1,4-Cyclohexanedimethanol supplier

Name
1,4-Cyclohexanedimethanol
EINECS 203-268-9
CAS No. 105-08-8
Article Data52
CAS DataBase
Density 1.004 g/cm³
Solubility soluble in water
Melting Point 31.5 °C
Formula C₈H₁₆O₂
Boiling Point 286.2 °C at 760 mmHg
Molecular Weight 144.214
Flash Point 161.1 °C
Transport Information
Appearance clear colourless viscous liquid
Safety 22-24/25-39-26
Risk Codes 36
Molecular Structure
Hazard Symbols R36:;
Synonyms 1,4-Bis(hydroxymethyl)cyclohexane;1,4-Cyclohexamethylenebis methylol;1,4-Dimethylolcyclohexane;CHDM;CHDM-D;Cyclohex-1,4-ylenedimethanol;NSC 44508;Rikabinol DM;Sky CHDM;Vibracure A240;1,4-Cyclohexane dimethanol;
PSA 40.46000
LogP 0.77740

Synthetic route

: 619-81-8, 619-82-9, 1076-97-7
cyclohexane-1,4-dicarboxylic acid

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With tin; hydrogen at 220℃; under 90009 Torr; for 0.75h; Temperature; Pressure;	100%
With hydrogen In water at 230℃; under 15001.5 - 75007.5 Torr; Catalytic behavior; Reagent/catalyst; Autoclave;	98.3%
With hydrogen In water at 230℃; under 63756.4 Torr; for 3h; Reagent/catalyst; Autoclave;	95.8%

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen In methanol at 200 - 240℃; under 30003 - 60006 Torr; for 8h;	92%
With Cat.7; hydrogen at 180 - 250℃; under 52505.3 - 67506.8 Torr; Reagent/catalyst; Temperature; Pressure;

: 589-29-7
p-xylylene glycol

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With Ru/Al2O3; hydrogen In tetrahydrofuran at 60℃; under 7.50075 Torr; for 3.5h; Pressure; Autoclave;	92%

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
Stage #1: Bis(2-Hydroxyethyl)terephthalat With tin(II) chloride dihdyrate; ruthenium(III) chloride trihydrate; alumina; Cl6H6Pt(2-)2H(1+)6H2O; hydrogen In water at 180 - 260℃; under 37503.8 Torr; for 10h; Autoclave; Stage #2: With sodium tetrahydroborate; sodium hydroxide at 500℃; for 5.5h; pH=9; Reagent/catalyst; Concentration; Temperature;	87.1%

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With C33H29FeMnN2O3P(1+)*Br(1-); potassium tert-butylate; hydrogen In isopropyl alcohol at 75℃; under 37503.8 Torr; Autoclave;	86%
Stage #1: dimethyl 1,4-cyclohexane dicarboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: With water In tetrahydrofuran
With hydrogen In methanol at 220℃; under 45004.5 Torr; Catalytic behavior; Time; Temperature; Green chemistry;

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

A: 94-08-6
4-methylbenzoic acid ethyl ester

B: 106-42-3
para-xylene

C: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen at 170 - 260℃; under 37503.8 Torr; for 8h; Autoclave;	A n/a B n/a C 78.4%

...Expand

: bis(2-hydroxyethyl) cyclohexane-1,4-dicarboxylate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen In neat (no solvent) at 269.84℃; under 78757.9 Torr; for 10h; Reagent/catalyst; Pressure; Temperature; Autoclave;	78%

: ethyl 4-formylcyclohex-3-enecarboxylate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen In water at 160℃; under 45004.5 Torr; for 12h; Reagent/catalyst;	56%

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

A: 94-08-6
4-methylbenzoic acid ethyl ester

B: 106-42-3
para-xylene

C: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

D: C10H18O3

E: C10H18O4

Conditions

Conditions	Yield
With hydrogen at 230℃; under 37503.8 Torr; for 8h; Autoclave;	A n/a B n/a C 47.2% D n/a E n/a

