Product Name

  • Name

    1,3-Dichloro-4-fluorobenzene

  • EINECS 215-858-3
  • CAS No. 1435-48-9
  • Article Data16
  • CAS DataBase
  • Density 1.403 g/cm3
  • Solubility insoluble in water
  • Melting Point -23 °C
  • Formula C6H3Cl2F
  • Boiling Point 178.2 °C at 760 mmHg
  • Molecular Weight 164.994
  • Flash Point 36.7 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance Clear colourless to yellow liquid
  • Safety 36/37-61-16-36-26
  • Risk Codes 22-38-48/20/22-51/53-10-36/37/38
  • Molecular Structure Molecular Structure of 1435-48-9 (1,3-Dichloro-4-fluorobenzene)
  • Hazard Symbols HarmfulXn,IrritantXi,DangerousN
  • Synonyms 1-Fluoro-2,4-dichlorobenzene;2,4-Dichloro-1-fluorobenzene;2,4-Dichlorofluorobenzene;2,6-Dichloro-3-fluorophenyl;1,3-Dichloro-4-fluorobenzene;
  • PSA 0.00000
  • LogP 3.13250

Synthetic route

2,4-Dichloroaniline
554-00-7

2,4-Dichloroaniline

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Stage #1: 2,4-Dichloroaniline With hydrogenchloride; fluoroboric acid; sodium nitrite In water at 25℃; for 0.00555556h; Balz-Schiemann Reaction;
Stage #2: In 1,2-dichloro-benzene at 190℃; for 0.0166667h; Balz-Schiemann Reaction;		93%
Stage #1: 2,4-Dichloroaniline With sodium tetrafluoroborate; sodium nitrite acidic conditions;
Stage #2: at 150 - 170℃; Schieman reaction; Further stages.;
1,2,4-Trichlorobenzene
120-82-1

1,2,4-Trichlorobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With potassium fluoride; 5,11,17,23,29,35-hexakis(tert-butyl)-37,38,39,40,41-hexakis(hydroxy)calix[6]arene In sulfolane at 185℃; for 5h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;92%
3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With chlorine at 170 - 180℃; for 8h; Temperature;91.7%
Multi-step reaction with 2 steps
1: titanium (III)-chloride; water
2: aqueous HCl / Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl
View Scheme
2,4-dichloroaniline hydrochloride
29084-76-2

2,4-dichloroaniline hydrochloride

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Stage #1: 2,4-dichloroaniline hydrochloride With hydrogenchloride at -5℃;
Stage #2: With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 0.0833333h;		50.1%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With hydrogenchloride Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl;
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With chlorine at 200℃;
2,3-dichlorofluorobenzene
36556-50-0

2,3-dichlorofluorobenzene

A

3,4-dichlorofluorobenzene
1435-49-0

3,4-dichlorofluorobenzene

B

3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

C

1,4-dichloro-2-fluorobenzene
348-59-4

1,4-dichloro-2-fluorobenzene

D

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
In acetonitrile for 10h; Product distribution; Irradiation;A 5 % Chromat.
B 5 % Chromat.
C 13 % Chromat.
D 1 % Chromat.
...Expand
2,4-dichlorophenylboronic acid
68716-47-2

2,4-dichlorophenylboronic acid

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With cesium fluoroxysulphate In methanol at -10℃; for 24h;28 % Spectr.
(N-B)-Perhydro-2-(2,4-dichlorophenyl)-6-methyl-1,3-dioxa-6-aza-2-boracine

(N-B)-Perhydro-2-(2,4-dichlorophenyl)-6-methyl-1,3-dioxa-6-aza-2-boracine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With meta-dinitrobenzene; cesium fluoroxysulphate In acetonitrile Ambient temperature;40 % Spectr.
fluorobenzene
462-06-6

fluorobenzene

iron-powder

iron-powder

A

3,4-dichlorofluorobenzene
1435-49-0

3,4-dichlorofluorobenzene

B

1-Chloro-4-fluorobenzene
352-33-0

1-Chloro-4-fluorobenzene

C

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Einleiten von 2 Mol Chlor;
...Expand
2.4-dichloro-benzodiazonium-(1)-tetrafluoroborate

