1,2-Dimethylpropylamine supplier

Name
1,2-Dimethylpropylamine
EINECS 209-949-7
CAS No. 598-74-3
Article Data30
CAS DataBase
Density 0.757
Solubility miscible in water
Melting Point -50 ºC
Formula C5H13 N
Boiling Point 84-87 ºC
Molecular Weight 87.1649
Flash Point -18 ºF
Transport Information UN 3286
Appearance colorless to yellow liquid
Safety Poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes R11;R21/22;R34
Molecular Structure
Hazard Symbols
Synonyms Propylamine,1,2-dimethyl- (6CI,7CI,8CI); (3-Methylbutan-2-yl)amine; (?à)-3-Methyl-2-butanamine; (?à)-3-Methyl-2-butylamine;1,2-Dimethylpropanamine; 1,2-Dimethylpropylamine; 2-Amino-3-methylbutane;3-Methyl-2-aminobutane; 3-Methyl-2-butanamine; 3-Methyl-2-butylamine
PSA 26.02000
LogP 1.68990

Synthetic route

: 72-18-4
L-valine

A: 110-96-3
diisobutylamine

B: 78-81-9
isobutylamine

C: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Stage #1: L-valine With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 5% B 50% C 7%

...Expand

: 563-80-4
3-methyl-butan-2-one

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With platinum(IV) oxide; ammonia; ammonium chloride under 735.5 - 2206.5 Torr; Hydrogenation;
(i) NH2OH, NaOAc, (ii) LiAlH4; Multistep reaction;
(reductive amination);

: 563-80-4
3-methyl-butan-2-one

A: 99868-53-8
bis-(1,2-dimethyl-propyl)-amine

B: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With methanol; platinum(IV) oxide; ammonia; ammonium chloride under 735.5 - 2206.5 Torr;

: 19838-95-0
bis-(1,2-dimethyl-propylidene)-hydrazine

A: 99868-53-8
bis-(1,2-dimethyl-propyl)-amine

B: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With hydrogen; nickel at 180 - 200℃;

: 600-20-4
3-methyl-butan-2-one oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With i-Amyl alcohol; sodium
With lithium aluminium tetrahydride
With sodium In ethanol

: 3238-16-2
2-chloro-2-methylbutan-3-one oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With hydrogenchloride; diethyl ether; tin(ll) chloride

: 2625-35-6
2-nitro-3-methyl-butane

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With hydrogenchloride; iron at 100℃;

: 3378-43-6
3-Chlor-3-methyl-2-nitrosobutan-5t,9t-dien-Dimer

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether

: 17123-14-7
2-Amino-1.1.2-trimethyl-aethanthiol

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With water; nickel

: 513-35-9
2-methyl-but-2-ene

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With chloro-trimethyl-silane; lithium dihydrido dimethyl borate; hydroxylamine-O-sulfonic acid 1) diethyl ether, 25 deg C, 4 h, 2) THF, 25 deg C, 12 h; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: diethyl ether; nitrosyl chloride / anschliessend mit Chlorwasserstoff 2: tin (II)-chloride; hydrogen chloride; diethyl ether View Scheme

β-hydroxyimino-α.α-dimethyl-butyronitrile: β-hydroxyimino-α.α-dimethyl-butyronitrile

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With ethanol; sodium

: 563-80-4
3-methyl-butan-2-one

: 67-56-1
methanol

: ammonium chloride

: 7664-41-7
ammonia

platinum: platinum

A: 99868-53-8
bis-(1,2-dimethyl-propyl)-amine

B: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
under 735.5 - 2206.5 Torr; Hydrogenation;

...Expand

α-bromomethyl-isobutylamine hydrobromide: α-bromomethyl-isobutylamine hydrobromide

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

(+-)-3-amino-2-methyl-butanol-(2)-hydrochloride: (+-)-3-amino-2-methyl-butanol-(2)-hydrochloride

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With chloroform; phosphorus pentachloride durch Hydrierung des Reaktionsprodukts an Palladium-Kohle in Methanol;

3-methyl-butanone oxime: 3-methyl-butanone oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With methanol; nickel at 70℃; under 36775.4 Torr; Hydrogenation;

3-methyl-butenone oxime: 3-methyl-butenone oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With ethanol; nickel Hydrogenation;