...Expand

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

A: 94-08-6
4-methylbenzoic acid ethyl ester

B: 106-42-3
para-xylene

C: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

D: 34885-03-5
(4-methylcyclohexyl)methanol

E: 589-90-2
1,4 dimethylcyclohexane

Conditions

Conditions	Yield
With hydrogen at 260℃; under 37503.8 Torr; for 8h; Autoclave;	A n/a B n/a C 28.5% D n/a E n/a

...Expand

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

A: 94-08-6
4-methylbenzoic acid ethyl ester

B: 106-42-3
para-xylene

C: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

D: C10H18O4

E: 34885-03-5
(4-methylcyclohexyl)methanol

F: 589-90-2
1,4 dimethylcyclohexane

Conditions

Conditions	Yield
With hydrogen at 170 - 260℃; under 37503.8 Torr; for 8h; Autoclave;	A n/a B n/a C 14.7% D n/a E n/a F n/a

...Expand

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

A: 94-08-6
4-methylbenzoic acid ethyl ester

B: 106-42-3
para-xylene

C: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

D: C10H18O4

Conditions

Conditions	Yield
With hydrogen at 170 - 260℃; under 37503.8 Torr; for 8h; Autoclave;	A n/a B n/a C 5.3% D n/a

...Expand

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

A: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

C: 62172-89-8
4-methyloxymethylhydroxymethylhydroxymethylcyclohexane

D: bis(4-hydroxymethylcyclohexyl) ether

Conditions

Conditions	Yield
With hydrogen; Pt1Ru5; silica gel In ethanol at 99.85℃; under 15001.2 Torr; for 8h; Product distribution; Further Variations:; Catalysts; reaction times;

...Expand

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

A: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen; Ru5PtSn; silica gel In ethanol at 99.85℃; under 15001.2 Torr; for 24h;

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

A: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

C: 51181-40-9
methyl 4-methyl-1-cyclohexanecarboxylate

D: 34885-03-5
(4-methylcyclohexyl)methanol

Conditions

Conditions	Yield
With hydrogen; Ru5PtSn; silica gel In ethanol at 119.85℃; under 30002.4 Torr; for 8h; Further byproducts given;
With hydrogen; Ru5PtSn; silica gel In ethanol at 119.85℃; under 15001.2 Torr; for 24h; Further byproducts given;

...Expand

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

A: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

C: 98955-27-2
[4-(methoxymethyl)cyclohexyl]methanol

D: bis(4-hydroxymethylcyclohexyl) ether

Conditions

Conditions	Yield
With hydrogen; Ru5PtSn; silica gel In ethanol at 99.85℃; under 15001.2 Torr; for 24h; Product distribution; Further Variations:; Catalysts; Temperatures; Pressures;
With hydrogen; Pt1Ru5; silica gel In ethanol at 99.85℃; under 15001.2 Torr; for 24h;

...Expand

: 100-21-0
terephthalic acid

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 6 h / 260 - 280 °C / 4535.33 Torr 2: dimethyl 1,4-cyclohexane dicarboxylate; Pd/Al2O3; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: (4-methylcyclohexyl)methanol; hydrogen / 5 h / 250 °C / 212036 Torr View Scheme
Stage #1: terephthalic acid With palladium on activated charcoal; hydrogen In water at 230℃; under 60006 Torr; Stage #2: at 230℃; Pressure; Temperature; Reagent/catalyst;	100 %Chromat.
With hydrogen In water at 20 - 230℃; under 60006 Torr; Catalytic behavior; Reagent/catalyst; Inert atmosphere;

: 95623-88-4
terephthalic acid 1,4-bis(4-methylcyclohexyl)methyl ester

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethyl 1,4-cyclohexane dicarboxylate; Pd/Al2O3; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 2: (4-methylcyclohexyl)methanol; hydrogen / 5 h / 250 °C / 212036 Torr View Scheme
With hydrogen at 150℃; under 22502.3 Torr; Temperature; Pressure;

