1,3,5-TRICHLOROBENZENE supplier

Name
1,3,5-Trichlorobenzene
EINECS 203-608-6
CAS No. 108-70-3
Article Data81
CAS DataBase
Density 1.448 g/cm³
Solubility Insoluble in water.
Melting Point 63 °C
Formula C₆H₃Cl₃
Boiling Point 211.3 °C at 760 mmHg
Molecular Weight 181.449
Flash Point 126.7 °C
Transport Information
Appearance white to beige crystalline powder
Safety 26-36-36/37-61
Risk Codes 20/21/22-36/37/38-38-22-52/53
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzene, 1,3,5-trichloro-;sym-trichlorobenzene;s-Trichlorobenzene;1,3,5-trichloro benzene;1,3,5-trichlorobenzol;
PSA 0.00000
LogP 3.64680

Synthetic route

: 634-90-2
1,2,3,5-tetrachlorobenzene

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

Conditions

Conditions	Yield
With radical anion of p,p'-di-tert-butylbiphenyl In tetrahydrofuran at -25℃; Irradiation;	A 2.8% B 97.2%

: 19752-55-7
1-bromo-3,5-dichlorobenzene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With chlorine; sodium thiosulfate	97.2%

: 634-93-5
2,4,6-trichloroaniline

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With sulfuric acid; hypophosphorous acid; sodium nitrite In water at -5 - 25℃;	95%
With tetrafluoroboric acid; N,N-dimethyl-formamide; sodium nitrite In water at 45℃; for 0.25h; Product distribution; or benzene, room temperature, 3 h;	94%
Stage #1: 2,4,6-trichloroaniline With sulfuric acid Stage #2: With sodium nitrite In water for 0.75h; Cooling with ice; Stage #3: With sodium hypophosphite hydrate In hexane; water at 20℃; Cooling with ice;	84%

: 626-43-7
3,5-Dichloroaniline

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With chloro-trimethyl-silane; N-benzyl-N,N,N-triethylammonium chloride; sodium nitrite In tetrachloromethane 1.) 0 deg C, 1.5 h, 2.) r.t., 14 h;	95%

: 14862-52-3
1,3-dibromo-5-chlorobenzene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With chlorine; sodium thiosulfate In tetrachloromethane	91%

: 58-89-9
LINDANE

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
With ammonia at 25℃; Product distribution; Further Variations:; Reagents; Dehalogenation;	A 5% B 87% C 8%
at 25℃; pH=8.32; Kinetics; Product distribution; Further Variations:; pH-values;
With (5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)iron(III) chloride; tetrabutylammonium perchlorate In N,N-dimethyl-formamide for 4h; Electrolysis;

...Expand

: 401631-89-8
C10H12Cl3N3

A: 108-70-3
1,3,5-trichlorobenzene

B: 6324-50-1
1,3,5-trichloro-2-iodobenzene

Conditions

Conditions	Yield
With tetrafluoroboric acid; hydrogen iodide In acetonitrile at 60℃; for 24h;	A 3% B 86%

: 634-90-2
1,2,3,5-tetrachlorobenzene

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
With radical anion of p,p'-di-tert-butylbiphenyl; triethylamine In tetrahydrofuran at 45℃; Irradiation;	A 18.8% B 75.5% C 5.7%
With radical anion of p,p'-di-tert-butylbiphenyl; triethylamine In tetrahydrofuran at 45℃; Product distribution; Rate constant; Mechanism; Irradiation; radical anion of naphthalene, different temperatures, without Et3N;	A 18.8% B 75.5% C 5.7%
With radical anion of p,p'-di-tert-butylbiphenyl In tetrahydrofuran at 45℃; Irradiation;	A 59.2% B 40.5% C 0.3%
In acetonitrile at 40℃; Product distribution; Mechanism; Quantum yield; Irradiation; in the presence of triethylamine;	A 18.77 % Chromat. B 75.45 % Chromat. C 5.78 % Chromat.
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 70℃; Rate constant; relative reactivity in dehalogenation;