2.4-dichloro-benzodiazonium-(1)-tetrafluoroborate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Thermolysis;
4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron-powder / Einleiten von Chlor
2: titanium (III)-chloride; water
3: aqueous HCl / Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl
View Scheme
1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C
2.1: potassium fluoride / 3 h / 140 - 150 °C
2.2: 7 h / 165 - 170 °C
3.1: chlorine / 8 h / 170 - 180 °C
View Scheme
3,4-dichloronitrobenzene
99-54-7

3,4-dichloronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium fluoride / 3 h / 140 - 150 °C
1.2: 7 h / 165 - 170 °C
2.1: chlorine / 8 h / 170 - 180 °C
View Scheme
C13H4Cl4F2O

C13H4Cl4F2O

A

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

B

C7H2Cl2FO2(1-)*Na(1+)

C7H2Cl2FO2(1-)*Na(1+)

Conditions
ConditionsYield
Stage #1: C13H4Cl4F2O With sodium hydroxide at 90 - 100℃; for 1h;
Stage #2: In 1,4-dioxane at 110 - 150℃; for 3h;
C13H4Cl4F2O

C13H4Cl4F2O

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With sodium hydroxide at 140 - 150℃; Temperature;
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluoronitrobenzene
2105-59-1

2,4-dichloro-5-fluoronitrobenzene

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 50℃; for 2h; Temperature;99.3%
With sulfuric acid; nitric acid at 50 - 60℃; for 3h;98%
With sulfuric acid; potassium nitrate at 0 - 20℃; for 12h;97%
With sulfuric acid; nitric acid
With sulfuric acid; sulfur trioxide; nitric acid
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,6-dichloro-3-fluorobenzenethiol

2,6-dichloro-3-fluorobenzenethiol

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1.5h; Inert atmosphere;
Stage #2: With sulfur In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;		99%
carbon dioxide
124-38-9

carbon dioxide

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

Conditions
ConditionsYield
With Cationic resin catalyst In tetrachloromethane at 40 - 60℃; under 15001.5 Torr; for 5h; Pressure; Temperature; Reagent/catalyst;98.8%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

Conditions
ConditionsYield
With aluminum (III) chloride at 40℃; for 4h; Temperature;95.2%
With phosphotungstic acid supported on magnetic ZrO2 for 0.5h; Autoclave; Reflux;94%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(3,5-dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(3,5-dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 6h; Inert atmosphere;94%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 18h; Inert atmosphere;
With (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;
methanol
67-56-1

methanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1,3-dichloro-4-methoxybenzene
553-82-2

1,3-dichloro-4-methoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Reagent/catalyst; Solvent; Irradiation;94%
4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
320366-66-3

4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide Reflux;91%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

acetyl chloride
75-36-5

acetyl chloride

2,4-dichloro-5-fluoroacetophenone
704-10-9

2,4-dichloro-5-fluoroacetophenone

Conditions
ConditionsYield
With aluminum (III) chloride at 110℃; Reagent/catalyst; Temperature;89.3%
With aluminum (III) chloride Friedel Crafts acylation;52%
With aluminum (III) chloride at 30 - 120℃; Product distribution / selectivity;
aluminum (III) chloride
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

isopropyl alcohol
67-63-0

isopropyl alcohol

2,4-dichloro-1-isopropoxybenzene
6851-40-7

2,4-dichloro-1-isopropoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;89%
ethanol
64-17-5

ethanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-ethoxybenzene
5392-86-9

2,4-dichloro-1-ethoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;87%
Cyclopropylmethanol
2516-33-8

Cyclopropylmethanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-(cyclopropylmethoxy)benzene