: 1420954-46-6
bis((4-methylcyclohexyl)methyl) cyclohexane-1,4-dicarboxylate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With (4-methylcyclohexyl)methanol; hydrogen at 250℃; under 212036 Torr; for 5h;

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 13380-85-3
4-hydroxymethylcyclohexanecarboxylic acid methyl ester

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

Conditions

Conditions	Yield
With hydrogen In methanol at 220℃; under 45004.5 Torr; Green chemistry;
With hydrogen In methanol at 219.84℃; under 37503.8 Torr; Reagent/catalyst; chemoselective reaction;
With hydrogen In isopropyl alcohol at 220℃; under 75007.5 Torr; for 10h; Reagent/catalyst; Autoclave;

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 13380-85-3
4-hydroxymethylcyclohexanecarboxylic acid methyl ester

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

C: 34885-03-5
(4-methylcyclohexyl)methanol

D: 92385-32-5
4-(hydroxymethyl)-1-cyclohexanecarboxaldehyde

Conditions

Conditions	Yield
With hydrogen at 220℃; under 45004.5 Torr; Catalytic behavior; Reagent/catalyst; Time; Overall yield = 98.7 %;

...Expand

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

B: 34885-03-5
(4-methylcyclohexyl)methanol

C: 92385-32-5
4-(hydroxymethyl)-1-cyclohexanecarboxaldehyde

Conditions

Conditions	Yield
With hydrogen at 220℃; under 45004.5 Torr; Catalytic behavior; Reagent/catalyst; Time; Overall yield = 67.4 %;

...Expand

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

B: 33424-83-8
1,4-cyclohexanedicarboxaldehyde

Conditions

Conditions	Yield
With hydrogen at 180℃; under 30003 Torr; Temperature; Pressure; Concentration;

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 13380-85-3
4-hydroxymethylcyclohexanecarboxylic acid methyl ester

B: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

C: 34885-03-5
(4-methylcyclohexyl)methanol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol at 220℃; under 75007.5 Torr; for 10h; Reagent/catalyst; Pressure; Autoclave;

...Expand

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

A: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

B: 34885-03-5
(4-methylcyclohexyl)methanol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol at 220℃; under 75007.5 Torr; for 10h; Reagent/catalyst; Pressure; Autoclave;

: 61-90-5
L-leucine

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 893447-84-2
L,L-leucine 1,4-cyclohexanedimethanol diester

Conditions

Conditions	Yield
Stage #1: L-leucine; bis-1,4-(hydroxymethyl)cyclohexane With toluene-4-sulfonic acid In toluene at 150℃; for 30h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In water; toluene at 60℃;	100%

: 61-90-5
L-leucine

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 893447-84-2
L,L-leucine 1,4-cyclohexanedimethanol diester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 20 - 150℃; for 30h; Heating / reflux;	100%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 108-24-7
acetic anhydride

: 6308-18-5
1,4-cyclohexanedimethylene diacetate

Conditions

Conditions	Yield
With pyridine at 125℃; for 3.5h; Reagent/catalyst; Large scale;	99%
With pyridine at 125℃; for 3.5h; Large scale;	99%

: 5453-80-5, 19926-90-0
5-Norbornene-2-carboxaldehyde

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 5-norbornene-2-(4-hydroxymethyl)cyklohexylmethoxymethanol

Conditions

Conditions	Yield
sodium hydride at 20℃; for 10h;	93%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 59274-95-2
7-oxa-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde

: oxabicyclo[2.2.1]-hept-5-ene-2-(4-hydroxymethyl)cyclohexylmethoxy methanol

Conditions

Conditions	Yield
sodium hydride at 20℃; for 10h;	93%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 62-53-3
aniline

: 1352050-49-7
C20H26N2

Conditions

Conditions	Yield
With Pt-Sn/γ-Al2O3 In o-xylene at 145℃; for 24h; Inert atmosphere;	93%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 824-93-1
cyclohexane-1,4-dimethyl chloride

Conditions

Conditions	Yield
With pyridine; thionyl chloride Chlorination; Heating;	92%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 1885-14-9
phenyl chloroformate

