1,3-Diiodopropane supplier

Name
1,3-Diiodopropane
EINECS 210-993-4
CAS No. 627-31-6
Article Data29
CAS DataBase
Density 2.557 g/cm³
Solubility Insoluble in water.
Melting Point -20°C
Formula C₃H₆I₂
Boiling Point 227.8 °C at 760 mmHg
Molecular Weight 295.89
Flash Point 109.9 °C
Transport Information
Appearance light brown-yellow liquid, darkening with exposure to light
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3-Diiodopropane;NSC 35647;Trimethylene diiodide;a,w-Diiodopropane;
PSA 0.00000
LogP 2.24650

Synthetic route

: 109-64-8
1,3-dibromo-propane

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With sodium iodide In acetone at 50℃;	99%
With potassium iodide In acetone for 72h; Reflux; Inert atmosphere;	63%
With ethanol; potassium iodide

: 134879-53-1
1,3-propanediylbis{triphenylplumbane}

A: 591-50-4
iodobenzene

B: 627-31-6
1,3-Diiodopropane

C: lead(II) iodide

Conditions

Conditions	Yield
With I2 In chloroform-d1 (N2), stirred, treated with 6 equiv I2 at 25°C; filtered; NMR, IR, mass. spectra;	A 87% B 72% C 90%

...Expand

: 504-63-2
trimethyleneglycol

A: 627-31-6
1,3-Diiodopropane

B: 627-32-7
1-iodopropan-3-ol

C: C6H13I2O3P

Conditions

Conditions	Yield
With diphosphorous tetraiodide In carbon disulfide for 4h; Ambient temperature;	A 15% B 68% C 2%

...Expand

: 53310-50-2
3-chloropropyl thiocyanate

A: 627-31-6
1,3-Diiodopropane

B: 7314-74-1
1,3-bis(thiocyanato)propane

C: 1453200-86-6
3-iodopropyl thiocyanate

Conditions

Conditions	Yield
With sodium iodide In acetone for 24h; Finkelstein Reaction; Reflux;	A n/a B n/a C 24%

...Expand

: 75-11-6
diiodomethane

: 74-85-1
ethene

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With water; dibenzoyl peroxide at 95℃; under 312591 - 330978 Torr;

: bis-(3-iodo-propyl)-sulfide

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
at 25℃; beim Aufbewehren;

: 67761-04-0
1,5-bis(p-toluenesulphonyl)-1,5-diazacyclooctane

: 67-64-1
acetone

: 74-88-4
methyl iodide

A: 627-31-6
1,3-Diiodopropane

B: 75-58-1
tertamethylammonium iodide

Conditions

Conditions	Yield
at 160℃;

...Expand

: 142-28-9
1,3-Dichloropropane

A: 6940-76-7
1-iodo-3-chloro-propane

B: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With acetone; sodium iodide

: 142-28-9
1,3-Dichloropropane

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With acetone; sodium iodide

: 57-55-6
propylene glycol

: 74-88-4
methyl iodide

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With triphenyl phosphite

: 504-63-2
trimethyleneglycol

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With hydrogen iodide
With hydrogen iodide at 100℃;
With phosphorous triiodide
With N,N'-dicyclohexyl-N-methylcarbodiimidium iodide In tetrahydrofuran
(i) P2I4, CS2, (ii) K2CO3; Multistep reaction;

: 110-94-1
1,5-pentanedioic acid

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With lead(IV) acetate; iodine In tetrachloromethane Irradiation;

: 5469-66-9
propane-1,3-diol ditosylate

: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
With sodium iodide In acetone Heating;

: 7553-56-2
iodine

: 75-19-4
cyclopropane

A: 187737-37-7
propene

B: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
at 250℃;

...Expand

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 109-64-8
1,3-dibromo-propane

sodium iodide: sodium iodide

A: 187737-37-7
propene

B: 627-31-6
1,3-Diiodopropane

Conditions

Conditions	Yield
at 170℃;

...Expand

: 10215-33-5
3-butoxypropanol

: 10034-85-2
hydrogen iodide

A: 542-69-8
1-iodo-butane

B: 627-31-6
1,3-Diiodopropane

...Expand

: 627-31-6
1,3-Diiodopropane

: 31255-13-7
7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane

: 97421-90-4
C17H36N2O4(2+)*2I(1-)