...Expand

: trichloro-benzenediazonium tetrafluoroborate

A: 108-70-3
1,3,5-trichlorobenzene

B: 33979-03-2
2,2',4,4',6,6'-Hexachlorobiphenyl

C: 134253-68-2
2,4,6-trichlorobenzenediazohydroxide

D: 23914-43-4, 18490-44-3
2,2',4,4',6,6'-Hexachlor-azobenzen

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol at 34℃; for 24h; Irradiation; Further byproducts given;	A 51.4% B 12.4% C 1.5% D 15.3%

...Expand

: trichloro-benzenediazonium tetrafluoroborate

A: 108-70-3
1,3,5-trichlorobenzene

B: 33979-03-2
2,2',4,4',6,6'-Hexachlorobiphenyl

C: 134253-68-2
2,4,6-trichlorobenzenediazohydroxide

D: 23914-43-4, 18490-44-3
2,2',4,4',6,6'-Hexachlor-azobenzen

E dichloro(trifluoroethoxy)benzene, hexachlorohydroxybiphenyl: dichloro(trifluoroethoxy)benzene, hexachlorohydroxybiphenyl

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol at 34℃; for 24h; Product distribution; influence of magnetic field;	A 51.4% B 12.4% C 1.5% D 15.3% E n/a

...Expand

: trichloro-benzenediazonium tetrafluoroborate

A: 108-70-3
1,3,5-trichlorobenzene

B: 33979-03-2
2,2',4,4',6,6'-Hexachlorobiphenyl

C: 23914-43-4, 18490-44-3
2,2',4,4',6,6'-Hexachlor-azobenzen

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol at 34℃; for 24h; Further byproducts given;	A 40.4% B 3.5% C 2.3%

...Expand

: 104891-98-7
3-Amino-3-(2,4,6-trichlor-phenylazo)propensaeuremethylester

A: 108-70-3
1,3,5-trichlorobenzene

B: 2724-66-5
2,4,6-trichlorophenylhydrazine hydrochloride

C: 23914-43-4, 18490-44-3
2,2',4,4',6,6'-Hexachlor-azobenzen

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 0.5h; Ambient temperature;	A 37% B 35% C n/a
With hydrogenchloride In methanol for 0.5h; Product distribution; Mechanism; Ambient temperature;	A 37% B 35% C n/a

...Expand

: 36997-05-4
2-methoxyacrylic acid ethyl ester

: 50-43-1
2,4,6-trichlorobenzoic acid

A: 108-70-3
1,3,5-trichlorobenzene

B: (Z)-ethyl 2-methoxy-3-(2,4,6-trichlorophenyl)acrylate

C: (E)-ethyl 2-methoxy-3-(2,4,6-trichlorophenyl)acrylate

D: diethyl 2,5-dimethoxyhexa-2,4-dienedioate

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 130℃; for 24h; Solvent; Sealed tube; Inert atmosphere; stereoselective reaction;	A n/a B 24% C 16% D n/a

...Expand

: trichloro-benzenediazonium tetrafluoroborate

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 34℃; for 24h; Irradiation;	13%
With trifluorormethanesulfonic acid at 34℃; for 24h;	6.8%

: 110-86-1
pyridine

: 319-84-6
alpha-hexachlorocyclohexane

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

...Expand

: 91-22-5
quinoline

: 319-84-6
alpha-hexachlorocyclohexane

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
at 105 - 110℃;

...Expand

: 99-35-4
1,3,5-trinitrobenzene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With tetrachloromethane at 290℃;
With hydrogenchloride at 260℃;

: 64-17-5
ethanol

: 319-86-8
delta-lindane

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
Product distribution;

...Expand

: 64-17-5
ethanol

: 58-89-9
LINDANE

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
Product distribution;

...Expand

: 64-17-5
ethanol

: 319-85-7
beta-hexachlorocyclohexane

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
Product distribution;