: 22563-70-8
1,4-cyclohexanedimethanol diphenyl dicarbonate

Conditions

Conditions	Yield
With pyridine; dmap In tetrahydrofuran at 0 - 20℃;	90.2%

: 30674-80-7
2-Isocyanatoethyl methacrylate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: C15H25NO5

Conditions

Conditions	Yield
With dibutyltin dilaurate In toluene for 5h;	90.1%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 75-36-5
acetyl chloride

: 6308-18-5
1,4-cyclohexanedimethylene diacetate

Conditions

Conditions	Yield
With pyridine; dmap In chloroform at 0 - 20℃;	87%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 60631-76-7
(R)-1-C-(1-Cyclohexen-5-yl)carbaldehyde

: 100-49-2
cyclohexylmethyl alcohol

acetal oligomer: acetal oligomer

Conditions

Conditions	Yield
With N,N-dimethyl acetamide; toluene-4-sulfonic acid at 140℃; for 20h;	85%

...Expand

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 476371-27-4
1,4-cyclohexanedimethanol bis(diphenyl phosphate)

Conditions

Conditions	Yield
With magnesium chloride In methanol; hexane	82.2%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 1033761-69-1
C17H20O5

: C42H52O10

Conditions

Conditions	Yield
With dmap; 2,6-di-tert-butyl-4-methyl-phenol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;	81%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 10534-13-1
cyclohexane-1,4-dicarbonitrile

Conditions

Conditions	Yield
With 1,10-Phenanthroline; ammonia; oxygen In 1,4-dioxane at 30 - 60℃; under 3750.38 Torr; for 12h; Pressure; Temperature; Reagent/catalyst; Solvent;	80.5%

: 108-31-6
maleic anhydride

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 551929-43-2
(Z)-2-butenedioic-acid-1,4-cyclohexanediylbis(methylene) ester

Conditions

Conditions	Yield
In acetonitrile at 50℃; for 72h;	80%
In acetonitrile at 50℃; for 72h;	80%

: 13380-84-2
4-(hydroxymethyl)cyclohexane-1-carboxylic acid

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: [4-(hydroxymethyl)cyclohexyl]methyl 4-(hydroxymethyl)cyclohexane-1-carboxylate

Conditions

Conditions	Yield
Stage #1: bis-1,4-(hydroxymethyl)cyclohexane With dmap; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: 4-(hydroxymethyl)cyclohexane-1-carboxylic acid In dimethyl sulfoxide at 20℃; for 5h;	80%
Stage #1: bis-1,4-(hydroxymethyl)cyclohexane With dmap; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: 4-(hydroxymethyl)cyclohexane-1-carboxylic acid In dimethyl sulfoxide at 20℃; for 5h;	80%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 2-(diphenylmethoxy)-pyridine

: (4-(benzhydryloxymethyl)cyclohexyl)methanol

Conditions

Conditions	Yield
With iron(III) chloride In 1,2-dichloro-ethane at 70℃; for 10h;	78%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 1187856-44-5
(4-chlorophenyl)(phenyl)carbamic chloride

: (4-(hydroxymethyl)cyclohexyl)methyl (4-chlorophenyl)(phenyl)carbamate

Conditions

Conditions	Yield
With pyridine at 120℃; for 18h;	78%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 110844-29-6
1,5-dioxa-3,3-bis(ethoxycarbonyl)-8,8,10,10-tetramethyl-9-azaspiro<5.5>undecane

: 110839-53-7
8,8,10,10-Tetramethyl-1,5-dioxa-9-azaspiro-[5.5]undecane-3,3-dicarboxylic acid

Conditions

Conditions	Yield
In dichloromethane; acetic acid	77%

: 108-22-5
Isopropenyl acetate

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

A: 6308-18-5
1,4-cyclohexanedimethylene diacetate

B: diisopropenyl 1,4-cyclohexanedimethanol ether

C: C13H22O3

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate In toluene at 100℃; for 6h;	A n/a B 75% C n/a