2,4-dichloro-1-(cyclopropylmethoxy)benzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;87%
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

5’-chloro-2’-fluoro-[1,1’-biphenyl]-2-carbonitrile

5’-chloro-2’-fluoro-[1,1’-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;86%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

Conditions
ConditionsYield
Stage #1: tetrachloromethane; 1,3-dichloro-4-fluorobenzene for 0.5h; Autoclave; Reflux;
Stage #2: With water at 20 - 40℃; for 1h; Reagent/catalyst;		86%
Methyl formate
107-31-3

Methyl formate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,6-dichloro-3-fluorobenzaldehyde

2,6-dichloro-3-fluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran at 10 - 15℃; for 16h; Inert atmosphere;		85.49%
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78 - -70℃; for 2h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran; hexanes at -78℃; Inert atmosphere;
Stage #3: With water; ammonium chloride In tetrahydrofuran; hexanes at 20℃; Inert atmosphere;
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water
3,5-dimethoxyphenol
500-99-2

3,5-dimethoxyphenol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-(3,5-dimethoxyphenoxy)benzene
1379803-44-7

2,4-dichloro-1-(3,5-dimethoxyphenoxy)benzene

Conditions
ConditionsYield
Stage #1: 3,5-dimethoxyphenol With caesium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Inert atmosphere;
Stage #2: 1,3-dichloro-4-fluorobenzene In 1-methyl-pyrrolidin-2-one at 120℃; for 2h; Inert atmosphere;		84%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

A

trimethylsilyl fluoride
420-56-4

trimethylsilyl fluoride

B

1-(2,4-dichlorophenyl)-1H-imidazole
190199-40-7

1-(2,4-dichlorophenyl)-1H-imidazole

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 20h; Inert atmosphere;A n/a
B 80%
...Expand
ethyl acetohydroximate
10576-12-2

ethyl acetohydroximate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

N-(2,4-Dichloro-phenoxy)-acetimidic acid ethyl ester

N-(2,4-Dichloro-phenoxy)-acetimidic acid ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide 1.) r.t., 30 min, 2.) 80 deg C, 1.5 h;77.8%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

B

dichloro-bis(2,4-dichloro-5-fluorophenyl)methane

dichloro-bis(2,4-dichloro-5-fluorophenyl)methane

Conditions
ConditionsYield
at 40℃; for 2h; Temperature;A 76.6%
B 22.6%
With iron(III) chloride at 70℃; for 2h;A 75.1%
B 20.3%
With aluminum (III) chloride at 40℃; for 8h;A 3.2 g
B 13.5 g
With aluminum (III) chloride at 40℃; for 8h;
...Expand
oxirane
75-21-8

oxirane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2-(2,6-dichloro-3-fluorophenyl)ethanol

2-(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: oxirane In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;		75%
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h;
Stage #2: oxirane In tetrahydrofuran at -78℃; for 2h;		75%
3-bromoquinoline
5332-24-1

3-bromoquinoline

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

3-(3,5-dichloro-2-fluorophenyl)quinoline

3-(3,5-dichloro-2-fluorophenyl)quinoline

B

C15H8Cl2FN

C15H8Cl2FN

C

C15H8Cl2FN

C15H8Cl2FN

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A 72%
B n/a
C n/a
...Expand
(R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol
865864-47-7

(R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

(R)-benzyl-[4-tert-butoxy-3-(2,4-dichloro-phenoxy)-butyl]-methyl amine
865865-21-0

(R)-benzyl-[4-tert-butoxy-3-(2,4-dichloro-phenoxy)-butyl]-methyl amine

Conditions
ConditionsYield
Stage #1: (R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol With sodium hydride In dimethyl sulfoxide for 0.5h;
Stage #2: 1,3-dichloro-4-fluorobenzene In dimethyl sulfoxide		71%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