...Expand

: 64-17-5
ethanol

: 319-84-6
alpha-hexachlorocyclohexane

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

Conditions

Conditions	Yield
Product distribution;

...Expand

: 64-17-5
ethanol

: 2,4,6,N-tetrachloro-N-nitro-aniline

: 108-70-3
1,3,5-trichlorobenzene

: 64-17-5
ethanol

: 2,4,6-trichloro-benzenediazonium; hydrogen sulfate

: 108-70-3
1,3,5-trichlorobenzene

: 593-63-5
chloroacetylene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With nitrogen bei Licht- und Waermestrahlung einer 100 Watt-Lampe;

: 6324-50-1
1,3,5-trichloro-2-iodobenzene

: 141-52-6
sodium ethanolate

: 108-70-3
1,3,5-trichlorobenzene

: 6324-50-1
1,3,5-trichloro-2-iodobenzene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With sodium ethanolate
With sodium methylate In methanol; dimethyl sulfoxide at 50.1℃; Rate constant;

: 618-62-2
3,5-dichloro-1-nitrobenzene

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
ueber mehrere Stufen;

: 24473-00-5
2,4,6-trichlorobenzaldehyde

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
With potassium hydroxide

: 33786-89-9
5-chloro-1,3-benzenediamine

: 108-70-3
1,3,5-trichlorobenzene

Conditions

Conditions	Yield
diazotiert und mit CuCl+HCl behandelt;

: 319-84-6
alpha-hexachlorocyclohexane

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 108-70-3
1,3,5-trichlorobenzene

B: 120-82-1
1,2,4-Trichlorobenzene

C: 87-61-6
1,2,3-trichlorobenzene

...Expand

: 108-70-3
1,3,5-trichlorobenzene

: 98-80-6
phenylboronic acid

: 612-71-5
1,3,5-triphenylbenzene

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; DavePhos In toluene at 90℃; Suzuki Coupling; Inert atmosphere; Schlenk technique;	100%
With potassium phosphate; palladium bis(dibenzylideneacetone)palladium(0); catacxium A In toluene at 110℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;	94%
With trans-chloro(9-phenanthrenyl)bis(triphenylphosphine)nickel(II); potassium carbonate; triphenylphosphine In toluene at 110℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere;	91%
With potassium carbonate In ethanol; water at 90℃; for 36h; Suzuki-Miyaura Coupling;	21%

: 108-70-3
1,3,5-trichlorobenzene

: 75-07-0
acetaldehyde

: 65426-68-8
1-(2,4,6-trichlorophenyl)ethanol

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: acetaldehyde In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;	99%

: 108-70-3
1,3,5-trichlorobenzene

: 124-38-9
carbon dioxide

: 51-36-5
3,5-dichlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With magnesium; ethylene dibromide; lithium chloride In tetrahydrofuran at 25℃; for 0.5h; Stage #2: carbon dioxide In tetrahydrofuran at 25℃; for 1h; Further stages;	99%

: 108-70-3
1,3,5-trichlorobenzene

: 5720-05-8
4-methylphenylboronic acid

: 50446-43-0
1,3,5-tris(4-methyl-phenyl)-benzene

Conditions

Conditions	Yield
With potassium phosphate; tetrabutylammomium bromide In water at 95℃; for 20h; Suzuki-Miyaura Coupling;	99%
With potassium phosphate; palladium bis(dibenzylideneacetone)palladium(0); catacxium A In toluene at 110℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;	90%
With potassium carbonate In ethanol; water at 90℃; for 24h; Suzuki-Miyaura Coupling;	12%

: decyl 2-hydroxyacetate

: 108-70-3
1,3,5-trichlorobenzene

: n-decyl 3,5-dichlorophenoxyacetate

Conditions

Conditions	Yield
Stage #1: n-decyl glycolate With sodium methylate at 120℃; Stage #2: 1,3,5-trichlorobenzene at 160℃;	98.9%