: 7647-01-0
hydrogenchloride

: 2625-35-6
2-nitro-3-methyl-butane

iron: iron

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
at 98℃;

...Expand

: 64-17-5
ethanol

: 114175-07-4
3-hydroxyimino-2,2-dimethyl-butyronitrile

sodium: sodium

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Reduktion;

...Expand

: 19838-95-0
bis-(1,2-dimethyl-propylidene)-hydrazine

hydrogen: hydrogen

nickel: nickel

A: 99868-53-8
bis-(1,2-dimethyl-propyl)-amine

B: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
at 180 - 200℃;

...Expand

: 123-51-3
i-Amyl alcohol

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminium sulfate / 400 - 415 °C 2: diethyl ether; nitrosyl chloride / anschliessend mit Chlorwasserstoff 3: tin (II)-chloride; hydrogen chloride; diethyl ether View Scheme

: 2648-71-7
3-bromo-3-methyl-2-butanone

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: (i) NaOH, EtOH, (ii) /BRN= 1742523/ 2: NH2OH*HCl, Py 3: Na, liq. NH3 4: LiAlH4 / diethyl ether 5: H2O / Raney-Ni View Scheme

: 867-70-9
3-mercapto-3-methyl-butan-2-one oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: H2O / Raney-Ni View Scheme

: 718-22-9
3-benzylsulfanyl-3-methyl-butan-2-one oxime

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Na, liq. NH3 2: LiAlH4 / diethyl ether 3: H2O / Raney-Ni View Scheme

: 831-89-0
3-Benzylthio-3-methyl-2-butanon

: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NH2OH*HCl, Py 2: Na, liq. NH3 3: LiAlH4 / diethyl ether 4: H2O / Raney-Ni View Scheme

: 563-80-4
3-methyl-butan-2-one

: 100-46-9
benzylamine

A: 100-52-7
benzaldehyde

B: 598-74-3
2-amino-3-methylbutane

Conditions

Conditions	Yield
With S-selective ω-transaminase from paracoccus denitrificans transaminase; NAD; aldehyde dehydrogenase In dimethyl sulfoxide Reagent/catalyst; Enzymatic reaction;

...Expand

: 1207531-78-9
6,7-dichloro-2-(4-fluorophenyl)-3-(2-fluoropyridin-4-yl)quinoxaline

: 598-74-3
2-amino-3-methylbutane

: 1207531-81-4
4-(6,7-dichloro-3-(4-fluorophenyl)quinoxalin-2-yl)-N-(3-methylbutan-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
at 160℃; for 15h; Sealed tube;	99%

: 100-52-7
benzaldehyde

: 598-74-3
2-amino-3-methylbutane

: C12H17NO

Conditions

Conditions	Yield
With dihydrogen peroxide; carbonic acid dimethyl ester In water at 20℃; for 15h; Green chemistry;	99%

: 1207531-76-7
2-(4-fluorophenyl)-3-(2-fluoropyridin-4-yl)quinoxaline

: 598-74-3
2-amino-3-methylbutane

: 1207531-79-0
4-(3-(4-fluorophenyl)quinoxalin-2-yl)-N-(3-methylbutan-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
at 160℃; for 15h; Sealed tube;	97%

: C15H17NO3

: 598-74-3
2-amino-3-methylbutane

: 1-butyl-8-methyl-3-{[(3-methylbutan-2-yl)amino]-methylidene}quinoline-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With acetic anhydride Reflux;	97%

: 882739-48-2
(2,2,2-trichloroethoxysulfonyl)carbonchloroimidothioic acid methyl ester

: 598-74-3
2-amino-3-methylbutane

: 882739-56-2
[1-(1,2-Dimethyl-propylamino)-1-methylsulfanyl-meth-(E)-ylidene]-sulfamic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 23℃; for 4h;	96%

: C10H4Cl2F3N3O

: 598-74-3
2-amino-3-methylbutane

: 1-(3-chloropyridin-2-yl)-N-(3-methylbutan-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 12h;	95%

: 908381-35-1
2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

: 598-74-3
2-amino-3-methylbutane

: (1,2-dimethylpropyl)-{4-[5-(4-fluorophenyl)-2-methanesulfanyl-3-(2-methoxyethyl)-3H-imidazol-4-yl]-pyridin-2-yl}-amine