Conditions

Conditions	Yield
In acetone at 25℃; under 10000 Torr; for 20h;	100%

: 1632-83-3
1-Methylbenzimidazole

: 627-31-6
1,3-Diiodopropane

: 3,3’-(propane-1,3-diyl)bis(1-methyl-1H-benzo[d]imidazol-3-ium) iodide

Conditions

Conditions	Yield
In acetonitrile for 48h; Inert atmosphere; Reflux;	100%
In acetonitrile for 72h; Heating;	95%
In acetonitrile for 48h; Reflux;	85%
In acetonitrile at 90℃; for 72h;	85%

: 627-31-6
1,3-Diiodopropane

: 605-45-8
diisopropyl phthalate

: 881839-06-1
diisopropyl cis-2,3-dihydro-1H-indene-3a,7a-dicarboxylate

Conditions

Conditions	Yield
Stage #1: diisopropyl phthalate With (trimethylstannyl)lithium In tetrahydrofuran; diethyl ether at -78℃; for 1h; Stage #2: 1,3-Diiodopropane In tetrahydrofuran; diethyl ether at -78℃; for 1h;	99%

: 627-31-6
1,3-Diiodopropane

: 2459-10-1
benzene-1,2,4-tricarboxylic acid trimethyl ester

: trimethyl 2,3,3a,7a-tetrahydro-1H-indene-3a,5,7a-tricarboxylate

Conditions

Conditions	Yield
Stage #1: benzene-1,2,4-tricarboxylic acid trimethyl ester With (trimethylstannyl)lithium In tetrahydrofuran; diethyl ether at -78℃; for 1h; Stage #2: 1,3-Diiodopropane In tetrahydrofuran; diethyl ether at -78 - 20℃; for 3h;	99%

: 1122-58-3
dmap

: 627-31-6
1,3-Diiodopropane

: 1,3-bis(N',N'-dimethyl-4-aminopyridinium)propane diiodide

Conditions

Conditions	Yield
In acetonitrile Inert atmosphere; Reflux;	98%
In acetonitrile Inert atmosphere; Reflux;	90.6%
In acetonitrile Inert atmosphere; Reflux;	89%
In acetonitrile Inert atmosphere; Reflux;	77%
In acetonitrile at 85℃;

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 627-31-6
1,3-Diiodopropane

: 141438-05-3
1,1'-(1,3-propanediyl)bis<4-aza-1-azoniabicyclo<2.2.2>octane> diiodide

Conditions

Conditions	Yield
In acetone at 20℃; for 14h;	97%

: 30837-62-8
1H-perimidine-2(3H)-thione

: 627-31-6
1,3-Diiodopropane

: 72391-43-6
10,11-dihydro-(9H)-1,3-thiazino<3,2-a>perimidine

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetonitrile for 0.333333h; Heating;	97%

: 627-31-6
1,3-Diiodopropane

: 177659-02-8
4,5-bis(2'-cyanoethylthio)-4,5-dimethyl-tetrathiafulvalene

: 327624-01-1
1,3-bis[3(2-cyanoethylthio)-6,7-bis(methyl)tetrathiafulvalen-2-ylthio]propane

Conditions

Conditions	Yield
Stage #1: 4,5-bis(2'-cyanoethylthio)-4,5-dimethyl-tetrathiafulvalene With cesium hydroxide In methanol; N,N-dimethyl-formamide for 0.25h; Stage #2: 1,3-Diiodopropane In methanol; N,N-dimethyl-formamide for 2h; Further stages.;	97%

: 627-31-6
1,3-Diiodopropane

: 16596-01-3
N,N'-bis(2-methylphenyl)formamidine

: 1,3-bis(2-methylphenyl)-3,4,5,6-tetrahydro-pyrimidin-1-ium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: 1,3-Diiodopropane; N,N'-bis(2-methylphenyl)formamidine With potassium carbonate In acetonitrile Reflux; Inert atmosphere; Stage #2: With sodium tetrafluoroborate In water; acetonitrile at 20℃; for 0.166667h;	97%

: 627-31-6
1,3-Diiodopropane

: 112-75-4
N,N-dimethyl-n-tetradecylamine

: N,N-dimethyl(3-iodopropyl)tetradecyl ammonium iodide

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In ethanol for 8h; Reflux;	96.5%

: 627-31-6
1,3-Diiodopropane

: 327624-11-3
2,3-bis(2-cyanoethylseleno)-6,7-ethylenediselenotetrathiafulvalene

: 327624-03-3
1,3-bis[3(2-cyanoethylseleno)-6,7-ethylenediselenotetrathiafulvalen-2-ylseleno]propane

Conditions

Conditions	Yield
Stage #1: 2,3-bis(2-cyanoethylseleno)-6,7-ethylenediselenotetrathiafulvalene With cesium hydroxide In methanol; N,N-dimethyl-formamide for 0.25h; Stage #2: 1,3-Diiodopropane In methanol; N,N-dimethyl-formamide for 2h; Further stages.;	96%