: 108-70-3
1,3,5-trichlorobenzene

: 6284-83-9
1,3,5-trichloro-2,4-dinitrobenzene

Conditions

Conditions	Yield
With nitric acid In sulfuric acid at 25 - 120℃; Product distribution;	98.5%
Stage #1: 1,3,5-trichlorobenzene With nitric acid at 40℃; for 0.25h; Stage #2: With sulfuric acid at 40 - 80℃; for 1.5h;	96%
With sulfuric acid; nitric acid	61%

: 108-70-3
1,3,5-trichlorobenzene

: 124-41-4
sodium methylate

: 33719-74-3
3,5-dichloroanisole

Conditions

Conditions	Yield
In dimethyl sulfoxide at 80 - 90℃; Concentration; Reagent/catalyst; Solvent; Temperature; Time;	98%
In N,N,N,N,N,N-hexamethylphosphoric triamide at 120℃; for 1h;	78%
In methanol; dimethyl sulfoxide at 50.1℃; Rate constant;
With methanol at 180℃;

: 108-70-3
1,3,5-trichlorobenzene

: 75-69-4
trichlorofluoromethane

: 567-59-9
1,3,5-trichloro-2-(trifluoromethyl)benzene

Conditions

Conditions	Yield
With aluminium trichloride Ambient temperature;	98%
With aluminium trichloride 1a) 4 h, r.t., 1b) 4 h, -10 deg C;	98%

: 108-70-3
1,3,5-trichlorobenzene

: 151721-79-8
1,3,5-trichloro-2,4,6-triiodo-benzene

Conditions

Conditions	Yield
With sulfuric acid; iodine; periodic acid at 20℃; Inert atmosphere;	98%
With sulfuric acid; iodine; periodic acid at 20℃;	98%
With sulfuric acid; periodic acid	96%

: 461-72-3
2,4-imidazolidinedione

: 108-70-3
1,3,5-trichlorobenzene

: 3,5-dichlorophenyl hydantoin

Conditions

Conditions	Yield
With triethylamine In toluene for 8h; Solvent; Time; Reflux;	96.5%

: 108-70-3
1,3,5-trichlorobenzene

: 33119-38-9
α-chlorobis(pentachlorophenyl)methane

: 105633-30-5
Bis-(2,4,6-trichlorophenyl)-methane

Conditions

Conditions	Yield
With aluminium trichloride at 85℃; for 2.5h;	96%

: 108-70-3
1,3,5-trichlorobenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 24473-00-5
2,4,6-trichlorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78℃; for 1.5h;	96%
Stage #1: 1,3,5-trichlorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;	95%
Stage #1: 1,3,5-trichlorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78℃; for 1.5h;	95%

: 108-70-3
1,3,5-trichlorobenzene

: 20607-43-6
sodium isopropanethiolate

: 74542-67-9
1,3,5-Trisbenzene

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 1h;	95%
In N,N-dimethyl acetamide at 100℃; for 24h;

: 108-70-3
1,3,5-trichlorobenzene

: 73183-34-3
bis(pinacol)diborane

: 365564-05-2
1,3,5-tris(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); lithium chloride In toluene at 100℃; for 15h;	95%

: 108-70-3
1,3,5-trichlorobenzene

: 86-74-8
9H-carbazole

: 148044-07-9
1,3,5-tris(9H-carbazol-9-yl)benzene

Conditions

Conditions	Yield
With di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 5℃; Buchwald-Hartwig Coupling; Inert atmosphere; Reflux;	94.6%
With di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 3h; Inert atmosphere;	67%

: 108-70-3
1,3,5-trichlorobenzene

: 5720-07-0
4-methoxyphenylboronic acid

: 7509-20-8
1,3,5-tris(4-methoxyphenyl)benzene

Conditions

Conditions	Yield
With potassium phosphate; palladium bis(dibenzylideneacetone)palladium(0); catacxium A In toluene at 110℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;	94%
With 1,3-bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine-2-oxide; potassium phosphate; chloro(1-naphthyl)bis(triphenylphosphine)nickel(II) In toluene at 110℃; for 18h; Suzuki Coupling; Schlenk technique; Inert atmosphere;	67%

