Product Name

  • Name

    1,3-Diphenylguanidine

  • EINECS 203-002-1
  • CAS No. 102-06-7
  • Article Data54
  • CAS DataBase
  • Density 1.1 g/cm3
  • Solubility slightly soluble in water
  • Melting Point 146-148 °C(lit.)
  • Formula C13H13N3
  • Boiling Point 338.5 °C at 760 mmHg
  • Molecular Weight 211.266
  • Flash Point 158.5 °C
  • Transport Information UN 3077 9/PG 3
  • Appearance White to cream-colored chalky powder
  • Safety 26-36/37/39-61
  • Risk Codes 22-36/37/38-51/53-62
  • Molecular Structure Molecular Structure of 102-06-7 (1,3-Diphenylguanidine)
  • Hazard Symbols HarmfulXn,DangerousN
  • Synonyms N,N Diphenyl guanidine;Chemicals & Rubber Accelerator DPG;Chemicals & Rubber Accelerator DPG (Dephenyl Guanidine);Accelerator DPG(D);Vulkacit D;N,N-Diphenylguanidine;Rhenogran DPG 80P;Perkacit DP;Chlorostain BR;Sanceler D;s-Diphenylguanidine;Melaniline;(amino-anilino-methylidene)-phenyl-azanium;1,2-diphenylguanidine;Accelerator D;Diphenylguanidine;Vulkazit;Guanidine, 1, 3-diphenyl-;Rubber Accelerator DPG (D);N-Oxydiethylene-2-Benzothiazole Sulfenamide (NOBS);Accelerator DPG (D);Accelerator DPG;Diphenyl guanidine;Accelerator D;Diphenyl guanidine;Rubber accelerator DPG;N,N′-diphenylguanidine;
  • PSA 47.91000
  • LogP 3.39110

Synthetic route

N,N-diphenylthiourea
102-08-9

N,N-diphenylthiourea

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With ammonium hydroxide; oxygen; copper diacetate In ethyl acetate; acetone at 60℃; under 1875.19 Torr; for 0.05h; Reagent/catalyst; Temperature; Pressure; Solvent;96.1%
With ammonia; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; acetonitrile at 20℃;90%
With lead; potassium hydroxide; ammonia; water dann mit verd.Salzsaeure;
iodobenzene
591-50-4

iodobenzene

guanidine nitrate
506-93-4

guanidine nitrate

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; sarcosine In acetonitrile at 70℃; for 8h; Ullmann reaction; Inert atmosphere;90%
With potassium phosphate; copper(l) iodide; N,N-diethylsalicylamide In acetonitrile at 80℃; Inert atmosphere;83%
bromobenzene
108-86-1

bromobenzene

guanidine nitrate
506-93-4

guanidine nitrate

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; sarcosine In acetonitrile at 90 - 100℃; for 20h; Ullmann reaction; Inert atmosphere;81%
(1,3-diphenyltetrazolium-5-yl)anilide

(1,3-diphenyltetrazolium-5-yl)anilide

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With acetic acid; zinc In dichloromethane at 20℃; Reduction; ultrasonication;78%
iodobenzene
591-50-4

iodobenzene

1-(4-methoxybenzyl)guanidine hemisulfate

1-(4-methoxybenzyl)guanidine hemisulfate

A

diphenylguanidine
102-06-7

diphenylguanidine

B

1-(4-methoxybenzyl)-3-phenylguanidine
1241493-92-4

1-(4-methoxybenzyl)-3-phenylguanidine

Conditions
ConditionsYield
With potassium phosphate; copper(I) thiophene-2-carboxylate; D-Prolin In acetonitrile at 100℃; for 3h; Modified Ullmann reaction; Inert atmosphere;A 15%
B 71%
aniline
62-53-3

aniline

tetrabutylammonium thiocyanate
3674-54-2

tetrabutylammonium thiocyanate

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
Multistep reaction;47%
aniline
62-53-3

aniline

N-phenyl-imidazole-1-carboxamidine
123564-74-9

N-phenyl-imidazole-1-carboxamidine

A

diphenylguanidine
102-06-7

diphenylguanidine

B

triphenyl melamine
1973-05-3

triphenyl melamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 90℃; for 12h;A 15%
B n/a
N-(N,N'-diphenylguanyl)-benzamidine
20028-19-7