Conditions

Conditions	Yield
With pyridine at 130℃; for 3h;	92.4%

: 1207531-77-8
2-(4-fluorophenyl)-3-(2-fluoropyridin-4-yl)-6,7-dimethylquinoxaline

: 598-74-3
2-amino-3-methylbutane

: 1207531-80-3
4-(3-(4-fluorophenyl)-6,7-dimethylquinoxalin-2-yl)-N-(3-methylbutan-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
at 160℃; for 15h; Sealed tube;	91%

: 598-74-3
2-amino-3-methylbutane

: 104400-30-8
(S)-2,5-dioxopyrrolidin-1-yl-2-(6-methoxynaphthalen-2-yl)propanoate

: N-[(R/S)-3-methyl-2-butyl]-(S)-2-(6-methoxynaphth-2-yl)propionamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h; Acylation;	90%

: 598-74-3
2-amino-3-methylbutane

: N-[3-chloro-6-(2-chloro-4-fluorophenyl)pyrazolo[1, 5-a]pyrimidin-7-yl]-N-(1,2-dimethylpropyl)amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 16h;	89%

: 7-chloro-6-(2-chloro-6-fluorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 598-74-3
2-amino-3-methylbutane

: 6-(2chloro-6-fluorophenyl)7-[(1,2-dimethylpropyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 16h;	89%

: 1061602-00-3
2-(4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio)ethanol

: 598-74-3
2-amino-3-methylbutane

: 1229571-92-9
4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridine-4-yl)-1,3-dihydro-2H-imidazol-2-one

Conditions

Conditions	Yield
at 160℃; for 10h; Microwave irradiation;	89%

: 598-74-3
2-amino-3-methylbutane

: 2625-35-6
2-nitro-3-methyl-butane

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane for 3h; Reflux;	87%

: 598-74-3
2-amino-3-methylbutane

: 193682-08-5
7-chloro-3-(1H-imidazol-1-yl)-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide

: (7-chloro-1,1-dioxo-1,4-dihydro-1λ6-pyrido[2,3-e][1,2,4]thiadiazin-3-yl)-(1,2-dimethyl-propyl)-amine

Conditions

Conditions	Yield
at 180℃; Substitution;	86%

: 598-74-3
2-amino-3-methylbutane

: 174676-47-2
4-methyl-3-methylsulfanyl-4H-pyrido<4.3-e>-1,2,4-thiadiazine 1,1-dioxide

: (1,2-Dimethyl-propyl)-(4-methyl-1,1-dioxo-1,4-dihydro-1λ6-pyrido[4,3-e][1,2,4]thiadiazin-3-yl)-amine

Conditions

Conditions	Yield
for 1h; Heating;	85%

: 124-38-9
carbon dioxide

: 598-74-3
2-amino-3-methylbutane

: 51354-18-8
Phosphorsaeure-diphenylestercyanid

: 1195163-32-6
(3-methylbutan-2-yl)carbamoyl cyanide

Conditions

Conditions	Yield
With tetramethylphenylguanidine In acetonitrile at 0℃; for 1h;	85%

...Expand

: 107-19-7
propargyl alcohol

: 143321-89-5
2,2,2-trifluoro-N-(2-iodophenyl)acetamide

: 598-74-3
2-amino-3-methylbutane

: N-((1H-indol-2-yl)methyl)-3-methylbutan-2-amine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 9h; Inert atmosphere;	85%

...Expand

: 4-(2-(((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)thio)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-2-fluoropyridine

: 598-74-3
2-amino-3-methylbutane

: 4-(2-(((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)thio)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-N-(3-methylbutan-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
at 160℃; for 16h;	85%

: 598-74-3
2-amino-3-methylbutane

: (3S,20S)-20-formylpregn-7-en-3-yl acetate

: (3S,20S)-20-[(1R,S)-(1,2-dimethyl-propylamino)-methyl]-pregn-7-en-3-yl acetate

Conditions

Conditions	Yield
With sodium cyanoborohydride; zinc(II) chloride In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;	84%

