1,2-Diformyloxyethane supplier

Name
1,2-Diformyloxyethane
EINECS 211-077-7
CAS No. 629-15-2
Article Data37
CAS DataBase
Density 1.158 g/cm³
Solubility Soluble in water
Melting Point
Formula C₄H₆O₄
Boiling Point 175 °C at 760 mmHg
Molecular Weight 118.089
Flash Point 86.2 °C
Transport Information
Appearance water-white liquid
Safety 26-36
Risk Codes 22-41
Molecular Structure
Hazard Symbols Xn
Synonyms 1,2-Ethanediol,diformate (9CI);Ethylene glycol, diformate (6CI,7CI,8CI);Ethylene diformate;Ethylene formate;Glycol diformate;NSC 8831;
PSA 52.60000
LogP 0.60420

Synthetic route

: 64-18-6
formic acid

: 107-21-1
ethylene glycol

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
ammonium cerium(IV) nitrate In chloroform at 55 - 60℃;	98%
Stage #1: formic acid With silica gel at 20℃; for 0.0166667h; Stage #2: ethylene glycol With silica gel at 110℃; for 0.166667h;	96%
phosphoric acid In benzene Acylation; Heating;	93.2%

: 1,4-Bis(1-hydroxyethoxy)-2-butyne diformate

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
In formic acid Mechanism; Heating;	92%

: 1,4-Bis(1-hydroxyethoxy)-2-butyne diformate

formic acid: formic acid

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
dodecacarbonyl-triangulo-triruthenium for 2h; Heating;	92%

: 127817-98-5
2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on-ethylenacetal

A: 629-15-2
ethylene glycol diformate

: 127817-99-6
2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

Conditions

Conditions	Yield
With formic acid for 6h; Ambient temperature;	A n/a B 49.3%

: 543-75-9
1,4-dioxene

: 106-51-4
p-benzoquinone

A: 629-15-2
ethylene glycol diformate

: 108165-10-2
spiro<2.3.5.7.10-pentaoxabicyclo<4.4.0>decane-4,1'-cyclohexa-2',5'-dien-4'-one>

Conditions

Conditions	Yield
With oxygen In tetrachloromethane at -5℃; under 7600 Torr; for 4h; Irradiation;	A 34% B 20%

...Expand

: 119-61-9
benzophenone

: 543-75-9
1,4-dioxene

A: 108165-08-8
7,7-diphenyl-2,5,8-trioxatricyclo<4.2.0> octane

B: 629-15-2
ethylene glycol diformate

: 108165-09-9
cis-2,3,5,7,10-pentaoxa-4,4-diphenylbicyclo<4.4.0>dodecane

Conditions

Conditions	Yield
With oxygen In tetrachloromethane at -5℃; under 7600 Torr; for 6h; Irradiation;	A 9% B 24% C 7%

...Expand

: 628-35-3
ethylene glycol monoformate

A: 629-15-2
ethylene glycol diformate

B: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With 1-Methylpyrrolidine; ruthenium(II) bis(triphenylphosphine) dichloride at 140℃; for 15h;	A 12% B 12%

: 75-21-8
oxirane

: 64-18-6
formic acid

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With sulfuric acid

: 123-91-1
1,4-dioxane

: 287-92-3
Cyclopentane

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
at 132℃; under 20594.2 Torr; Behandeln mit Luft;

...Expand

: 123-91-1
1,4-dioxane

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With clorine; oxygen; nitrogen(II) oxide at 21.9℃; under 700 Torr; Product distribution; Mechanism; FTIR study of atmospheric fate of title comp.;
With air; Cyclopentane; cobalt(II) acetate at 132℃; under 22065.2 Torr;
With OH radicals; nitrogen(II) oxide Kinetics; Oxidation; UV-irradiation;

: 144-62-7
oxalic acid

: 107-21-1
ethylene glycol

: 629-15-2
ethylene glycol diformate

: 107-21-1
ethylene glycol

: 2258-42-6
Acetic formic anhydride

: 629-15-2
ethylene glycol diformate

: 141-53-7
sodium formate

: 107-06-2
1,2-dichloro-ethane

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With methanol at 165℃;

: 543-75-9
1,4-dioxene

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
(i) O2, (ii) (thermolysis); Multistep reaction;
With 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin for 1h; Irradiation; Atmospheric conditions;	77 %Spectr.

: C11H11N2O4

A: 50-00-0
formaldehyd

B: 628-35-3
ethylene glycol monoformate

C: 629-15-2
ethylene glycol diformate

D: 31125-07-2
4-cyanonitrosobenzene

E: 22347-47-3
1,4-dioxane-2-ol

F: 3041-16-5
p-dioxanone

Conditions

Conditions	Yield
With dinitrogen monoxide In water Mechanism; Product distribution; Rate constant; Ambient temperature; Irradiation; other ethers;

...Expand

: 64-18-6
formic acid

: 107-21-1
ethylene glycol

A: 628-35-3
ethylene glycol monoformate

B: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With acid at 20℃; Esterification;

...Expand

: 141-53-7
sodium formate

: 106-93-4
ethylene dibromide

A: 628-35-3
ethylene glycol monoformate

B: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
In formic acid for 30h; Substitution; Heating;

...Expand

: 107-21-1
ethylene glycol

CO: CO

A: 629-15-2
ethylene glycol diformate

B ethylene glycol monoformate: ethylene glycol monoformate

Conditions

Conditions	Yield
With sodium ethane-1,2-diolate at 70 - 100℃; under 147102 - 294203 Torr;

...Expand

: 123-91-1
1,4-dioxane

A: 50-00-0
formaldehyd

B: 64-18-6
formic acid

C: 629-15-2
ethylene glycol diformate

D: 625-45-6
2-methoxyacetic acid

Conditions

Conditions	Yield
With water; oxygen at 25℃; for 2h; pH=7.5; Kinetics; Product distribution; Further Variations:; ultrasonic frequencies; sparge gases: Ar/O2 mixtures, pure Ar; Decomposition; ultrasonic irradiation;

...Expand

: 764-78-3
ethylene glycol divinyl ether

A: 50-00-0
formaldehyd

B: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With ozone at 24.84℃; under 760.051 Torr; Kinetics; Concentration; Time; Gas phase;	A 47 %Chromat. B 50 %Chromat.