1-(2,4-dichlorophenyl)-1H-imidazole
190199-40-7

1-(2,4-dichlorophenyl)-1H-imidazole

Conditions
ConditionsYield
With copper(l) iodide In methanol; N,N-dimethyl-formamide at 100℃; Inert atmosphere;70%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluoro-benzoic acid
86522-89-6

2,4-dichloro-5-fluoro-benzoic acid

Conditions
ConditionsYield
66%
Multi-step reaction with 3 steps
1: 2 h / 40 °C
2: iron(III) chloride; water / 90 °C
3: potassium perchlorate / N,N-dimethyl-formamide / Reflux
View Scheme
4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

C13H6Cl2FN

C13H6Cl2FN

B

C13H6Cl2FN

C13H6Cl2FN

C

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbonitrile

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbonitrile

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A n/a
B n/a
C 66%
...Expand
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

A

C13H7Cl2FO

C13H7Cl2FO

B

C13H7Cl2FO

C13H7Cl2FO

C

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbaldehyde

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbaldehyde

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A n/a
B n/a
C 66%
...Expand
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

cyclohexanol
108-93-0

cyclohexanol

2,4-dichloro-1-(cyclohexyloxy)benzene

2,4-dichloro-1-(cyclohexyloxy)benzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;64%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

C6H2Cl3FO2S

C6H2Cl3FO2S

Conditions
ConditionsYield
With chlorosulfonic acid at 100℃; for 12h;63%

1,3-Dichloro-4-fluorobenzene Specification

The 1,3-Dichloro-4-fluorobenzene, with the CAS registry number 1435-48-9, is also known as 1,3-Dichloro-4-fluorobenzene. It belongs to the product categories of Aromatic Hydrocarbons (substituted) & Derivatives; Fluorobenzene; Chlorine Compounds; Fluorine Compounds; Aryl; C6; Halogenated Hydrocarbons. Its EINECS number is 406-160-1. This chemical's molecular formula is C6H3Cl2F and formula weight is 164.99. What's more, its IUPAC name is 2,4-dichloro-1-fluorobenzene. It is a Clear colourless to yellow liquid.

Physical properties of 1,3-Dichloro-4-fluorobenzene are:
(1)ACD/LogP:  3.643; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  3.64; (4)ACD/LogD (pH 7.4):  3.64; (5)ACD/BCF (pH 5.5):  345.61; (6)ACD/BCF (pH 7.4):  345.61; (7)ACD/KOC (pH 5.5):  2284.13; (8)ACD/KOC (pH 7.4):  2284.13; (9)#H bond acceptors:  0; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  0; (12)Index of Refraction:  1.525; (13)Molar Refractivity:  36.037 cm3; (14)Molar Volume:  117.545 cm3; (15)Surface Tension:  35.1139984130859 dyne/cm; (16)Density:  1.404 g/cm3; (17)Flash Point:  36.667 °C; (18)Enthalpy of Vaporization:  39.746 kJ/mol; (19)Boiling Point:  178.176 °C at 760 mmHg; (20)Vapour Pressure:  1.35300004482269 mmHg at 25°C.

Uses of 1,3-Dichloro-4-fluorobenzene:
it can be used to produce N-(2,4-dichloro-phenoxy)-acetimidic acid ethyl ester at the temperature of 80°C. It will need reagent t-BuOK and solvent dimethylformamide with the reaction time of 1.5 hours. The yield is about 77.8%.

Safety information of 1,3-Dichloro-4-fluorobenzene:
When you are using this chemical, please be cautious about it as the following:It is harmful if swallowed. It can cause danger of serious damage to health by prolonged exposure through inhalation and if swallowed. It is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. It is flammable and is irritating to eyes, respiratory system and skin. When using it, you must wear suitable protective clothing and gloves. It should be avoided release to the environment refering to special instructions/safety data sheet. You need keep it away from sources of ignition - No smoking. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)F
(2)InChI: InChI=1S/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H
(3)InChIKey: BDJZCCWUSOZUQG-UHFFFAOYSA-N

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