: 108-70-3
1,3,5-trichlorobenzene

: 24473-00-5
2,4,6-trichlorobenzaldehyde

: Bis-<2,4,5-trichlor-phenyl>-methanol

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 2,4,6-trichlorobenzaldehyde In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;	94%
Stage #1: 1,3,5-trichlorobenzene With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 2,4,6-trichlorobenzaldehyde In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;	94%

: 108-70-3
1,3,5-trichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With ammonium sulfate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate; tert-butyl XPhos In 1,4-dioxane at 100℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere;	93%
With lithium amide; ammonia at -50℃;
With ammonia

: 108-70-3
1,3,5-trichlorobenzene

: 1639-09-4
heptanethiol

A: 10496-16-9
diheptyldisulfide

B: 1,3-Dichloro-5-heptylsulfanyl-benzene

Conditions

Conditions	Yield
With potassium hydroxide; (Tricyclohexyl-n-dodecyl)phosphonium bromide In toluene at 50℃; for 3h;	A n/a B 93%

...Expand

: 108-70-3
1,3,5-trichlorobenzene

: 17049-50-2
n-decyl magnesium bromide

: 87969-78-6
1,3,5-tridecylbenzene

Conditions

Conditions	Yield
1,2-bis(diphenylphosphino)ethane nickel(II) chloride In diethyl ether 1.) 18 h, 0 deg C to room temperature, 2.) 2 h, reflux;	93%

: 108-70-3
1,3,5-trichlorobenzene

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 1392512-49-0
C30H30

Conditions

Conditions	Yield
With Pd-PEPPSI-IPrAn; potassium tert-butylate In toluene at 80℃; for 24h; Suzuki coupling; Inert atmosphere;	93%

: 108-70-3
1,3,5-trichlorobenzene

: 22479-78-3
4-(4-nitrophenoxy)phenol

: 1,3,5-tris[4-(4-nitrophenoxy)phenoxy]benzene

Conditions

Conditions	Yield
Stage #1: 4-(4-nitrophenoxy)phenol With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere; Stage #2: 1,3,5-trichlorobenzene In N,N-dimethyl-formamide at 150℃; for 12h; Inert atmosphere;	92.8%

: 75-77-4
chloro-trimethyl-silane

: 108-70-3
1,3,5-trichlorobenzene

: 363598-46-3
(2,4,6-trichlorophenyl)trimethylsilane

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With sec.-butyllithium In tetrahydrofuran; cyclohexane at -100℃; for 2h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; cyclohexane	92%
Stage #1: 1,3,5-trichlorobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at -75℃;	72%

: 108-70-3
1,3,5-trichlorobenzene

: 67-66-3
chloroform

: 40860-87-5
α,α,α',α',α'',α'',2,4,6-nonachloromesitylene

Conditions

Conditions	Yield
With aluminum (III) chloride at 125℃; for 72h; Friedel Crafts alkylation; pressure tube;	91%
With aluminum (III) chloride at 125℃; for 72h; Autoclave;	73%
With aluminium trichloride at 100℃; for 18h;	64%
With aluminum (III) chloride for 67h; Friedel-Crafts Alkylation; Sealed tube; Heating;	32%
With aluminum (III) chloride at 125℃; for 72h;

: 108-70-3
1,3,5-trichlorobenzene

: 6324-50-1
1,3,5-trichloro-2-iodobenzene

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h; Stage #2: With iodine In tetrahydrofuran; hexane at -75℃;	91%

: 108-70-3
1,3,5-trichlorobenzene

: 4294-57-9
para-methylphenylmagnesium bromide

: 50446-43-0
1,3,5-tris(4-methyl-phenyl)-benzene

Conditions

Conditions	Yield
With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether at 20℃; for 2h;	91%
Stage #1: 1,3,5-trichlorobenzene; para-methylphenylmagnesium bromide; 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether for 2h; Stage #2: With methanol In diethyl ether Product distribution / selectivity;	91%