: 627-31-6
1,3-Diiodopropane

: 70851-51-3
1-[3-(trimethoxysilyl)propyl]imidazole

: 1,1'-di(3-propyltrimethoxysilane)-3,3'-propylenediimidazolium diiodide

Conditions

Conditions	Yield
at 110℃; for 17h;	96%

: 627-31-6
1,3-Diiodopropane

: 28890-73-5
Pyridine-2,5-dicarboxylic acid diisopropyl ester

: 320340-01-0
(RS)-2,3-dihydroindolizine-6,8a(1H)-dicarboxylic acid diisopropyl ester

Conditions

Conditions	Yield
Stage #1: Pyridine-2,5-dicarboxylic acid diisopropyl ester With (trimethylstannyl)lithium In tetrahydrofuran; diethyl ether at -78℃; for 1h; Stage #2: 1,3-Diiodopropane In tetrahydrofuran; diethyl ether at -78 - 20℃; for 16h;	96%

: 627-31-6
1,3-Diiodopropane

: C11H12ClNO2

: 6-(4-chloroanilino)-5-propionyl-3,4-dihydropyran

Conditions

Conditions	Yield
With ammonium acetate; tetrabutyl-ammonium chloride; potassium carbonate In water at 20℃; for 10h;	96%

: 112-18-5
N,N-dimethylaminododecane

: 627-31-6
1,3-Diiodopropane

: N,N-dimethyl(3-iodopropyl)dodecyl ammonium iodide

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In ethanol for 8h; Reflux;	96%

: 627-31-6
1,3-Diiodopropane

: tert-butyl 2-((ethylthio)carbonyl)hydrazine-1-carboxylate

: tert-butyl 2-((ethylthio)carbonyl)pyrazolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tert-butyl 2-((ethylthio)carbonyl)hydrazine-1-carboxylate With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: 1,3-Diiodopropane In tetrahydrofuran at 0℃; for 1h; Reagent/catalyst; Solvent;	96%

: 627-31-6
1,3-Diiodopropane

: 46224-49-1
(pyridin-1-iumyl)[(pyridin-2-yl)aminide]

: 1-[3-iodopropyl(pyridin-2-yl)amino]pyridinium iodide

Conditions

Conditions	Yield
In acetone at 20℃;	95%

: 627-31-6
1,3-Diiodopropane

: 158871-27-3
4,5-bis(cyanoethylthio)-1,3-dithiole-2-[(4,5-ethylenedithio)-1,3-dithiole-2-ylidene]

: 327624-00-0
1,3-bis[3(2-cyanoethylthio)-6,7-ethylenedithiotetrathiafulvalen-2-ylthio]propane

Conditions

Conditions	Yield
Stage #1: 4,5-bis(cyanoethylthio)-1,3-dithiole-2-[(4,5-ethylenedithio)-1,3-dithiole-2-ylidene] With cesium hydroxide In methanol; N,N-dimethyl-formamide for 0.25h; Stage #2: 1,3-Diiodopropane In methanol; N,N-dimethyl-formamide for 2h; Further stages.;	95%

: (hydridotris-(3,5-dimethylpyrazoyl)borate)(CO)(I)W(HCCCH3)

: 627-31-6
1,3-Diiodopropane

: (hydridotris-(3,5-dimethylpyrazoyl)borate)(CO)(I)W(H3CCC(CH2)3I)

Conditions

Conditions	Yield
With BuLi In tetrahydrofuran N2-atmosphere; stirring (room temp., 1 h); evapn., chromy. (alumina, hexane / CH2Cl2), crystn. (CH2Cl2 / pentane); elem. anal.;	95%

: 288-47-1
1,3-thiazole

: 627-31-6
1,3-Diiodopropane

: 3-(3-iodopropyl)thiazol-3-ium

Conditions

Conditions	Yield
In acetonitrile for 5h; Reflux;	95%

: 120-75-2
2-Methylbenzothiazole

: 627-31-6
1,3-Diiodopropane

: 3-(3-iodopropyl)-2-methylbenzo[d]thiazol-3-ium iodide

Conditions

Conditions	Yield
In toluene for 24h; Reflux;	94.24%
In acetonitrile for 24h; Inert atmosphere; Reflux;	75%

: 627-31-6
1,3-Diiodopropane

: 879283-39-3, 879283-40-6, 215809-07-7
3-(2-aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione

: 2,2'-(propane-1,3-diyldi(sulfanediyl))bis[3-(2-aminophenyl)-4-methyl-1,3-thiazol-3-ium] diiodide

Conditions

Conditions	Yield
In chloroform for 24h; Reflux;	94%

: 627-31-6
1,3-Diiodopropane

: 77116-69-9
4-(Triphenylphosphoranylidenamino)pyridin

: 1,3-bis(4,4’-triphenyliminophosphoranopyridinium)propane diiodide

Conditions

Conditions	Yield
In acetonitrile at 85℃; for 18h;	94%

: 52394-35-1
(dimethylamino(methyl))carbene(pentacarbonyl)tungsten(0)

: 627-31-6
1,3-Diiodopropane

: W(CO)5(C(N(CH3)2(CH2)4I))

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane (Ar or N2); W-compound in THF treated with n-BuLi in hexane at -78°C, stirred (-78°C, 30 min), treated with 1,3-diiodopropane, stirred (6 h), warmed to 25°C; solvent removed (vac.), flash chromy. (silica gel, 20% CH2Cl2/80% hexane), yellow fractions are collected, solvent removed under vac.; elem. anal.;	93%

: 627-31-6
1,3-Diiodopropane

: 108-59-8
malonic acid dimethyl ester

: 82031-49-0
dimethyl 2,6-bis(methoxycarbonyl)heptandioate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 28h;	93%

: 627-31-6
1,3-Diiodopropane

: 124177-35-1
Potassium; 2,2,5,5-tetrakis-trifluoromethyl-2,5-dihydro-thiazole-4-thiolate

: 124177-39-5
4,4'-<1,3-Propandiylbis(thio)bis<2,5-dihydro-2,2,5,5-tetrakis(trifluormethyl)thiazol>>

Conditions

Conditions	Yield
In acetonitrile for 2h; Heating;	92%

: 627-31-6
1,3-Diiodopropane

: 67705-41-3
1,5,9-triazatricyclo[7.3.1.05,13 ]tridecane

: C23H44N6(2+)*2I(1-)

Conditions

Conditions	Yield
	92%

: 627-31-6
1,3-Diiodopropane

: 22348-31-8, 119237-64-8
(S)-2-(diphenylmethyl)pyrrolidine

: N,N'-1,3-propane-bis((2S)-2-(diphenylmethyl)pyrrolidine)

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 8h; Heating;	92%

: 627-31-6
1,3-Diiodopropane

: 207855-09-2
N-(1,3-dimethylimidazolidin-2-ylidene)pyridin-4-amine

: 1,3-bis[4-(1,3-dimethylimidazolidin-2-ylidene)aminopyridinium]propane diiodide

Conditions

Conditions	Yield
In acetonitrile Inert atmosphere; Reflux;	92%

1,3-Diiodopropane Chemical Properties

IUPAC Name: 1,3-Diiodopropane
The MF of 1,3-Diiodopropane (627-31-6) is C₃H₆I₂.

The MW of 1,3-Diiodopropane (627-31-6) is 295.89.
Synonyms of 1,3-Diiodopropane (627-31-6): Propane, 1,3-diiodo- ; TL8004252 ; Trimethylene diiodide
Form: light brown-yellow liquid, darkening with exposure to light
Stability: Stable, but light sensitive - store in the dark. Incompatible with strong bases, strong oxidizing agents.
Product Categories: Iodine Compounds
Index of Refraction: 1.643
EINECS: 210-993-4
Density: 2.557 g/ml
Flash Point: 109.9 °C
Boiling Point: 227.8 °C
Melting Point: -20 °C
Sensitive: Light Sensitive
BRN: 1731117

1,3-Diiodopropane Uses

1,3-Diiodopropane (627-31-6) is reagents for organic synthesis.

1,3-Diiodopropane Toxicity Data With Reference

mmo-sat 10 µmol/plate

MUREAV Mutation Research. 141 (1984),11.

1,3-Diiodopropane Consensus Reports

Reported in EPA TSCA Inventory.

1,3-Diiodopropane Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of I⁻.
Safety information of 1,3-Diiodopropane (627-31-6):
Hazard Codes Xi,C
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
RIDADR 2810
WGK Germany 3
RTECS TY1080000
F 8
Hazard Note Irritant
HazardClass 6.1(b)
PackingGroup III
HS Code 29033080

Product Name

1,3-Diiodopropane

Synthetic route

1,3-Diiodopropane Chemical Properties

1,3-Diiodopropane Uses

1,3-Diiodopropane Toxicity Data With Reference

1,3-Diiodopropane Consensus Reports

1,3-Diiodopropane Safety Profile

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