: 589-40-2
sec-butyl formate

: 107-21-1
ethylene glycol

: 629-15-2
ethylene glycol diformate

Conditions

Conditions	Yield
With potassium carbonate at 100 - 130℃; for 6h; Reagent/catalyst; Concentration; Reflux;

: 107-31-3
Methyl formate

A: 67-56-1
methanol

B: 629-15-2
ethylene glycol diformate

C: 124-38-9
carbon dioxide

D: 201230-82-2
carbon monoxide

Conditions

Conditions	Yield
With oxygen at 560℃; under 15001.5 Torr;

...Expand

: 90-52-8
6-methoxyquinolin-8-amine

: 629-15-2
ethylene glycol diformate

: 105-14-6
5-diethylamino-2-pentanone

: 491-92-9
pamaquine

...Expand

: 629-15-2
ethylene glycol diformate

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With di-tert-butyl peroxide at 140℃; for 3h; conversion, concentration of products;

: 629-15-2
ethylene glycol diformate

A: 64-18-6
formic acid

B: 201230-82-2
carbon monoxide

C: 1558-67-4
formic anhydride

Conditions

Conditions	Yield
With OH radicals; chlorine Kinetics; Product distribution; Oxidation; UV-irradiation;

...Expand

: 629-15-2
ethylene glycol diformate

A: 74-85-1
ethene

B: 463-79-6
carbonic-acid

C: 7732-18-5
water

D carbon monoxide: carbon monoxide

Conditions

Conditions	Yield
at 220 - 240℃;

...Expand

: 629-15-2
ethylene glycol diformate

: 93625-19-5
N-ethyl-N(2-formyloxyethyl)formamide

A: 617-84-5
N-formyldiethylamine

B: 109-94-4
formic acid ethyl ester

C CO2: CO2

Conditions

Conditions	Yield
With di-tert-butyl peroxide In chlorobenzene at 140℃; for 1.5h; Product distribution;

...Expand

: 629-15-2
ethylene glycol diformate

A: 617-84-5
N-formyldiethylamine

B: 112-32-3
octyl formate

C: 93625-20-8
N-ethyl-N-octyl formamide

D: 109-94-4
formic acid ethyl ester

E CO2: CO2

Conditions

Conditions	Yield
With competition reaction with N-ethyl-N(2-formyloxyethyl)formamide and 1-hexene In chlorobenzene at 140℃; for 1.5h; Product distribution;

...Expand

: 64-17-5
ethanol

: 629-15-2
ethylene glycol diformate

A: 109-94-4
formic acid ethyl ester

B ethylene glycol monoformate: ethylene glycol monoformate

...Expand

: 629-15-2
ethylene glycol diformate

: vanadyl phosphate intercalated with 2-propanol

: vanadyl phosphate intercalated with ethylene glycol diformate

Conditions

Conditions	Yield
In not given react. by refluxing 1 h;

1,2-Diformyloxyethane Consensus Reports

Reported in EPA TSCA Inventory.

1,2-Diformyloxyethane Specification

The Ethylene glycol diformate, with the CAS registry number 629-15-2, is also known as Formic acid, ethylene ester. Its EINECS registry number is 211-077-7. This chemical's molecular formula is C₄H₆O₄ and molecular weight is 118.08804. Its IUPAC name is called 2-formyloxyethyl formate. This chemical's classification code is Skin / Eye Irritant.

Physical properties of Ethylene glycol diformate: (1)ACD/LogP: -0.37; (2)ACD/LogD (pH 5.5): -0.37; (3)ACD/LogD (pH 7.4): -0.37; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 14.91; (7)ACD/KOC (pH 7.4): 14.91; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 5; (10)Index of Refraction: 1.395; (11)Molar Refractivity: 24.44 cm³; (12)Molar Volume: 101.9 cm³; (13)Surface Tension: 35.2 dyne/cm; (14)Density: 1.158 g/cm³; (15)Flash Point: 86.2 °C; (16)Enthalpy of Vaporization: 41.13 kJ/mol; (17)Boiling Point: 175 °C at 760 mmHg; (18)Vapour Pressure: 1.17 mmHg at 25°C.

Preparation of Ethylene glycol diformate: this chemical can be prepared by formic acid 2-[4-(2-formyloxy-ethoxy)-but-2-ynyloxy]-ethyl ester by heating. This reaction will need solvent formic acid. The yield is about 92%.

Ethylene glycol diformate can be prepared by formic acid 2-[4-(2-formyloxy-ethoxy)-but-2-ynyloxy]-ethyl ester by heating

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful if swallowed. In addition, there will be a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(COC=O)OC=O
(2)InChI: InChI=1S/C4H6O4/c5-3-7-1-2-8-4-6/h3-4H,1-2H2
(3)InChIKey: IKCQWKJZLSDDSS-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	390mg/kg (390mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
rat	LD50	oral	1510mg/kg (1510mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

Product Name

1,2-Diformyloxyethane

Synthetic route

1,2-Diformyloxyethane Consensus Reports

1,2-Diformyloxyethane Specification

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