N-(N,N'-diphenylguanyl)-benzamidine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With potassium carbonate
N-benzoyl-N',N''-diphenyl-guanidine
5067-80-1

N-benzoyl-N',N''-diphenyl-guanidine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With potassium hydroxide
bromocyane
506-68-3

bromocyane

aniline
62-53-3

aniline

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With water at 80 - 85℃;
Ethyl isothiocyanate
542-85-8

Ethyl isothiocyanate

aniline
62-53-3

aniline

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With mercury dichloride at 120℃;
S-(2-acetoxy-ethyl)-N-phenyl-isothiourea

S-(2-acetoxy-ethyl)-N-phenyl-isothiourea

aniline
62-53-3

aniline

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
at 150℃;
N-phenyl-guanidine hydrochloride
6522-91-4

N-phenyl-guanidine hydrochloride

aniline
62-53-3

aniline

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
at 150℃;
mercury fulminate
92114-96-0

mercury fulminate

aniline
62-53-3

aniline

A

diphenylguanidine
102-06-7

diphenylguanidine

B

phenyl carbamate
64-10-8

phenyl carbamate

Conditions
ConditionsYield
With ethanol
aniline
62-53-3

aniline

cyanogen chloride
506-77-4

cyanogen chloride

diphenylguanidine
102-06-7

diphenylguanidine

aniline hydrochloride
142-04-1

aniline hydrochloride

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
at 190 - 200℃;
aniline benzenesulfonate
4484-20-2

aniline benzenesulfonate

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
at 200℃;
N-hydroxybenzenecarboximidamide
613-92-3

N-hydroxybenzenecarboximidamide

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With pyridine; benzenesulfonyl chloride; benzene Erwaermen des Reaktionsgemisches mit Anilin;
aniline hydrochloride
142-04-1

aniline hydrochloride

1-phenylbiguanide
102-02-3

1-phenylbiguanide

A

diphenylguanidine
102-06-7

diphenylguanidine

B

guanidine nitrate
113-00-8

guanidine nitrate

C

1-phenylguanidine
2002-16-6

1-phenylguanidine

Conditions
ConditionsYield
das Hydrochlorid reagiert;
aniline hydrochloride
142-04-1

aniline hydrochloride

1-phenylcyanamide
622-34-4

1-phenylcyanamide

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With ethanol
dipropyldithiophosphoric acid N,N'-diphenylguanidinium salt
135672-76-3

dipropyldithiophosphoric acid N,N'-diphenylguanidinium salt

A

dithiophosphoric acid O,O',S-tripropyl ester
18944-65-5

dithiophosphoric acid O,O',S-tripropyl ester

B

diphenylguanidine
102-06-7

diphenylguanidine

C

Dithiophosphoric acid O-propyl ester
135672-88-7

Dithiophosphoric acid O-propyl ester

D

O.O-Dipropyl-dithyophosphat
2253-43-2

O.O-Dipropyl-dithyophosphat

Conditions
ConditionsYield
at 143℃; for 0.5h;
N-Phenylaminoiminomethanesulfonic acid
25343-52-6

N-Phenylaminoiminomethanesulfonic acid

aniline
62-53-3

aniline

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
In acetonitrile at 35℃; for 0.25h; Yield given;
aniline
62-53-3

aniline

monophenylthiourea
103-85-5

monophenylthiourea

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; chlorotriisopropylsilane; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid 1.) THF; 3.) CH2Cl2; Yield given. Multistep reaction;
monophenylthiourea
103-85-5

monophenylthiourea

p-amino-phenylmercury chloride

p-amino-phenylmercury chloride

diphenylguanidine
102-06-7

diphenylguanidine

2-ethylisothiourea hydrobromide
1071-37-0

2-ethylisothiourea hydrobromide

aniline
62-53-3

aniline

A

diphenylguanidine
102-06-7

diphenylguanidine

B

phenylguanidine, guanidine

phenylguanidine, guanidine

Conditions
ConditionsYield
With water at 100℃;
With pyridine at 100℃;
S-(4-dimethylamino-phenyl)-N,N'-diphenyl-isothiourea
854695-59-3