: 107535-73-9
2,3,5,6-tetrafluorobenzoic acid chloride

: 598-74-3
2-amino-3-methylbutane

: 1117700-42-1
N-(1,2-dimethylpropyl)-2,3,5,6-tetrafluoro-benzamide

Conditions

Conditions	Yield
	81%

: 598-74-3
2-amino-3-methylbutane

: 433-27-2
Trifluoroacetaldehyde ethyl hemiacetal

: 1268828-24-5
3-methyl-N-[(1E)-2,2,2-trifluoroethylidene]butan-2-amine

Conditions

Conditions	Yield
In water at 105℃; for 1h; stereoselective reaction;	81%

: 141109-47-9
[di(propan-2-yl)amino](oxo)acetyl chloride

: 598-74-3
2-amino-3-methylbutane

: N1,N1-diisopropyl-N2-(3-methylbutan-2-yl)oxalamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	81%

: 16013-85-7
2,6-dicholoro-3-nitropyridine

: 598-74-3
2-amino-3-methylbutane

: 1152564-37-8
6-chloro-N-(3-methylbutan-2-yl)-3-nitropyridin-2-amine

Conditions

Conditions	Yield
With triethylamine In tert-butyl methyl ether at -5 - 20℃; Inert atmosphere;	79%

: 148564-88-9
2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-ynyl)phenyl)acetamide

: 598-74-3
2-amino-3-methylbutane

: N-((1H-indol-2-yl)methyl)-3-methylbutan-2-amine

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate In acetonitrile at 80℃; Reagent/catalyst;	79%

: 2-fluoro-4-(4-(4-fluorophenyl)-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)thio)-1H-imidazol-5-yl)pyridine

: 598-74-3
2-amino-3-methylbutane

: 4-(4-(4-fluorophenyl)-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)thio)-1H-imidazol-5-yl)-N-(3-methylbutan-2-yl)-pyridin-2-amine

Conditions

Conditions	Yield
at 160℃; for 16h;	77%

: 14371-10-9
(E)-3-phenylpropenal

: 598-74-3
2-amino-3-methylbutane

: 133284-78-3
1-(α-Isopropylethyl)-4-phenyl-1-azabuta-1,3-diene

Conditions

Conditions	Yield
at 0℃; for 0.25h;	76%

: 1120-71-4
1,3-propanesultone

: 598-74-3
2-amino-3-methylbutane

: 3-(1,2-dimethyl-1-propyl)amino-1-propanesulfonic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 2h; Heating / reflux;	76%

: 137906-30-0
diethyl (Z)-4-bromo-3,4,4-trifluoro-2-butenylphosphonate

: 598-74-3
2-amino-3-methylbutane

: 137906-33-3
diethyl (Z)-3-<(1,2-dimethylpropyl)carbamoyl>-3-fluoro-2-propenylphosphonate

Conditions

Conditions	Yield
In tetrahydrofuran a) 0 deg C, 1 h, b) r.t., 12 h;	75%

: 598-74-3
2-amino-3-methylbutane

: 549505-66-0
2-fluoro-4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

: (1,2-dimethylpropyl)-{4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-amine

Conditions

Conditions	Yield
at 75 - 150℃; for 7h;	74.7%

: 103922-89-0
4-(4-piperidinomethyl-pyridin-2-yloxy)-cis-2-butenylamine

: 598-74-3
2-amino-3-methylbutane

: N-(1,2-Dimethylpropyl)-N'-[4-(4-piperidinomethyl-pyridin-2-yloxy)-cis-2-butenyl]urea

Conditions

Conditions	Yield
	73%

1,2-Dimethylpropylamine Toxicity Data With Reference

ipr-mus LD50:279 mg/kg

JJPAAZ Japanese Journal of Pharmacology. 17 (1967),475.

1,2-Dimethylpropylamine Consensus Reports

Reported in EPA TSCA Inventory.

1,2-Dimethylpropylamine Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NO_x.

1,2-Dimethylpropylamine Standards and Recommendations

DOT Classification: 8; Label: Corrosive, Flammable Liquid (UN 2734); DOT Class: 3; Label: Flammable Liquid, Corrosive (UN 2733)

Product Name

1,2-Dimethylpropylamine

Synthetic route

1,2-Dimethylpropylamine Toxicity Data With Reference

1,2-Dimethylpropylamine Consensus Reports

1,2-Dimethylpropylamine Safety Profile

1,2-Dimethylpropylamine Standards and Recommendations

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