyl-formamide for 1h; Stage #2: 1,2-dihydroxybutane In N,N-dimethyl-formamide at 130℃; for 48h;	96%

...Expand

: 108-24-7
acetic anhydride

: 584-03-2
1,2-dihydroxybutane

: 13814-27-2
1,2-butanediol diacetate

Conditions

Conditions	Yield
With phosphorus pentoxide; silica gel at 20℃;	95%
With dmap; triethylamine In dichloromethane at 20℃; for 16h; Cooling with ice;	86%
With sulfuric acid for 0.25h; Heating;	73%
With pyridine

: 95-54-5
1,2-diamino-benzene

: 584-03-2
1,2-dihydroxybutane

: 29750-44-5
2-ethylquinoxaline

Conditions

Conditions	Yield
With C39H31BMnNO2P2; potassium hydride In toluene at 150℃; for 36h;	95%
With cesiumhydroxide monohydrate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;	94%
With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;	93%

: 121-33-5
vanillin

: 584-03-2
1,2-dihydroxybutane

: vanillin-1,2-butylene glycol acetal

Conditions

Conditions	Yield
toluene-4-sulfonic acid In water; toluene at 135℃; for 4h; Heating / reflux; with Dean-Stark tube;	94.3%

: 57-13-6
urea

: 584-03-2
1,2-dihydroxybutane

: 4437-85-8, 90970-72-2, 90971-04-3, 127128-77-2
1,2-butylene carbonate

Conditions

Conditions	Yield
With 1-hexadecyl-3-methylimidazolium chloride; zinc(II) chloride In neat (no solvent) at 160℃; under 112.511 Torr; for 3h; Green chemistry;	94.3%

: 584-03-2
1,2-dihydroxybutane

: C4H9O5P(2-)*Ba(2+)

Conditions

Conditions	Yield
With water-d2; phospho(enol)pyruvic acid mono potassium salt; adenosine 5'-triphosphate disodium salt; barium(II) chloride; magnesium chloride; glycerol kinase from S. cerevisiae or from E. coli and pyruvate kinase In various solvent(s) for 72h; Ambient temperature;	94%

: 88-74-4
2-nitro-aniline

: 584-03-2
1,2-dihydroxybutane

: 29750-44-5
2-ethylquinoxaline

Conditions

Conditions	Yield
With cesiumhydroxide monohydrate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;	94%
With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;	92%
With trimethylamine-N-oxide; tricarbonyl(η4-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron In toluene at 150℃; for 24h; Green chemistry;	78%

: 584-03-2
1,2-dihydroxybutane

: 4949-44-4
ethyl propanoylacetate

: C10H18O4

Conditions

Conditions	Yield
With Amberlyst15 In cyclohexane Reflux;	94%

: 22664-18-2, 60322-66-9, 60362-79-0, 60362-80-3, 99881-01-3, 108266-76-8, 108266-77-9
5-exo-methylbicyclo-[2.2.1]heptan-2-exo-ol

: 584-03-2
1,2-dihydroxybutane

: 1-(exo-5-methylbicyclo[2.2.1]hept-exo-2-yloxy)butan-2-ol

Conditions

Conditions	Yield
With naphthalene-1,5-disulfonate In benzene at 80℃; for 3h;	92.9%

: 75-36-5
acetyl chloride

: 584-03-2
1,2-dihydroxybutane

A: 13814-27-2
1,2-butanediol diacetate

B: 24469-20-3
(+/-)-2-hydroxybutyl acetate

Conditions

Conditions	Yield
With 2,4,6-trimethyl-pyridine In dichloromethane at -78℃; Yields of byproduct given;	A n/a B 92%
With 2,4,6-trimethyl-pyridine In dichloromethane at -78℃; Yield given. Yields of byproduct given;

...Expand

: 584-03-2
1,2-dihydroxybutane

: 600-15-7, 565-70-8
2-Hydroxybutanoic acid

Conditions

Conditions	Yield
With C24H33IrN4O3; water; sodium carbonate for 18h; Reflux;	92%
at 35℃; for 12h; Product distribution; production by resting cells of sp. strain TB-42; optimization of culture medium for preparation of this strain; effect of CaCO3; effect of aeration; pH 7.0; effect of temperature;

: 98-59-9
p-toluenesulfonyl chloride

: 584-03-2
1,2-dihydroxybutane

: 185215-29-6
1,2-Bis(4-toluenesulfonyloxy)butane

Conditions

Conditions	Yield
With trimethylamine hydrochloride; triethylamine In acetonitrile at 0 - 5℃; for 1h;	92%
With N,N,N',N'-tetramethylhexamethylenediamine In acetonitrile at 0 - 5℃; for 1h; Tosylation;	91%

1,2-BUTANEDIOL Chemical Properties

MF: C₄H₁₀O₂
MW: 90.12
EINECS: 209-527-2
mp： -50 °C
bp： 191-192 °C747 mm Hg(lit.)
density： 1.006 g/mL at 25 °C(lit.)
refractive index： n20/D 1.438(lit.)
Fp： 200 °F
CAS DataBase Reference： 584-03-2(CAS DataBase Reference)
The structure of 1,2-BUTANEDIOL is:

1,2-BUTANEDIOL Toxicity Data With Reference

1、RTECS#: CAS# 584-03-2: EK0380000
2、LD50/LC50: RTECS: CAS# 584-03-2: Oral, mouse: LD50 = 3720 mg/kg;Oral, rat: LD50 = 16 gm/kg;
3、Carcinogenicity: 1,2-Butanediol - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.

1,2-BUTANEDIOL Consensus Reports

1,2-BUTANEDIOL is reported in EPA TSCA Inventory.

1,2-BUTANEDIOL Safety Profile

Safety Statements： 24/25
WGK Germany： 2
RTECS： EK0380000
Moderately toxic by ingestion. Combustible when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits acrid and irritating fumes.

1,2-BUTANEDIOL Specification

1、Fire Fighting Measures of 1,2-BUTANEDIOL
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
2、Handling and Storage of 1,2-BUTANEDIOL
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

Product Name

1,2-Butanediol

Synthetic route

1,2-BUTANEDIOL Chemical Properties

1,2-BUTANEDIOL Toxicity Data With Reference

1,2-BUTANEDIOL Consensus Reports

1,2-BUTANEDIOL Safety Profile

1,2-BUTANEDIOL Specification

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