S-(4-dimethylamino-phenyl)-N,N'-diphenyl-isothiourea

ammonia
7664-41-7

ammonia

A

N,N-dimethyl-4-aminothiophenol
4946-22-9

N,N-dimethyl-4-aminothiophenol

B

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
at 120℃;
N,N''-diphenyl-μ-disulfido-dicarboxamidine; dihydrobromide
14779-12-5

N,N''-diphenyl-μ-disulfido-dicarboxamidine; dihydrobromide

aqueous methanol.NaOH

aqueous methanol.NaOH

A

diphenylguanidine
102-06-7

diphenylguanidine

B

1-phenylcyanamide
622-34-4

1-phenylcyanamide

C

monophenylthiourea
103-85-5

monophenylthiourea

D

sulfur

sulfur

monophenylthiourea
103-85-5

monophenylthiourea

alcoholic iodine

alcoholic iodine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / NaCl, Na2MoO4*2H2O, 30percent H2O2 / H2O
2: acetonitrile / 0.25 h / 35 °C
View Scheme
diphenylguanidine
20277-92-3

diphenylguanidine

diphenylguanidine
102-06-7

diphenylguanidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: alcohol; lead oxide; ammonia
View Scheme
diphenylguanidine
102-06-7

diphenylguanidine

2-(vinyloxy)ethyl isothiocyanate
59565-09-2

2-(vinyloxy)ethyl isothiocyanate

C18H20N4OS

C18H20N4OS

Conditions
ConditionsYield
at 60℃; for 0.5h;100%
diphenylguanidine
102-06-7

diphenylguanidine

O.O-Dipropyl-dithyophosphat
2253-43-2

O.O-Dipropyl-dithyophosphat

dipropyldithiophosphoric acid N,N'-diphenylguanidinium salt
135672-76-3

dipropyldithiophosphoric acid N,N'-diphenylguanidinium salt

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;98%
diphenylguanidine
102-06-7

diphenylguanidine

3-phenyl-isothiazole-4,5-dicarboxylic acid dimethyl ester
27545-53-5

3-phenyl-isothiazole-4,5-dicarboxylic acid dimethyl ester

methyl 5-<(NN'-diphenylamidino)carbamoyl>-3-phenylisothiazole-4-carboxylate
76240-12-5

methyl 5-<(NN'-diphenylamidino)carbamoyl>-3-phenylisothiazole-4-carboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 6h; Heating;97%
formaldehyd
50-00-0

formaldehyd

diphenylguanidine
102-06-7

diphenylguanidine

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With platinum(II) acetylacetonate; 1-carboxyethyl-3-methylimidazolium hydrogen bisulfate; zinc diacetate; copper(II) bis(trifluoromethanesulfonate) at 50℃; for 8h; Reagent/catalyst;96.8%
O,O'-diisobutyldithiophosphoric acid
2253-52-3

O,O'-diisobutyldithiophosphoric acid

diphenylguanidine
102-06-7

diphenylguanidine

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-diisobutyl ester
135672-79-6

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-diisobutyl ester

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;96%
diphenylguanidine
102-06-7

diphenylguanidine

dithiophosphoric acid O,O'-di-m-tolyl ester
7595-89-3

dithiophosphoric acid O,O'-di-m-tolyl ester

Dithiophosphoric acid O,O'-di-m-tolyl ester; compound with N,N'-diphenyl-guanidine
135672-85-4

Dithiophosphoric acid O,O'-di-m-tolyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;96%
diphenylguanidine
102-06-7

diphenylguanidine

O,O-dimethyl phosphorodithioic acid
756-80-9

O,O-dimethyl phosphorodithioic acid

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-dimethyl ester
135672-74-1

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-dimethyl ester

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature; other diorganyldithiophosphoric acids;96%
In chloroform for 0.25h; Ambient temperature;96%
diphenylguanidine
102-06-7

diphenylguanidine

O,O-diisopropyl hydrogen phosphorodithioate
107-56-2

O,O-diisopropyl hydrogen phosphorodithioate

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-diisopropyl ester
135672-77-4