1,3,5-TRICHLOROBENZENE Chemical Properties

1,3,5-TRICHLOROBENZENE(108-70-3) is the chemical compound with the formula C₆H₃Cl₃.Its molar weight is 181.45g/mol.
1,3,5-TRICHLOROBENZENE(108-70-3) is also named SYM-TRICHLOROBENZENE;1,3,5-trichloro-benzen;ai3-22031;Benzene,1,3,5-trichloro-;I,3,5-TrichlorbenzolVW,16;s-Trichlorobenzene;trichloro-1,3,5benzene;1,3,5-TCB
Meiting Point: 63 ^oC
Boiling Point: 208 ^oC(lit.)
Flash Point: 260 ^oF
Storage temp.: 0-6^oC
Stability: Stable. Incompatible with acids, strong oxidizing agents.
Index of Refraction: 1.567
Molar Refractivity: 40.93 cm³
Molar Volume: 125.2 cm³
Surface Tension: 39.9 dyne/cm
Density: 1.448 g/cm³
Enthalpy of Vaporization: 42.93 kJ/mol
Vapour Pressure: 0.267 mmHg at 25^oC
The chemical structure of 1,3,5-TRICHLOROBENZENE(108-70-3) is

1,3,5-TRICHLOROBENZENE Uses

1,3,5-TRICHLOROBENZENE(108-70-3) is used as intermediate of medicine and pesticide.

1,3,5-TRICHLOROBENZENE Toxicity Data With Reference

1.	dlt-oin-oin-par 10 ppm	EVETBX Environmental Entomology. 2 (1973),1029.
2.	dlt-oin-oin-skn 10 ppm	EVETBX Environmental Entomology. 2 (1973),1029.
3.	mnt-mus-ipr 425 mg/kg/24H	MUTAEX Mutagenesis. 2 (1987),111.
4.	orl-rat LD50:800 mg/kg	48RKAL Industrial and Environmental Xenobiotics: Metabolism and Pharmacokinetics of Organic Chemicals and Metals, Proceedings of an International Conference, Prague ,Gut, I., et al.,Berlin, Fed. Rep, Ger..: Springer-Verlag,1981,389.
5.	orl-mus LD50:3350 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) UCRL-13701 .
6.	ipr-mus LD50:2260 mg/kg	MUTAEX Mutagenesis. 2 (1987),111.

1,3,5-TRICHLOROBENZENE Consensus Reports

Reported in EPA TSCA Inventory.

1,3,5-TRICHLOROBENZENE Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic vapors of Cl⁻.
Hazard Codes:

Xn,Xi
Risk Statements: 20/21/22-36/37/38-38-22-52/53
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
38: Irritating to the skin
22: Harmful if swallowed
52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 26-36-36/37-61
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
36/37: Wear suitable protective clothing and gloves
61: Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR: 3077
WGK Germany: 3
RTECS: DC2100100
Hazard Note: Harmful/Irritant
HazardClass: 9
PackingGroup: III
Hazardous Substances Data: 108-70-3(Hazardous Substances Data) .

1,3,5-TRICHLOROBENZENE Standards and Recommendations

DFG MAK: 5 ppm

1,3,5-TRICHLOROBENZENE Specification

(1)It must be separated from strong oxidants and keep in a well-ventilated room.
(2)When spilled,sweep it into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment.

Product Name

1,3,5-Trichlorobenzene

Synthetic route

1,3,5-TRICHLOROBENZENE Chemical Properties

1,3,5-TRICHLOROBENZENE Uses

1,3,5-TRICHLOROBENZENE Toxicity Data With Reference

1,3,5-TRICHLOROBENZENE Consensus Reports

1,3,5-TRICHLOROBENZENE Safety Profile

1,3,5-TRICHLOROBENZENE Standards and Recommendations

1,3,5-TRICHLOROBENZENE Specification

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