...Expand

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With Ni/NiO-diatomite at 200℃; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere;	72.6%
Multi-step reaction with 2 steps 1: 52.1 percent / 140 - 165 °C 2: 46.3 percent / aq. NaOH / 10 h / Heating View Scheme

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 98-59-9
p-toluenesulfonyl chloride

: 109004-13-9
[4-(p-toluenesulfonyloxymethyl)cyclohexyl]methanol

Conditions

Conditions	Yield
With pyridine; dmap; triethylamine In dichloromethane at 20℃; for 3h;	72%
In pyridine at 20℃; for 36h;	61%
With pyridine In dichloromethane	186 g

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 89607-68-1
ethyl 3-diazoindole-2-carboxylate

: 3-(4-hydroxymethyl-cyclohexylmethoxy)-3H-indole-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
dirhodium tetraacetate In dichloromethane at 85℃; for 3h; Substitution; O-H insertation;	72%

1,4-Cyclohexanedimethanol Consensus Reports

1,4-BIS(HYDROXYMETHYL)CYCLOHEXANE is reported in EPA TSCA Inventory.

1,4-Cyclohexanedimethanol Specification

The 1,4-Bis(hydroxymethyl)cyclohexane is an organic compound with the formula C₈H₁₆O₂. The IUPAC name of this chemical is [4-(hydroxymethyl)cyclohexyl]methanol. With the CAS registry number 105-08-8, it is also named as Cyclohexan-1,4-diyldimethanol. The product's category is Alkohols. Besides, it is clear colourless viscous liquid, which should be stored in a cool and well-ventilated place. It is used in the manufacture of polyester fiber, polyester electrical appliances, unsaturated polyester resin, polyester glaze, polyurethane foam.

Physical properties about 1,4-Bis(hydroxymethyl)cyclohexane are: (1)ACD/LogP: 0.36; (2)ACD/LogD (pH 5.5): 0.36; (3)ACD/LogD (pH 7.4): 0.36; (4)ACD/BCF (pH 5.5): 1.1; (5)ACD/BCF (pH 7.4): 1.1; (6)ACD/KOC (pH 5.5): 37.33; (7)ACD/KOC (pH 7.4): 37.33; (8)#H bond acceptors: 2; (9)H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 18.46 Å²; (12)Index of Refraction: 1.47; (13)Molar Refractivity: 40.12 cm³; (14)Molar Volume: 143.5 cm³; (15)Polarizability: 15.9×10^-24cm³; (16)Surface Tension: 40.5 dyne/cm; (17)Density: 1.004 g/cm³; (18)Flash Point: 161.1 °C; (19)Enthalpy of Vaporization: 60.96 kJ/mol; (20)Boiling Point: 286.2 °C at 760 mmHg; (21)Vapour Pressure: 0.000303 mmHg at 25°C.

Preparation: this chemical can be prepared by trans-1,4-bis-acetoxymethyl-cyclohexane. This reaction will need reagent methanolic potassium carbonate at ambient temperature. The yield is about 100%.

Uses of 1,4-Bis(hydroxymethyl)cyclohexane: it can be used to produce trans-1,4-Bis(chloromethyl)-cyclohexane. It will need reagent CCl₄, Ph₃P. The yield is about 64%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes. When you are using it, wear suitable protective clothing, do not breathe dust and avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: OCC1CCC(CO)CC1
(2)InChI: InChI=1/C8H16O2/c9-5-7-1-2-8(6-10)4-3-7/h7-10H,1-6H2
(3)InChIKey: YIMQCDZDWXUDCA-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C8H16O2/c9-5-7-1-2-8(6-10)4-3-7/h7-10H,1-6H2
(5)Std. InChIKey: YIMQCDZDWXUDCA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	oral	1600mg/kg (1600mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
mouse	LDLo	intraperitoneal	1600mg/kg (1600mg/kg)	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 194, 1969.
rat	LD50	oral	3200mg/kg (3200mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
rat	LDLo	intraperitoneal	800mg/kg (800mg/kg)	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 194, 1969.

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1,4-Cyclohexanedimethanol

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