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-diisopropyl ester

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;96%
diphenylguanidine
102-06-7

diphenylguanidine

O,O-Diethyl hydrogen phosphorodithioate
298-06-6

O,O-Diethyl hydrogen phosphorodithioate

diethyldithiophosphoric acid N,N'-diphenylguanidinium salt
135672-75-2

diethyldithiophosphoric acid N,N'-diphenylguanidinium salt

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;94%
diphenylguanidine
102-06-7

diphenylguanidine

2-(4-chloro-phenylsulfonyl)acetic acid
3405-89-8

2-(4-chloro-phenylsulfonyl)acetic acid

C13H13N3*C8H7ClO4S

C13H13N3*C8H7ClO4S

Conditions
ConditionsYield
In methanol94%
O,O-diphenyl phosphorodithioic acid
2253-60-3

O,O-diphenyl phosphorodithioic acid

diphenylguanidine
102-06-7

diphenylguanidine

Dithiophosphoric acid O,O'-diphenyl ester; compound with N,N'-diphenyl-guanidine
135672-83-2

Dithiophosphoric acid O,O'-diphenyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;93%
diphenylguanidine
102-06-7

diphenylguanidine

3-methyl-4-nitroisoxazol-5(4H)-one
112330-33-3

3-methyl-4-nitroisoxazol-5(4H)-one

1,3-diphenylguanidinium 5-oxo-3-phenyl-4,5-dihydroisoxazole-4-nitronate

1,3-diphenylguanidinium 5-oxo-3-phenyl-4,5-dihydroisoxazole-4-nitronate

Conditions
ConditionsYield
In water93%
diphenylguanidine
102-06-7

diphenylguanidine

p-benzoquinone
106-51-4

p-benzoquinone

1-phenyl-2-(phenylamino)-1H-benzo[d]imidazol-6-ol
1550369-57-7

1-phenyl-2-(phenylamino)-1H-benzo[d]imidazol-6-ol

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 16h; regioselective reaction;93%
diphenylguanidine
102-06-7

diphenylguanidine

di-n-octyl dithiophosphate
2253-57-8

di-n-octyl dithiophosphate

Dithiophosphoric acid O,O'-dioctyl ester; compound with N,N'-diphenyl-guanidine
56867-55-1

Dithiophosphoric acid O,O'-dioctyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;92%
diphenylguanidine
102-06-7

diphenylguanidine

MCPA
94-74-6

MCPA

C13H13N3*C9H9ClO3

C13H13N3*C9H9ClO3

Conditions
ConditionsYield
In methanol92%
dithiophosphoric acid O,O'-dihexyl ester
78-64-8

dithiophosphoric acid O,O'-dihexyl ester

diphenylguanidine
102-06-7

diphenylguanidine

Dithiophosphoric acid O,O'-dihexyl ester; compound with N,N'-diphenyl-guanidine
135672-84-3

Dithiophosphoric acid O,O'-dihexyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;91%
methacryloyl isocyanate
4474-60-6

methacryloyl isocyanate

diphenylguanidine
102-06-7

diphenylguanidine

1,2-diphenyl-3-methacryloylcarbamoylguanidine

1,2-diphenyl-3-methacryloylcarbamoylguanidine

Conditions
ConditionsYield
91%
diphenylguanidine
102-06-7

diphenylguanidine

O,O-di-p-tolyl hydrogen phosphorodithioate
14366-43-9

O,O-di-p-tolyl hydrogen phosphorodithioate

Dithiophosphoric acid O,O'-di-p-tolyl ester; compound with N,N'-diphenyl-guanidine
135672-86-5

Dithiophosphoric acid O,O'-di-p-tolyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;91%
diphenylguanidine
102-06-7

diphenylguanidine

C12H23O2PS2
6028-46-2

C12H23O2PS2

Dithiophosphoric acid O,O'-dicyclohexyl ester; compound with N,N'-diphenyl-guanidine
135700-26-4

Dithiophosphoric acid O,O'-dicyclohexyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;90%
diphenylguanidine
102-06-7

diphenylguanidine

methyl 3-benzoyl-1-(4-methoxyphenyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate
113416-39-0

methyl 3-benzoyl-1-(4-methoxyphenyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate

9-benzoyl-8-hydroxy-2-imino-6-(4-methoxyphenyl)-1,3-diphenyl-1,3,6-triazaspiro[4.4]non-8-ene-4,7-dione
1309922-94-8

9-benzoyl-8-hydroxy-2-imino-6-(4-methoxyphenyl)-1,3-diphenyl-1,3,6-triazaspiro[4.4]non-8-ene-4,7-dione

Conditions
ConditionsYield
In 1,2-dichloro-ethane for 1h; Reflux;89%
diphenylguanidine
102-06-7

diphenylguanidine

diethyl 2-methylpyrimidine-4,5-dicarboxylate
1860-98-6

diethyl 2-methylpyrimidine-4,5-dicarboxylate

ethyl 4-oxo-7-methyl-1-phenyl-2-(phenylimino)-1,3,6,8-tetraazaspiro<4.5>deca-6,9-diene-10-carboxylate
76240-18-1

ethyl 4-oxo-7-methyl-1-phenyl-2-(phenylimino)-1,3,6,8-tetraazaspiro<4.5>deca-6,9-diene-10-carboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Ambient temperature;88.5%
dithiophosphoric acid O,O'-bis-decyl ester
2253-59-0

dithiophosphoric acid O,O'-bis-decyl ester

diphenylguanidine
102-06-7

diphenylguanidine

Dithiophosphoric acid O,O'-didecyl ester; compound with N,N'-diphenyl-guanidine
135672-87-6

Dithiophosphoric acid O,O'-didecyl ester; compound with N,N'-diphenyl-guanidine

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;88%
diphenylguanidine
102-06-7

diphenylguanidine

ethyl 5-methylisoxazole-3-carboxylate
3209-72-1

ethyl 5-methylisoxazole-3-carboxylate

3-<(N1,N2-diphenylamidino)carbamoyl>-5-methylisoxazole
103912-60-3

3-<(N1,N2-diphenylamidino)carbamoyl>-5-methylisoxazole

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 24h; Ambient temperature;88%
O,O-diisoamylphosphorodithioic acid
32650-55-8

O,O-diisoamylphosphorodithioic acid

diphenylguanidine
102-06-7

diphenylguanidine

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-bis-(3-methyl-butyl) ester
135672-82-1

N,N'-Diphenyl-guanidine; compound with dithiophosphoric acid O,O'-bis-(3-methyl-butyl) ester

Conditions
ConditionsYield
In chloroform for 0.25h; Ambient temperature;85%
formaldehyd
50-00-0

formaldehyd

diphenylguanidine
102-06-7

diphenylguanidine

3,5,9,11,15,17,21,23-octaphenyl-1,7,13,19-tetrathia-3,5,9,11,15,17,21,23-octaazacyclotetracosane-4,10,16,22-tetraimine
1293386-46-5

3,5,9,11,15,17,21,23-octaphenyl-1,7,13,19-tetrathia-3,5,9,11,15,17,21,23-octaazacyclotetracosane-4,10,16,22-tetraimine

Conditions
ConditionsYield
With hydrogen sulfide; sodium butanolate In water; butan-1-ol at 40℃; for 4h;85%
diphenylguanidine
102-06-7

diphenylguanidine

1-chloroacetophenone
532-27-4

1-chloroacetophenone

N,1,5-triphenyl-1H-imidazol-2-amine

N,1,5-triphenyl-1H-imidazol-2-amine

Conditions
ConditionsYield
With choline chloride; triethylamine; glycerol at 80℃; Reagent/catalyst; Green chemistry;85%
diphenylguanidine
102-06-7

diphenylguanidine

1,2-dibromobenzene
583-53-9

1,2-dibromobenzene

1-phenyl-2-phenylamino-1H-benzo[d]imidazole
31413-80-6

1-phenyl-2-phenylamino-1H-benzo[d]imidazole

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 140℃; for 24h; Molecular sieve; Inert atmosphere; regiospecific reaction;84%
(S)-1-isopropyl-pyrrolidine-2-carboxylic acid
342793-00-4

(S)-1-isopropyl-pyrrolidine-2-carboxylic acid

diphenylguanidine
102-06-7

diphenylguanidine

(S)-N-(N,N'-diphenylcarbamimidoyl)-1-isopropylpyrrolidine-2-carboxamide

(S)-N-(N,N'-diphenylcarbamimidoyl)-1-isopropylpyrrolidine-2-carboxamide

Conditions
ConditionsYield
Stage #1: (S)-1-isopropyl-pyrrolidine-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 5h;
Stage #2: diphenylguanidine In N,N-dimethyl-formamide at 0 - 20℃; for 16h;
84%

1,3-Diphenylguanidine Chemical Properties

Molecular Structure of 1,3-Diphenylguanidine (CAS NO.102-06-7):

IUPAC Name: 1,2-diphenylguanidine 
Empirical Formula: C13H13N3
Molecular Weight: 211.2624
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 2
Polar Surface Area: 18.84Å2
Index of Refraction: 1.604
Molar Refractivity: 65.14 cm3
Molar Volume: 189.2 cm3
Surface Tension: 46.8 dyne/cm
Density: 1.11 g/cm3
Flash Point: 158.5 °C
Enthalpy of Vaporization: 58.18 kJ/mol
Boiling Point: 338.5 °C at 760 mmHg
Vapour Pressure: 9.81E-05 mmHg at 25°C
Melting point: 146-148 °C(lit.)
Water Solubility: slightly soluble
Merck: 14,3324
BRN: 1875653
InChI
InChI=1/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
Smiles
c1(NC(Nc2ccccc2)=N)ccccc1
EINECS: 203-002-1
Stability: Stable. Combustible. Incompatible with strong oxidizing agents. Moisture sensitive
Product Categories: Industrial/Fine Chemicals; Organics; DIO - DIZCertified Reference Materials (CRMs);Alphabetic; Application CRMs; Titrimetry; Guanidines; Nitrogen Compounds; Organic Building Blocks

1,3-Diphenylguanidine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TETANY
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 143, Pg. 815, 1949.
guinea pig LD50 oral 250mg/kg (250mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 974, 1986.
guinea pig LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TETANY
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 143, Pg. 815, 1949.
mammal (species unspecified) LDLo oral 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 150mg/kg (150mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
mouse LD50 unreported 258mg/kg (258mg/kg) BLOOD: NORMOCYTIC ANEMIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.
rabbit LD50 oral 250mg/kg (250mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 974, 1986.
rabbit LD50 skin > 794mg/kg (794mg/kg)   National Toxicology Program Technical Report Series. Vol. NIH-95-3933,
rabbit LD50 unreported 246mg/kg (246mg/kg) BLOOD: NORMOCYTIC ANEMIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.
rat LD50 intraperitoneal 75mg/kg (75mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 16, Pg. 35, 1965.
rat LD50 oral 323mg/kg (323mg/kg)   National Toxicology Program Technical Report Series. Vol. NIH-95-3933,
rat LD50 unreported 323mg/kg (323mg/kg) BLOOD: NORMOCYTIC ANEMIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.

1,3-Diphenylguanidine Consensus Reports

Reported in EPA TSCA Inventory.

1,3-Diphenylguanidine Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: HarmfulXn,DangerousN
Risk Statements : 
R22:Harmful if swallowed.;
R36/37/38:Irritating to eyes, respiratory system and skin.;
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.;
R62:Possible risk of impaired fertility.;
Safety Statements : 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.;
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.;
S61:Avoid release to the environment. Refer to special instructions / Safety data sheets.;
RIDADR: UN 3077 9/PG 3

1,3-Diphenylguanidine Specification

 1,3-Diphenylguanidine , with CAS number of 102-06-7, can be called 1,3-Diphenylguanidine ; Dwufenyloguanidyna ; Diphenylguanidine ; DPG accelerator ; Guanidine, N,N'-diphenyl- ; Guanidine, 1,3-diphenyl- ; N,N'-Diphenylguanidine ; s-Diphenylguanidine ; Vulkazit . It is a white to cream-colored chalky powder. Bitter taste and slight odor. 1,3-Diphenylguanidine (CAS NO.102-06-7) behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Besides 1,3-Diphenylguanidine (CAS NO.102-06-7) is incompatible with strong oxidizers.

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